Karen H Ashe

1984 …2023
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Research Output 1984 2019

2019
Open Access
Staphylococcal Protein A
Artifacts
Brain
Western Blotting
Antibodies

A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease

Smith, B., Nelson, K. M., Kemper, L. J., Leinonen-Wright, K., Petersen, A., Keene, C. D. & Ashe, K. H., Jul 30 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Caspase 2
Lewy Body Disease
Dementia
Lewy Bodies
Parkinson Disease

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients

Liu, P., Smith, B., Huang, E. S., Mahesh, A., Vonsattel, J. P. G., Petersen, A. J., Gomez-Pastor, R. & Ashe, K. H., Jul 30 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Caspase 2
Huntington Disease
Brain Diseases
Neurodegenerative Diseases
Trinucleotide Repeat Expansion

Factors other than hTau overexpression that contribute to tauopathy-like phenotype in rTg4510 mice

Gamache, J., Benzow, K., Forster, C., Kemper, L., Hlynialuk, C., Furrow, E., Ashe, K. H. & Koob, M. D., Dec 1 2019, In : Nature communications. 10, 1, 2479.

Research output: Contribution to journalArticle

Open Access
Tauopathies
phenotype
Trans-Activators
Tetracycline
Transgenes

Human cerebrospinal fluid 6E10- immunoreactive protein species contain amyloid precursor protein fragments

Grant, M. K. O., Handoko, M., Rozga, M., Brinkmalm, G., Portelius, E., Blennow, K., Ashe, K. H., Zahs, K. R. & Liu, P., Feb 1 2019, In : PloS one. 14, 2, e0212815.

Research output: Contribution to journalArticle

Open Access
Cerebrospinal fluid
Amyloid beta-Protein Precursor
cerebrospinal fluid
amyloid
Cerebrospinal Fluid

Phosphorylation in two discrete tau domains regulates a stepwise process leading to postsynaptic dysfunction

Teravskis, P. J., Oxnard, B. R., Miller, E. C., Kemper, L. J., Ashe, K. H. & Liao, D., Jan 1 2019, In : Journal of Physiology.

Research output: Contribution to journalArticle

Dendritic Spines
Phosphorylation
Cyclin-Dependent Kinase 5
Proline
Glycogen Synthase
2017
2 Citations (Scopus)

Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice

Liu, P., Reichl, J. H., Rao, E. R., McNellis, B. M., Huang, E. S., Hemmy, L. S., Forster, C. L., Kuskowski, M. A., Borchelt, D. R., Vassar, R., Ashe, K. H. & Zahs, K. R., Jan 1 2017, In : Journal of Alzheimer's Disease. 56, 2, p. 743-761 19 p.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Amyloid Plaques
Transgenic Mice
Alzheimer Disease
Amyloidosis
2016
41 Citations (Scopus)

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K. R., Ramsden, M., Cleary, J. & Ashe, K. H., Nov 1 2016, In : Nature Medicine. 22, 11, p. 1268-1276 9 p.

Research output: Contribution to journalArticle

Caspase 2
Tauopathies
Dendritic Spines
Alzheimer Disease
Data storage equipment
2015
12 Citations (Scopus)

Characterization of a novel mouse model of Alzheimer's disease - Amyloid pathology and unique β-amyloid oligomer profile

Liu, P., Paulson, J. B., Forster, C. L., Shapiro, S. L., Ashe, K. H. & Zahs, K. R., May 6 2015, In : PLoS One. 10, 5, e0126317.

Research output: Contribution to journalArticle

Pathology
amyloid
Alzheimer disease
Tetracycline
Oligomers
1 Citation (Scopus)

More than a FAD: The invivo effects of disease-linked presenilin-1 mutations

Zahs, K. R. & Ashe, K. H., Mar 4 2015, In : Neuron. 85, 5, p. 893-895 3 p.

Research output: Contribution to journalShort survey

Presenilin-1
Flavin-Adenine Dinucleotide
Presenilins
Amyloid Precursor Protein Secretases
Mutation
14 Citations (Scopus)

Morris water maze test: Optimization for mouse strain and testing environment

Weitzner, D. S., Engler-Chiurazzi, E. B., Kotilinek, L. A., Ashe, K. H. & Reed, M. N., Jun 22 2015, In : Journal of Visualized Experiments. 2015, 100, e52706.

Research output: Contribution to journalArticle

Water
Testing
Transgenes
Alzheimer Disease
Aptitude
69 Citations (Scopus)

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

Liu, P., Reed, M. N., Kotilinek, L. A., Grant, M. K. O., Forster, C. L., Qiang, W., Shapiro, S. L., Reichl, J. H., Chiang, A. C. A., Jankowsky, J. L., Wilmot, C. M., Cleary, J. P., Zahs, K. R. & Ashe, K. H., Jun 23 2015, In : Cell Reports. 11, 11, p. 1760-1771 12 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Alzheimer Disease
Poisons
Amyloid Plaques
2014
19 Citations (Scopus)

Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents

Qi, Y., Klyubin, I., Harney, S. C., Hu, N. W., Cullen, W. K., Grant, M. K., Steffen, J., Wilson, E. N., Do Carmo, S., Remy, S., Fuhrmann, M., Ashe, K. H., Cuello, A. C. & Rowan, M. J., Jan 27 2014, In : Acta Neuropathologica Communications. 2, 1, 175.

Research output: Contribution to journalArticle

Transgenic Rats
Long-Term Potentiation
Alzheimer Disease
Neuronal Plasticity
Amyloidosis
2013
234 Citations (Scopus)

Brain amyloid-β oligomers in ageing and Alzheimer's disease

Lesné, S. E., Sherman, M. A., Grant, M., Kuskowski, M., Schneider, J. A., Bennett, D. A. & Ashe, K. H., Jan 1 2013, In : Brain. 136, 5, p. 1383-1398 16 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Brain
Microtubule Proteins
tau Proteins
51 Citations (Scopus)

Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults

Handoko, M., Grant, M., Kuskowski, M. A., Zahs, K. R., Wallin, A., Blennow, K. & Ashe, K. H., Jan 1 2013, In : JAMA Neurology. 70, 5, p. 594-599 6 p.

Research output: Contribution to journalArticle

Amyloid
Cerebrospinal Fluid
Alzheimer Disease
Sampling Studies
Investigational Therapies
59 Citations (Scopus)

Prions, prionoids and pathogenic proteins in Alzheimer disease

Ashe, K. H. & Aguzzi, A., Jan 1 2013, In : Prion. 7, 1, p. 55-59 5 p.

Research output: Contribution to journalArticle

Prions
Alzheimer Disease
Proteins
Toxicity
Prion Diseases
40 Citations (Scopus)

β-Amyloid oligomers in aging and alzheimer's disease

Zahs, K. R. & Ashe, K. H., Sep 12 2013, In : Frontiers in Aging Neuroscience. 5, JUL, article 28.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Dementia
Serum Amyloid A Protein
Neurodegenerative Diseases
2012
6 Citations (Scopus)

Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau

Orr, M. E., Pitstick, R., Canine, B., Ashe, K. H. & Carlson, G. A., Jun 18 2012, In : PLoS One. 7, 6, e39328.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Phosphorylation
dementia
Neurology
Stem cells
3 Citations (Scopus)

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L. & Hyman, B. T., Oct 18 2012, In : Neuron. 76, 2, 1 p.

Research output: Contribution to journalComment/debate

Alzheimer Disease
Pathology
700 Citations (Scopus)

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

De Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., Spires-Jones, T. L. & Hyman, B. T., Feb 23 2012, In : Neuron. 73, 4, p. 685-697 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Pathology
Neurons
Entorhinal Cortex
Transgenes
2011
90 Citations (Scopus)

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

Reed, M. N., Hofmeister, J. J., Jungbauer, L., Welzel, A. T., Yu, C., Sherman, M. A., Lesne, S. E., LaDu, M. J., Walsh, D. M., Ashe, K. H. & Cleary, J. P., Oct 1 2011, In : Neurobiology of Aging. 32, 10, p. 1784-1794 11 p.

Research output: Contribution to journalArticle

Brain
Amyloid
Cognition
Transgenic Mice
Uncertainty
220 Citations (Scopus)

Extended results of the Alzheimer's disease anti-inflammatory prevention trial

Breitner, J. C., Baker, L. D., Montine, T. J., Meinert, C. L., Lyketsos, C. G., Ashe, K. H., Brandt, J., Craft, S., Evans, D. E., Green, R. C., Ismail, M. S., Martin, B. K., Mullan, M. J., Sabbagh, M. & Tariot, P. N., Jul 1 2011, In : Alzheimer's and Dementia. 7, 4, p. 402-411 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Anti-Inflammatory Agents
Naproxen
Pharmaceutical Preparations
Cerebrospinal Fluid
31 Citations (Scopus)

Grape seed polyphenolic extract specifically decreases Aβ*56 in the brains of Tg2576 mice

Liu, P., Kemper, L. J., Wang, J., Zahs, K. R., Ashe, K. H. & Pasinetti, G. M., Jan 1 2011, In : Journal of Alzheimer's Disease. 26, 4, p. 657-666 10 p.

Research output: Contribution to journalArticle

Grape Seed Extract
Alzheimer Disease
Brain
Transgenic Mice
Amyloid beta-Protein Precursor
1 Citation (Scopus)

Neurobiology of disease

Nelson, S. & Ashe, K. H., Dec 1 2011, In : Current Opinion in Neurobiology. 21, 6, p. 823-826 4 p.

Research output: Contribution to journalEditorial

Neurobiology
Nervous System Diseases
2010

Alzheimer's Disease: Transgenic Mouse Models

Ashe, K. H., Dec 1 2010, Encyclopedia of Neuroscience. Elsevier Ltd, p. 283-287 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transgenic Mice
Alzheimer Disease
tau Proteins
Amyloid
Research Personnel

Animal Models to Study the Biology of Amyloid-β Protein Misfolding in Alzheimer Disease

Ashe, K. H., Jul 2 2010, Protein Misfolding Diseases: Current and Emerging Principles and Therapies. John Wiley and Sons, p. 213-229 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyloid beta-Peptides
Alzheimer Disease
Animals
Animal Models
24 Citations (Scopus)

Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

Reed, M. N., Liu, P., Kotilinek, L. A. & Ashe, K. H., Sep 1 2010, In : Behavioural Brain Research. 212, 1, p. 115-120 6 p.

Research output: Contribution to journalArticle

Memory Disorders
Water
Alzheimer Disease
284 Citations (Scopus)

Probing the Biology of Alzheimer's Disease in Mice

Ashe, K. H. & Zahs, K. R., Jun 1 2010, In : Neuron. 66, 5, p. 631-645 15 p.

Research output: Contribution to journalReview article

Alzheimer Disease
Dementia
Asymptomatic Diseases
Amyloid beta-Protein Precursor
Primary Prevention
394 Citations (Scopus)

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., Pitstick, R., Carlson, G. A., Lanier, L. M., Yuan, L. L., Ashe, K. H. & Liao, D., Dec 22 2010, In : Neuron. 68, 6, p. 1067-1081 15 p.

Research output: Contribution to journalArticle

Dendritic Spines
Phosphorylation
Neurons
Microtubule-Associated Proteins
Glutamate Receptors
105 Citations (Scopus)
Alzheimer Disease
Transgenic Mice
Asymptomatic Diseases
Biomarkers
Technology
2008
46 Citations (Scopus)

Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

Paulson, J. B., Ramsden, M., Forster, C., Sherman, M. A., McGowan, E. & Ashe, K. H., Jan 1 2008, In : American Journal of Pathology. 173, 3, p. 762-772 11 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Amyloid Plaques
Transgenes
Alzheimer Disease
Pathology
148 Citations (Scopus)

Amyloid-β deposits lead to retinal degeneration in a mouse model of Alzheimer disease

Ning, A., Cui, J., To, E., Ashe, K. H. & Matsubara, J., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5136-5143 8 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Amyloid Plaques
Amyloid
Alzheimer Disease
Chemokine CCL2
156 Citations (Scopus)

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Kotilinek, L. A., Westerman, M. A., Wang, Q., Panizzon, K., Lim, G. P., Simonyi, A., Lesne, S. E., Falinska, A., Younkin, L. H., Younkin, S. G., Rowan, M., Cleary, J., Wallis, R. A., Sun, G. Y., Cole, G., Frautschy, S., Anwyl, R. & Ashe, K. H., Mar 1 2008, In : Brain. 131, 3, p. 651-664 14 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Non-Steroidal Anti-Inflammatory Agents
Cyclooxygenase 2
Amyloid
Serum Amyloid A Protein
80 Citations (Scopus)

Genes contributing to prion pathogenesis

Tamgüney, G., Giles, K., Glidden, D. V., Lessard, P., Wille, H., Tremblay, P., Groth, D. F., Yehiely, F., Korth, C., Moore, R. C., Tatzelt, J., Rubinstein, E., Boucheix, C., Yang, X., Stanley, P., Lisanti, M. P., Dwek, R. A., Rudd, P. M., Moskovitz, J., Epstein, C. J. & 13 others, Cruz, T. D., Kuziel, W. A., Maeda, N., Sap, J., Ashe, K. H., Carlson, G. A., Tesseur, I., Wyss-Coray, T., Mucke, L., Weisgraber, K. H., Mahley, R. W., Cohen, F. E. & Prusiner, S. B., Jul 1 2008, In : Journal of General Virology. 89, 7, p. 1777-1778 2 p.

Research output: Contribution to journalArticle

Prions
Prion Diseases
Genes
Protein Isoforms
Interleukin-1 Type I Receptors
106 Citations (Scopus)

In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons

Spires-Jones, T. L., De Calignon, A., Matsui, T., Zehr, C., Pitstick, R., Wu, H. Y., Osetek, J. D., Jones, P. B., Bacskai, B. J., Feany, M. B., Carlson, G. A., Ashe, K. H., Lewis, J. & Hyman, B. T., Jan 23 2008, In : Journal of Neuroscience. 28, 4, p. 862-867 6 p.

Research output: Contribution to journalArticle

Caspases
Neurons
Neurofibrillary Tangles
Tauopathies
Uridine Triphosphate
64 Citations (Scopus)

Oligomers of the amyloid-β protein disrupt working memory: Confirmation with two behavioral procedures

Poling, A., Morgan-Paisley, K., Panos, J. J., Kim, E. M., O'Hare, E., Cleary, J. P., Lesne, S. E., Ashe, K. H., Porritt, M. & Baker, L. E., Nov 21 2008, In : Behavioural Brain Research. 193, 2, p. 230-234 5 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Short-Term Memory
Amyloid
Culture Media
Alzheimer Disease
121 Citations (Scopus)

Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function

Lesne, S. E., Kotilinek, L. & Ashe, K. H., Feb 6 2008, In : Neuroscience. 151, 3, p. 745-749 5 p.

Research output: Contribution to journalArticle

Amyloid
Amyloid Plaques
Memory Disorders
Serum Amyloid A Protein
Brain
2007
297 Citations (Scopus)

Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models

Cheng, I. H., Scearce-Levie, K., Legleiter, J., Palop, J. J., Gerstein, H., Bien-Ly, N., Puoliväli, J., Lesne, S. E., Ashe, K. H., Muchowski, P. J. & Mucke, L., Aug 17 2007, In : Journal of Biological Chemistry. 282, 33, p. 23818-23828 11 p.

Research output: Contribution to journalArticle

Oligomers
Amyloid
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid Plaques
296 Citations (Scopus)

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy

Berger, Z., Roder, H., Hanna, A., Carlson, A., Rangachari, V., Yue, M., Wszolek, Z., Ashe, K. H., Knight, J., Dickson, D., Andorfer, C., Rosenberry, T. L., Lewis, J., Hutton, M. & Janus, C., Apr 4 2007, In : Journal of Neuroscience. 27, 14, p. 3650-3662 13 p.

Research output: Contribution to journalArticle

Tauopathies
Memory Disorders
Neurofibrillary Tangles
tau Proteins
Alzheimer Disease
16 Citations (Scopus)

A tale about tau

Ashe, K. H., Aug 30 2007, In : New England Journal of Medicine. 357, 9

Research output: Contribution to journalArticle

tau Proteins
Memory Disorders
Mutant Proteins
Amyloid
3 Citations (Scopus)

Cognitive impairment in transgenic Aβ and tau models of alzheimer's disease

Ashe, K. H., Dec 1 2007, Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. Springer US, p. 77-91 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Transgenic Mice
Alzheimer Disease
Memory Disorders
Brain
Research
87 Citations (Scopus)

Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

Huifang, M., Lesne, S. E., Kotilinek, L., Steidl-Nichols, J. V., Sherman, M. A., Younkin, L., Younkin, S., Forster, C., Sergeant, N., Delacourte, A., Vassar, R., Citron, M., Kofuji, P., Boland, L. M. & Ashe, K. H., May 8 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 19, p. 8167-8172 6 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Amyloid beta-Protein Precursor
Enzymes
Alzheimer Disease
Serum Amyloid A Protein
2006
2131 Citations (Scopus)

A specific amyloid-β protein assembly in the brain impairs memory

Lesne, S. E., Ming, T. K., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Mar 16 2006, In : Nature. 440, 7082, p. 352-357 6 p.

Research output: Contribution to journalArticle

Serum Amyloid A Protein
Alzheimer Disease
Brain
Amyloid
Amyloidogenic Proteins
6 Citations (Scopus)

In search of the molecular basis of memory loss in Alzheimer disease

Ashe, K. H., Oct 1 2006, In : Alzheimer Disease and Associated Disorders. 20, 4, p. 200-201 2 p.

Research output: Contribution to journalArticle

Animal Disease Models
Amyloid beta-Peptides
Memory Disorders
Transgenic Mice
Alzheimer Disease
12 Citations (Scopus)
Memory Disorders
Alzheimer Disease
Amyloid Plaques
Animal Models
Serum Amyloid A Protein
12 Citations (Scopus)

Molecular basis of memory loss in the TG2576 mouse model of Alzheimer's disease

Ashe, K. H., Jul 2006, In : Journal of Alzheimer's Disease. 9, SUPPL. 3, p. 123-126 4 p.

Research output: Contribution to journalArticle

Memory Disorders
Alzheimer Disease
Amyloid Plaques
Animal Models
Serum Amyloid A Protein
247 Citations (Scopus)

Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy

Spires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H. & Hyman, B. T., Jan 1 2006, In : American Journal of Pathology. 168, 5, p. 1598-1607 10 p.

Research output: Contribution to journalArticle

Tauopathies
Pathology
Neurons
Transgenes
Dementia
2005
327 Citations (Scopus)

Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L)

Ramsden, M., Kotilinek, L., Forster, C., Paulson, J., McGowan, E., SantaCruz, K., Guimaraes, A., Yue, M., Lewis, J., Carlson, G., Hutton, M. & Ashe, K. H., Nov 16 2005, In : Journal of Neuroscience. 25, 46, p. 10637-10647 11 p.

Research output: Contribution to journalArticle

Tauopathies
Neurofibrillary Tangles
Memory Disorders
Transgenes
Neocortex
36 Citations (Scopus)

Mechanisms of memory loss in Aβ and tau mouse models

Ashe, K. H., Aug 1 2005, In : Biochemical Society transactions. 33, 4, p. 591-594 4 p.

Research output: Contribution to journalArticle

Memory Disorders
Alzheimer Disease
Amyloid
Data storage equipment
Dementia
1223 Citations (Scopus)

Medicine: Tau suppression in a neurodegenerative mouse model improves memory function

Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McCowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M. & Ashe, K. H., Jul 15 2005, In : Science. 309, 5733, p. 476-481 6 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Medicine
Tauopathies
Neurodegenerative Diseases
Neurons