Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Caspase inhibitors for the treatment of dementia
Ashe, K. H. (PI), Dhawan, S. K. (Other Role), Kemper, L. J. (Other Role), Liu, P. (Other Role), Loude, T. J. (Other Role), Steuer, E. L. (Other Role) & Yang, M. (Other Role)
1/1/26 → 12/31/27
Project: Research project
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Targeting caspase-2 to repair synaptic function in tauopathies
Ashe, K. H. (PI)
ALZHEIMER'S DRUG DISCOVERY FOUNDATION
10/1/24 → 10/1/26
Project: Research project
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Structure and toxicity of a specific tau oligomer related to dementia
Liu, P. (PI), Ashe, K. H. (CoI) & Liao, D. (CoI)
8/1/24 → 7/31/27
Project: Research project
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Repairing synapses in neurodegenerative disorders by inhibiting caspase-2
Ashe, K. H. (PI)
MYRIEL, INC., THE LUCAS BROTHERS FOUNDATION
10/1/22 → 12/31/27
Project: Research project
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Prodrugs of potent and selective protease inhibitors as tauopathy therapeutics
Ashe, K. H. (PI), Walters, M. A. (CoI) & Wong, H. L. (CoI)
MYRIEL, INC., NATIONAL INSTITUTES OF HEALTH (NIH)
9/20/23 → 8/31/25
Project: Research project
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Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies
Fuller, J. L., Shi, K., Pockes, S., Finzel, B. C., Ashe, K. H. & Walters, M. A., Apr 18 2025, In: ACS Chemical Biology. 20, 4, p. 845-857 13 p.Research output: Contribution to journal › Article › peer-review
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Aβ∗56 is a stable oligomer that impairs memory function in mice
Liu, P., Lapcinski, I. P., Hlynialuk, C. J. W., Steuer, E. L., Loude, T. J., Shapiro, S. L., Kemper, L. J. & Ashe, K. H., Mar 15 2024, In: iScience. 27, 3, 109239.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations -
Retraction Note: A specific amyloid-β protein assembly in the brain impairs memory (Nature, (2006), 440, 7082, (352-357), 10.1038/nature04533)
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M. & Ashe, K. H., Jul 4 2024, In: Nature. 631, 8019, p. 240 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease
Lilek, J., Ajroud, K., Feldman, A. Z., Krishnamachari, S., Ghourchian, S., Gefen, T., Spencer, C. L., Kawles, A., Mao, Q., Tranovich, J. F., Jack, C. R., Mesulam, M. M., Reichard, R. R., Zhang, H., Murray, M. E., Knopman, D., Dickson, D. W., Petersen, R. C., Smith, B. & Ashe, K. H. & 3 others, , 2023, In: Journal of Alzheimer's Disease. 92, 1, p. 241-260 20 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Link opens in a new tab Scopus citations -
An electrophilic fragment screening for the development of small molecules targeting caspase-2
Cuellar, M. E., Yang, M., Karavadhi, S., Zhang, Y. Q., Zhu, H., Sun, H., Shen, M., Hall, M. D., Patnaik, S., Ashe, K. H., Walters, M. A. & Pockes, S., Nov 5 2023, In: European Journal of Medicinal Chemistry. 259, 115632.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations