Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Repairing synapses in neurodegenerative disorders by inhibiting caspase-2
10/1/22 → 12/31/23
Project: Research project
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Repairing neurotransmission in Alzheimer's disease and related disorders by targeting caspase-2
Alzheimer's Drug Discovery Foundation
3/1/22 → 3/1/24
Project: Research project
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Caspase-2 Probe Compounds
Ashe, K. H., Finzel, B. C. & Nelson, K.
NIH NAT'L INSTITUTE ON AGING (NIA)
2/15/19 → 11/30/23
Project: Research project
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Role of Tau Cleavage and Phosphorylation in Tauopathy
NIH NAT'L INSTITUTE ON AGING (NIA)
8/15/18 → 8/31/23
Project: Research project
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Curing Alzheimer's Disease: A Proposal for the Lucas Brothers Foundation
6/1/17 → 12/31/23
Project: Research project
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Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias
Pockes, S., Walters, M. A. & Ashe, K. H., Apr 2023, In: Translational Research. 254, p. 34-40 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Alzheimer's target still viable but untested
Ashe, K. H., Aug 26 2022, In: Science (New York, N.Y.). 377, 6609, p. 935 1 p.Research output: Contribution to journal › Letter › peer-review
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Blocking Site-Specific Cleavage of Human Tau Delays Progression of Disease-Related Phenotypes in Genetically Matched Tau-Transgenic Mice Modeling Frontotemporal Dementia
Steuer, E. L., Kemper, L. J., Hlynialuk, C. J. W., Leinonen-Wright, K., Montonye, M. L., Lapcinski, I. P., Forster, C. L., Ashe, K. H. & Liu, P., Jun 8 2022, In: Journal of Neuroscience. 42, 23, p. 4737-4754 18 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy
Singh, G., Liu, P., Yao, K. R., Strasser, J. M., Hlynialuk, C., Leinonen-Wright, K., Teravskis, P. J., Choquette, J. M., Ikramuddin, J., Bresinsky, M., Nelson, K. M., Liao, D., Ashe, K. H., Walters, M. A. & Pockes, S., 2022, (Accepted/In press) In: ACS Chemical Neuroscience. 13, 10Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer’s disease, Huntington’s disease, or Lewy Body dementia
Hlynialuk, C., Kemper, L., Leinonen-Wright, K., Petersen, R. C., Ashe, K. & Smith, B., Sep 2022, In: PloS one. 17, 9 September, e0274784.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations