Justin M Drake

20052021
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Research Output 2005 2019

2019
1 Citation (Scopus)

DNA-dependent protein kinase drives prostate cancer progression through transcriptional regulation of the Wnt signaling pathway

Kothari, V., Goodwin, J. F., Zhao, S. G., Drake, J. M., Yin, Y., Chang, S. L., Evans, J. R., Wilder-Romans, K., Gabbara, K., Dylgjeri, E., Chou, J., Sun, G., Tomlins, S. A., Mehra, R., Hege, K., Filvaroff, E. H., Schaeffer, E. M., Karnes, R. J., Quigley, D. A., Rathkopf, D. E. & 9 others, He, H. H., Speers, C., Spratt, D. E., Gilbert, L. A., Ashworth, A., Chinnaiyan, A. M., Raj, G. V., Knudsen, K. E. & Feng, F. Y., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5608-5622 15 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Wnt Signaling Pathway
Prostatic Neoplasms
Phosphotransferases
Wnt Proteins

Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

Brian, B. F., Jolicoeur, A. S., Guerrero, C. R., Nunez, M. G., Sychev, Z. E., Hegre, S. A., Sætrom, P., Habib, N., Drake, J. M., Schwertfeger, K. & Freedman, T. S., Jul 1 2019, In : eLife. 8, e46043.

Research output: Contribution to journalArticle

Open Access
Phosphorylation
src-Family Kinases
Macrophages
Myeloid Cells
Tuning
2018
3 Citations (Scopus)

Impact of phosphoproteomics in the era of precision medicine for prostate cancer

Ramroop, J. R., Stein, M. N. & Drake, J. M., Feb 16 2018, In : Frontiers in Oncology. 8, FEB, 28.

Research output: Contribution to journalReview article

Precision Medicine
Prostatic Neoplasms
Castration
Phosphopeptides
Mass Spectrometry
6 Citations (Scopus)

MAPK Reliance via acquired CDK4/6 inhibitor resistance in cancer

De Leeuw, R., McNair, C., Schiewer, M. J., Neupane, N. P., Brand, L. J., Augello, M. A., Li, Z., Cheng, L. C., Yoshida, A., Courtney, S. M., Starr Hazard, E., Hardiman, G., Hussain, M. H., Alan Diehl, J., Drake, J. M., Kevin Kelly, W. & Knudsen, K. E., Sep 1 2018, In : Clinical Cancer Research. 24, 17, p. 4201-4214 14 p.

Research output: Contribution to journalArticle

Open Access
Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Neoplasms
Mitogen-Activated Protein Kinase Kinases
Cell Cycle Checkpoints
17 Citations (Scopus)

Nutraceutical or pharmacological potential of Moringa oleifera Lam.

Kou, X., Li, B., Olayanju, J. B., Drake, J. M. & Chen, N., Mar 12 2018, In : Nutrients. 10, 3, 343.

Research output: Contribution to journalReview article

Open Access
Moringa oleifera
Dietary Supplements
functional foods
Pharmacology
Isothiocyanates
1 Citation (Scopus)

Phosphopeptide enrichment coupled with label-free quantitative mass spectrometry to investigate the phosphoproteome in prostate cancer

Cheng, L. C., Li, Z., Graeber, T. G., Graham, N. A. & Drake, J. M., Aug 2 2018, In : Journal of Visualized Experiments. 2018, 138, e57996.

Research output: Contribution to journalArticle

Open Access
Phosphopeptides
Mass spectrometry
Labels
Mass Spectrometry
Prostatic Neoplasms
2017
8 Citations (Scopus)

Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression

Yue, X., Zhang, C., Zhao, Y., Liu, J., Lin, A. W., Tan, V. M., Drake, J. M., Liu, L., Boateng, M. N., Li, J., Feng, Z. & Hu, W., Aug 15 2017, In : Genes and Development. 31, 16, p. 1641-1654 14 p.

Research output: Contribution to journalArticle

Open Access
Sumoylation
Monomeric GTP-Binding Proteins
Neoplasms
RNA Interference
Carcinogenesis
13 Citations (Scopus)

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

Lue, H. W., Podolak, J., Kolahi, K., Cheng, L., Rao, S., Garg, D., Xue, C. H., Rantala, J. K., Tyner, J. W., Thornburg, K. L., Martinez-Acevedo, A., Liu, J. J., Amling, C. L., Truillet, C., Louie, S. M., Anderson, K. E., Evans, M. J., O’Donnell, V. B., Nomura, D. K., Drake, J. M. & 2 others, Ritz, A. & Thomas, G. V., Oct 15 2017, In : Genes and Development. 31, 20, p. 2067-2084 18 p.

Research output: Contribution to journalArticle

Open Access
Cell Survival
Autophagy
Phospholipases A2
Oxidative Phosphorylation
Neoplasms
2016
16 Citations (Scopus)

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Stoyanova, T., Riedinger, M., Lin, S., Faltermeier, C. M., Smith, B. A., Zhang, K. X., Going, C. C., Goldstein, A. S., Lee, J. K., Drake, J. M., Rice, M. A., Hsu, E. C., Nowroozizadeh, B., Castor, B., Orellana, S. Y., Blum, S. M., Cheng, D., Pienta, K. J., Reiter, R. E., Pitteri, S. J. & 2 others, Huang, J. & Witte, O. N., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6457-E6466

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Prostate
Neoplasms
Epithelial-Mesenchymal Transition
3 Citations (Scopus)

Complementing genomics and transcriptomics: Phosphoproteomics illuminates systems biology in prostate cancer

Tan, V. M., Cheng, L. C. & Drake, J. M., Nov 1 2016, In : Molecular and Cellular Oncology. 3, 6, e1246075.

Research output: Contribution to journalComment/debate

Systems Biology
Genomics
Prostatic Neoplasms
Phosphotransferases
21 Citations (Scopus)

Functional screen identifies kinases driving prostate cancer visceral and bone metastasis

Faltermeier, C. M., Drake, J. M., Clark, P. M., Smith, B. A., Zong, Y., Volpe, C., Mathis, C., Morrissey, C., Castor, B., Huang, J. & Witte, O. N., Jan 12 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 2, p. E172-E181

Research output: Contribution to journalArticle

Bone Neoplasms
Prostatic Neoplasms
Phosphotransferases
Neoplasm Metastasis
Prostate
59 Citations (Scopus)

Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer

Drake, J. M., Paull, E. O., Graham, N. A., Lee, J. K., Smith, B. A., Titz, B., Stoyanova, T., Faltermeier, C. M., Uzunangelov, V., Carlin, D. E., Fleming, D. T., Wong, C. K., Newton, Y., Sudha, S., Vashisht, A. A., Huang, J., Wohlschlegel, J. A., Graeber, T. G., Witte, O. N. & Stuart, J. M., Aug 11 2016, In : Cell. 166, 4, p. 1041-1054 14 p.

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Phosphorylation
Phosphotransferases
Genes
2015
70 Citations (Scopus)

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

Goodwin, J. F., Kothari, V., Drake, J. M., Zhao, S., Dylgjeri, E., Dean, J. L., Schiewer, M. J., McNair, C., Jones, J. K., Aytes, A., Magee, M. S., Snook, A. E., Zhu, Z., Den, R. B., Birbe, R. C., Gomella, L. G., Graham, N. A., Vashisht, A. A., Wohlschlegel, J. A., Graeber, T. G. & 9 others, Karnes, R. J., Takhar, M., Davicioni, E., Tomlins, S. A., Abate-Shen, C., Sharifi, N., Witte, O. N., Feng, F. Y. & Knudsen, K. E., Jul 13 2015, In : Cancer Cell. 28, 1, p. 97-113 17 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
DNA
Neoplasms
Polynucleotide 5'-Hydroxyl-Kinase
2014
27 Citations (Scopus)

Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer

Drake, J. M., Lee, J. K. & Witte, O. N., Jan 1 2014, In : Molecular and cellular biology. 34, 10, p. 1722-1732 11 p.

Research output: Contribution to journalShort survey

Protein-Tyrosine Kinases
Neoplasms
Phosphotransferases
Mutation
Poisons
5 Citations (Scopus)

PIP5K1α inhibition as a therapeutic strategy for prostate cancer

Drake, J. M. & Huang, J., Sep 2 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 35, p. 12578-12579 2 p.

Research output: Contribution to journalComment/debate

Isoquinolines
Diketopiperazines
Tetrahydroisoquinolines
Indoles
Prostatic Neoplasms
2013
21 Citations (Scopus)

Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization

Varzavand, A., Drake, J. M., Svensson, R. U., Herndon, M. E., Zhou, B., Henry, M. D. & Stipp, C. S., Apr 1 2013, In : Clinical and Experimental Metastasis. 30, 4, p. 541-552 12 p.

Research output: Contribution to journalArticle

Stromal Cells
Integrins
Prostatic Neoplasms
Neoplasms
Growth
52 Citations (Scopus)

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

Drake, J. M., Graham, N. A., Lee, J. K., Stoyanova, T., Faltermeier, C. M., Sud, S., Titz, B., Huang, J., Pienta, K. J., Graeber, T. G. & Witte, O. N., Dec 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49

Research output: Contribution to journalArticle

Castration
Prostatic Neoplasms
Phosphotransferases
Therapeutics
Phosphopeptides

Phospho-proteomics reveals oncogenic phospho-tyrosine signaling networks in cancers lacking mutated or amplified tyrosine kinases

Graham, N. A., Drake, J. M., Tahmasian, M., Pienta, K. J., Witte, O. N. & Graeber, T. G., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, p. 297-298 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Proteomics
proteomics
Protein-Tyrosine Kinases
Tyrosine
tyrosine
78 Citations (Scopus)

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

Stoyanova, T., Cooper, A. R., Drake, J. M., Liu, X., Armstrong, A. J., Pienta, K. J., Zhang, H., Kohn, D. B., Huang, J., Witte, O. N. & Goldstein, A. S., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20111-20116 6 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Adenocarcinoma
Neoplasms
Prostate
Phenotype
2012
90 Citations (Scopus)

Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression

Drake, J. M., Graham, N. A., Stoyanova, T., Sedghi, A., Goldstein, A. S., Cai, H., Smith, D. A., Zhangh, H., Komisopoulou, E., Huang, J., Graeber, T. G. & Witte, O. N., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1643-1648 6 p.

Research output: Contribution to journalArticle

Oncogenes
Protein-Tyrosine Kinases
Prostatic Neoplasms
Tyrosine
Phosphotransferases
54 Citations (Scopus)

Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling

Stoyanova, T., Goldstein, A. S., Cai, H., Drake, J. M., Huang, J. & Witte, O. N., Oct 15 2012, In : Genes and Development. 26, 20, p. 2271-2285 15 p.

Research output: Contribution to journalArticle

Catenins
Proteolysis
Hyperplasia
Epithelial Cells
Neoplasms
2011
51 Citations (Scopus)

Purification and direct transformation of epithelial progenitor cells from primary human prostate

Goldstein, A. S., Drake, J. M., Burnes, D. L., Finley, D. S., Zhang, H., Reiter, R. E., Huang, J. & Witte, O. N., Apr 1 2011, In : Nature Protocols. 6, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

Purification
Prostate
Stem Cells
Epithelial Cells
Tissue
2010
20 Citations (Scopus)

Bone-specific growth inhibition of prostate cancer metastasis by atrasentan

Drake, J. M., Danke, J. R. & Henry, M. D., Apr 15 2010, In : Cancer Biology and Therapy. 9, 8, p. 607-614 8 p.

Research output: Contribution to journalArticle

Bone Development
Prostatic Neoplasms
Neoplasm Metastasis
Endothelins
Bone and Bones
49 Citations (Scopus)

ZEB1 coordinately regulates laminin-332 and β4 integrin expression altering the invasive phenotype of prostate cancer cells

Drake, J. M., Barnes, J. M., Madsen, J. M., Domann, F. E., Stipp, C. S. & Henry, M. D., Oct 29 2010, In : Journal of Biological Chemistry. 285, 44, p. 33940-33948 9 p.

Research output: Contribution to journalArticle

Integrins
Prostatic Neoplasms
Cells
Phenotype
Epithelial-Mesenchymal Transition
2009
12 Citations (Scopus)

Endothelin-1 inhibits prostate cancer growth in vivo through vasoconstriction of tumor-feeding arterioles

Weydert, C. J., Esser, A. K., Mejia, R. A., Drake, J. M., Barnes, J. M. & Henry, M. D., Apr 15 2009, In : Cancer Biology and Therapy. 8, 8, p. 720-729 10 p.

Research output: Contribution to journalArticle

Arterioles
Endothelin-1
Vasoconstriction
Prostatic Neoplasms
Growth
109 Citations (Scopus)

ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells

Drake, J. M., Strohbehn, G., Bair, T. B., Moreland, J. G. & Henry, M. D., Apr 15 2009, In : Molecular biology of the cell. 20, 8, p. 2207-2217 11 p.

Research output: Contribution to journalArticle

Transendothelial and Transepithelial Migration
Prostatic Neoplasms
Phenotype
Cadherins
Epithelial-Mesenchymal Transition
2005
60 Citations (Scopus)

Assessing tumor growth and distribution in a model of prostate cancer metastasis using bioluminescence imaging

Drake, J. M., Gabriel, C. L. & Henry, M. D., Dec 1 2005, In : Clinical and Experimental Metastasis. 22, 8, p. 674-684 11 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Injections