Julie Eisengart

Assistant Professor

Assistant Professor, Pediatrics - Neuropsychology

https://orcid.org/0000-0001-5340-017X

Emaileisen139@umn.edu

Research activity per year

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Personal profile

Research interests

I am an assistant professor in the Department of Pediatrics and a pediatric neuropsychologist. My research focuses on the natural histories and treatment outcomes of rare diseases involving the central nervous system, particularly lysosomal storage disorders with emphasis on the mucopolysaccharidoses. As part of this research I characterize unique neurocognitive profiles and progression of various neurodegenerative disorders, as well as quantify treatment outcomes and their correlates. In particular, my MPS research has examined longitudinal associations of cognitive deficits with abnormalities in biomarkers and brain structure.

A complete list of published work is available here:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Julie+Eisengart

Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

Research Interest Keywords

lysosomal storage disorders
mucopolysaccharidosis
adrenoleukodystrophy
neurocognitive endpoints
neurocognitive decline
IQ and developmental quotient
biomarkers

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4 Active
7 Finished

An Open-label, Phase 1/2 Study to Evaluate the Safety and Efficacy of Single-dose PR001A in Infants with Type 2 Gaucher Disease
Whitley, C. B., Eisengart, J., Jarnes, J. R. & Miller, B. S.
PREVAIL THERAPEUTICS INC
9/8/20 → 1/1/26
Project: Research project
Pilot Study Anakinra in MPS III
Eisengart, J.
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNO
1/7/20 → 1/6/22
Project: Research project
Lysosomal Disease Network
Whitley, C. B., Ahmed, A., Braunlin, E. A., Cortez, D., Eisengart, J., King, K. E., Nestrasil, I. & Orchard, P. J.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/19 → 7/31/24
Project: Research project
An Open-Label, Single-Arm, Multicenter Study of Intracerebral Administration of Adeno-Associated Viral Vectors Serotype rh10 Carrying the Human N-sulfoglucosamine sulfohydrolase(SGSH) cDNA for the Treatment ofMucopolysaccharidosis Type IIIA
Whitley, C. B., Belani, K. G. & Eisengart, J.
Lysogene
1/25/19 → 2/28/22
Project: Research project
Data on outcomes with allogenic haematopoietic stem cell transplants in Mucopolysaccharidosis type I
Orchard, P. J., Eisengart, J., Lund, T. C. & Miller, B. S.
ORCHARD THERAPEUTICS
9/9/20 → 3/31/21
Project: Research project

23 Article
3 Review article
1 Letter

Biomarkers for prediction of skeletal disease progression in mucopolysaccharidosis type I
Lund, T. C., Doherty, T. M., Eisengart, J. B., Freese, R. L., Rudser, K. D., Fung, E. B., Miller, B. S., White, K. K., Orchard, P. J., Whitley, C. B. & Polgreen, L. E., Mar 1 2021, In: JIMD Reports. 58, 1, p. 89-99 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
Mucopolysaccharidosis type I: Current treatments, limitations and prospects for improvement
Hampe, C. S., Wesley, J., Lund, T. C., Orchard, P. J., Polgreen, L. E., Eisengart, J. B., McLoon, L. K., Cureoglu, S., Schachern, P. & McIvor, R. S., Feb 2021, In: Biomolecules. 11, 2, p. 1-25 25 p., 189.
Research output: Contribution to journal › Review article › peer-review

Open Access
The natural history of neurocognition in MPS disorders: A review
Shapiro, E. G. & Eisengart, J. B., May 2021, In: Molecular Genetics and Metabolism. 133, 1, p. 8-34 27 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
Clinical trial of laronidase in Hurler syndrome after hematopoietic cell transplantation
Polgreen, L. E., Lund, T. C., Braunlin, E., Tolar, J., Miller, B. S., Fung, E., Whitley, C. B., Eisengart, J. B., Northrop, E., Rudser, K., Miller, W. P. & Orchard, P. J., Jan 1 2020, In: Pediatric Research. 87, 1, p. 104-111 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Scopus citations
Intrathecal enzyme replacement for cognitive decline in mucopolysaccharidosis type I, a randomized, open-label, controlled pilot study
Chen, A. H., Harmatz, P., Nestrasil, I., Eisengart, J. B., King, K. E., Rudser, K., Kaizer, A. M., Svatkova, A., Wakumoto, A., Le, S. Q., Madden, J., Young, S., Zhang, H., Polgreen, L. E. & Dickson, P. I., Feb 2020, In: Molecular Genetics and Metabolism. 129, 2, p. 80-90 11 p.
Research output: Contribution to journal › Article › peer-review
4 Scopus citations