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Julie Eisengart

Assistant Professor

 https://orcid.org/0000-0001-5340-017X
20062021
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Personal profile

Research interests

I am an assistant professor in the Department of Pediatrics and a pediatric neuropsychologist. My research focuses on the natural histories and treatment outcomes of rare diseases involving the central nervous system, particularly lysosomal storage disorders with emphasis on the mucopolysaccharidoses. As part of this research I characterize unique neurocognitive profiles and progression of various neurodegenerative disorders, as well as quantify treatment outcomes and their correlates. In particular, my MPS research has examined longitudinal associations of cognitive deficits with abnormalities in biomarkers and brain structure.

A complete list of published work is available here:

https://www.ncbi.nlm.nih.gov/pubmed/?term=Julie+Eisengart

Research interests

  • lysosomal storage disorders
  • mucopolysaccharidosis
  • adrenoleukodystrophy
  • neurocognitive endpoints
  • neurocognitive decline
  • IQ and developmental quotient
  • biomarkers

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Mucopolysaccharidosis I Medicine & Life Sciences
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Projects 2017 2021

Biomarker correlates of neurocognitive outcomes in the cerebrospinal fluid in MPS I

Eisengart, J. & Lund, T. C.

University of Pennsylvania

2/1/19 → 1/31/20

Project: Research project

Cerebrospinal Fluid
Biomarkers

An Open-Label, Single-Arm, Multicenter Study of Intracerebral Administration of Adeno-Associated Viral Vectors Serotype rh10 Carrying the Human N-sulfoglucosamine sulfohydrolase(SGSH) cDNA for the Treatment ofMucopolysaccharidosis Type IIIA

Whitley, C. B., Belani, K. G. & Eisengart, J.

Lysogene

1/25/19 → 2/28/21

Project: Research project

Mucopolysaccharidosis III
Multicenter Studies
Complementary DNA
Serogroup
N-sulfoglucosamine sulfohydrolase

Clinical signs and biomarkers in the early natural history of attenuated MPS I

Eisengart, J. & Ahmed, A.

GENE SPOTLIGHT, INC

9/1/18 → 1/15/19

Project: Research project

Biomarkers

Patient- and Observer-Reported Outcomes as Critical Meas

Eisengart, J.

MPS Society

1/8/18 → 12/31/18

Project: Research project

A Feasibility Study for Development of a Behavioral Rati

Eisengart, J. & King, K. E.

SHIRE HUMAN GENETIC THERAPIES, INC.

9/21/17 → 6/30/19

Project: Research project

Feasibility Studies
Behavior Rating Scale

Research Output 2006 2019

A longitudinal study of neurocognition and behavior in patients with Hurler-Scheie syndrome heterozygous for the L238Q mutation

Ahmed, A., Ou, L., Rudser, K., Shapiro, E., Eisengart, J., King, K. E., Chen, A., Dickson, P. & Whitley, C. B., Sep 1 2019, In : Molecular Genetics and Metabolism Reports. 20, 100484.

Research output: Contribution to journal › Article

Open Access
Mucopolysaccharidosis I
Longitudinal Studies
Iduronidase
Mutation
Computational Biology

Attention and corpus callosum volumes in individuals with mucopolysaccharidosis type I

King, K. E., Rudser, K., Nestrasil, I., Kovac, V., Delaney, K. A., Wozniak, J. R., Mueller, B. A., Lim, K. O., Eisengart, J., Mamak, E. G., Raiman, J., Ali, N., Cagle, S., Harmatz, P., Whitley, C. B. & Shapiro, E. G., May 14 2019, In : Neurology. 92, 20, p. e2321-e2328

Research output: Contribution to journal › Article

Mucopolysaccharidosis I
Corpus Callosum
Cell Transplantation
Research

Biochemical and clinical response after umbilical cord blood transplant in a boy with early childhood-onset beta-mannosidosis

Lund, T. C., Miller, W. P., Eisengart, J., Simmons, K., Pollard, L., Renaud, D. L., Wenger, D. A., Patterson, M. C. & Orchard, P. J., Jul 1 2019, In : Molecular Genetics and Genomic Medicine. 7, 7, e00712.

Research output: Contribution to journal › Article

Open Access
beta-Mannosidosis
Mannosidases
Fetal Blood
Transplants
Mannosidase Deficiency Diseases

Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes

Eisengart, J., Pierpont, R., Kaizer, A. M., Rudser, K., King, K. E., Pasquali, M., Polgreen, L. E., Dickson, P. I., Le, S. Q., Miller, W. P., Tolar, J., Orchard, P. J. & Lund, T. C., Jan 1 2019, In : Genetics in Medicine.

Research output: Contribution to journal › Article

Open Access
Mucopolysaccharidosis I
Enzyme Replacement Therapy
Biomarkers
Cerebrospinal Fluid
Enzymes
3 Citations (Scopus)

Beneath the floor: Re-analysis of neurodevelopmental outcomes in untreated Hurler syndrome

Shapiro, E. G., Whitley, C. B. & Eisengart, J., May 11 2018, In : Orphanet Journal of Rare Diseases. 13, 1, 76.

Research output: Contribution to journal › Article

Mucopolysaccharidosis I
Benchmarking
Cell Transplantation
Neurodegenerative Diseases
Newborn Infant