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Article
2003

Transgenic sickle mice have vascular inflammation

Belcher, J. D., Bryant, C. J., Nguyen, J., Bowlin, P. R., Kielbik, M. C., Bischof, J. C., Hebbel, R. P. & Vercellotti, G. M., May 15 2003, In : Blood. 101, 10, p. 3953-3959 7 p.

Research output: Contribution to journalArticle

152 Scopus citations
2005

Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions

Fernandez-L, A., Sanz-Rodriguez, F., Zarrabeitia, R., Pérez-Molino, A., Hebbel, R. P., Nguyen, J., Bernabéu, C. & Botella, L. M., Nov 1 2005, In : Cardiovascular Research. 68, 2, p. 235-248 14 p.

Research output: Contribution to journalArticle

61 Scopus citations
2006
44 Scopus citations
2007

The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapy

Somani, A., Nguyen, J., Milbauer, L. C., Solovey, A., Sajja, S. & Hebbel, R. P., Jul 2007, In : Translational Research. 150, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases

Zwolak, P., Dudek, A. Z., Bodempudi, V. D., Nguyen, J., Hebbel, R. P., Gallus, N. J., Ericson, M. E., Goblirsch, M. J. & Clohisy, D. R., Feb 1 2008, In : International Journal of Cancer. 122, 3, p. 681-688 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Morphine induces mesangial cell proliferation and glomerulopathy via κ-opioid receptors

Weber, M. L., Farooqui, M., Nguyen, J., Ansonoff, M., Pintar, J. E., Hebbel, R. P. & Gupta, K., Jun 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 6, p. F1388-F1397

Research output: Contribution to journalArticle

29 Scopus citations
3 Scopus citations
2009

Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

Beckman, J. D., Belcher, J. D., Vineyard, J. V., Chen, C., Nguyen, J., Nwaneri, M. O., O'Sullivan, G., Gulbahce, E., Hebbel, R. P. & Vercellotti, G. M., Oct 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1243-H1253

Research output: Contribution to journalArticle

30 Scopus citations
2010
60 Scopus citations

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids

Kohli, D. R., Li, Y., Khasabov, S. G., Gupta, P., Kehl, L. J., Ericson, M. E., Nguyen, J., Gupta, V., Hebbel, R. P., Simone, D. A. & Gupta, K., Jul 22 2010, In : Blood. 116, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

Hebbel, R. P., Vercellotti, G. M., Pace, B. S., Solovey, A. N., Kollander, R., Abanonu, C. F., Nguyen, J., Vineyard, J. V., Belcher, J. D., Abdulla, F., Osifuye, S., Eaton, J. W., Kelm, R. J. & Slungaard, A., Mar 25 2010, In : Blood. 115, 12, p. 2483-2490 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)

Mitra, R., Guo, Z., Milani, M., Mesaros, C., Rodriguez, M., Nguyen, J., Luo, X., Clarke, D., Lamba, J., Schuetz, E., Donner, D. B., Puli, N., Falck, J. R., Capdevila, J., Gupta, K., Blair, I. A. & Potter, D. A., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17543-17559 17 p.

Research output: Contribution to journalArticle

51 Scopus citations
22 Scopus citations

Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer

Fujioka, N., Nguyen, J., Chen, C., Li, Y., Pasrija, T., Niehans, G., Johnson, K. N., Gupta, V., Kratzke, R. A. & Gupta, K., Dec 1 2011, In : Anesthesia and Analgesia. 113, 6, p. 1353-1364 12 p.

Research output: Contribution to journalArticle

59 Scopus citations
67 Scopus citations
2012

Influence of morphine on pericyte-endothelial interaction: Implications for antiangiogenic therapy

Luk, K., Boatman, S., Johnson, K. N., Dudek, O. A., Ristau, N., Vang, D., Nguyen, J. & Gupta, K., Feb 6 2012, In : Journal of Oncology. 458385.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Mast cell activation contributes to sickle cell pathobiology and pain in mice

Vincent, L., Vang, D., Nguyen, J., Gupta, M., Luk, K., Ericson, M. E., Simone, D. A. & Gupta, K., Jan 1 2013, In : Blood. 122, 11, p. 1853-1862 10 p.

Research output: Contribution to journalArticle

96 Scopus citations
10 Scopus citations

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

Belcher, J. D., Young, M., Chen, C., Nguyen, J., Burhop, K., Tran, P. & Vercellotti, G. M., Jan 1 2013, In : Blood. 122, 15, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

49 Scopus citations
2014

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

251 Scopus citations

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

22 Scopus citations

Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer

Nguyen, J., Luk, K., Vang, D., Soto, W., Vincent, L., Robiner, S., Saavedra, R., Li, Y., Gupta, P. & Gupta, K., Jan 1 2014, In : British Journal of Anaesthesia. 113, SUPPL. 1, p. i4-i13

Research output: Contribution to journalArticle

54 Scopus citations
2015
20 Scopus citations

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Vang, D., Paul, J. A., Nguyen, J., Tran, H., Vincent, L., Yasuda, D., Zaveri, N. T. & Gupta, K., Jan 1 2015, In : Haematologica. 100, 12, p. 1517-1525 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-κB activation in transgenic sickle mice

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Nguyen, P., Nguyen, M., Okeley, N. M., Benjamin, D. R., Senter, P. D. & Vercellotti, G. M., Feb 23 2015, In : PloS one. 10, 2, e0117772.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

Vincent, L., Vang, D., Nguyen, J., Benson, B., Lei, J. & Gupta, K., Apr 30 2016, In : Haematologica. 101, 5, p. 566-577 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
20 Scopus citations

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

Shi, P. A., Choi, E., Chintagari, N. R., Nguyen, J., Guo, X., Yazdanbakhsh, K., Mohandas, N., Alayash, A. I., Manci, E. A., Belcher, J. D. & Vercellotti, G. M., Nov 1 2016, In : British journal of haematology. 175, 4, p. 714-723 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Belcher, J. D., Chen, C., Nguyen, J., Zhang, P., Abdulla, F., Nguyen, P., Killeen, T., Xu, P., O'Sullivan, G., Nath, K. A. & Vercellotti, G. M., May 10 2017, In : Antioxidants and Redox Signaling. 26, 14, p. 748-762 15 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2018

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H., Nguyen, P., Killeen, T., Miescher, S. M., Brinkman, N., Nath, K. A., Steer, C. J. & Vercellotti, G. M., Apr 2018, In : PloS one. 13, 4, e0196455.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vasoocclusion, inflammation and anemia

Belcher, J. D., Gomperts, E., Nguyen, J., Chen, C., Abdulla, F., Kiser, Z. M., Gallo, D., Levy, H., Otterbein, L. E. & Vercellotti, G. M., Oct 2018, In : PloS one. 13, 10, e0205194.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Critical role of C5a in sickle cell disease

Vercellotti, G. M., Dalmasso, A. P., Schaid, T. R., Nguyen, J., Chen, C., Ericson, M. E., Abdulla, F., Killeen, T., Lindorfer, M. A., Taylor, R. P. & Belcher, J. D., Mar 2019, In : American Journal of Hematology. 94, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mast cells induce blood brain barrier damage in SCD by causing endoplasmic reticulum stress in the endothelium

Tran, H., Mittal, A., Sagi, V., Luk, K., Nguyen, A., Gupta, M., Nguyen, J., Lamarre, Y., Lei, J., Guedes, A. & Gupta, K., Jan 29 2019, In : Frontiers in Cellular Neuroscience. 13, p. 1-12 12 p., 56.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations