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Research Output 2003 2019

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Article
2019
5 Citations (Scopus)

Critical role of C5a in sickle cell disease

Vercellotti, G. M., Dalmasso, A. P., Schaid, T. R., Nguyen, J., Chen, C., Ericson, M. E., Abdulla, F., Killeen, T., Lindorfer, M. A., Taylor, R. P. & Belcher, J. D., Mar 2019, In : American Journal of Hematology. 94, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Anaphylatoxin C5a Receptor
P-Selectin
Complement Activation
Immunoglobulin G
2 Citations (Scopus)

Mast cells induce blood brain barrier damage in SCD by causing endoplasmic reticulum stress in the endothelium

Tran, H., Mittal, A., Sagi, V., Luk, K., Nguyen, A., Gupta, M., Nguyen, J., Lamarre, Y., Lei, J., Guedes, A. & Gupta, K., Jan 29 2019, In : Frontiers in Cellular Neuroscience. 13, p. 1-12 12 p., 56.

Research output: Contribution to journalArticle

Open Access
Endoplasmic Reticulum Stress
Sickle Cell Anemia
Blood-Brain Barrier
Mast Cells
Endothelium
2018
14 Citations (Scopus)

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H., Nguyen, P., Killeen, T., Miescher, S. M., Brinkman, N., Nath, K. A., Steer, C. J. & Vercellotti, G. M., Apr 2018, In : PloS one. 13, 4, e0196455.

Research output: Contribution to journalArticle

Open Access
heme oxygenase (biliverdin-producing)
Hemopexin
sickle cell anemia
Heme Oxygenase-1
Haptoglobins
2 Citations (Scopus)

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vasoocclusion, inflammation and anemia

Belcher, J. D., Gomperts, E., Nguyen, J., Chen, C., Abdulla, F., Kiser, Z. M., Gallo, D., Levy, H., Otterbein, L. E. & Vercellotti, G. M., Oct 2018, In : PloS one. 13, 10, e0205194.

Research output: Contribution to journalArticle

Open Access
sickle cell anemia
carbon monoxide
Sickle Cell Anemia
Carbon Monoxide
anemia
2017
22 Citations (Scopus)

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Belcher, J. D., Chen, C., Nguyen, J., Zhang, P., Abdulla, F., Nguyen, P., Killeen, T., Xu, P., O'Sullivan, G., Nath, K. A. & Vercellotti, G. M., May 10 2017, In : Antioxidants and Redox Signaling. 26, 14, p. 748-762 15 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Inflammation
Heme
2016
23 Citations (Scopus)

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

Vincent, L., Vang, D., Nguyen, J., Benson, B., Lei, J. & Gupta, K., Apr 30 2016, In : Haematologica. 101, 5, p. 566-577 12 p.

Research output: Contribution to journalArticle

Neurogenic Inflammation
Cannabinoid Receptors
Sickle Cell Anemia
Mast Cells
Cannabinoids
20 Citations (Scopus)
Hemopexin
Sickle Cell Anemia
Blood Vessels
Inflammation
Liver
9 Citations (Scopus)

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

Shi, P. A., Choi, E., Chintagari, N. R., Nguyen, J., Guo, X., Yazdanbakhsh, K., Mohandas, N., Alayash, A. I., Manci, E. A., Belcher, J. D. & Vercellotti, G. M., Nov 1 2016, In : British Journal of Haematology. 175, 4, p. 714-723 10 p.

Research output: Contribution to journalArticle

Apoferritins
Haptoglobins
Sickle Cell Anemia
Iron
Kidney
2015
20 Citations (Scopus)
Proximal Kidney Tubule
Heme Oxygenase-1
Haptoglobins
Sickle Cell Anemia
Hemoglobins
27 Citations (Scopus)

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Vang, D., Paul, J. A., Nguyen, J., Tran, H., Vincent, L., Yasuda, D., Zaveri, N. T. & Gupta, K., Jan 1 2015, In : Haematologica. 100, 12, p. 1517-1525 9 p.

Research output: Contribution to journalArticle

Mast Cells
Opioid Receptors
Pain
Narcotic Antagonists
mu Opioid Receptor
13 Citations (Scopus)

The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-κB activation in transgenic sickle mice

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Nguyen, P., Nguyen, M., Okeley, N. M., Benjamin, D. R., Senter, P. D. & Vercellotti, G. M., Feb 23 2015, In : PloS one. 10, 2, e0117772.

Research output: Contribution to journalArticle

sickle cell anemia
Sickle Cell Anemia
endothelium
Transgenic Mice
Endothelium
2014
248 Citations (Scopus)

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Sickle Cell Anemia
Heme
Endothelial Cells
Chemical activation
22 Citations (Scopus)

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

Apoferritins
Ceruloplasmin
Sickle Cell Anemia
Transgenic Mice
Heme Oxygenase-1
51 Citations (Scopus)

Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer

Nguyen, J., Luk, K., Vang, D., Soto, W., Vincent, L., Robiner, S., Saavedra, R., Li, Y., Gupta, P. & Gupta, K., Jan 1 2014, In : British Journal of Anaesthesia. 113, SUPPL. 1, p. i4-i13

Research output: Contribution to journalArticle

Mast Cells
Morphine
Transgenic Mice
Breast Neoplasms
Survival
2013
94 Citations (Scopus)

Mast cell activation contributes to sickle cell pathobiology and pain in mice

Vincent, L., Vang, D., Nguyen, J., Gupta, M., Luk, K., Ericson, M. E., Simone, D. A. & Gupta, K., Jan 1 2013, In : Blood. 122, 11, p. 1853-1862 10 p.

Research output: Contribution to journalArticle

Mast Cells
Chemical activation
Pain
Morphine
Skin
10 Citations (Scopus)
Platelet-Derived Growth Factor Receptors
Mesangial Cells
Morphine
Transgenic Mice
Kidney
48 Citations (Scopus)

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

Belcher, J. D., Young, M., Chen, C., Nguyen, J., Burhop, K., Tran, P. & Vercellotti, G. M., Jan 1 2013, In : Blood. 122, 15, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Carbon Monoxide
Modulators
Transgenic Mice
Hemoglobins
2012
22 Citations (Scopus)

Influence of morphine on pericyte-endothelial interaction: Implications for antiangiogenic therapy

Luk, K., Boatman, S., Johnson, K. N., Dudek, O. A., Ristau, N., Vang, D., Nguyen, J. & Gupta, K., Feb 6 2012, In : Journal of Oncology. 458385.

Research output: Contribution to journalArticle

Pericytes
Morphine
Platelet-Derived Growth Factor Receptors
Neoplasms
Therapeutics
2011
51 Citations (Scopus)

CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)

Mitra, R., Guo, Z., Milani, M., Mesaros, C., Rodriguez, M., Nguyen, J., Luo, X., Clarke, D., Lamba, J., Schuetz, E., Donner, D. B., Puli, N., Falck, J. R., Capdevila, J., Gupta, K., Blair, I. A. & Potter, D. A., May 20 2011, In : Journal of Biological Chemistry. 286, 20, p. 17543-17559 17 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Biosynthesis
Estrogen Receptors
Cells
Breast Neoplasms
22 Citations (Scopus)
Vascular Diseases
African Americans
Endothelial Cells
Gene Expression
Health
57 Citations (Scopus)

Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer

Fujioka, N., Nguyen, J., Chen, C., Li, Y., Pasrija, T., Niehans, G., Johnson, K. N., Gupta, V., Kratzke, R. A. & Gupta, K., Dec 1 2011, In : Anesthesia and Analgesia. 113, 6, p. 1353-1364 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Non-Small Cell Lung Carcinoma
Morphine
Opioid Receptors
67 Citations (Scopus)
Heme Oxygenase-1
Hemin
MicroRNAs
Proteins
Enzyme activity
2010
60 Citations (Scopus)
Beauty
Heme Oxygenase-1
Sickle Cell Anemia
Blood Vessels
Genes
102 Citations (Scopus)

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids

Kohli, D. R., Li, Y., Khasabov, S. G., Gupta, P., Kehl, L. J., Ericson, M. E., Nguyen, J., Gupta, V., Hebbel, R. P., Simone, D. A. & Gupta, K., Jul 22 2010, In : Blood. 116, 3, p. 456-465 10 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
Cannabinoids
Modulation
Cannabinoid Receptor Agonists
Hyperalgesia
46 Citations (Scopus)

The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice

Hebbel, R. P., Vercellotti, G. M., Pace, B. S., Solovey, A. N., Kollander, R., Abanonu, C. F., Nguyen, J., Vineyard, J. V., Belcher, J. D., Abdulla, F., Osifuye, S., Eaton, J. W., Kelm, R. J. & Slungaard, A., Mar 25 2010, In : Blood. 115, 12, p. 2483-2490 8 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Transgenic Mice
Blood Vessels
Chemical activation
2009
30 Citations (Scopus)

Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

Beckman, J. D., Belcher, J. D., Vineyard, J. V., Chen, C., Nguyen, J., Nwaneri, M. O., O'Sullivan, G., Gulbahce, E., Hebbel, R. P. & Vercellotti, G. M., Oct 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1243-H1253

Research output: Contribution to journalArticle

Leukocytosis
Sickle Cell Anemia
Carbon Monoxide
Anti-Inflammatory Agents
Blood Vessels
2008
13 Citations (Scopus)

Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases

Zwolak, P., Dudek, A. Z., Bodempudi, V. D., Nguyen, J., Hebbel, R. P., Gallus, N. J., Ericson, M. E., Goblirsch, M. J. & Clohisy, D. R., Feb 1 2008, In : International Journal of Cancer. 122, 3, p. 681-688 8 p.

Research output: Contribution to journalArticle

Bone Neoplasms
Radiation
Neoplasm Metastasis
Bone and Bones
Neoplasms
29 Citations (Scopus)

Morphine induces mesangial cell proliferation and glomerulopathy via κ-opioid receptors

Weber, M. L., Farooqui, M., Nguyen, J., Ansonoff, M., Pintar, J. E., Hebbel, R. P. & Gupta, K., Jun 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 6, p. F1388-F1397

Research output: Contribution to journalArticle

Mesangial Cells
Opioid Receptors
Morphine
Cell Proliferation
STAT3 Transcription Factor
3 Citations (Scopus)
Gene therapy
Heme Oxygenase-1
Polymerase chain reaction
Polymorphism
Transgenes
2007
27 Citations (Scopus)

The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapy

Somani, A., Nguyen, J., Milbauer, L. C., Solovey, A., Sajja, S. & Hebbel, R. P., Jul 2007, In : Translational Research. 150, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Gene therapy
Endothelial cells
Genetic Therapy
CD31 Antigens
Blood
2006
44 Citations (Scopus)
Peroxidases
Cell Adhesion Molecules
Phagocytes
Oxidants
Neutrophils
2005
61 Citations (Scopus)

Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesions

Fernandez-L, A., Sanz-Rodriguez, F., Zarrabeitia, R., Pérez-Molino, A., Hebbel, R. P., Nguyen, J., Bernabéu, C. & Botella, L. M., Nov 1 2005, In : Cardiovascular Research. 68, 2, p. 235-248 14 p.

Research output: Contribution to journalArticle

Hereditary Hemorrhagic Telangiectasia
Blood Vessels
Endothelial Cells
Stress Fibers
Cytoskeleton
2003
152 Citations (Scopus)

Transgenic sickle mice have vascular inflammation

Belcher, J. D., Bryant, C. J., Nguyen, J., Bowlin, P. R., Kielbik, M. C., Bischof, J. C., Hebbel, R. P. & Vercellotti, G. M., May 15 2003, In : Blood. 101, 10, p. 3953-3959 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Blood Vessels
Vascular Cell Adhesion Molecule-1
Endothelial cells
Cell Adhesion Molecules