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Research Output

2020

Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management

Pastick, K. A., Nalintya, E., Tugume, L., Ssebambulidde, K., Stephens, N., Evans, E. E., Ndyetukira, J. F., Nuwagira, E., Skipper, C., Muzoora, C., Meya, D. B., Rhein, J., Boulware, D. R. & Rajasingham, R., Apr 1 2020, In : Medical mycology. 58, 3, p. 282-292 11 p.

Research output: Contribution to journalArticle

Evaluation of serum cryptococcal antigen testing using two novel semiquantitative lateral flow assays in persons with cryptococcal antigenemia

Skipper, C., Tadeo, K., Martyn, E., Nalintya, E., Rajasingham, R., Meya, D. B., Kafufu, B., Rhein, J. & Boulware, D. R., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02046-19.

Research output: Contribution to journalArticle

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

ASTRO-CM Team, Mar 2020, In : The Lancet Infectious Diseases. 20, 3, p. 308-317 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Adjunctive sertraline for HIV-associated cryptococcal meningitis: a randomised, placebo-controlled, double-blind phase 3 trial

ASTRO-CM Team, Aug 2019, In : The Lancet Infectious Diseases. 19, 8, p. 843-851 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Case report: Three's a crowd: A case report examining the diagnostic and pharmacokinetic challenges in hiv-tuberculous meningitis-malaria co-infection [version 2; referees: 2 approved]

Ellis, J., Eneh, P. C., Ssebambulidde, K., Rutakingirwa, M. K., Lamorde, M., Rhein, J., Cresswell, F. V., Boulware, D. R. & Nicol, M. R., Jan 1 2019, In : Wellcome Open Research. 3, 111.

Research output: Contribution to journalArticle

Open Access

Cerebrospinal Fluid and Brain Tissue Penetration of Tenofovir, Lamivudine, and Efavirenz in Postmortem Tissues with Cryptococcal Meningitis

Nicol, M. R., Pastick, K. A., Taylor, J., Namuju, O. C., Rhein, J., Williams, D. A., Meya, D. B., Boulware, D. R. & Lukande, R., Sep 1 2019, In : Clinical and translational science. 12, 5, p. 445-449 5 p.

Research output: Contribution to journalArticle

Open Access

Culture-negative cryptococcal meningitis

Ssebambulidde, K., Skipper, C. & Rhein, J., Sep 2019, In : The Lancet Infectious Diseases. 19, 9, p. 929-930 2 p.

Research output: Contribution to journalLetter

Open Access
Open Access
Open Access

HIV-Associated cryptococcal meningitis occurring at relatively higher CD4 counts

Tugume, L., Rhein, J., Hullsiek, K. H., Mpoza, E., Kiggundu, R., Ssebambulidde, K., Schutz, C., Taseera, K., Williams, D. A., Abassi, M., Muzoora, C., Musubire, A. K., Meintjes, G., Meya, D. B., Boulware, D. R., Nabeta, H. W., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Namuju, C. & 28 others, Sadiq, A., Namudde, A., Mwesigye, J., Kandole, T. K., Kwizera, R., Kirumira, P., Okirwoth, M., Akampurira, A., Luggya, T., Kaboggoza, J., Laker, E., Atwine, L., Muganzi, D., Evans, E. E., Bridge, S. C., Velamakanni, S. S., Rajasingham, R., Pastick, K., Stadelman, A., Flynn, A., Fujita, A. W., Mukaremera, L., Lofgren, S. M., Morawski, B. M., Bangdiwala, A., Nielsen, K., Bohjanen, P. R. & Kambugu, A., Feb 23 2019, In : Journal of Infectious Diseases. 219, 6, p. 877-883 7 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: A prospective cohort study

Ahimbisibwe, C., Kwizera, R., Ndyetukira, J. F., Kugonza, F., Sadiq, A., Hullsiek, K. H., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jun 26 2019, In : BMC infectious diseases. 19, 1, 558.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations

Performance of lipoarabinomannan assay using cerebrospinal fluid for the diagnosis of tuberculous meningitis among HIV patients [version 1; peer review: 2 approved]

Kwizera, R., Cresswell, F. V., Mugumya, G., Okirwoth, M., Kagimu, E., Bangdiwala, A. S., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jan 1 2019, In : Wellcome Open Research. 4, 123.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

ASTRO-CM Study Team, Dec 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics. 46, 6, p. 565-576 12 p.

Research output: Contribution to journalArticle

Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania

the KIULARCO Study Group, Dec 1 2019, In : Mycoses. 62, 12, p. 1127-1132 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis with Negative Cerebral Spinal Fluid Analysis

For the Adjunctive Sertraline for Treatment of HIV-associated Cryptococcal Meningitis Team, Jun 2019, In : Clinical Infectious Diseases. 68, 12, p. 2094-2098 5 p., ciy817.

Research output: Contribution to journalArticle

7 Scopus citations

The conundrum of clinical trials and standard of care in sub-Saharan Africa – the research nurse perspective

Frances Ndyetukira, J., Kwizera, R., Kugonza, F., Ahimbisibwe, C., Namujju, C., Sadiq, A., Namudde, A., Williams, D., Abassi, M., Rhein, J., Boulware, D. R. & Meya, D. B., Dec 1 2019, In : Journal of Research in Nursing. 24, 8, p. 649-660 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Blood neutrophil counts in HIV-infected patients with cryptococcal meningitis: Association with mortality

the COAT and ASTRO trial teams, Dec 2018, In : PloS one. 13, 12, e0209337.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cerebral oximetry for detecting high-mortality risk patients with cryptococcal meningitis

ASTRO-CM Trial Team, Jan 1 2018, In : Open Forum Infectious Diseases. 5, 6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cryptococcal Disease in the Era of "test and Treat": Is There Cause for Concern?

Abassi, M., Rhein, J., Meya, D. B. & Boulware, D. R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 1, ofx274.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Ellis, J., Cresswell, F. V., Rhein, J., Ssebambulidde, K. & Boulware, D. R., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 8

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Delta-like 1 protein, Vitamin D binding protein and fetuin for detection of Mycobacterium tuberculosis meningitis

Bahr, N. C., Halupnick, R., Linder, G., Kiggundu, R., Nabeta, H. W., Williams, D. A., Musubire, A. K., Morawski, B. M., Sreevatsan, S., Meya, D. B., Rhein, J. R. & Boulware, D. R., Jul 2018, In : Biomarkers in Medicine. 12, 7, p. 707-716 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Detrimental outcomes of unmasking cryptococcal meningitis with recent ARt initiation

ASTRO-CM Study Team, Jan 1 2018, In : Open Forum Infectious Diseases. 5, 8

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis

Mpoza, E., Rhein, J. & Abassi, M., Mar 2018, In : Medical Mycology Case Reports. 19, p. 30-32 3 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Evaluation of a point-of-care immunoassay test kit ‘StrongStep’ for cryptococcal antigen detection

Mpoza, E., Mukaremera, L., Kundura, D. A., Akampurira, A., Luggya, T., Tadeo, K. K., Pastick, K. A., Bridge, S. C., Tugume, L., Kiggundu, R., Musubire, A. K., Williams, D. A., Muzoora, C., Nalintya, E., Rajasingham, R., Rhein, J., Boulware, D. R., Meya, D. B. & Abassi, M., Jan 2018, In : PloS one. 13, 1, e0190652.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
3 Scopus citations
Open Access
1 Scopus citations

Tuberculous meningitis diagnosis and outcomes during the xpert MTB/Rif era: A 6.5-year cohort study in Uganda [version 2; referees: 3 approved]

Cresswell, F. V., Bangdiwala, A. S., Bahr, N. C., Trautner, E., Nuwagira, E., Ellis, J., Rajasingham, R., Rhein, J., Williams, D. A., Muzoora, C., Elliott, A. M., Meya, D. B. & Boulware, D. R., Jan 1 2018, In : Wellcome Open Research. 3, 64.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2017

Differences in immunologic factors among patients presenting with altered mental status during cryptococcal meningitis

Lofgren, S., Hullsiek, K. H., Morawski, B. M., Nabeta, H. W., Kiggundu, R., Taseera, K., Musubire, A., Schutz, C., Abassi, M., Bahr, N. C., Tugume, L., Muzoora, C., Williams, D. A., Rolfes, M. A., Velamakanni, S. S., Rajasingham, R., Meintjes, G., Rhein, J., Meya, D. B. & Boulware, D. R., Jan 1 2017, In : Journal of Infectious Diseases. 215, 5, p. 693-697 5 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Evaluation of trypan blue stain in a haemocytometer for rapid detection of cerebrospinal fluid sterility in HIV patients with cryptococcal meningitis

Kwizera, R., Akampurira, A., Kandole, T. K., Nielsen, K., Kambugu, A., Meya, D. B., Boulware, D. R. & Rhein, J., Aug 22 2017, In : BMC microbiology. 17, 1, 182.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evolving failures in the delivery of human immunodeficiency virus care: Lessons from a Ugandan meningitis cohort 2006-2016

Flynn, A. G., Meya, D. B., Hullsiek, K. H., Rhein, J., Williams, D. A., Musubire, A., Morawski, B. M., Taseera, K., Sadiq, A., Ndyatunga, L., Roediger, M., Rajasingham, R., Bohjanen, P. R., Muzoora, C. & Boulware, D. R., Mar 1 2017, In : Open Forum Infectious Diseases. 4, 2, ofx077.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Neurocognitive function in HIV-infected persons with asymptomatic cryptococcal antigenemia: A comparison of three prospective cohorts

Montgomery, M. P., Nakasujja, N., Morawski, B. M., Rajasingham, R., Rhein, J., Nalintya, E., Williams, D. A., Huppler Hullsiek, K., Kiragga, A., Rolfes, M. A., Donahue Carlson, R., Bahr, N. C., Birkenkamp, K. E., Manabe, Y. C., Bohjanen, P. R., Kaplan, J. E., Kambugu, A., Meya, D. B., Boulware, D. R. & and on behalf of the COAT and ORCAS Trial Teams, Jun 12 2017, In : BMC neurology. 17, 1, 110.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Prognostic implications of baseline anaemia and changes in haemoglobin concentrations with amphotericin B therapy for cryptococcal meningitis

Tugume, L., Morawski, B., Abassi, M., Bahr, N., Kiggundu, R., Nabeta, H., Hullsiek, K., Taseera, K., Musubire, A., Schutz, C., Muzoora, C., Williams, D., Rolfes, M., Meintjes, G., Rhein, J., Meya, D. & Boulware, D., Jan 1 2017, In : HIV Medicine. 18, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
5 Scopus citations
2016

Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda

Rhein, J., Bahr, N. C., Hemmert, A. C., Cloud, J. L., Bellamkonda, S., Oswald, C., Lo, E., Nabeta, H., Kiggundu, R., Akampurira, A., Musubire, A., Williams, D. A., Meya, D. B., Boulware, D. R., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Velamakanni, S. S., Namudde, A., Sadiq, A. & 15 others, Kandole, T. K., Kaboggoza, J., Laker, E., Luggya, T., Tugume, L., Butler, E., Dyal, J., Neborak, J., King, L., Yueh, N., Hullsiek, K. H., Halupnick, R., Bohjanen, P. R., Kambugu, A. & ASTRO-CM Team, Mar 1 2016, In : Diagnostic Microbiology and Infectious Disease. 84, 3, p. 268-273 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2 Scopus citations

Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: An open-label dose-ranging study

Rhein, J., Morawski, B. M., Hullsiek, K. H., Nabeta, H. W., Kiggundu, R., Tugume, L., Musubire, A., Akampurira, A., Smith, K. D., Alhadab, A., Williams, D. A., Abassi, M., Bahr, N. C., Velamakanni, S. S., Fisher, J., Nielsen, K., Meya, D. B. & Boulware, D. R., Jul 1 2016, In : The Lancet Infectious Diseases. 16, 7, p. 809-818 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Human immune response varies by the degree of relative cryptococcal antigen shedding

Boulware, D. R., von Hohenberg, M., Rolfes, M. A., Bahr, N. C., Rhein, J., Akampurira, A., Williams, D. A., Taseera, K., Schutz, C., McDonald, T., Muzoora, C., Meintjes, G., Meya, D. B., Nielsen, K., Hullsiek, K. H., Musubire, A. K., Nabeta, H. W., Thienemann, F., Rajasingham, R., Scriven, J. E. & 25 others, Mwesigy, J., Wagubi, R., Kajumbula, H., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Ndyatunga, L., Noeme, B., Memela, B., Sigila, Y., Sadiq, A., Magwayi, M., Kwizera, R., Ninsiima, E., Najjuka, G., Strain, A., Wiesner, D., Nanteza, C., Mushagara, R., Hassanally, L., Namawejje, M., Ssennono, M., Kiragga, A., Butler, E. K. & For the Cryptococcal Optimal ART Timing (COAT) Trial Team, Jan 1 2016, In : Open Forum Infectious Diseases. 3, 1

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Reproducibility of CSF quantitative culture methods for estimating rate of clearance in cryptococcal meningitis

Dyal, J., Akampurira, A., Rhein, J., Morawski, B. M., Kiggundu, R., Nabeta, H. W., Musubire, A. K., Bahr, N. C., Williams, D. A., Bicanic, T., Larsen, R. A., Meya, D. B. & Boulware, D. R., Apr 1 2016, In : Medical mycology. 54, 4, p. 361-369 9 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Sertraline for HIV-associated cryptococcal meningitis – Authors' reply

Rhein, J., Nielsen, K., Boulware, D. R. & Meya, D. B., Oct 1 2016, In : The Lancet Infectious Diseases. 16, 10, p. 1111-1112 2 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations
2015

1,3-β-D-glucan in cryptococcal meningitis

Rhein, J., Boulware, D. R. & Bahr, N. C., Oct 1 2015, In : The Lancet Infectious Diseases. 15, 10, p. 1136-1137 2 p., 238.

Research output: Contribution to journalLetter

3 Scopus citations

Cerebrospinal fluid culture positivity and clinical outcomes after amphotericin-based induction therapy for cryptococcal meningitis

Rolfes, M. A., Rhein, J., Schutz, C., Taseera, K., Nabeta, H. W., Hullsiek, K. H., Akampuira, A., Rajasingham, R., Musubire, A., Williams, D. A., Thienemann, F., Bohjanen, P. R., Muzoora, C., Meintjes, G., Meya, D. B. & Boulware, D. R., Jan 1 2015, In : Open Forum Infectious Diseases. 2, 4, p. 1-8 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cryptococcal Meningitis: Diagnosis and Management Update

Abassi, M., Boulware, D. R. & Rhein, J., Jun 1 2015, In : Current Tropical Medicine Reports. 2, 2, p. 90-99 10 p.

Research output: Contribution to journalReview article

27 Scopus citations

Early ART after cryptococcal meningitis is associated with cerebrospinal fluid pleocytosis and macrophage activation in a multisite randomized trial

Scriven, J. E., Rhein, J., Hullsiek, K. H., Von Hohenberg, M., Linder, G., Rolfes, M. A., Williams, D. A., Taseera, K., Meya, D. B., Meintjes, G. & Boulware, D. R., Jan 1 2015, In : Journal of Infectious Diseases. 212, 5, p. 769-778 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Epidemiology of meningitis in an HIV-infected Ugandan cohort

Rajasingham, R., Rhein, J., Klammer, K., Musubire, A., Nabeta, H., Akampurira, A., Mossel, E. C., Williams, D. A., Boxrud, D. J., Crabtree, M. B., Miller, B. R., Rolfes, M. A., Tengsupakul, S., Andama, A. O., Meya, D. B. & Boulware, D. R., Feb 1 2015, In : American Journal of Tropical Medicine and Hygiene. 92, 2, p. 274-279 6 p.

Research output: Contribution to journalArticle

32 Scopus citations

Evaluation of Fingerstick Cryptococcal Antigen Lateral Flow Assay in HIV-Infected Persons: A Diagnostic Accuracy Study

Williams, D. A., Kiiza, T., Kwizera, R., Kiggundu, R., Velamakanni, S., Meya, D. B., Rhein, J. & Boulware, D. R., Aug 1 2015, In : Clinical Infectious Diseases. 61, 3, p. 464-467 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

Improved diagnostic sensitivity for tuberculous meningitis with Xpert® MTB/RIF of centrifuged CSF

Bahr, N. C., Tugume, L., Rajasingham, R., Kiggundu, R., Williams, D. A., Morawski, B., Alland, D., Meya, D. B., Rhein, J. R. & Boulware, D. R., Oct 1 2015, In : International Journal of Tuberculosis and Lung Disease. 19, 10, p. 1209-1215 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Increased antifungal drug resistance in clinical isolates of Cryptococcus neoformans in Uganda

Smith, K. D., Achan, B., Hullsiek, K. H., McDonald, T. R., Okagaki, L. H., Alhadab, A. A., Akampurira, A., Rhein, J. R., Meya, D. B., Boulware, D. R., Nielsen, K., Musubire, A., Nabeta, H. W., Williams, D. A., Morawski, B., Rolfes, M. A., Ndyetukira, J. F., Ahimbisibwe, C., Kugonza, F., Sadiq, A. & 22 others, Dyal, J., Neborak, J. M., King, A. M., Yueh, N., Velamakanni, S. S., Namudde, A., Kandole, T. K., Kaboggoza, J., Laker, E., Luggya, T., Tugume, L., Abassi, M., Birkenkamp, K., Butler, E. K., Fujita, A. W., Halupnick, R., Strain, A. K., Vedula, P., Rajasingham, R., Kambugu, A., Bohjanen, P. R. & on behalf of the ASTRO-CM/COAT Team, Dec 1 2015, In : Antimicrobial agents and chemotherapy. 59, 12, p. 7197-7204 8 p.

Research output: Contribution to journalArticle

73 Scopus citations
2014

Accuracy of noninvasive intraocular pressure or optic nerve sheath diameter measurements for predicting elevated intracranial pressure in cryptococcal meningitis

Nabeta, H. W., Bahr, N. C., Rhein, J., Fossland, N., Kiragga, A. N., Meya, D. B., Dunlop, S. J. & Boulware, D. R., Jan 1 2014, In : Open Forum Infectious Diseases. 1, 3

Research output: Contribution to journalArticle

20 Scopus citations