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Joseph M Metzger

1984 …2023
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Research Output 1984 2019

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Review article
2019

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Houang, E. M., Bartos, J. A., Hackel, B. J., Lodge, T. P., Yannopoulos, D., Bates, F. S. & Metzger, J. M., Apr 1 2019, In : JACC: Basic to Translational Science. 4, 2, p. 275-287 13 p.

Research output: Contribution to journal › Review article

Open Access
Myocardial Reperfusion Injury
Myocardium
Membranes
Muscles
Heart Diseases
2018
2 Citations (Scopus)

Muscle membrane integrity in Duchenne muscular dystrophy: Recent advances in copolymer-based muscle membrane stabilizers

Houang, E. M., Sham, Y. Y., Bates, F. S. & Metzger, J. M., Oct 10 2018, In : Skeletal Muscle. 8, 1, 31.

Research output: Contribution to journal › Review article

Open Access
Duchenne Muscular Dystrophy
Muscles
Membranes
Poloxamer
Striated Muscle
2016
10 Citations (Scopus)

Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction

Bartos, J. A., Matsuura, T. R., Tsangaris, A., Olson, M., McKnite, S. H., Rees, J. N., Haman, K., Shekar, K. C., Riess, M. L., Bates, F. S., Metzger, J. M. & Yannopoulos, D., Jun 1 2016, In : JACC: Basic to Translational Science. 1, 4, p. 224-234 11 p.

Research output: Contribution to journal › Review article

Poloxamer
Reperfusion Injury
Swine
Reperfusion
Troponin I
39 Citations (Scopus)

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Bedada, F. B., Wheelwright, M. & Metzger, J. M., Jul 1 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 7, p. 1829-1838 10 p.

Research output: Contribution to journal › Review article

Sarcomeres
Cardiac Myocytes
Induced Pluripotent Stem Cells
Developmental Biology
Regenerative Medicine
10 Citations (Scopus)

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Prins, K. W., Asp, M. L., Zhang, H., Wang, W. & Metzger, J. M., Apr 1 2016, In : JACC: Basic to Translational Science. 1, 3, p. 122-130 9 p.

Research output: Contribution to journal › Review article

Inbred mdx Mouse
Microtubules
Cardiac Myocytes
Calcium
Calcium Signaling
2009
25 Citations (Scopus)

Cardiac Consequences to Skeletal Muscle-Centric Therapeutics for Duchenne Muscular Dystrophy

Townsend, D., Yasuda, S., Chamberlain, J. & Metzger, J. M., Feb 1 2009, In : Trends in Cardiovascular Medicine. 19, 2, p. 49-54 6 p.

Research output: Contribution to journal › Review article

Duchenne Muscular Dystrophy
Dystrophin
Skeletal Muscle
Striated Muscle
Therapeutics
2008
38 Citations (Scopus)

Designing heart performance by gene transfer

Davis, J., Westfall, M. V., Townsend, D., Blankinship, M., Herron, T. J., Guerrero-Serna, G., Wang, W., Devaney, E. & Metzger, J. M., Oct 1 2008, In : Physiological Reviews. 88, 4, p. 1567-1651 85 p.

Research output: Contribution to journal › Review article

Technology Transfer
Myocardium
Genes
Gene Transfer Techniques
Sarcomeres
6 Citations (Scopus)

Molecular cardiology in translation: gene, cell and chemical-based experimental therapeutics for the failing heart.

Turner, I., Bedada, F. B., Martindale, J., Townsend, D., Wang, W., Palpant, N., Yasuda, S. C., Barnabei, M., Fomicheva, E. & Metzger, J. M., Jan 1 2008, In : Journal of Cardiovascular Translational Research. 1, 4, p. 317-327 11 p.

Research output: Contribution to journal › Review article

Cardiology
Heart Diseases
Genes
Therapeutics
Clinical Medicine
6 Citations (Scopus)

Parvalbumin isoforms for enhancing cardiac diastolic function

Wang, W. & Metzger, J. M., May 1 2008, In : Cell biochemistry and biophysics. 51, 1, p. 1-8 8 p.

Research output: Contribution to journal › Review article

Diastolic Heart Failure
Parvalbumins
Protein Isoforms
Cardiac Myocytes
Heart Failure
2007
22 Citations (Scopus)

Cardiomyopathy of Duchenne muscular dystrophy: Pathogenesis and prospect of membrane sealants as a new therapeutic approach

Townsend, D. W., Yasuda, S. & Metzger, J., Jan 1 2007, In : Expert Review of Cardiovascular Therapy. 5, 1, p. 99-109 11 p.

Research output: Contribution to journal › Review article

Duchenne Muscular Dystrophy
Cardiomyopathies
Membranes
Poloxamer
Striated Muscle
30 Citations (Scopus)

Tuning cardiac performance in ischemic heart disease and failure by modulating myofilament function

Day, S. M., Westfall, M. V. & Metzger, J. M., Sep 1 2007, In : Journal of Molecular Medicine. 85, 9, p. 911-921 11 p.

Research output: Contribution to journal › Review article

Myofibrils
Myocardial Ischemia
Heart Failure
Troponin I
Ischemia
2004
132 Citations (Scopus)

Covalent and Noncovalent Modification of Thin Filament Action: The Essential Role of Troponin in Cardiac Muscle Regulation

Metzger, J. M. & Westfall, M. V., Feb 6 2004, In : Circulation research. 94, 2, p. 146-158 13 p.

Research output: Contribution to journal › Review article

Troponin
Myocardium
Missense Mutation
Post Translational Protein Processing
Protein Isoforms
2003
18 Citations (Scopus)

Targeting diastolic dysfunction by genetic engineering of calcium handling proteins

Coutu, P., Hirsch, J. C., Szatkowski, M. L. & Metzger, J. M., Jan 1 2003, In : Trends in Cardiovascular Medicine. 13, 2, p. 63-67 5 p.

Research output: Contribution to journal › Review article

Diastolic Heart Failure
Parvalbumins
Genetic Engineering
Diastole
Buffers
2002
3 Citations (Scopus)

A "wringing" endorsement for myosin phosphorylation in the heart.

Vandenboom, R. & Metzger, J. M., Jan 1 2002, In : Molecular interventions. 2, 7, p. 422-424 3 p.

Research output: Contribution to journal › Review article

Myosin-Light-Chain Kinase
Myosins
Phosphorylation
Myocardium
Cardiomyopathies
2000
8 Citations (Scopus)

Contractile dysfunction in hypertrophic cardiomyopathy: Elucidating primary defects of mutant contractile proteins by gene transfer

Michele, D. E. & Metzger, J. M., Dec 1 2000, In : Trends in Cardiovascular Medicine. 10, 4, p. 177-182 6 p.

Research output: Contribution to journal › Review article

Contractile Proteins
Hypertrophic Cardiomyopathy
Mutant Proteins
Cardiac Myocytes
Technology Transfer
34 Citations (Scopus)

Physiological consequences of tropomyosin mutations associated with cardiac and skeletal myopathies

Michele, D. E. & Metzger, J. M., Dec 1 2000, In : Journal of Molecular Medicine. 78, 10, p. 543-553 11 p.

Research output: Contribution to journal › Review article

Tropomyosin
Muscular Diseases
Nemaline Myopathies
Mutation
Mutant Proteins
1997
16 Citations (Scopus)

Embryonic stem cell cardiogenesis applications for cardiovascular research

Metzger, J. M., Samuelson, L. C., Rust, E. M. & Westfall, M. V., Jan 1 1997, In : Trends in Cardiovascular Medicine. 7, 2, p. 63-68 6 p.

Research output: Contribution to journal › Review article

Embryonic Stem Cells
Cardiac Myocytes
Blastocyst Inner Cell Mass
Research
Drug Discovery