Joseph M Metzger

1984 …2023
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Research Output 1984 2019

2019

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Houang, E. M., Bartos, J. A., Hackel, B. J., Lodge, T. P., Yannopoulos, D., Bates, F. S. & Metzger, J. M., Apr 1 2019, In : JACC: Basic to Translational Science. 4, 2, p. 275-287 13 p.

Research output: Contribution to journalReview article

Open Access
Myocardial Reperfusion Injury
Myocardium
Membranes
Muscles
Heart Diseases
Sarcomeres
Nucleic Acids
Troponin
Cytoplasm
Biological Phenomena

Gene transfer of calcium-binding proteins into adult cardiac myocytes

Thompson, B. R., Cohen, H., Angulski, A. B. B. & Metzger, J. M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 187-205 19 p. (Methods in Molecular Biology; vol. 1929).

Research output: Chapter in Book/Report/Conference proceedingChapter

Parvalbumins
Calcium-Binding Proteins
Cardiac Myocytes
Diastolic Heart Failure
Genes
1 Citation (Scopus)

Influence of Cholesterol and Bilayer Curvature on the Interaction of PPO-PEO Block Copolymers with Liposomes

Zhang, W., Coughlin, M. L., Metzger, J. M., Hackel, B. J., Bates, F. S. & Lodge, T. P., Jun 4 2019, In : Langmuir. 35, 22, p. 7231-7241 11 p.

Research output: Contribution to journalArticle

Polyphenylene oxides
Liposomes
Cholesterol
cholesterol
Polyethylene oxides
2018
Open Access
Cardiomyopathies
Knockout Mice
Dystrophin
Duchenne Muscular Dystrophy
Muscle Cells
5 Citations (Scopus)

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

Wheelwright, M., Win, Z., Mikkila, J. L., Amen, K. Y., Alford, P. W. & Metzger, J. M., Apr 2018, In : PloS one. 13, 4, e0194909.

Research output: Contribution to journalArticle

Open Access
traction (mechanics)
Induced Pluripotent Stem Cells
Atomic Force Microscopy
Traction
Cardiac Myocytes
2 Citations (Scopus)
Open Access
Duchenne Muscular Dystrophy
Muscles
Membranes
Poloxamer
Striated Muscle
1 Citation (Scopus)

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility

Vetter, A. D., Houang, E. M., Sell, J. J., Thompson, B. R., Sham, Y. Y. & Metzger, J. M., Apr 10 2018, In : Biophysical journal. 114, 7, p. 1646-1656 11 p.

Research output: Contribution to journalArticle

Troponin I
Proline
Sarcomeres
Molecular Dynamics Simulation
Histidine
2017
7 Citations (Scopus)
Lipid bilayers
Surface tension
lipids
Molecular dynamics
copolymers
10 Citations (Scopus)

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

Houang, E. M., Haman, K. J., Kim, M., Zhang, W., Lowe, D. A., Sham, Y. Y., Lodge, T. P., Hackel, B. J., Bates, F. S. & Metzger, J. M., Jul 3 2017, In : Molecular pharmaceutics. 14, 7, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

Open Access
Membranes
Poloxamer
Ethylene Oxide
Muscular Dystrophies
Molecular Dynamics Simulation
9 Citations (Scopus)
Right Ventricular Function
Colchicine
Pulmonary Hypertension
Microtubules
Monocrotaline
1 Citation (Scopus)

Molecular mechanism of sarcomeric cardiomyopathies

Thompson, B. R., Asp, M. L. & Metzger, J. M., Jun 1 2017, Congestive Heart Failure and Cardiac Transplantation: Clinical, Pathology, Imaging and Molecular Profiles. Springer International Publishing, p. 151-160 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiomyopathies
Mutation
Restrictive Cardiomyopathy
Investigational Therapies
Hypertrophic Cardiomyopathy
7 Citations (Scopus)

PEO-PPO Diblock Copolymers Protect Myoblasts from Hypo-Osmotic Stress in Vitro Dependent on Copolymer Size, Composition, and Architecture

Kim, M., Haman, K. J., Houang, E. M., Zhang, W., Yannopoulos, D., Metzger, J. M., Bates, F. S. & Hackel, B. J., Jul 10 2017, In : Biomacromolecules. 18, 7, p. 2090-2101 12 p.

Research output: Contribution to journalArticle

Open Access
Polypropylene oxides
Polyethylene oxides
Block copolymers
Copolymers
Chemical analysis
10 Citations (Scopus)

Quantifying Binding of Ethylene Oxide-Propylene Oxide Block Copolymers with Lipid Bilayers

Zhang, W., Haman, K. J., Metzger, J. M., Hackel, B. J., Bates, F. S. & Lodge, T. P., Nov 7 2017, In : Langmuir. 33, 44, p. 12624-12634 11 p.

Research output: Contribution to journalArticle

Open Access
Ethylene Oxide
propylene oxide
Lipid bilayers
ethylene oxide
block copolymers
2016
64 Citations (Scopus)

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

Davis, J., Davis, L. C., Correll, R. N., Makarewich, C. A., Schwanekamp, J. A., Moussavi-Harami, F., Wang, D., York, A. J., Wu, H., Houser, S. R., Seidman, C. E., Seidman, J. G., Regnier, M., Metzger, J. M., Wu, J. C. & Molkentin, J. D., May 19 2016, In : Cell. 165, 5, p. 1147-1159 13 p.

Research output: Contribution to journalArticle

Dilated Cardiomyopathy
Cardiomyopathies
Mutation
Calcium
Induced Pluripotent Stem Cells
4 Citations (Scopus)

Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function

Asp, M. L., Sjaastad, F. V., Siddiqui, J. K., Davis, J. P. & Metzger, J. M., May 10 2016, In : Biophysical journal. 110, 9, p. 2094-2105 12 p.

Research output: Contribution to journalArticle

EF Hand Motifs
Parvalbumins
Cardiac Myocytes
Muscle Cells
Sarcomeres
10 Citations (Scopus)

Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction

Bartos, J. A., Matsuura, T. R., Tsangaris, A., Olson, M., McKnite, S. H., Rees, J. N., Haman, K., Shekar, K. C., Riess, M. L., Bates, F. S., Metzger, J. M. & Yannopoulos, D., Jun 1 2016, In : JACC: Basic to Translational Science. 1, 4, p. 224-234 11 p.

Research output: Contribution to journalReview article

Poloxamer
Reperfusion Injury
Swine
Reperfusion
Troponin I
39 Citations (Scopus)

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Bedada, F. B., Wheelwright, M. & Metzger, J. M., Jul 1 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 7, p. 1829-1838 10 p.

Research output: Contribution to journalReview article

Sarcomeres
Cardiac Myocytes
Induced Pluripotent Stem Cells
Developmental Biology
Regenerative Medicine
10 Citations (Scopus)

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Prins, K. W., Asp, M. L., Zhang, H., Wang, W. & Metzger, J. M., Apr 1 2016, In : JACC: Basic to Translational Science. 1, 3, p. 122-130 9 p.

Research output: Contribution to journalReview article

Inbred mdx Mouse
Microtubules
Cardiac Myocytes
Calcium
Calcium Signaling
2 Citations (Scopus)

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling

Bedada, F. B., Martindale, J. J., Arden, E. & Metzger, J. M., Nov 11 2016, In : Scientific reports. 6, 36803.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Phosphoproteins
MicroRNAs
Troponin I
Phosphorylation
3 Citations (Scopus)
Sarcomeres
Myofibrils
Cardiomyopathies
Troponin I
Restrictive Cardiomyopathy
6 Citations (Scopus)

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

Duan, D., Rafael-Fortney, J. A., Blain, A., Kass, D. A., McNally, E. M., Metzger, J. M., Spurney, C. F. & Kinnett, K., Feb 1 2016, In : Journal of cardiovascular translational research. 9, 1, p. 85-86 2 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
National Heart, Lung, and Blood Institute (U.S.)
Group Processes
Muscular Dystrophies
Cardiomyopathies
2015

APSselect: Year one a success!

Metzger, J. M. & Samuelson, L. C., 2015, In : Physiologist. 58, 4, p. 188-190 3 p.

Research output: Contribution to journalArticle

Editorial Policies
Biomedical Research
21 Citations (Scopus)

Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest

Bartos, J. A., Matsuura, T. R., Sarraf, M., Youngquist, S. T., McKnite, S. H., Rees, J. N., Sloper, D. T., Bates, F. S., Segal, N., Debaty, G., Lurie, K. G., Neumar, R. W., Metzger, J. M., Riess, M. L. & Yannopoulos, D., Feb 1 2015, In : Resuscitation. 87, p. 7-13 7 p.

Research output: Contribution to journalArticle

Cardiopulmonary Resuscitation
Poloxamer
Heart Arrest
Nervous System
Hemodynamics

Ca2+regulation of the cardiac thin filament

Vetter, A. D., Thompson, B. R. & Metzger, J. M., Jan 1 2015, Cardiac Cytoarchitecture: How to Maintain a Working Heart. Springer International Publishing, p. 89-108 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Calcium
Cardiac Myocytes
Biophysics
Excitation Contraction Coupling
Biochemistry
90 Citations (Scopus)

Contemporary cardiac issues in Duchenne muscular dystrophy

McNally, E. M., Kaltman, J. R., Woodrow Benson, D., Canter, C. E., Cripe, L. H., Duan, D., Finder, J. D., Hoffman, E. P., Judge, D. P., Kertesz, N., Kinnett, K., Kirsch, R., Metzger, J. M., Pearson, G. D., Rafael-Fortney, J. A., Raman, S. V., Spurney, C. F., Targum, S. L., Wagner, K. R. & Markham, L. W., Jan 1 2015, In : Circulation. 131, 18, p. 1590-1598 9 p.

Research output: Contribution to journalArticle

Cardiovascular Diagnostic Techniques
Biological Specimen Banks
Respiration Disorders
Animal Disease Models
Combined Modality Therapy
5 Citations (Scopus)

Early detection of myocardial bioenergetic deficits: A 9.4 tesla complete non invasive 31P MR spectroscopy study in mice with muscular dystrophy

Cui, W., Jang, A., Zhang, P., Thompson, B., Townsend, D., Metzger, J. M. & Zhang, J., Aug 11 2015, In : PloS one. 10, 8, e0135000.

Research output: Contribution to journalArticle

muscular dystrophy
Duchenne Muscular Dystrophy
Muscular Dystrophies
energy metabolism
Energy Metabolism
16 Citations (Scopus)
Skeletal Muscle
Poloxamer
Duchenne Muscular Dystrophy
Membranes
Sarcolemma
8 Citations (Scopus)

Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator

Heinis, F. I., Vermillion, K. L., Andrews, M. T. & Metzger, J. M., Aug 18 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 4, p. R368-R377

Research output: Contribution to journalArticle

Ischemic Contracture
Torpor
Hibernation
Excitation Contraction Coupling
Sciuridae
12 Citations (Scopus)

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment

Barnabei, M. S., Sjaastad, F. V., Townsend, D., Bedada, F. B. & Metzger, J. M., Jul 1 2015, In : Science Translational Medicine. 7, 294, 294ra106.

Research output: Contribution to journalArticle

Dystrophin
Cardiomyopathies
Peptide Hydrolases
Sarcolemma
Membranes
2014
71 Citations (Scopus)

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes

Bedada, F. B., Chan, S. S. K., Metzger, S. K., Zhang, L., Zhang, J., Garry, D. J., Kamp, T. J., Kyba, M. & Metzger, J. M., Oct 14 2014, In : Stem Cell Reports. 3, 4, p. 594-605 12 p.

Research output: Contribution to journalArticle

Stem cells
Cardiac Myocytes
Stem Cells
Induced Pluripotent Stem Cells
Protein Isoforms
6 Citations (Scopus)

Cell biology of sarcomeric protein engineering: Disease modeling and therapeutic potential

Thompson, B. R. & Metzger, J. M., Jan 1 2014, In : Anatomical Record. 297, 9, p. 1663-1669 7 p.

Research output: Contribution to journalArticle

protein engineering
Protein Engineering
cell biology
Cell Biology
replacement
7 Citations (Scopus)

Differential effects of S100 proteins A2 and A6 on cardiac Ca2+ cycling and contractile performance

Wang, W., Asp, M. L., Guerrero-Serna, G. & Metzger, J. M., Jan 1 2014, In : Journal of Molecular and Cellular Cardiology. 72, p. 117-125 9 p.

Research output: Contribution to journalArticle

S100 Proteins
varespladib methyl
Cardiac Myocytes
Ryanodine Receptor Calcium Release Channel
Sequence Homology
7 Citations (Scopus)

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific tni residues

Thompson, B. R., Houang, E. M., Sham, Y. Y. & Metzger, J. M., May 20 2014, In : Biophysical journal. 106, 10, p. 2105-2114 10 p.

Research output: Contribution to journalArticle

Troponin I
Cardiac Myocytes
Protein Isoforms
Molecular Dynamics Simulation
Chordata
35 Citations (Scopus)
Myocardial Reperfusion Injury
Sarcolemma
Reperfusion Injury
Myocardial Ischemia
Oxidative Stress
2013
19 Citations (Scopus)

Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies

Asp, M. L., Martindale, J. J., Heinis, F. I., Wang, W. & Metzger, J. M., Apr 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 4, p. 895-900 6 p.

Research output: Contribution to journalArticle

Parvalbumins
Calcium
Cardiac Myocytes
Therapeutics
Sarcoplasmic Reticulum Calcium-Transporting ATPases
11 Citations (Scopus)

Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling

Asp, M. L., Martindale, J. J. & Metzger, J. M., Oct 24 2013, In : PloS one. 8, 10, e78768.

Research output: Contribution to journalArticle

tamoxifen
Tamoxifen
Cardiac Myocytes
Calcium
calcium
23 Citations (Scopus)

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

Wang, W., Barnabei, M. S., Asp, M. L., Heinis, F. I., Arden, E., Davis, J., Braunlin, E., Li, Q., Davis, J. P., Potter, J. D. & Metzger, J. M., Mar 1 2013, In : Nature Medicine. 19, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

EF Hand Motifs
Parvalbumins
Biological systems
Cations
Buffers
6 Citations (Scopus)

Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency

Heinis, F. I., Andersson, K. B., Christensen, G. & Metzger, J. M., Nov 4 2013, In : PloS one. 8, 11, e79609.

Research output: Contribution to journalArticle

Genetic Models
heart
calcium
heart failure
Heart Failure
2012
15 Citations (Scopus)

Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy

Davis, J., Yasuda, S., Palpant, N. J., Martindale, J., Stevenson, T., Converso, K. & Metzger, J. M., Sep 1 2012, In : Journal of Molecular and Cellular Cardiology. 53, 3, p. 446-457 12 p.

Research output: Contribution to journalArticle

Restrictive Cardiomyopathy
Muscle Cells
Sarcomeres
Troponin I
Blood Pressure
9 Citations (Scopus)

Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts

Barnabei, M. S. & Metzger, J. M., Mar 9 2012, In : PloS one. 7, 3, e32880.

Research output: Contribution to journalArticle

dystrophin
Dystrophin
mechanical properties
heart
Mechanical properties

Innovations in twenty-first century cardiovascular medicine

Garry, M. G., Metzger, J. M., Shi, X. & Garry, D. J., Jun 1 2012, Coronary Heart Disease: Clinical, Pathological, Imaging, and Molecular Profiles. Springer US, Vol. 9781461414759. p. 509-523 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heart Diseases
Medicine
Technology
Hope
Cause of Death
8 Citations (Scopus)

PH-responsive titratable inotropic performance of histidine-modified cardiac troponin i

Palpant, N. J., Houang, E. M., Sham, Y. Y. & Metzger, J. M., Apr 4 2012, In : Biophysical journal. 102, 7, p. 1570-1579 10 p.

Research output: Contribution to journalArticle

Troponin
Troponin I
Histidine
Myofibrils
Muscle Cells
2011
11 Citations (Scopus)

Age-dependent Dystrophin Loss and Genetic Reconstitution Establish a Molecular Link between Dystrophin and Heart Performance during Aging

Townsend, D., Daly, M., Chamberlain, J. S. & Metzger, J. M., Jan 1 2011, In : Molecular Therapy. 19, 10, p. 1821-1825 5 p.

Research output: Contribution to journalArticle

Dystrophin
Cytoskeletal Proteins
Heart Diseases
Public Health
4 Citations (Scopus)

Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies

Palpant, N. J., Bedada, F. B., Peacock, B., Blazar, B. R., Metzger, J. M. & Tolar, J., Jan 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 1, p. H356-H365

Research output: Contribution to journalArticle

Mucopolysaccharidosis I
Heart Diseases
Hemodynamics
Iduronidase
Cardiac Output
31 Citations (Scopus)

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex

Townsend, D., Yasuda, S., McNally, E. & Metzger, J. M., Sep 1 2011, In : FASEB Journal. 25, 9, p. 3106-3114 9 p.

Research output: Contribution to journalArticle

Sarcoglycans
Dystrophin
Cardiomyopathies
Limb-Girdle Muscular Dystrophies
Muscle
58 Citations (Scopus)

ER71 directs mesodermal fate decisions during embryogenesis

Rasmussen, T. L., Kweon, J., Diekmann, M. A., Belema-Bedada, F., Song, Q., Bowlin, K., Shi, X., Ferdous, A., Li, T., Kyba, M., Metzger, J. M., Koyano-Nakagawa, N. & Garry, D. J., Nov 1 2011, In : Development. 138, 21, p. 4801-4812 12 p.

Research output: Contribution to journalArticle

Embryonic Development
Transgenic Mice
functional role
embryo
reporter
3 Citations (Scopus)

Exercise and muscular dystrophy: Implications and analysis of effects on musculoskeletal and cardiovascular systems

Barnabei, M. S., Martindale, J. M., Townsend, D. & Metzger, J. M., Jul 1 2011, In : Comprehensive Physiology. 1, 3, p. 1353-1363 11 p.

Research output: Contribution to journalArticle

Musculoskeletal System
Dystrophin
Muscular Dystrophies
Cardiovascular System
Duchenne Muscular Dystrophy
2 Citations (Scopus)
Myosin Heavy Chains
Myofibrils
Myosins
Cardiac Myocytes
Sarcomeres
2010
23 Citations (Scopus)

Aesthetic cardiology: Adipose-derived stem cells for myocardial repair

Palpant, N. J. & Metzger, J. M., Jul 2 2010, In : Current Stem Cell Research and Therapy. 5, 2, p. 145-152 8 p.

Research output: Contribution to journalArticle

Cardiology
Esthetics
Stem Cells
Cell Biology
Heart Diseases