Joseph M Metzger

1984 …2020

Research output per year

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Research Output

2020
1 Scopus citations

Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo

Bez Batti Angulski, A., Bauer, J., Cohen, H., Kobuke, K., Campbell, K. P. & Metzger, J. M., Dec 1 2020, In : Scientific reports. 10, 1, 10967.

Research output: Contribution to journalArticle

Open Access

Social stress is lethal in the mdx model of Duchenne muscular dystrophy

Razzoli, M., Lindsay, A., Law, M. L., Chamberlain, C. M., Southern, W. M., Berg, M., Osborn, J., Engeland, W. C., Metzger, J. M., Ervasti, J. M. & Bartolomucci, A., May 2020, In : EBioMedicine. 55, 102700.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Spatial Distribution of PEO-PPO-PEO Block Copolymer and PEO Homopolymer in Lipid Bilayers

Kim, M., Heinrich, F., Haugstad, G., Yu, G., Yuan, G., Satija, S. K., Zhang, W., Seo, H. S., Metzger, J. M., Azarin, S. M., Lodge, T. P., Hackel, B. J. & Bates, F. S., Apr 7 2020, In : Langmuir. 36, 13, p. 3393-3403

Research output: Contribution to journalArticle

2019

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Houang, E. M., Bartos, J. A., Hackel, B. J., Lodge, T. P., Yannopoulos, D., Bates, F. S. & Metzger, J. M., Apr 2019, In : JACC: Basic to Translational Science. 4, 2, p. 275-287 13 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Gene transfer of calcium-binding proteins into adult cardiac myocytes

Thompson, B. R., Cohen, H., Angulski, A. B. B. & Metzger, J. M., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 187-205 19 p. (Methods in Molecular Biology; vol. 1929).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Influence of Cholesterol and Bilayer Curvature on the Interaction of PPO-PEO Block Copolymers with Liposomes

Zhang, W., Coughlin, M. L., Metzger, J. M., Hackel, B. J., Bates, F. S. & Lodge, T. P., Jun 4 2019, In : Langmuir. 35, 22, p. 7231-7241 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Treatments targeting inotropy

Maack, C., Eschenhagen, T., Hamdani, N., Heinze, F. R., Lyon, A. R., Manstein, D. J., Metzger, J., Papp, Z., Tocchetti, C. G., Yilmaz, M. B., Anker, S. D., Balligand, J. L., Bauersachs, J., Brutsaert, D., Carrier, L., Chlopicki, S., Cleland, J. G., De Boer, R. A., Dietl, A., Fischmeister, R. & 19 others, Harjola, V. P., Heymans, S., Hilfiker-Kleiner, D., Holzmeister, J., De Keulenaer, G., Limongelli, G., Linke, W. A., Lund, L. H., Masip, J., Metra, M., Mueller, C., Pieske, B., Ponikowski, P., Risti, A., Ruschitzka, F., Seferovi, P. M., Skouri, H., Zimmermann, W. H. & Mebazaa, A., 2019, In : European heart journal. 40, 44, p. 3626-3640D

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2018
Open Access

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

Wheelwright, M., Win, Z., Mikkila, J. L., Amen, K. Y., Alford, P. W. & Metzger, J. M., Apr 2018, In : PloS one. 13, 4, e0194909.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
Open Access
6 Scopus citations

TnI Structural Interface with the N-Terminal Lobe of TnC as a Determinant of Cardiac Contractility

Vetter, A. D., Houang, E. M., Sell, J. J., Thompson, B. R., Sham, Y. Y. & Metzger, J. M., Apr 10 2018, In : Biophysical journal. 114, 7, p. 1646-1656 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017
9 Scopus citations

Chemical End Group Modified Diblock Copolymers Elucidate Anchor and Chain Mechanism of Membrane Stabilization

Houang, E. M., Haman, K. J., Kim, M., Zhang, W., Lowe, D. A., Sham, Y. Y., Lodge, T. P., Hackel, B. J., Bates, F. S. & Metzger, J. M., Jul 3 2017, In : Molecular pharmaceutics. 14, 7, p. 2333-2339 7 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
Open Access
14 Scopus citations

Molecular mechanism of sarcomeric cardiomyopathies

Thompson, B. R., Asp, M. L. & Metzger, J. M., Jun 1 2017, Congestive Heart Failure and Cardiac Transplantation: Clinical, Pathology, Imaging and Molecular Profiles. Springer International Publishing, p. 151-160 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

PEO-PPO Diblock Copolymers Protect Myoblasts from Hypo-Osmotic Stress in Vitro Dependent on Copolymer Size, Composition, and Architecture

Kim, M., Haman, K. J., Houang, E. M., Zhang, W., Yannopoulos, D., Metzger, J. M., Bates, F. S. & Hackel, B. J., Jul 10 2017, In : Biomacromolecules. 18, 7, p. 2090-2101 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Quantifying Binding of Ethylene Oxide-Propylene Oxide Block Copolymers with Lipid Bilayers

Zhang, W., Haman, K. J., Metzger, J. M., Hackel, B. J., Bates, F. S. & Lodge, T. P., Nov 7 2017, In : Langmuir. 33, 44, p. 12624-12634 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2016

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

Davis, J., Davis, L. C., Correll, R. N., Makarewich, C. A., Schwanekamp, J. A., Moussavi-Harami, F., Wang, D., York, A. J., Wu, H., Houser, S. R., Seidman, C. E., Seidman, J. G., Regnier, M., Metzger, J. M., Wu, J. C. & Molkentin, J. D., May 19 2016, In : Cell. 165, 5, p. 1147-1159 13 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations

Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function

Asp, M. L., Sjaastad, F. V., Siddiqui, J. K., Davis, J. P. & Metzger, J. M., May 10 2016, In : Biophysical journal. 110, 9, p. 2094-2105 12 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction

Bartos, J. A., Matsuura, T. R., Tsangaris, A., Olson, M., McKnite, S. H., Rees, J. N., Haman, K., Shekar, K. C., Riess, M. L., Bates, F. S., Metzger, J. M. & Yannopoulos, D., Jun 1 2016, In : JACC: Basic to Translational Science. 1, 4, p. 224-234 11 p.

Research output: Contribution to journalReview article

Open Access
13 Scopus citations

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Bedada, F. B., Wheelwright, M. & Metzger, J. M., Jul 1 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 7, p. 1829-1838 10 p.

Research output: Contribution to journalReview article

Open Access
52 Scopus citations

Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice

Prins, K. W., Asp, M. L., Zhang, H., Wang, W. & Metzger, J. M., Apr 1 2016, In : JACC: Basic to Translational Science. 1, 3, p. 122-130 9 p.

Research output: Contribution to journalReview article

Open Access
13 Scopus citations

Molecular inotropy mediated by cardiac miR-based PDE4D/PRKAR1α/phosphoprotein signaling

Bedada, F. B., Martindale, J. J., Arden, E. & Metzger, J. M., Nov 11 2016, In : Scientific reports. 6, 36803.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
Open Access
3 Scopus citations

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

Duan, D., Rafael-Fortney, J. A., Blain, A., Kass, D. A., McNally, E. M., Metzger, J. M., Spurney, C. F. & Kinnett, K., Feb 1 2016, In : Journal of cardiovascular translational research. 9, 1, p. 85-86 2 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2015

APSselect: Year one a success!

Metzger, J. M. & Samuelson, L. C., 2015, In : Physiologist. 58, 4, p. 188-190 3 p.

Research output: Contribution to journalArticle

Bundled postconditioning therapies improve hemodynamics and neurologic recovery after 17 min of untreated cardiac arrest

Bartos, J. A., Matsuura, T. R., Sarraf, M., Youngquist, S. T., McKnite, S. H., Rees, J. N., Sloper, D. T., Bates, F. S., Segal, N., Debaty, G., Lurie, K. G., Neumar, R. W., Metzger, J. M., Riess, M. L. & Yannopoulos, D., Feb 1 2015, In : Resuscitation. 87, p. 7-13 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ca2+regulation of the cardiac thin filament

Vetter, A. D., Thompson, B. R. & Metzger, J. M., Jan 1 2015, Cardiac Cytoarchitecture: How to Maintain a Working Heart. Springer International Publishing, p. 89-108 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Contemporary cardiac issues in Duchenne muscular dystrophy

McNally, E. M., Kaltman, J. R., Woodrow Benson, D., Canter, C. E., Cripe, L. H., Duan, D., Finder, J. D., Hoffman, E. P., Judge, D. P., Kertesz, N., Kinnett, K., Kirsch, R., Metzger, J. M., Pearson, G. D., Rafael-Fortney, J. A., Raman, S. V., Spurney, C. F., Targum, S. L., Wagner, K. R. & Markham, L. W., Jan 1 2015, In : Circulation. 131, 18, p. 1590-1598 9 p.

Research output: Contribution to journalArticle

110 Scopus citations

Early detection of myocardial bioenergetic deficits: A 9.4 tesla complete non invasive 31P MR spectroscopy study in mice with muscular dystrophy

Cui, W., Jang, A., Zhang, P., Thompson, B., Townsend, D., Metzger, J. M. & Zhang, J., Aug 11 2015, In : PloS one. 10, 8, e0135000.

Research output: Contribution to journalArticle

5 Scopus citations
19 Scopus citations

Myocardial performance and adaptive energy pathways in a torpid mammalian hibernator

Heinis, F. I., Vermillion, K. L., Andrews, M. T. & Metzger, J. M., Aug 18 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309, 4, p. R368-R377

Research output: Contribution to journalArticle

9 Scopus citations

Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment

Barnabei, M. S., Sjaastad, F. V., Townsend, D., Bedada, F. B. & Metzger, J. M., Jul 1 2015, In : Science Translational Medicine. 7, 294, 294ra106.

Research output: Contribution to journalArticle

14 Scopus citations
2014

Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes

Bedada, F. B., Chan, S. S. K., Metzger, S. K., Zhang, L., Zhang, J., Garry, D. J., Kamp, T. J., Kyba, M. & Metzger, J. M., Oct 14 2014, In : Stem Cell Reports. 3, 4, p. 594-605 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Cell biology of sarcomeric protein engineering: Disease modeling and therapeutic potential

Thompson, B. R. & Metzger, J. M., Sep 2014, In : Anatomical Record. 297, 9, p. 1663-1669 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Differential effects of S100 proteins A2 and A6 on cardiac Ca2+ cycling and contractile performance

Wang, W., Asp, M. L., Guerrero-Serna, G. & Metzger, J. M., Jul 2014, In : Journal of Molecular and Cellular Cardiology. 72, p. 117-125 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular determinants of cardiac myocyte performance as conferred by isoform-specific tni residues

Thompson, B. R., Houang, E. M., Sham, Y. Y. & Metzger, J. M., May 20 2014, In : Biophysical journal. 106, 10, p. 2105-2114 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
37 Scopus citations
2013

Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies

Asp, M. L., Martindale, J. J., Heinis, F. I., Wang, W. & Metzger, J. M., Apr 1 2013, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 4, p. 895-900 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling

Asp, M. L., Martindale, J. J. & Metzger, J. M., Oct 24 2013, In : PloS one. 8, 10, e78768.

Research output: Contribution to journalArticle

13 Scopus citations

Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance

Wang, W., Barnabei, M. S., Asp, M. L., Heinis, F. I., Arden, E., Davis, J., Braunlin, E., Li, Q., Davis, J. P., Potter, J. D. & Metzger, J. M., Mar 1 2013, In : Nature Medicine. 19, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency

Heinis, F. I., Andersson, K. B., Christensen, G. & Metzger, J. M., Nov 4 2013, In : PloS one. 8, 11, e79609.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy

Davis, J., Yasuda, S., Palpant, N. J., Martindale, J., Stevenson, T., Converso, K. & Metzger, J. M., Sep 1 2012, In : Journal of Molecular and Cellular Cardiology. 53, 3, p. 446-457 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts

Barnabei, M. S. & Metzger, J. M., Mar 9 2012, In : PloS one. 7, 3, e32880.

Research output: Contribution to journalArticle

9 Scopus citations

Innovations in twenty-first century cardiovascular medicine

Garry, M. G., Metzger, J. M., Shi, X. & Garry, D. J., Jun 1 2012, Coronary Heart Disease: Clinical, Pathological, Imaging, and Molecular Profiles. Springer US, Vol. 9781461414759. p. 509-523 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

PH-responsive titratable inotropic performance of histidine-modified cardiac troponin i

Palpant, N. J., Houang, E. M., Sham, Y. Y. & Metzger, J. M., Apr 4 2012, In : Biophysical journal. 102, 7, p. 1570-1579 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Age-dependent Dystrophin Loss and Genetic Reconstitution Establish a Molecular Link between Dystrophin and Heart Performance during Aging

Townsend, D., Daly, M., Chamberlain, J. S. & Metzger, J. M., Oct 2011, In : Molecular Therapy. 19, 10, p. 1821-1825 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies

Palpant, N. J., Bedada, F. B., Peacock, B., Blazar, B. R., Metzger, J. M. & Tolar, J., Jan 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 1, p. H356-H365

Research output: Contribution to journalArticle

4 Scopus citations