Joseph J Topczewski

20092022
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  • 2 Similar Profiles
Azides Chemical Compounds
Cyclization Chemical Compounds
Fluorination Chemical Compounds
Halogenation Medicine & Life Sciences
Acetylcholinesterase Chemical Compounds
Stereochemistry Chemical Compounds
Kinetics Chemical Compounds
Substitution reactions Chemical Compounds

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Projects 2016 2022

Research Output 2009 2019

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Ligands
Oxidative stress
Neurotransmitter Agents
Assays

Additive-Free Palladium-Catalyzed Decarboxylative Cross-Coupling of Aryl Chlorides

Daley, R. A., Liu, E. C. & Topczewski, J. J., Jun 21 2019, In : Organic Letters. 21, 12, p. 4734-4738 5 p.

Research output: Contribution to journalArticle

cross coupling
Palladium
Chlorides
palladium
Salts
2 Citations (Scopus)

Allylic azides: Synthesis, reactivity, and the Winstein rearrangement

Carlson, A. S. & Topczewski, J. J., Jan 1 2019, In : Organic and Biomolecular Chemistry. 17, 18, p. 4406-4429 24 p.

Research output: Contribution to journalReview article

Azides
azides (organic)
isomers
reactivity
synthesis

Double-click enables synthesis of chemical libraries for drug discovery

Topczewski, J. J. & Liu, E. C., Oct 1 2019, In : Nature. 574, 7776, p. 42-43 2 p.

Research output: Contribution to journalComment/debate

Open Access
Combinatorial Chemistry Techniques
Click Chemistry
Organic Chemistry
Small Molecule Libraries
Azides
4 Citations (Scopus)

Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution

Liu, E. C. & Topczewski, J. J., Apr 3 2019, In : Journal of the American Chemical Society. 141, 13, p. 5135-5138 4 p.

Research output: Contribution to journalArticle

Triazoles
Alkynes
Azides
Cycloaddition
Cycloaddition Reaction