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Research Output 2003 2019

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Article
2019

Adhesive thermosensitive gels for local delivery of viral vectors

Caronia, J. M., Sorensen, D. W., Leslie, H. M., van Berlo, J. & Azarin, S. M., Jan 1 2019, In : Biotechnology and bioengineering. 116, 9, p. 2353-2363 11 p.

Research output: Contribution to journalArticle

Open Access
UCON 50-HB-5100
Poloxamer
Transition Temperature
Adhesives
Gels
11 Citations (Scopus)

The N-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

Dorn, L. E., Lasman, L., Chen, J., Xu, X., Hund, T. J., Medvedovic, M., Hanna, J. H., van Berlo, J. & Accornero, F., Jan 22 2019, In : Circulation. 139, 4, p. 533-545 13 p.

Research output: Contribution to journalArticle

Methyltransferases
Cardiomegaly
Methylation
Cardiac Myocytes
Homeostasis
2018
5 Citations (Scopus)
Salamandridae
Hedgehogs
regeneration
Regeneration
Cardiac Myocytes
1 Citation (Scopus)

A Small Peptide Ac-SDKP Inhibits Radiation-Induced Cardiomyopathy

Sharma, U. C., Sonkawade, S. D., Spernyak, J. A., Sexton, S., Nguyen, J., Dahal, S., Attwood, K. M., Singh, A. K., van Berlo, J. & Pokharel, S., Aug 1 2018, In : Circulation. Heart failure. 11, 8, p. e004867

Research output: Contribution to journalArticle

Cardiomyopathies
Radiation
Peptides
Macrophages
Fibrosis
9 Citations (Scopus)

Cardiac c-Kit biology revealed by inducible transgenesis

Gude, N. A., Firouzi, F., Broughton, K. M., Ilves, K., Nguyen, K. P., Payne, C. R., Sacchi, V., Monsanto, M. M., Casillas, A. R., Khalafalla, F. G., Wang, B. J., Ebeid, D. E., Alvarez, R., Dembitsky, W. P., Bailey, B. A., van Berlo, J. & Sussman, M. A., Jan 1 2018, In : Circulation research. 123, 1, p. 57-72 16 p.

Research output: Contribution to journalArticle

Open Access
Gene Transfer Techniques
Stem Cells
Cardiac Myocytes
Proto-Oncogene Proteins c-kit
Doxycycline

Development of a Click-Chemistry Reagent Compatible with Mass Cytometry

Shaklee, J., Srivastava, K., Brown, H., Arriaga, E., Pierre, V. C. & van Berlo, J., Dec 1 2018, In : Scientific reports. 8, 1, 6657.

Research output: Contribution to journalArticle

Click Chemistry
Lanthanoid Series Elements
Azides
DNA
Flow Cytometry
3 Citations (Scopus)

Van Berlo et al. reply

van Berlo, J., Kanisicak, O., Maillet, M., Vagnozzi, R. J., Karch, J., Lin, S. C. J., Middleton, R. C., Marbán, E. & Molkentin, J. D., Mar 21 2018, In : Nature. 555, 7697, p. E1-E5

Research output: Contribution to journalArticle

cardiology
cardiovascular system
genetic analysis
rodent
membrane
2017
4 Citations (Scopus)

BEX1 is an RNA-dependent mediator of cardiomyopathy

Accornero, F., Schips, T. G., Petrosino, J. M., Gu, S. Q., Kanisicak, O., Van Berlo, J. H. & Molkentin, J. D., Dec 1 2017, In : Nature communications. 8, 1, 1875.

Research output: Contribution to journalArticle

Open Access
Cardiomyopathies
genes
RNA
Heart Failure
Messenger RNA
10 Citations (Scopus)

Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit+ Cells

Chen, Z., Zhu, W., Bender, I., Gong, W., Kwak, I. Y., Yellamilli, A., Hodges, T. J., Nemoto, N., Zhang, J., Garry, D. J. & van Berlo, J., Dec 12 2017, In : Circulation. 136, 24, p. 2359-2372 14 p.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Doxorubicin
Endothelial Cells
DNA Damage
Blood Vessels
66 Citations (Scopus)

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

Luongo, T. S., Lambert, J. P., Gross, P., Nwokedi, M., Lombardi, A. A., Shanmughapriya, S., Carpenter, A. C., Kolmetzky, D., Gao, E., Van Berlo, J. H., Tsai, E. J., Molkentin, J. D., Chen, X., Madesh, M., Houser, S. R. & Elrod, J. W., May 4 2017, In : Nature. 545, 7652, p. 93-97 5 p.

Research output: Contribution to journalArticle

Open Access
Homeostasis
Cell Death
Heart Failure
Gene Transfer Techniques
Tamoxifen
2016
16 Citations (Scopus)

DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling

Liu, R., van Berlo, J. H., York, A. J., Maillet, M., Vagnozzi, R. J. & Molkentin, J. D., Jul 8 2016, In : Circulation research. 119, 2, p. 249-260 12 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Cardiac Myocytes
Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
20 Citations (Scopus)

Most of the Dust Has Settled: CKit+ Progenitor Cells Are an Irrelevant Source of Cardiac Myocytes in Vivo

van Berlo, J. & Molkentin, J. D., Jan 8 2016, In : Circulation research. 118, 1, p. 17-19 3 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-kit
Dust
Cardiac Myocytes
Regeneration
Stem Cells
2015
41 Citations (Scopus)

Genetic analysis of connective tissue growth factor as an effector of transforming growth factor β signaling and cardiac remodeling

Accornero, F., van Berlo, J. H., Correll, R. N., Elrod, J. W., Sargent, M. A., York, A., Rabinowitz, J. E., Leask, A. & Molkentin, J. D., Jan 1 2015, In : Molecular and cellular biology. 35, 12, p. 2154-2164 11 p.

Research output: Contribution to journalArticle

Connective Tissue Growth Factor
Transforming Growth Factors
Fibrosis
Pressure
Mutant Proteins
40 Citations (Scopus)

STIM1 elevation in the heart results in aberrant Ca2+ handling and cardiomyopathy

Correll, R. N., Goonasekera, S. A., van Berlo, J. H., Burr, A. R., Accornero, F., Zhang, H., Makarewich, C. A., York, A. J., Sargent, M. A., Chen, X., Houser, S. R. & Molkentin, J. D., Oct 1 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 38-47 10 p.

Research output: Contribution to journalArticle

Cardiomyopathies
Transgenic Mice
Sarcoplasmic Reticulum
Sarcolemma
1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole
2014
405 Citations (Scopus)

C-kit + cells minimally contribute cardiomyocytes to the heart

Van Berlo, J. H., Kanisicak, O., Maillet, M., Vagnozzi, R. J., Karch, J., Lin, S. C. J., Middleton, R. C., Marbán, E. & Molkentin, J. D., Jan 1 2014, In : Nature. 509, 7500, p. 337-341 5 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Wounds and Injuries
Cell Lineage
Tamoxifen
Myocardium
2013
67 Citations (Scopus)

Differential expression of embryonic epicardial progenitor markers and localization of cardiac fibrosis in adult ischemic injury and hypertensive heart disease

Braitsch, C. M., Kanisicak, O., van Berlo, J. H., Molkentin, J. D. & Yutzey, K. E., Dec 1 2013, In : Journal of Molecular and Cellular Cardiology. 65, p. 108-119 12 p.

Research output: Contribution to journalArticle

Heart Diseases
Fibrosis
Wounds and Injuries
Fibroblasts
Pericardium
15 Citations (Scopus)

Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response

van Berlo, J., Aronow, B. J. & Molkentin, J. D., Dec 31 2013, In : PloS one. 8, 12, e84591.

Research output: Contribution to journalArticle

GATA4 Transcription Factor
heart
Cardiomegaly
heart failure
Transgenes
43 Citations (Scopus)

Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.

Auger-Messier, M., Accornero, F., Goonasekera, S. A., Bueno, O. F., Lorenz, J. N., van Berlo, J. H., Willette, R. N. & Molkentin, J. D., Jan 4 2013, In : Unknown Journal. 112, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Cardiomyopathies
Mitogen-Activated Protein Kinases
Fibroblasts
Dual-Specificity Phosphatases
2011
54 Citations (Scopus)

Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism

Accornero, F., Van Berlo, J. H., Benard, M. J., Lorenz, J. N., Carmeliet, P. & Molkentin, J. D., Jul 22 2011, In : Circulation research. 109, 3, p. 272-280 9 p.

Research output: Contribution to journalArticle

Cardiomegaly
Intercellular Signaling Peptides and Proteins
Fibroblasts
Pressure
Muscle Cells
58 Citations (Scopus)

Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo

Van Berlo, J. H., Elrod, J. W., Aronow, B. J., Pu, W. T. & Molkentin, J. D., Jul 26 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 30, p. 12331-12336 6 p.

Research output: Contribution to journalArticle

GATA4 Transcription Factor
Cardiomegaly
Serine
Phosphorylation
Hypertrophy
2010
53 Citations (Scopus)

The transcription factor GATA-6 regulates pathological cardiac hypertrophy

Van Berlo, J. H., Elrod, J. W., Van Den Hoogenhof, M. M. G., York, A. J., Aronow, B. J., Duncan, S. A. & Molkentin, J. D., Oct 15 2010, In : Circulation research. 107, 8, p. 1032-1040 9 p.

Research output: Contribution to journalArticle

GATA6 Transcription Factor
Cardiomegaly
Pressure
Hypertrophy
GATA Transcription Factors
2007
48 Citations (Scopus)

Severe Myocardial Fibrosis Caused by a Deletion of the 5' End of the Lamin A/C Gene

van Tintelen, J. P., Tio, R. A., Kerstjens-Frederikse, W. S., van Berlo, J. H., Boven, L. G., Suurmeijer, A. J. H., White, S. J., den Dunnen, J. T., te Meerman, G. J., Vos, Y. J., van der Hout, A. H., Osinga, J., van den Berg, M. P., van Veldhuisen, D. J., Buys, C. H. C. M., Hofstra, R. M. W. & Pinto, Y. M., Jun 26 2007, In : Journal of the American College of Cardiology. 49, 25, p. 2430-2439 10 p.

Research output: Contribution to journalArticle

Lamin Type A
Lamins
Fibrosis
Genes
Exons
2005
103 Citations (Scopus)

A-type lamins are essential for TGF-β1 induced PP2A to dephosphorylate transcription factors

Van Berlo, J. H., Voncken, J. W., Kubben, N., Broers, J. L. V., Duisters, R., van Leeuwen, R. E. W., Crijns, H. J. G. M., Ramaekers, F. C. S., Hutchison, C. J. & Pinto, Y. M., Oct 1 2005, In : Human molecular genetics. 14, 19, p. 2839-2849 11 p.

Research output: Contribution to journalArticle

Lamin Type A
Transforming Growth Factors
Transcription Factors
Lamins
Retinoblastoma Protein
2004
501 Citations (Scopus)

Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction

Sharma, U. C., Pokharel, S., Van Brakel, T. J., Van Berlo, J. H., Cleutjens, J. P. M., Schroen, B., André, S., Crijns, H. J. G. M., Gabius, H. J., Maessen, J. & Pinto, Y. M., Nov 9 2004, In : Circulation. 110, 19, p. 3121-3128 8 p.

Research output: Contribution to journalArticle

Galectin 3
Macrophages
Heart Failure
Collagen
Fibroblasts
2003
65 Citations (Scopus)

108th ENMC International Workshop, 3rd Workshop of the MYO-CLUSTER project: EUROMEN, 7th International Emery-Dreifuss Muscular Dystrophy (EDMD) Workshop, 13-15 September 2002, Naarden, The Netherlands

Bonne, G., Yaou, R. B., Béroud, C., Boriani, G., Brown, S., De Visser, M., Duboc, D., Ellis, J., Hausmanowa-Petrusewicz, I., Lattanzi, G., Merlini, L., Morris, G., Muntoni, F., Opolski, G., Pinto, Y. M., Sangiuolo, F., Toniolo, D., Trembath, R., Van Berlo, J. H., Van Der Kooi, A. J. & 1 others, Wehnert, M., Jan 1 2003, In : Neuromuscular Disorders. 13, 6, p. 508-515 8 p.

Research output: Contribution to journalArticle