20082019
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Research Output 2008 2019

2019

Comparative Approach to the Temporo-Spatial Organization of the Tumor Microenvironment

Langsten, K. L., Kim, J. H., Sarver, A. L., Dewhirst, M. & Modiano, J. F., Nov 7 2019, In : Frontiers in Oncology. 9, 1185.

Research output: Contribution to journalReview article

Open Access
Tumor Microenvironment
Neoplasms
Dogs
Canidae
Cellular Microenvironment

Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma

Megquier, K., Turner-Maier, J., Swofford, R., Kim, J. H., Sarver, A. L., Wang, C., Sakthikumar, S., Johnson, J., Koltookian, M., Lewellen, M., Scott, M. C., Schulte, A. J., Borst, L., Tonomura, N., Alfoldi, J., Painter, C., Thomas, R., Karlsson, E. K., Breen, M., Modiano, J. F. & 2 others, Elvers, I. & Lindblad-Toh, K., Jan 1 2019, In : Molecular Cancer Research. 17, 12, p. 2410-2421 12 p.

Research output: Contribution to journalArticle

Open Access
Hemangiosarcoma
Genomics
Canidae
Dogs
Exome
2018
Hemangiosarcoma
Tumor Microenvironment
Interleukin-8
Canidae
Cell Line
1 Citation (Scopus)
fatty acid metabolism
Fatty Acids
Dogs
neoplasms
dogs
2017
2 Citations (Scopus)

Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type

Im, K. S., Kim, J. H., Graef, A. J., Cornax, I., Seelig, D. M., O'Sullivan, M. G., Kovi, R. C. & Modiano, J. F., Jan 1 2017, In : Journal of Comparative Pathology. 156, 1, p. 37-41 5 p.

Research output: Contribution to journalArticle

Enteropathy-Associated T-Cell Lymphoma
digestive system diseases
lymphoma
Heterografts
Canidae
4 Citations (Scopus)

Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma

Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F. & Kim, J. H., Jun 2017, In : Veterinary and Comparative Oncology. 15, 2, p. 315-327 13 p.

Research output: Contribution to journalArticle

hemangiosarcoma
Hemangiosarcoma
cell invasion
cell movement
Cell Movement
11 Citations (Scopus)

Safe and effective sarcoma therapy through bispecific targeting of EGFR and uPAR

Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., Rizzardi, A. E., Henriksen, J. C., Schmechel, S., Forster, C. L., Kim, J. H., Froelich, J., Walz, J., Henson, M. S., Breen, M., Lindblad-Toh, K., Oh, F., Pilbeam, K., Modiano, J. F. & Vallera, D. A., May 1 2017, In : Molecular Cancer Therapeutics. 16, 5, p. 956-965 10 p.

Research output: Contribution to journalArticle

Open Access
Sarcoma
Dogs
Hemangiosarcoma
Therapeutics
Canidae
2016
2 Citations (Scopus)

Anti-insulin immune responses are detectable in dogs with spontaneous diabetes

Kim, J. H., Furrow, E., Ritt, M. G., Utz, P. J., Robinson, W. H., Yu, L., Eckert, A., Stuebner, K., O'Brien, T. D., Steinman, L. & Modiano, J., Mar 1 2016, In : PloS one. 11, 3, e0152397.

Research output: Contribution to journalArticle

Medical problems
diabetes
insulin
immune response
Dogs
11 Citations (Scopus)

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

Song, J. M., Anandharaj, A., Upadhyaya, P., Kirtane, A. R., Kim, J. H., Hong, K. H., Panyam, J. & Kassie, F., Jan 1 2016, In : Oncotarget. 7, 36, p. 57752-57769 18 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Lung
Magnolia
Neoplasms
2015
10 Citations (Scopus)

Association of sphingosine-1-phosphate (S1P)/S1P receptor-1 pathway with cell proliferation and survival in canine hemangiosarcoma

Rodriguez, A. M., Graef, A. J., LeVine, D. N., Cohen, I. R., Modiano, J. F. & Kim, J. H., Jan 1 2015, In : Journal of veterinary internal medicine. 29, 4, p. 1088-1097 10 p.

Research output: Contribution to journalArticle

Lysosphingolipid Receptors
sphingosine
hemangiosarcoma
Hemangiosarcoma
cell viability
8 Citations (Scopus)

CD44+/CD24– Cancer Stem Cells Are Associated With Higher Grade of Canine Mammary Carcinomas

Im, K. S., Jang, Y. G., Shin, J. I., Kim, N. H., Lim, H. Y., Lee, S. M., Kim, J. H. & Sur, J. H., Nov 1 2015, In : Veterinary pathology. 52, 6, p. 1041-1044 4 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
breast neoplasms
stem cells
Canidae
Breast Neoplasms
30 Citations (Scopus)

Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., Sarver, A. L., Swofford, R., Frantz, A. M., Ito, D., Mauceli, E., Arendt, M., Noh, H. J., Koltookian, M., Biagi, T., Fryc, S., Williams, C., Avery, A. C., Kim, J. H., Barber, L. & 7 others, Burgess, K., Lander, E. S., Karlsson, E. K., Azuma, C., Modiano, J. F., Breen, M. & Lindblad-Toh, K., Jan 1 2015, In : PLoS genetics. 11, 2, p. 1-24 24 p., e1004922.

Research output: Contribution to journalArticle

Golden Retriever
Genome-Wide Association Study
B-Cell Lymphoma
B-lymphocytes
Hemangiosarcoma
17 Citations (Scopus)

Pathobiology of hemangiosarcoma in dogs: Research advances and future perspectives

Kim, J. H., Graef, A. J., Dickerson, E. B. & Modiano, J. F., Dec 1 2015, In : Veterinary Sciences. 2, 4, p. 388-405 18 p.

Research output: Contribution to journalReview article

hemangiosarcoma
Hemangiosarcoma
Dogs
neoplasms
dogs
2014
36 Citations (Scopus)

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization

Gorden, B. H., Kim, J. H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., O'Brien, T. D., Sharkey, L. C., Modiano, J. F. & Dickerson, E. B., Apr 2014, In : American Journal of Pathology. 184, 4, p. 985-995 11 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Gene Expression Profiling
Canidae
Stem Cells
Neoplasms
26 Citations (Scopus)

Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment

Kim, J. H., Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., Sharkey, L. C., O'Brien, T. D., Dickerson, E. B. & Modiano, J. F., Apr 15 2014, In : Experimental Cell Research. 323, 1, p. 155-164 10 p.

Research output: Contribution to journalArticle

Hemangiosarcoma
Tumor Microenvironment
Interleukin-8
Canidae
Growth
2013
10 Citations (Scopus)

Breed-related differences in altered BRCA1 expression, phenotype and subtype in malignant canine mammary tumors

Im, K. S., Kim, I. H., Kim, N. H., Lim, H. Y., Kim, J. H. & Sur, J. H., Mar 1 2013, In : Veterinary Journal. 195, 3, p. 366-372 7 p.

Research output: Contribution to journalArticle

mammary neoplasms (animal)
Canidae
Breast Neoplasms
breeds
Phenotype
6 Citations (Scopus)
Tumor-Infiltrating Lymphocytes
breast neoplasms
Canidae
lymphocytes
Lymphocytes
33 Citations (Scopus)

Identification of Triple-negative and Basal-like Canine Mammary Carcinomas using Four Basal Markers

Kim, N. H., Lim, H. Y., Im, K. S., Kim, J. H. & Sur, J. H., May 1 2013, In : Journal of Comparative Pathology. 148, 4, p. 298-306 9 p.

Research output: Contribution to journalArticle

breast neoplasms
Canidae
Breast Neoplasms
Phenotype
phenotype
9 Citations (Scopus)

Infiltrating Foxp3+ Regulatory T cells and histopathological features in canine classical and spermatocytic seminomas

Kim, J. H., Chon, S. K., Im, K. S., Kim, N. H., Cho, K. W. & Sur, J. H., Apr 1 2013, In : Reproduction in Domestic Animals. 48, 2, p. 218-222 5 p.

Research output: Contribution to journalArticle

Seminoma
Regulatory T-Lymphocytes
Canidae
T-lymphocytes
dogs
2012
6 Citations (Scopus)

Angiogenesis and Expression of Vascular Endothelial Growth Factor, Tumour Necrosis Factor-α and Hypoxia Inducible Factor-1α in Canine Renal Cell Carcinoma

Yhee, J. Y., Yu, C. H., Kim, J. H., Im, K. S., Kim, N. H., Brodersen, B. W., Doster, A. R. & Sur, J. H., Aug 1 2012, In : Journal of Comparative Pathology. 147, 2-3, p. 129-138 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
vascular endothelial growth factors
tumor necrosis factors
kidney cells
angiogenesis
17 Citations (Scopus)

Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

Kim, J. H., Hur, J. H., Lee, S. M., Im, K. S., Kim, N. H. & Sur, J. H., Jul 1 2012, In : Veterinary Journal. 193, 1, p. 222-227 6 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
breast neoplasms
Canidae
T-lymphocytes
Breast Neoplasms
2 Citations (Scopus)

Increased expression of vascular endothelial growth factor in neo-vascularized canine brain tissue

Yu, C. H., Yhee, J. Y., Kim, J. H., Im, K., Kim, N. H., Kwon, S. Y., Hur, T. Y. & Sur, J. H., Jan 13 2012, In : Canadian Journal of Veterinary Research. 76, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

vascular endothelial growth factors
Vascular Endothelial Growth Factor A
Canidae
brain
dogs
3 Citations (Scopus)

P-glycoprotein expression in canine mammary gland tumours related with myoepithelial cells

Kim, N. H., Hwang, Y. H., Im, K. S., Kim, J. H., Chon, S. K., Kim, H. Y. & Sur, J. H., Dec 1 2012, In : Research in veterinary science. 93, 3, p. 1346-1352 7 p.

Research output: Contribution to journalArticle

mammary neoplasms (animal)
P-Glycoprotein
Human Mammary Glands
Canidae
Breast Neoplasms
6 Citations (Scopus)

Possible Role of Snail Expression as a Prognostic Factor in Canine Mammary Neoplasia

Im, K. S., Kim, J. H., Kim, N. H., Yu, C. H., Hur, T. Y. & Sur, J. H., Aug 1 2012, In : Journal of Comparative Pathology. 147, 2-3, p. 121-128 8 p.

Research output: Contribution to journalArticle

Snails
breasts
snails
Canidae
Breast
1 Citation (Scopus)

Primary central nervous system B-cell lymphoma in a young dog

Kim, N. H., Ciesielski, T., Kim, J. H., Yhee, J. Y., Im, K. S., Nam, H. M., Kim, I. H., Kim, J. H. & Sur, J. H., May 1 2012, In : Canadian Veterinary Journal. 53, 5, p. 559-564 6 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
lymphoma
B-lymphocytes
central nervous system
Central Nervous System
2011
13 Citations (Scopus)

CDX-2 and HER-3 Expression in Canine Gastric and Colorectal Adenocarcinomas

Doster, A. R., Yhee, J. Y., Kim, J. H., Im, K. S. & Sur, J. H., Jul 1 2011, In : Journal of Comparative Pathology. 145, 1, p. 12-19 8 p.

Research output: Contribution to journalArticle

adenocarcinoma
Canidae
Stomach
stomach
Adenocarcinoma
24 Citations (Scopus)

Expression of HER-2 and nuclear localization of HER-3 protein in canine mammary tumors: Histopathological and immunohistochemical study

Kim, J. H., Im, K. S., Kim, N. H., Yhee, J. Y., Nho, W. G. & Sur, J. H., Sep 1 2011, In : Veterinary Journal. 189, 3, p. 318-322 5 p.

Research output: Contribution to journalArticle

mammary neoplasms (animal)
Canidae
Breast Neoplasms
neoplasms
dogs
27 Citations (Scopus)

Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer's Disease and the Brain of Aged Dogs with Cognitive Dysfunction

Yu, C. H., Song, G. S., Yhee, J. Y., Kim, J. H., Im, K. S., Nho, W. G., Lee, J. H. & Sur, J. H., Jul 1 2011, In : Journal of Comparative Pathology. 145, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

Alzheimer disease
Alzheimer Disease
Dogs
brain
Ubiquitin
7 Citations (Scopus)

Inflammatory mammary carcinoma with metastasis to the brain and distant organs in a spayed Shih Tzu dog

Kim, J. H., Im, K., Kim, N. H., Chon, S. K., Doster, A. R. & Sur, J. H., Sep 1 2011, In : Journal of Veterinary Diagnostic Investigation. 23, 5, p. 1079-1082 4 p.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
metastasis
breast neoplasms
Dogs
Neoplasm Metastasis
20 Citations (Scopus)

Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury

Yu, C. H., Yhee, J. Y., Kim, J. H., Im, K. S., Kim, N. H., Jung, D. I., Lee, H. C., Chon, S. K. & Sur, J. H., Aug 31 2011, In : Journal of veterinary science. 12, 3, p. 299-301 3 p.

Research output: Contribution to journalArticle

Canidae
cytokines
Anti-Inflammatory Agents
Cytokines
brain
5 Citations (Scopus)

Tryptase-Positive Mast Cells Correlate with Angiogenesis in Canine Mammary Carcinoma

Im, K. S., Kim, J. H., Yhee, J. Y., Yu, C. H., Kim, N. H., Nho, W. G. & Sur, J. H., Feb 1 2011, In : Journal of Comparative Pathology. 144, 2-3, p. 157-163 7 p.

Research output: Contribution to journalArticle

tryptase
Tryptases
mast cells
angiogenesis
Mast Cells
2010
13 Citations (Scopus)

Canine classical seminoma: A specific malignant type with human classifications is highly correlated with tumor angiogenesis

Kim, J. H., Yu, C. H., Yhee, J. Y., Im, K., Kim, N. H. & Sur, J. H., May 28 2010, In : BMC Cancer. 10, 243.

Research output: Contribution to journalArticle

Seminoma
Canidae
Neoplasms
Microvessels
Blood Vessels
8 Citations (Scopus)

Characterization of canine oral papillomavirus by histopathological and genetic analysis in Korea.

Yhee, J. Y., Kwon, B. J., Kim, J. H., Yu, C. H., Im, K. S., Lee, S. S., Lyoo, Y. S., Chang, B. J. & Sur, J. H., Mar 2010, In : Journal of veterinary science. 11, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

Lambdapapillomavirus
Canine oral papillomavirus
Korea
Korean Peninsula
genetic techniques and protocols
7 Citations (Scopus)

Histopathological retrospective study of canine renal disease in Korea, 2003~2008

Yhee, J. Y., Yu, C. H., Kim, J. H., Im, K. S., Chon, S. K. & Sur, J. H., Dec 2 2010, In : Journal of veterinary science. 11, 4, p. 277-283 7 p.

Research output: Contribution to journalArticle

Dog Diseases
glomerulonephritis
Korea
kidney diseases
retrospective studies
22 Citations (Scopus)
Neoplasm Genes
mammary neoplasms (animal)
interleukin-1
Interleukin-1
interleukin-6
2009
36 Citations (Scopus)

Brief communication: Retrospective study of melamine/cyanuric acid-induced renal failure in dogs in Korea between 2003 and 2004

Yhee, J. Y., Brown, C. A., Yu, C. H., Kim, J. H., Poppenga, R. & Sur, J. H., Mar 2009, In : Veterinary pathology. 46, 2, p. 348-354 7 p.

Research output: Contribution to journalArticle

pet foods
melamine
Pets
renal failure
Korea
25 Citations (Scopus)

Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors

Yu, C. H., Hwang, D. N., Yhee, J. Y., Kim, J. H., Im, K. S., Nho, W. G., Lyoo, Y. S. & Sur, J. H., Mar 1 2009, In : Journal of veterinary science. 10, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Sertoli Cell Tumor
Seminoma
Sertoli cells
Testicular Neoplasms
Canidae
2008
13 Citations (Scopus)

Effects of T lymphocytes, interleukin-1, and interleukin-6 on renal fibrosis in canine end-stage renal disease

Yhee, J. Y., Yu, C. H., Kim, J. H. & Sur, J. H., Sep 1 2008, In : Journal of Veterinary Diagnostic Investigation. 20, 5, p. 585-592 8 p.

Research output: Contribution to journalArticle

interleukin-1
kidney diseases
fibrosis
Interleukin-1
interleukin-6