20002024
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 5 Similar Profiles
Synucleins Medicine & Life Sciences
Molecular Dynamics Simulation Medicine & Life Sciences
Lipid Bilayers Medicine & Life Sciences
Lipid bilayers Chemical Compounds
TNF-Related Apoptosis-Inducing Ligand Receptors Medicine & Life Sciences
Molecular dynamics Chemical Compounds
Membranes Medicine & Life Sciences
Computer simulation Chemical Compounds

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Projects 2007 2024

Research Output 2000 2019

Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain

Yang, J., Price, M. A., Wanshura, L. E. C., He, J., Yi, M., Welch, D. R., Li, G., Conner, S., Sachs, J., Turley, E. A. & Mc Carthy, J. B., Aug 1 2019, In : Melanoma research. 29, 4, p. 365-375 11 p.

Research output: Contribution to journalArticle

Cysteine
Melanoma
Growth
Focal Adhesion Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinase 3

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Chemical activation
Dimerization
Molecules
Ligands
Synucleins
Membranes
6 Citations (Scopus)

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Lo, C. H., Vunnam, N., Lewis, A. K., Chiu, T. L., Brummel, B. E., Schaaf, T. M., Grant, B. D., Bawaskar, P., Thomas, D. D. & Sachs, J. N., Sep 1 2017, In : SLAS Discovery. 22, 8, p. 950-961 12 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptors
Screening
triclabendazole
Throughput
Ligands
1 Citation (Scopus)

Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer

Vunnam, N., Campbell-Bezat, C. K., Lewis, A. K. & Sachs, J. N., Jul 25 2017, In : Biophysical Journal. 113, 2, p. 381-392 12 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Fluorescence Resonance Energy Transfer
Ligands
Tumor Necrosis Factor Receptors
Lipid Bilayers