Jonathan N Sachs

Professor, Biomedical Engineering

Emailjnsachs@umn.edu

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Expertise related to UN SDGs

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

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7 Active
13 Finished

Exploiting New Fibril Structures to Understand the Biophysical Basis for Oligomerization and Toxicity of Alpha-Synuclein
Sachs, J. N., Odde, D. J. & Pomerantz, W. C.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/30/20 → 8/31/25
Project: Research project
HbS oligomers as a therapeutic target in sickle cell disease
Wood, D. K. & Sachs, J. N.
NIH NAT'L HEART, LUNG, AND BLOOD INSTITU
4/16/20 → 3/31/22
Project: Research project
Fluorescence lifetime platform to discover small-molecule inhibitors of tau and alpha-synuclein oligomerization
Sachs, J. N.
PHOTONIC PHARMA LLC
9/15/19 → 8/31/21
Project: Research project
Understanding the structural dynamics of TNF receptors
Sachs, J. N.
NIH NIGMS NATL INST OF GENERAL
6/1/19 → 3/31/24
Project: Research project
Understanding and targeting the Methionine-Aromatic motif in oxidized alpha-Synuclein
Sachs, J. N. & Pomerantz, W. C.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/27/18 → 6/30/21
Project: Research project

58 Article
2 Comment/debate
2 Editorial
2 Review article
More
- 1 Chapter

Fluorescence-Based TNFR1 Biosensor for Monitoring Receptor Structural and Conformational Dynamics and Discovery of Small Molecule Modulators
Lo, C. H., Schaaf, T. M., Thomas, D. D. & Sachs, J. N., 2021, Methods in Molecular Biology. Humana Press Inc., Vol. 2248. p. 121-137 17 p. (Methods in Molecular Biology; vol. 2248).
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Conformational states of TNFR1 as a molecular switch for receptor function
Lo, C. H., Huber, E. C. & Sachs, J. N., Jun 1 2020, In: Protein Science. 29, 6, p. 1401-1415 15 p.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Discovery of Small Molecule Inhibitors of Huntingtin Exon 1 Aggregation by FRET-Based High-Throughput Screening in Living Cells
Lo, C. H., Pandey, N. K., Lim, C. K. W., Ding, Z., Tao, M., Thomas, D. D., Langen, R. & Sachs, J. N., Aug 5 2020, In: ACS Chemical Neuroscience. 11, 15, p. 2286-2295 10 p.
Research output: Contribution to journal › Article › peer-review
2 Scopus citations
How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes?
West, A., Zoni, V., Teague, W. E., Leonard, A. N., Vanni, S., Gawrisch, K., Tristram-Nagle, S., Sachs, J. N. & Klauda, J. B., Feb 6 2020, In: Journal of Physical Chemistry B. 124, 5, p. 828-839 12 p.
Research output: Contribution to journal › Article › peer-review
7 Scopus citations
Noncompetitive Allosteric Antagonism of Death Receptor 5 by a Synthetic Affibody Ligand
Vunnam, N., Szymonski, S., Hirsova, P., Gores, G. J., Sachs, J. N. & Hackel, B. J., Oct 13 2020, In: Biochemistry. 59, 40, p. 3856-3868 13 p.
Research output: Contribution to journal › Article › peer-review

Data-driven science is the only way to beat COVID-19
Jonathan N Sachs
5/7/20
1 item of Media coverage
Press/Media: Expert Comment