Projects per year
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
- 5 Similar Profiles
Synucleins
Medicine & Life Sciences
Molecular Dynamics Simulation
Medicine & Life Sciences
Lipid Bilayers
Medicine & Life Sciences
Lipid bilayers
Chemical Compounds
TNF-Related Apoptosis-Inducing Ligand Receptors
Medicine & Life Sciences
Molecular dynamics
Chemical Compounds
Membranes
Medicine & Life Sciences
Computer simulation
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2007 2024
Understanding the structural dynamics of TNF receptors
NIH NIGMS NATL INST OF GENERAL
6/1/19 → 3/31/24
Project: Research project
dynamic structural analysis
Protein engineered inhibitors of TNF Receptor activation: new therapeutics and new technology
NIH Nat'l Inst of Allergy & Infect Dis
2/1/19 → 1/31/21
Project: Research project
Tumor Necrosis Factor Receptors
Technology
Proteins
Therapeutics
Understanding and targeting the Methionine-Aromatic motif in oxidized alpha-Synuclein
Sachs, J. N. & Pomerantz, W. C.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/27/18 → 6/30/20
Project: Research project
alpha-Synuclein
Methionine
In-Situ Visualization of Enhanced Irreversible Electropo
Bischof, J. C., Provenzano, P., Sachs, J. N. & Shimizu, Y.
1/1/17 → 6/30/20
Project: Research project
Research Output 2000 2019
Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain
Yang, J., Price, M. A., Wanshura, L. E. C., He, J., Yi, M., Welch, D. R., Li, G., Conner, S., Sachs, J., Turley, E. A. & Mc Carthy, J. B., Aug 1 2019, In : Melanoma research. 29, 4, p. 365-375 11 p.Research output: Contribution to journal › Article
Cysteine
Melanoma
Growth
Focal Adhesion Protein-Tyrosine Kinases
Mitogen-Activated Protein Kinase 3
Noncompetitive inhibitors of TNFR1 probe conformational activation states
Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.Research output: Contribution to journal › Article
Tumor Necrosis Factor Receptors
Chemical activation
Dimerization
Molecules
Ligands
Correction to: α-Synuclein’s Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity (The Journal of Membrane Biology, (2017), 250, 2, (183-193), 10.1007/s00232-017-9946-1)
Braun, A. R., Lacy, M. M., Ducas, V. C., Chen, Z., Baumgart, T., Rhoades, E. & Sachs, J. N., Dec 1 2018, In : Journal of Membrane Biology. 251, 5-6, 1 p.Research output: Contribution to journal › Comment/debate
Synucleins
Membranes
6
Citations
(Scopus)
An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors
Lo, C. H., Vunnam, N., Lewis, A. K., Chiu, T. L., Brummel, B. E., Schaaf, T. M., Grant, B. D., Bawaskar, P., Thomas, D. D. & Sachs, J. N., Sep 1 2017, In : SLAS Discovery. 22, 8, p. 950-961 12 p.Research output: Contribution to journal › Article
Tumor Necrosis Factor Receptors
Screening
triclabendazole
Throughput
Ligands
1
Citation
(Scopus)
Death Receptor 5 Activation Is Energetically Coupled to Opening of the Transmembrane Domain Dimer
Vunnam, N., Campbell-Bezat, C. K., Lewis, A. K. & Sachs, J. N., Jul 25 2017, In : Biophysical Journal. 113, 2, p. 381-392 12 p.Research output: Contribution to journal › Article
TNF-Related Apoptosis-Inducing Ligand Receptors
Fluorescence Resonance Energy Transfer
Ligands
Tumor Necrosis Factor Receptors
Lipid Bilayers