John W Osborn Jr

1984 …2022
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Research Output 1984 2019

2019

Chronic low-level vagus nerve stimulation improves long-term survival in salt-sensitive hypertensive rats

Annoni, E. M., Van Helden, D., Guo, Y., Levac, B., Libbus, I., KenKnight, B. H., Osborn Jr, J. W. & Talkachova, A., Jan 1 2019, In : Frontiers in Physiology. 10, JAN, 25.

Research output: Contribution to journalArticle

Open Access
Vagus Nerve Stimulation
Salts
Hypertension
Therapeutics
Heart Rate
1 Citation (Scopus)

Renal Denervation for Treating Hypertension: Current Scientific and Clinical Evidence

Weber, M. A., Mahfoud, F., Schmieder, R. E., Kandzari, D. E., Tsioufis, K. P., Townsend, R. R., Kario, K., Böhm, M., Sharp, A. S. P., Davies, J. E., Osborn Jr, J. W., Fink, G. D., Euler, D. E., Cohen, D. L., Schlaich, M. P. & Esler, M. D., Jun 24 2019, In : JACC: Cardiovascular Interventions. 12, 12, p. 1095-1105 11 p.

Research output: Contribution to journalReview article

Denervation
Hypertension
Renal Artery
Kidney
Blood Pressure

Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review

Kiuchi, M. G., Esler, M. D., Fink, G. D., Osborn Jr, J. W., Banek, C. T., Böhm, M., Denton, K. M., DiBona, G. F., Everett, T. H., Grassi, G., Katholi, R. E., Knuepfer, M. M., Kopp, U. C., Lefer, D. J., Lohmeier, T. E., May, C. N., Mahfoud, F., Paton, J. F. R., Schmieder, R. E., Pellegrino, P. R. & 2 others, Sharabi, Y. & Schlaich, M. P., Jun 18 2019, In : Journal of the American College of Cardiology. 73, 23, p. 3006-3017 12 p.

Research output: Contribution to journalReview article

Sympathetic Nervous System
Denervation
Kidney
Blood Pressure
Renal Hypertension

Renal Inflammation in DOCA-Salt Hypertension

Banek, C. T., Gauthier, M. M., Van Helden, D. A., Fink, G. D. & Osborn Jr, J. W., May 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 5, p. 1079-1086 8 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Salts
Hypertension
Inflammation
Kidney
2018
7 Citations (Scopus)

Catheter-based renal nerve ablation as a novel hypertension therapy: Lost, and then found, in translation

Osborn Jr, J. W. & Banek, C. T., Jan 1 2018, In : Hypertension. 71, 3, p. 383-388 6 p.

Research output: Contribution to journalArticle

Catheters
Hypertension
Kidney
Therapeutics

Lesion of the OVLT markedly attenuates chronic DOCA-salt hypertension in rats

Collister, J. P., Nahey, D. B., Hartson, R., Wiedmeyer, C. E., Banek, C. T. & Osborn Jr, J. W., Sep 1 2018, In : American journal of physiology. Regulatory, integrative and comparative physiology. 315, 3, p. R568-R575

Research output: Contribution to journalArticle

Open Access
Desoxycorticosterone
Acetates
Salts
Hypertension
Subfornical Organ

Role of afferent and efferent renal nerves in the development of AngII-salt hypertension in rats

Foss, J. D., Fiege, J., Shimizu, Y., Collister, J. P., Mayerhofer, T., Wood, L. & Osborn Jr, J. W., Feb 1 2018, In : Physiological Reports. 6, 3, e13602.

Research output: Contribution to journalArticle

Open Access
Angiotensin II
Salts
Hypertension
Kidney
Denervation
2 Citations (Scopus)

Targeted afferent renal denervation reduces arterial pressure but not renal inflammation in established DOCA-salt hypertension in the rat

Banek, C. T., Gauthier, M. M., Baumann, D. C., Van Helden, D., Asirvatham-Jeyaraj, N., Panoskaltsis-Mortari, A., Fink, G. D. & Osborn, J. W., Jun 1 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 314, 6, p. R883-R891

Research output: Contribution to journalArticle

Open Access
Desoxycorticosterone
Denervation
Arterial Pressure
Acetates
Salts
2017
32 Citations (Scopus)

Recording sympathetic nerve activity in conscious humans and other mammals: Guidelines and the road to standardization

Hart, E. C., Head, G. A., Carter, J. R., Wallin, B. G., May, C. N., Hamza, S. M., Hall, J. E., Charkoudian, N. & Osborn, J. W., May 15 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 312, 5, p. H1031-H1051

Research output: Contribution to journalReview article

Open Access
Mammals
Guidelines
Sheep
Rabbits
Baroreflex
13 Citations (Scopus)

Renal nerves and long-term control of arterial pressure

Osborn Jr, J. W. & Foss, J. D., Apr 1 2017, In : Comprehensive Physiology. 7, 2, p. 263-320 58 p.

Research output: Contribution to journalArticle

Arterial Pressure
Kidney
Hypertension
Blood Vessels
Reflex
2016
16 Citations (Scopus)
S Phase
Maintenance
Inbred Dahl Rats
Hypertension
Kidney
9 Citations (Scopus)

Renal Denervation Normalizes Arterial Pressure with No Effect on Glucose Metabolism or Renal Inflammation in Obese Hypertensive Mice

Asirvatham Jeyaraj, N. M. J., Fiege, J. K., Han, R., Foss, J., Banek, C. T., Burbach, B. J., Razzoli, M., Bartolomucci, A., Shimizu, Y., Panoskaltsis-Mortari, A. & Osborn Jr, J. W., Oct 1 2016, In : Hypertension. 68, 4, p. 929-936 8 p.

Research output: Contribution to journalArticle

Obese Mice
Denervation
Arterial Pressure
Inflammation
Kidney
20 Citations (Scopus)

Resting Afferent Renal Nerve Discharge and Renal Inflammation: Elucidating the Role of Afferent and Efferent Renal Nerves in Deoxycorticosterone Acetate Salt Hypertension

Banek, C. T., Knuepfer, M. M., Foss, J. D., Fiege, J. K., Asirvatham-Jeyaraj, N., Van Helden, D., Shimizu, Y. & Osborn, J. W., Dec 1 2016, In : Hypertension. 68, 6, p. 1415-1423 9 p.

Research output: Contribution to journalArticle

Desoxycorticosterone
Acetates
Salts
Hypertension
Inflammation
2015
17 Citations (Scopus)

A mathematical model of salt-sensitive hypertension: The neurogenic hypothesis

Averina, V. A., Othmer, H. G., Fink, G. D. & Osborn Jr, J. W., Jan 1 2015, In : Journal of Physiology. 593, 14, p. 3065-3075 11 p.

Research output: Contribution to journalReview article

Theoretical Models
Salts
Hypertension
Kidney
Arterial Pressure
34 Citations (Scopus)

A novel method of selective ablation of afferent renal nerves by periaxonal application of capsaicin

Foss, J. D., Wainford, R. D., Engeland, W. C., Fink, G. D. & Osborn, J. W., Jan 15 2015, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 308, 2, p. R112-R122

Research output: Contribution to journalArticle

Capsaicin
Kidney
Denervation
Arterial Pressure
Salts
10 Citations (Scopus)

Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation

Han, R., Wang, X., Bachovchin, W., Zukowska, Z. & Osborn Jr, J. W., Aug 5 2015, In : Scientific reports. 5, 12348.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
Adipocytes
Adipogenesis
Fibroblasts
Dipeptidyl Peptidase 4
14 Citations (Scopus)
Vagus Nerve
Electrophysiology
Electric Stimulation
Vagus Nerve Stimulation
Cardiac Arrhythmias
71 Citations (Scopus)

Renal denervation prevents immune cell activation and renal inflammation in Angiotensin II-induced hypertension

Xiao, L., Kirabo, A., Wu, J., Saleh, M. A., Zhu, L., Wang, F., Takahashi, T., Loperena, R., Foss, J. D., Mernaugh, R. L., Chen, W., Roberts, J., Osborn Jr, J. W., Itani, H. A. & Harrison, D. G., Aug 28 2015, In : Circulation research. 117, 6, p. 547-557 11 p.

Research output: Contribution to journalArticle

Denervation
Angiotensin II
Hypertension
Inflammation
Kidney
2014
5 Citations (Scopus)
Angiotensin II
Arterial Pressure
Hypertension
Pressure
Infusion Pumps
22 Citations (Scopus)

Critical issues in patient selection, efficacy, and safety of renal denervation

Schlaich, M. P., Esler, M. D., Fink, G. D., Osborn Jr, J. W. & Euler, D. E., Mar 1 2014, In : Hypertension. 63, 3, p. 426-432 7 p.

Research output: Contribution to journalReview article

Sympathetic Nervous System
Denervation
Patient Safety
Patient Selection
Blood Pressure
3 Citations (Scopus)

Renal nerves: Time for reassessment of their role in hypertension?

Fink, G. D. & Osborn Jr, J. W., Jan 1 2014, In : American Journal of Hypertension. 27, 10, p. 1245-1247 3 p.

Research output: Contribution to journalComment/debate

Sympathectomy
Catheter Ablation
Sympathetic Nervous System
Obstructive Sleep Apnea
Obesity

Response to more research is needed to investigate the effect of denervation on blood pressure

Schlaich, M., Esler, M., Fink, G., Osborn Jr, J. W. & Euler, D., Apr 1 2014, In : Hypertension. 63, 4

Research output: Contribution to journalLetter

Sympathetic Nervous System
Denervation
Patient Selection
Blood Pressure
Hypertension
2 Citations (Scopus)

Role of cardiac sympathetic nerves in blood pressure regulation

Wehrwein, E. A., Yoshimoto, M., Guzman, P., Shah, A., Kreulen, D. L. & Osborn Jr, J. W., Jan 1 2014, In : Autonomic Neuroscience: Basic and Clinical. 183, p. 30-35 6 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Blood Pressure
Arterial Pressure
Rivers
Sprague Dawley Rats
18 Citations (Scopus)

The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure

Fargali, S., Garcia, A. L., Sadahiro, M., Jiang, C., Janssen, W. G., Lin, W. J., Cogliani, V., Elste, A., Mortillo, S., Cero, C., Veitenheimer, B., Graiani, G., Pasinetti, G. M., Mahata, S. K., Osborn Jr, J. W., Huntley, G. W., Phillips, G. R., Benson, D. L., Bartolomucci, A. & Salton, S. R., Jan 1 2014, In : FASEB Journal. 28, 5, p. 2120-2133 14 p.

Research output: Contribution to journalArticle

Chromogranins
Blood pressure
Secretory Vesicles
Chromogranin B
Catecholamines
2013
27 Citations (Scopus)

Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression

Lund, T. C., Kobs, A. J., Kramer, A., Nyquist, M., Kuroki, M. T., Osborn, J., Lidke, D. S., Low-Nam, S. T., Blazar, B. R. & Tolar, J., Mar 8 2013, In : PloS one. 8, 3, e58945.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
blood vessels
smooth muscle
bone marrow
myocytes
2 Citations (Scopus)
Kynurenic Acid
Osmotic Pressure
Arterial Pressure
Water Deprivation
Desoxycorticosterone Acetate
9 Citations (Scopus)

OVLT lesion decreases basal arterial pressure and the chronic hypertensive response to angii in rats on a high-salt diet

Collister, J. P., Olson, M. K., Nahey, D. B., Vieira, A. A. & Osborn Jr, J. W., Jan 1 2013, In : Physiological Reports. 1, 5, e00128.

Research output: Contribution to journalArticle

Angiotensin II
Arterial Pressure
Salts
Diet
Brain

Reply from V. A. Averina, H. G. Othmer, G. D. Fink and J. W. Osborn

Averina, V. A., Othmer, H. G., Fink, G. D. & Osborn, J. W., Jun 1 2013, In : Journal of Physiology. 591, 11, p. 2965 1 p.

Research output: Contribution to journalLetter

Biological Models
Angiotensin II
Sodium
Hypertension
6 Citations (Scopus)

Restoring autonomic balance: Future therapeutic targets

Sobotka, P. A., Osborn Jr, J. W. & Paton, J. F. R., Jan 1 2013, In : EuroIntervention. 9, p. R140-R148

Research output: Contribution to journalArticle

Carotid Body
Sympathectomy
Sympathetic Nervous System
Cardiovascular System
Reflex
51 Citations (Scopus)

Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation

Foss, J. D., Fink, G. D. & Osborn Jr, J. W., Apr 1 2013, In : Hypertension. 61, 4, p. 806-811 6 p.

Research output: Contribution to journalArticle

Salts
Hypertension
Kidney
Inbred Dahl Rats
Splanchnic Nerves
2012
25 Citations (Scopus)

A new conceptual paradigm for the haemodynamics of salt-sensitive hypertension: A mathematical modelling approach

Averina, V. A., Othmer, H. G., Fink, G. D. & Osborn Jr, J. W., Dec 1 2012, In : Journal of Physiology. 590, 23, p. 5975-5992 18 p.

Research output: Contribution to journalArticle

Natriuresis
Salts
Hemodynamics
Hypertension
Arterial Pressure
6 Citations (Scopus)

Effect of global and regional sympathetic blockade on arterial pressure during water deprivation in conscious rats

Veitenheimer, B. J., Engeland, W. C., Guzman, P. A., Fink, G. D. & Osborn Jr, J. W., Oct 15 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 303, 8

Research output: Contribution to journalArticle

Water Deprivation
Arterial Pressure
Sympathetic Nervous System
Blood Vessels
Heart Rate
1 Citation (Scopus)

High-fat food, sympathetic nerve activity, and hypertension: Danger soon after the first bite?

Brooks, V. L. & Osborn Jr, J. W., Dec 1 2012, In : Hypertension. 60, 6, p. 1387-1388 2 p.

Research output: Contribution to journalEditorial

Sympathetic Nervous System
Adiposity
High Fat Diet
Bites and Stings
Arterial Pressure
15 Citations (Scopus)

Sympathetic signatures of cardiovascular disease: A blueprint for development of targeted sympathetic ablation therapies

Osborn Jr, J. W. & Kuroki, M. T., Mar 1 2012, In : Hypertension. 59, 3, p. 545-547 3 p.

Research output: Contribution to journalComment/debate

Angiotensin II Type 1 Receptor Blockers
Losartan
Sympathetic Nervous System
Cardiovascular Diseases
Heart Failure
31 Citations (Scopus)

The role of the subfornical organ in angiotensin II-salt hypertension in the rat

Osborn Jr, J. W., Hendel, M. D., Collister, J. P., Ariza-Guzman, P. A. & Fink, G. D., Jan 1 2012, In : Experimental Physiology. 97, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

Subfornical Organ
Angiotensin II
Salts
Hypertension
Arterial Pressure
3 Citations (Scopus)

The Splanchnic Circulation

Fink, G. D. & Osborn Jr, J. W., Dec 1 2012, Primer on the Autonomic Nervous System. Elsevier Inc., p. 211-213 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Splanchnic Circulation
Viscera
Splanchnic Nerves
Blood Volume
Vascular Resistance
22 Citations (Scopus)
Viscera
Vascular Resistance
Salts
Heart Rate
Hypertension
2011
56 Citations (Scopus)

Neural mechanisms of angiotensin II-salt hypertension: Implications for therapies targeting neural control of the splanchnic circulation

Osborn Jr, J. W., Fink, G. D. & Kuroki, M. T., Jun 1 2011, In : Current Hypertension Reports. 13, 3, p. 221-228 8 p.

Research output: Contribution to journalArticle

Splanchnic Circulation
Sympathetic Nervous System
Angiotensin II
Salts
Hypertension
15 Citations (Scopus)
Osmotic Pressure
Arterial Pressure
Vasopressins
Motor Activity
Heart Rate
12 Citations (Scopus)
Ganglionectomy
Sympathectomy
Ventricular Fibrillation
Action Potentials
Atenolol
2010
70 Citations (Scopus)

Chronic angiotensin II infusion causes differential responses in regional sympathetic nerve activity in rats

Yoshimoto, M., Miki, K., Fink, G. D., King, A. & Osborn Jr, J. W., Mar 1 2010, In : Hypertension. 55, 3, p. 644-651 8 p.

Research output: Contribution to journalArticle

Angiotensin II
Salts
Hindlimb
Diet
Hypertension
2 Citations (Scopus)

Direct assessment of organ specific sympathetic nervous system activity in normal and cardiovascular disease states

Knuepfer, M. M. & Osborn Jr, J. W., Jan 1 2010, In : Experimental Physiology. 95, 1, p. 32-33 2 p.

Research output: Contribution to journalEditorial

Organ Specificity
Sympathetic Nervous System
Cardiovascular System
Cardiovascular Diseases
48 Citations (Scopus)

Does enhanced respiratory-sympathetic coupling contribute to peripheral neural mechanisms of angiotensin II-salt hypertension?

Toney, G. M., Pedrino, G. R., Fink, G. D. & Osborn Jr, J. W., May 1 2010, In : Experimental Physiology. 95, 5, p. 587-594 8 p.

Research output: Contribution to journalArticle

Angiotensin II
Salts
Hypertension
Neurons
Viscera
16 Citations (Scopus)
Desoxycorticosterone Acetate
Paraventricular Hypothalamic Nucleus
Salts
Arterial Pressure
Supraoptic Nucleus
10 Citations (Scopus)

Integrative mechanisms of blood pressure regulation in humans and rats: Cross-species similarities

Charkoudian, N., Gusman, E., Joyner, M. J., Wallin, B. G. & Osborn Jr, J. W., Mar 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 3

Research output: Contribution to journalArticle

Cardiac Output
Vascular Resistance
Blood Pressure
Desoxycorticosterone
Arterial Pressure
64 Citations (Scopus)

Region-specific changes in sympathetic nerve activity in angiotensin II-salt hypertension in the rat

Osborn Jr, J. W. & Fink, G. D., Jan 1 2010, In : Experimental Physiology. 95, 1, p. 61-68 8 p.

Research output: Contribution to journalArticle

Angiotensin II
Salts
Hypertension
Denervation
Diet

Reply to Willie and Tzeng

Charkoudian, N., Gunnar Wallin, B., Joyner, M. J. & Osborn Jr, J. W., Jun 1 2010, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 298, 6

Research output: Contribution to journalLetter

1 Citation (Scopus)

The Kidney is not always the target in neurogenic hypertension

Osborn Jr, J. W. & Fink, G. D., Dec 1 2010, In : Journal of Applied Physiology. 109, 6, 1 p.

Research output: Contribution to journalComment/debate

Hypertension
Kidney
2009
7 Citations (Scopus)

Commentary on 'Understanding the contribution of Guyton's large circulatory model to long-term control of arterial pressure'

Osborn Jr, J. W., Averina, V. A. & Fink, G. D., Apr 1 2009, In : Experimental Physiology. 94, 4, p. 388-389 2 p.

Research output: Contribution to journalComment/debate

Cardiovascular Models
Natriuresis
Sympathetic Nervous System
Blood Volume
Reproducibility of Results