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Research Output 1971 2019

Article
62 Citations (Scopus)

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

Dioxygenases
Electronic structure
Iron
Enzymes
Chemical activation

Spectroscopic characterization of substrate binding to the oxygenase component of benzoate 1,2-dioxygenase

Wolfe, M. D., Altier, D. J. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1303

Research output: Contribution to journalArticle

Oxygenases
benzoates
oxygenases
nitric oxide
Nitric Oxide
15 Citations (Scopus)

Spectroscopic investigation of reduced protocatechuate 3,4-dioxygenase: Charge-induced alterations in the active site iron coordination environment

Davis, M. I., Wasinger, E. C., Westre, T. E., Zaleski, J. M., Orville, A. M., Lipscomb, J. D., Hedman, B., Hodgson, K. O. & Solomon, E. I., Dec 1 1999, In : Inorganic Chemistry. 38, 16, p. 3676-3683 8 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
dichroism
X ray absorption
Iron
Ligands
54 Citations (Scopus)

Spectroscopic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Molecular mechanism and CO2 activation in the biosynthesis of ethylene

Zhou, J., Rocklin, A. M., Lipscomb, J. D., Que, L. & Solomon, E. I., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

Biosynthesis
Carboxylic acids
Ethylene
Chemical activation
Enzymes
134 Citations (Scopus)

Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe2+ oxidase with metal coordination sites for small molecules and substrate

Chen, V. J., Orville, A. M., Harpel, M. R., Frolik, C. A., Surerus, K. K., Munck, E. & Lipscomb, J. D., Dec 1 1989, In : Journal of Biological Chemistry. 264, 36, p. 21677-21681 5 p.

Research output: Contribution to journalArticle

Oxidoreductases
Iron
Metals
Molecules
Substrates
34 Citations (Scopus)

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

Horsman, G. P., Jirasek, A., Vaillancourt, F. H., Barbosa, C. J., Jarzecki, A. A., Xu, C., Mekmouche, Y., Spiro, T. G., Lipscomb, J. D., Blades, M. W., Turner, R. F. B. & Eltis, L. D., Dec 7 2005, In : Journal of the American Chemical Society. 127, 48, p. 16882-16891 10 p.

Research output: Contribution to journalArticle

Catechol 1,2-Dioxygenase
Enzymes
Ligands
Substrates
Protonation
5 Citations (Scopus)
methane monooxygenase
Hemerythrin
Azides
Mixed Function Oxygenases
Iron
83 Citations (Scopus)
methane monooxygenase
Hemerythrin
Azides
Dichroism
Circular Dichroism
20 Citations (Scopus)

Spectroscopic studies of the effect of ligand donor strength on the Fe-NO bond in intradiol dioxygenases

Wasinger, E. C., Davis, M. I., Pau, M. Y. M., Orville, A. M., Zaleski, J. M., Hedman, B., Lipscomb, J. D., Hodgson, K. O. & Solomon, E. I., Jan 27 2003, In : Inorganic Chemistry. 42, 2, p. 365-376 12 p.

Research output: Contribution to journalArticle

Dioxygenases
X ray absorption
dichroism
Ligands
ligands
41 Citations (Scopus)

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

Hemerythrin
Iron
Iron Regulatory Protein 2
Ubiquitin-Protein Ligases
Regulator Genes
14 Citations (Scopus)

Structural aspects of the active site of cytochrome P-450cam.

Lipscomb, J. D. & Gunsalus, I. C., Jan 1 1973, In : Drug Metabolism and Disposition. 1, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Iron Radioisotopes
Magnetic resonance spectroscopy
Electron spin resonance spectroscopy
Molecular Conformation
Spectrophotometry
15 Citations (Scopus)

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Histidine
Protons
Catalytic Domain
Chemical activation
22 Citations (Scopus)

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Tyrosine
Chemical activation
Oxygen
Substrates

Structure, reactivity, and regulation of methane monooxygenase catalytic cycle intermediates

Nesheim, J. C. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

methane monooxygenase
methane
iron
Oxygen
oxygen
235 Citations (Scopus)

Structure and assembly of protocatechuate 3,4-dioxygenase

Ohlendorf, D. H., Lipscomb, J. D. & Weber, P. C., Jan 1 1988, In : Nature. 336, 6197, p. 403-405 3 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Dioxygenases
NSC 153174
Oxygen
Iron
4 Citations (Scopus)

Structure and function of dioxygenases. One approach to lignin degradation

Wood, J. M., Crawford, R. L., Howard, J. B., Orme-johnson, W. H., Lipscomb, J. D., Bromley, J. W., Stephens, R. S., Münck, E., Zimmerman, R. & Que, L., Jul 1 1977, In : Journal of Agricultural and Food Chemistry. 25, 4, p. 698-704 7 p.

Research output: Contribution to journalArticle

Dioxygenases
Lignin
Biological Products
mixed function oxidase
lignin
2 Citations (Scopus)

Structure and reactions of oxygenase active centres: cytochrome P-450 and iron-sulphur proteins.

Gunsalus, I. C., Lipscomb, J. D., Marshall, V., Frauenfelder, H., Münck, E. & Greenbaum, E., Jan 1 1971, In : The Biochemical journal. 125, 2

Research output: Contribution to journalArticle

Iron-Sulfur Proteins
Chemical Models
Camphor
Oxygenases
Enzyme Induction
20 Citations (Scopus)

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Hydroxylation
Biosynthesis
Viperidae
Mixed Function Oxygenases
161 Citations (Scopus)

Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 Å resolution

Ohlendorf, D. H., Orville, A. M. & Lipscomb, J. D., Dec 15 1994, In : Journal of Molecular Biology. 244, 5, p. 586-608 23 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Pseudomonas aeruginosa
Catalytic Domain
R388
Iron
102 Citations (Scopus)

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methane
Methanol
Oxygen
Raman Spectrum Analysis
71 Citations (Scopus)

Structures of competitive inhibitor complexes of protocatechuate 3,4- Dioxygenase: Multiple exogenous ligand binding orientations within the active site

Orville, A. M., Elango, N., Lipscomb, J. D. & Ohlendorf, D. H., Aug 19 1997, In : Biochemistry. 36, 33, p. 10039-10051 13 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Catalytic Domain
Ligands
Iron
R388
41 Citations (Scopus)

Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7056-7066 11 p.

Research output: Contribution to journalArticle

Dioxygenases
Electron Spin Resonance Spectroscopy
Naphthalene
Spectrum Analysis
Spectroscopy
27 Citations (Scopus)

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Tyrosine
Chemical activation
Electrons
Chromophores
9 Citations (Scopus)

Substrate radical intermediates in soluble methane monooxygenase

Liu, A., Jin, Y., Zhang, J., Brazeau, B. J. & Lipscomb, J. D., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 254-261 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Substrates
Oxides
NAD
Paramagnetic resonance
99 Citations (Scopus)

Superoxide anion production by the autoxidation of cytochrome P450cam

Sligar, S. G., Lipscomb, J. D., Debrunner, P. G. & Gunsalus, I. C., Nov 6 1974, In : Biochemical and Biophysical Research Communications. 61, 1, p. 290-296 7 p.

Research output: Contribution to journalArticle

Camphor 5-Monooxygenase
Singlet Oxygen
Chemiluminescence
Cytochromes
Luminescence
85 Citations (Scopus)

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

Emerson, J. P., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7347-7352 6 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxidation-Reduction
Metals
Oxygen
Enzymes
6 Citations (Scopus)

Synthesis of 17O- or 18O-Enriched dihydroxy aromatic compounds

Orville, A. M., Harpel, M. R. & Lipscomb, J. D., Jan 1 1990, In : Methods in enzymology. 188, C, p. 107-115 9 p.

Research output: Contribution to journalArticle

Oxygen Isotopes
Catechols
Brevibacterium
Isotope Labeling
Phenols
51 Citations (Scopus)

Tetraheme cytochrome c-554 from Nitrosomonas europaea. Heme-heme interactions and ligand binding

Andersson, K. K., Lipscomb, J. D., Valentine, M., Münck, E. & Hooper, A. B., Jul 9 1986, In : Journal of Biological Chemistry. 261, 3, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

Nitrosomonas europaea
Cytochromes c
Heme
Ligands
Paramagnetic resonance
40 Citations (Scopus)

The Active Site of Hydroxylamine Oxidoreductase from Nitrosomonas: Evidence for a New Metal Cluster in Enzymes

Hendrich, M. P., Logan, M., Andersson, K. K., Arriero, D. M., Hooper, A. B. & Lipscomb, J. D., Dec 1 1994, In : Journal of the American Chemical Society. 116, 26, p. 11961-11968 8 p.

Research output: Contribution to journalArticle

hydroxylamine dehydrogenase
Nitrosomonas
Heme
Catalytic Domain
Enzymes
53 Citations (Scopus)

The axial tyrosinate Fe3+ ligand in protocatechuate 3,4-dioxygenase influences substrate binding and product release: Evidence for new reaction cycle intermediates

Frazee, R. W., Orville, A. M., Dolbeare, K. B., Yu, H., Ohlendorf, D. H. & Lipscomb, J. D., Feb 24 1998, In : Biochemistry. 37, 8, p. 2131-2144 14 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Dioxygenases
Catalytic Domain
Ligands
R388
24 Citations (Scopus)

The magnetic susceptibility of reduced cytochrome P-450cam

Champion, P. M., Münck, E., Debrunner, P. G., Moss, T. H., Lipscomb, J. D. & Gunsalus, I. C., Mar 20 1975, In : BBA - Bioenergetics. 376, 3, p. 579-582 4 p.

Research output: Contribution to journalArticle

Cytochromes
Magnetic susceptibility
Camphor
Hamiltonians
Pseudomonas putida
3 Citations (Scopus)

Thermodynamic and kinetic evidence for a two-step reaction between methane monooxygenase compound Q and substrates

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2002, In : International Congress Series. 1233, C, p. 229-233 5 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Methane
Thermodynamics
Activation Analysis
153 Citations (Scopus)

The role of putidaredoxin and P450 cam in methylene hydroxylation.

Tyson, C. A., Lipscomb, J. D. & Gunsalus, I. C., Sep 25 1972, In : Journal of Biological Chemistry. 247, 18, p. 5777-5784 8 p.

Research output: Contribution to journalArticle

Camphor
Photochemistry
Ferredoxins
Biological Models
Hydroxylation
78 Citations (Scopus)

Thiolate Ligation of the Active Site Fe2+of Isopenicillin N Synthase Derives from Substrate Rather Than Endogenous Cysteine: Spectroscopic Studies of Site-Specific Cys Â-Ser Mutated Enzymes

Orville, A. M., Chen, V. J., Kriauciunas, A., Harpel, M. R., Fox, B. G., Münck, E. & Lipscomb, J. D., Feb 1 1992, In : Biochemistry. 31, 19, p. 4602-4612 11 p.

Research output: Contribution to journalArticle

Cysteine
Ligation
Catalytic Domain
Substrates
Enzymes
293 Citations (Scopus)

Transient intermediates of the methane monooxygenase catalytic cycle

Lee, S. K., Nesheim, J. C. & Lipscomb, J. D., Oct 15 1993, In : Journal of Biological Chemistry. 268, 29, p. 21569-21577 9 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Rate constants
Substrates
Paramagnetic resonance
39 Citations (Scopus)
Protocatechuate-3,4-Dioxygenase
Kinetics
Substrates
Enzymes
Bleaching
105 Citations (Scopus)

Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Bominaar, E. L., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16788-16793 6 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Iron
Enzymes
Heme
Catalytic Domain
52 Citations (Scopus)

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

Pathogens
Cystic Fibrosis
Pseudomonas aeruginosa
Nitric Oxide
Respiration
9 Citations (Scopus)

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

Jasniewski, A. J., Komor, A. J., Lipscomb, J. D. & Que, L., Aug 2 2017, In : Journal of the American Chemical Society. 139, 30, p. 10472-10485 14 p.

Research output: Contribution to journalArticle

Open Access
X-Ray Absorption Spectroscopy
Oxygenases
X ray absorption spectroscopy
Oxidants
Catalytic Domain
5 Citations (Scopus)

Unusual spin interactions in the 24 heme hydroxylamine oxidoreductase and diheme cytochrome c 554 from nitrosomonas

Andersson, K. K., Lipscomb, J. D. & Hooper, A. B., Jan 1 1983, In : Inorganica Chimica Acta. 79, p. 181-182 2 p.

Research output: Contribution to journalArticle

hydroxylamine dehydrogenase
Heme
diheme cytochrome c
76 Citations (Scopus)
Catechol 2,3-Dioxygenase
Azides
Dichroism
Magnetic Fields
Circular Dichroism
80 Citations (Scopus)

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

Oxygenases
Probability density function
Charge transfer
Oxidoreductases
Enzymes
152 Citations (Scopus)

X-ray Absorption Spectroscopic Studies of the Fe(II) Active Site of Catechol 2,3-Dioxygenase. Implications for the Extradiol Cleavage Mechanism

Shu, L., Chiou, Y. M., Orville, A. M., Miller, M. A., Lipscomb, J. D. & Que, L., May 1 1995, In : Biochemistry. 34, 20, p. 6649-6659 11 p.

Research output: Contribution to journalArticle

Catechol 2,3-Dioxygenase
X ray absorption
Catalytic Domain
X-Rays
Ligands
43 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
X ray absorption
Mixed Function Oxygenases
X-Rays
Chapter
2 Citations (Scopus)

Catalysis and regulation in the soluble methane monooxygenase system: Applications of isotopes and isotope effects

Lipscomb, J. D., Jan 1 2005, Isotope Effects in Chemistry and Biology. CRC Press, p. 931-953 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Methane
Catalysis
Isotopes
Bacteria

Intermediates in the reaction cycle of methane monooxygenase: Structure and chemistry

Lipscomb, J. D., Lee, S. K., Nesheim, J. C., Jin, Y., Wallar, B. J. & Zhang, X. Y., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. Wiley, p. 323-339 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Mossbauer spectroscopy
Greenhouse gases
5 Citations (Scopus)

Use of Isotopes and Isotope Effects for Investigations of Diiron Oxygenase Mechanisms

Banerjee, R., Komor, A. J. & Lipscomb, J. D., Jan 1 2017, Methods in Enzymology. Academic Press Inc., p. 239-290 52 p. (Methods in Enzymology; vol. 596).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxygenases
Isotopes
methane monooxygenase
Vibrational spectroscopy
Biosynthetic Pathways
Comment/debate
1 Citation (Scopus)

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Crystallography
corrigendum
3 Citations (Scopus)

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journalComment/debate

Biguanides
Mitochondria
Heme
Cytochrome P-450 Enzyme System
Cell Biology