1971 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Article

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Spectroscopic characterization of substrate binding to the oxygenase component of benzoate 1,2-dioxygenase

Wolfe, M. D., Altier, D. J. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1303

Research output: Contribution to journalArticle

Spectroscopic investigation of reduced protocatechuate 3,4-dioxygenase: Charge-induced alterations in the active site iron coordination environment

Davis, M. I., Wasinger, E. C., Westre, T. E., Zaleski, J. M., Orville, A. M., Lipscomb, J. D., Hedman, B., Hodgson, K. O. & Solomon, E. I., Dec 1 1999, In : Inorganic Chemistry. 38, 16, p. 3676-3683 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Spectroscopic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Molecular mechanism and CO2 activation in the biosynthesis of ethylene

Zhou, J., Rocklin, A. M., Lipscomb, J. D., Que, L. & Solomon, E. I., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe2+ oxidase with metal coordination sites for small molecules and substrate

Chen, V. J., Orville, A. M., Harpel, M. R., Frolik, C. A., Surerus, K. K., Munck, E. & Lipscomb, J. D., Dec 1 1989, In : Journal of Biological Chemistry. 264, 36, p. 21677-21681 5 p.

Research output: Contribution to journalArticle

135 Scopus citations

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

Horsman, G. P., Jirasek, A., Vaillancourt, F. H., Barbosa, C. J., Jarzecki, A. A., Xu, C., Mekmouche, Y., Spiro, T. G., Lipscomb, J. D., Blades, M. W., Turner, R. F. B. & Eltis, L. D., Dec 7 2005, In : Journal of the American Chemical Society. 127, 48, p. 16882-16891 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
83 Scopus citations

Spectroscopic studies of the effect of ligand donor strength on the Fe-NO bond in intradiol dioxygenases

Wasinger, E. C., Davis, M. I., Pau, M. Y. M., Orville, A. M., Zaleski, J. M., Hedman, B., Lipscomb, J. D., Hodgson, K. O. & Solomon, E. I., Jan 27 2003, In : Inorganic Chemistry. 42, 2, p. 365-376 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Structural aspects of the active site of cytochrome P-450cam.

Lipscomb, J. D. & Gunsalus, I. C., Jan 1 1973, In : Drug Metabolism and Disposition. 1, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structure, reactivity, and regulation of methane monooxygenase catalytic cycle intermediates

Nesheim, J. C. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Structure and assembly of protocatechuate 3,4-dioxygenase

Ohlendorf, D. H., Lipscomb, J. D. & Weber, P. C., Jan 1 1988, In : Nature. 336, 6197, p. 403-405 3 p.

Research output: Contribution to journalArticle

236 Scopus citations

Structure and function of dioxygenases. One approach to lignin degradation

Wood, J. M., Crawford, R. L., Howard, J. B., Orme-johnson, W. H., Lipscomb, J. D., Bromley, J. W., Stephens, R. S., Münck, E., Zimmerman, R. & Que, L., Jul 1 1977, In : Journal of agricultural and food chemistry. 25, 4, p. 698-704 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure and reactions of oxygenase active centres: cytochrome P-450 and iron-sulphur proteins.

Gunsalus, I. C., Lipscomb, J. D., Marshall, V., Frauenfelder, H., Münck, E. & Greenbaum, E., Nov 1971, In : The Biochemical journal. 125, 2, p. 5P-6P

Research output: Contribution to journalArticle

2 Scopus citations

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 Å resolution

Ohlendorf, D. H., Orville, A. M. & Lipscomb, J. D., Dec 15 1994, In : Journal of Molecular Biology. 244, 5, p. 586-608 23 p.

Research output: Contribution to journalArticle

161 Scopus citations

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

107 Scopus citations

Structures of competitive inhibitor complexes of protocatechuate 3,4- Dioxygenase: Multiple exogenous ligand binding orientations within the active site

Orville, A. M., Elango, N., Lipscomb, J. D. & Ohlendorf, D. H., Aug 19 1997, In : Biochemistry. 36, 33, p. 10039-10051 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7056-7066 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Substrate radical intermediates in soluble methane monooxygenase

Liu, A., Jin, Y., Zhang, J., Brazeau, B. J. & Lipscomb, J. D., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 254-261 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Superoxide anion production by the autoxidation of cytochrome P450cam

Sligar, S. G., Lipscomb, J. D., Debrunner, P. G. & Gunsalus, I. C., Nov 6 1974, In : Biochemical and Biophysical Research Communications. 61, 1, p. 290-296 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

Emerson, J. P., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7347-7352 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Synthesis of 17O- or 18O-Enriched dihydroxy aromatic compounds

Orville, A. M., Harpel, M. R. & Lipscomb, J. D., Jan 1 1990, In : Methods in enzymology. 188, C, p. 107-115 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tetraheme cytochrome c-554 from Nitrosomonas europaea. Heme-heme interactions and ligand binding

Andersson, K. K., Lipscomb, J. D., Valentine, M., Münck, E. & Hooper, A. B., Jul 9 1986, In : Journal of Biological Chemistry. 261, 3, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

The Active Site of Hydroxylamine Oxidoreductase from Nitrosomonas: Evidence for a New Metal Cluster in Enzymes

Hendrich, M. P., Logan, M., Andersson, K. K., Arriero, D. M., Hooper, A. B. & Lipscomb, J. D., Dec 1 1994, In : Journal of the American Chemical Society. 116, 26, p. 11961-11968 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

The axial tyrosinate Fe3+ ligand in protocatechuate 3,4-dioxygenase influences substrate binding and product release: Evidence for new reaction cycle intermediates

Frazee, R. W., Orville, A. M., Dolbeare, K. B., Yu, H., Ohlendorf, D. H. & Lipscomb, J. D., Feb 24 1998, In : Biochemistry. 37, 8, p. 2131-2144 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

The magnetic susceptibility of reduced cytochrome P-450cam

Champion, P. M., Münck, E., Debrunner, P. G., Moss, T. H., Lipscomb, J. D. & Gunsalus, I. C., Mar 20 1975, In : BBA - Bioenergetics. 376, 3, p. 579-582 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Thermodynamic and kinetic evidence for a two-step reaction between methane monooxygenase compound Q and substrates

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2002, In : International Congress Series. 1233, C, p. 229-233 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of putidaredoxin and P450 cam in methylene hydroxylation.

Tyson, C. A., Lipscomb, J. D. & Gunsalus, I. C., Sep 25 1972, In : Journal of Biological Chemistry. 247, 18, p. 5777-5784 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

Thiolate Ligation of the Active Site Fe2+of Isopenicillin N Synthase Derives from Substrate Rather Than Endogenous Cysteine: Spectroscopic Studies of Site-Specific Cys Â-Ser Mutated Enzymes

Orville, A. M., Chen, V. J., Kriauciunas, A., Harpel, M. R., Fox, B. G., Münck, E. & Lipscomb, J. D., Feb 1 1992, In : Biochemistry. 31, 19, p. 4602-4612 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Transient intermediates of the methane monooxygenase catalytic cycle

Lee, S. K., Nesheim, J. C. & Lipscomb, J. D., Oct 15 1993, In : Journal of Biological Chemistry. 268, 29, p. 21569-21577 9 p.

Research output: Contribution to journalArticle

294 Scopus citations
39 Scopus citations

Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Bominaar, E. L., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16788-16793 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

Jasniewski, A. J., Komor, A. J., Lipscomb, J. D. & Que, L., Aug 2 2017, In : Journal of the American Chemical Society. 139, 30, p. 10472-10485 14 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Unusual spin interactions in the 24 heme hydroxylamine oxidoreductase and diheme cytochrome c 554 from nitrosomonas

Andersson, K. K., Lipscomb, J. D. & Hooper, A. B., Jan 1 1983, In : Inorganica Chimica Acta. 79, p. 181-182 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
76 Scopus citations

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

X-ray Absorption Spectroscopic Studies of the Fe(II) Active Site of Catechol 2,3-Dioxygenase. Implications for the Extradiol Cleavage Mechanism

Shu, L., Chiou, Y. M., Orville, A. M., Miller, M. A., Lipscomb, J. D. & Que, L., May 1 1995, In : Biochemistry. 34, 20, p. 6649-6659 11 p.

Research output: Contribution to journalArticle

153 Scopus citations
43 Scopus citations
Chapter

Catalysis and regulation in the soluble methane monooxygenase system: Applications of isotopes and isotope effects

Lipscomb, J. D., Jan 1 2005, Isotope Effects in Chemistry and Biology. CRC Press, p. 931-953 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Intermediates in the reaction cycle of methane monooxygenase: Structure and chemistry

Lipscomb, J. D., Lee, S. K., Nesheim, J. C., Jin, Y., Wallar, B. J. & Zhang, X. Y., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. Wiley, p. 323-339 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Use of Isotopes and Isotope Effects for Investigations of Diiron Oxygenase Mechanisms

Banerjee, R., Komor, A. J. & Lipscomb, J. D., Jan 1 2017, Methods in Enzymology. Academic Press Inc., p. 239-290 52 p. (Methods in Enzymology; vol. 596).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
Comment/debate

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journalComment/debate

3 Scopus citations