1971 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

16 Scopus citations

Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene

Rocklin, A. M., Tierney, D. L., Kofman, V., Brunhuber, N. M. W., Hoffman, B. M., Christoffersen, R. E., Reich, N. O., Lipscomb, J. D. & Que L., J., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 7905-7909 5 p.

Research output: Contribution to journalArticle

92 Scopus citations

Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis

Valley, M. P., Brown, C. K., Burk, D. L., Vetting, M. W., Ohlendorf, D. H. & Lipscomb, J. D., Aug 23 2005, In : Biochemistry. 44, 33, p. 11024-11039 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Roles of the methane monooxygenase reductase component in the regulation of catalysis

Liu, Y., Nesheim, J. C., Paulsen, K. E., Stankovich, M. T. & Lipscomb, J. D., Apr 29 1997, In : Biochemistry. 36, 17, p. 5223-5233 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Salicylate 5-Hydroxylase: Intermediates in Aromatic Hydroxylation by a Rieske Monooxygenase

Rogers, M. S. & Lipscomb, J. D., Dec 31 2019, In : Biochemistry. 58, 52, p. 5305-5319 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
52 Scopus citations

Single turnover chemistry and regulation of O2 activation by the oxygenase component of naphthalene 1,2-dioxygenase

Wolfe, M. D., Parales, J. V., Gibson, D. T. & Lipscomb, J. D., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

150 Scopus citations

Single-turnover kinetics of homoprotocatechuate 2,3-dioxygenase

Groce, S. L., Miller-Rodeberg, M. A. & Lipscomb, J. D., Dec 7 2004, In : Biochemistry. 43, 48, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase

Yan, F., Li, T., Lipscomb, J. D., Liu, A. & Liu, H. W., Oct 1 2005, In : Archives of Biochemistry and Biophysics. 442, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Soluble cytochromes from the marine methanotroph Methylomonas sp. strain A4

DiSpirito, A. A., Lipscomb, J. D. & Lidstrom, M. E., Jan 1 1990, In : Journal of bacteriology. 172, 9, p. 5360-5367 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Soluble methane monooxygenase

Banerjee, R., Jones, J. C. & Lipscomb, J. D., Jun 20 2019, In : Annual Review of Biochemistry. 88, p. 409-431 23 p.

Research output: Contribution to journalArticle

7 Scopus citations

Solution structure of component B from methane monooxygenase derived through heteronuclear NMR and molecular modeling

Chang, S. L., Wallar, B. J., Lipscomb, J. D. & Mayo, K. H., May 4 1999, In : Biochemistry. 38, 18, p. 5799-5812 14 p.

Research output: Contribution to journalArticle

55 Scopus citations

Spectroscopic and electronic structure studies of protocatechuate 3,4-dioxygenase: Nature of tyrosinate-Fe(III) bonds and their contribution to reactivity

Davis, M. I., Orville, A. M., Neese, F., Zaleski, J. M., Lipscomb, J. D. & Solomon, E. I., Jan 30 2002, In : Journal of the American Chemical Society. 124, 4, p. 602-614 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Spectroscopic characterization of substrate binding to the oxygenase component of benzoate 1,2-dioxygenase

Wolfe, M. D., Altier, D. J. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1303

Research output: Contribution to journalArticle

Spectroscopic investigation of reduced protocatechuate 3,4-dioxygenase: Charge-induced alterations in the active site iron coordination environment

Davis, M. I., Wasinger, E. C., Westre, T. E., Zaleski, J. M., Orville, A. M., Lipscomb, J. D., Hedman, B., Hodgson, K. O. & Solomon, E. I., Dec 1 1999, In : Inorganic Chemistry. 38, 16, p. 3676-3683 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Spectroscopic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Molecular mechanism and CO2 activation in the biosynthesis of ethylene

Zhou, J., Rocklin, A. M., Lipscomb, J. D., Que, L. & Solomon, E. I., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Spectroscopic studies of isopenicillin N synthase. A mononuclear nonheme Fe2+ oxidase with metal coordination sites for small molecules and substrate

Chen, V. J., Orville, A. M., Harpel, M. R., Frolik, C. A., Surerus, K. K., Munck, E. & Lipscomb, J. D., Dec 1 1989, In : Journal of Biological Chemistry. 264, 36, p. 21677-21681 5 p.

Research output: Contribution to journalArticle

135 Scopus citations

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

Horsman, G. P., Jirasek, A., Vaillancourt, F. H., Barbosa, C. J., Jarzecki, A. A., Xu, C., Mekmouche, Y., Spiro, T. G., Lipscomb, J. D., Blades, M. W., Turner, R. F. B. & Eltis, L. D., Dec 7 2005, In : Journal of the American Chemical Society. 127, 48, p. 16882-16891 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
83 Scopus citations

Spectroscopic studies of the effect of ligand donor strength on the Fe-NO bond in intradiol dioxygenases

Wasinger, E. C., Davis, M. I., Pau, M. Y. M., Orville, A. M., Zaleski, J. M., Hedman, B., Lipscomb, J. D., Hodgson, K. O. & Solomon, E. I., Jan 27 2003, In : Inorganic Chemistry. 42, 2, p. 365-376 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Structural aspects of the active site of cytochrome P-450cam.

Lipscomb, J. D. & Gunsalus, I. C., Jan 1 1973, In : Drug Metabolism and Disposition. 1, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structure, reactivity, and regulation of methane monooxygenase catalytic cycle intermediates

Nesheim, J. C. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Structure and assembly of protocatechuate 3,4-dioxygenase

Ohlendorf, D. H., Lipscomb, J. D. & Weber, P. C., Jan 1 1988, In : Nature. 336, 6197, p. 403-405 3 p.

Research output: Contribution to journalArticle

236 Scopus citations

Structure and function of dioxygenases. One approach to lignin degradation

Wood, J. M., Crawford, R. L., Howard, J. B., Orme-johnson, W. H., Lipscomb, J. D., Bromley, J. W., Stephens, R. S., Münck, E., Zimmerman, R. & Que, L., Jul 1 1977, In : Journal of agricultural and food chemistry. 25, 4, p. 698-704 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure and reactions of oxygenase active centers: cytochrome P-450 and iron sulfur proteins.

Gunsalus, I. C., Lipscomb, J. D., Marshall, V., Frauenfelder, H., Greenbaum, E. & Münck, E., Dec 1 1972, In : Biochemical Society Symposia. 34, p. 135-157 23 p.

Research output: Contribution to journalReview article

8 Scopus citations

Structure and reactions of oxygenase active centres: cytochrome P-450 and iron-sulphur proteins.

Gunsalus, I. C., Lipscomb, J. D., Marshall, V., Frauenfelder, H., Münck, E. & Greenbaum, E., Nov 1971, In : The Biochemical journal. 125, 2, p. 5P-6P

Research output: Contribution to journalArticle

2 Scopus citations

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 Å resolution

Ohlendorf, D. H., Orville, A. M. & Lipscomb, J. D., Dec 15 1994, In : Journal of Molecular Biology. 244, 5, p. 586-608 23 p.

Research output: Contribution to journalArticle

161 Scopus citations

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

107 Scopus citations

Structures of competitive inhibitor complexes of protocatechuate 3,4- Dioxygenase: Multiple exogenous ligand binding orientations within the active site

Orville, A. M., Elango, N., Lipscomb, J. D. & Ohlendorf, D. H., Aug 19 1997, In : Biochemistry. 36, 33, p. 10039-10051 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Substrate activation for O2 reactions by oxidized metal centers in biology

Pau, M. Y. M., Lipscomb, J. D. & Solomon, E. I., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18355-18362 8 p.

Research output: Contribution to journalReview article

71 Scopus citations

Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7056-7066 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Substrate radical intermediates in soluble methane monooxygenase

Liu, A., Jin, Y., Zhang, J., Brazeau, B. J. & Lipscomb, J. D., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 254-261 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Superoxide anion production by the autoxidation of cytochrome P450cam

Sligar, S. G., Lipscomb, J. D., Debrunner, P. G. & Gunsalus, I. C., Nov 6 1974, In : Biochemical and Biophysical Research Communications. 61, 1, p. 290-296 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

Emerson, J. P., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7347-7352 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Synthesis of 17O- or 18O-Enriched dihydroxy aromatic compounds

Orville, A. M., Harpel, M. R. & Lipscomb, J. D., Jan 1 1990, In : Methods in enzymology. 188, C, p. 107-115 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Tetraheme cytochrome c-554 from Nitrosomonas europaea. Heme-heme interactions and ligand binding

Andersson, K. K., Lipscomb, J. D., Valentine, M., Münck, E. & Hooper, A. B., Jul 9 1986, In : Journal of Biological Chemistry. 261, 3, p. 1126-1138 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

The Active Site of Hydroxylamine Oxidoreductase from Nitrosomonas: Evidence for a New Metal Cluster in Enzymes

Hendrich, M. P., Logan, M., Andersson, K. K., Arriero, D. M., Hooper, A. B. & Lipscomb, J. D., Dec 1 1994, In : Journal of the American Chemical Society. 116, 26, p. 11961-11968 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

The axial tyrosinate Fe3+ ligand in protocatechuate 3,4-dioxygenase influences substrate binding and product release: Evidence for new reaction cycle intermediates

Frazee, R. W., Orville, A. M., Dolbeare, K. B., Yu, H., Ohlendorf, D. H. & Lipscomb, J. D., Feb 24 1998, In : Biochemistry. 37, 8, p. 2131-2144 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

The magnetic susceptibility of reduced cytochrome P-450cam

Champion, P. M., Münck, E., Debrunner, P. G., Moss, T. H., Lipscomb, J. D. & Gunsalus, I. C., Mar 20 1975, In : BBA - Bioenergetics. 376, 3, p. 579-582 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Thermodynamic and kinetic evidence for a two-step reaction between methane monooxygenase compound Q and substrates

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2002, In : International Congress Series. 1233, C, p. 229-233 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

The role of putidaredoxin and P450 cam in methylene hydroxylation.

Tyson, C. A., Lipscomb, J. D. & Gunsalus, I. C., Sep 25 1972, In : Journal of Biological Chemistry. 247, 18, p. 5777-5784 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

Thiolate Ligation of the Active Site Fe2+of Isopenicillin N Synthase Derives from Substrate Rather Than Endogenous Cysteine: Spectroscopic Studies of Site-Specific Cys Â-Ser Mutated Enzymes

Orville, A. M., Chen, V. J., Kriauciunas, A., Harpel, M. R., Fox, B. G., Münck, E. & Lipscomb, J. D., Feb 1 1992, In : Biochemistry. 31, 19, p. 4602-4612 11 p.

Research output: Contribution to journalArticle

78 Scopus citations