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Research Output 1971 2019

2006
14 Citations (Scopus)

Methane monooxygenase hydroxylase and B component interactions

Zhang, J., Wallar, B. J., Popescu, C. V., Renner, D. B., Thomas, D. D. & Lipscomb, J. D., Mar 7 2006, In : Biochemistry. 45, 9, p. 2913-2926 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Catalytic Domain
Fluorescent Dyes
Detergents
Cysteine
35 Citations (Scopus)

Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling

Zheng, H. & Lipscomb, J. D., Feb 14 2006, In : Biochemistry. 45, 6, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Ethane
Catalysis
Methane
Oxidation
16 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
Chemical activation
Oxygen
Rate constants
2007
257 Citations (Scopus)

Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates

Kovaleva, E. G. & Lipscomb, J. D., Apr 20 2007, In : Science. 316, 5823, p. 453-457 5 p.

Research output: Contribution to journalArticle

Dioxygenases
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Oxygenases
Enzymes
Atmosphere
25 Citations (Scopus)

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

Yan, F., Moon, S. J., Liu, P., Zhao, Z., Lipscomb, J. D., Liu, A. & Liu, H. W., Nov 6 2007, In : Biochemistry. 46, 44, p. 12628-12638 11 p.

Research output: Contribution to journalArticle

Organophosphonates
Catalytic Domain
Hydroxyl Radical
Iron
Epoxy Compounds
172 Citations (Scopus)

Finding intermediates in the O2 activation pathways of non-heme iron oxygenases

Kovaleva, E. G., Neibergall, M. B., Chakrabarty, S. & Lipscomb, J. D., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 475-483 9 p.

Research output: Contribution to journalArticle

Oxygenases
methane monooxygenase
Iron
Chemical activation
Dioxygenases
55 Citations (Scopus)

Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase

Neibergall, M. B., Stubna, A., Mekmouche, Y., Münck, E. & Lipscomb, J. D., Jul 10 2007, In : Biochemistry. 46, 27, p. 8004-8016 13 p.

Research output: Contribution to journalArticle

Benzoates
Oxygenases
Hydrogen Peroxide
Peroxides
Iron
78 Citations (Scopus)

Radical intermediates in monooxygenase reactions of Rieske dioxygenases

Chakrabarty, S., Austin, R. N., Deng, D., Groves, J. T. & Lipscomb, J. D., Mar 28 2007, In : Journal of the American Chemical Society. 129, 12, p. 3514-3515 2 p.

Research output: Contribution to journalArticle

Dioxygenases
Naphthalene
Mixed Function Oxygenases
Substrates
Molecules
60 Citations (Scopus)

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

Dioxygenases
Electronic structure
Iron
Enzymes
Chemical activation
69 Citations (Scopus)

Substrate activation for O2 reactions by oxidized metal centers in biology

Pau, M. Y. M., Lipscomb, J. D. & Solomon, E. I., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18355-18362 8 p.

Research output: Contribution to journalReview article

Metals
Enzymes
Dioxygenases
Iron
Electrons
52 Citations (Scopus)

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

Pathogens
Cystic Fibrosis
Pseudomonas aeruginosa
Nitric Oxide
Respiration
80 Citations (Scopus)

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

Oxygenases
Probability density function
Charge transfer
Oxidoreductases
Enzymes
2008
23 Citations (Scopus)

CD and MCD studies of the effects of component B variant binding on the biferrous active site of methane monooxygenase

Mitić, N., Schwartz, J. K., Brazeau, B. J., Lipscomb, J. D. & Solomon, E. I., Aug 12 2008, In : Biochemistry. 47, 32, p. 8386-8397 12 p.

Research output: Contribution to journalArticle

methane monooxygenase
Catalytic Domain
Ligands
Methane
Mixed Function Oxygenases
61 Citations (Scopus)

Electron paramagnetic resonance detection of intermediates in the enzymatic cycle of an extradiol dioxygenase

Gunderson, W. A., Zatsman, A. I., Emerson, J. P., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Nov 5 2008, In : Journal of the American Chemical Society. 130, 44, p. 14465-14467 3 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Enzymes
Substrates
Metalloids
44 Citations (Scopus)

Intermediate in the O-O bond cleavage reaction of an extradiol dioxygenase

Kovaleva, E. G. & Lipscomb, J. D., Oct 28 2008, In : Biochemistry. 47, 43, p. 11168-11170 3 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Dioxygenases
Crystals
Substrates
Gems

Intermediates in the reaction cycle of methane monooxygenase: Structure and chemistry

Lipscomb, J. D., Lee, S. K., Nesheim, J. C., Jin, Y., Wallar, B. J. & Zhang, X. Y., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. Wiley, p. 323-339 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Mossbauer spectroscopy
Greenhouse gases
109 Citations (Scopus)

Mechanism of extradiol aromatic ring-cleaving dioxygenases

Lipscomb, J. D., Dec 1 2008, In : Current Opinion in Structural Biology. 18, 6, p. 644-649 6 p.

Research output: Contribution to journalReview article

Dioxygenases
Metals
Oxygen
Biomimetics
Catalytic Domain
23 Citations (Scopus)
Dioxygenases
Crystallography
Naphthalene
Catalytic Domain
Substrates
83 Citations (Scopus)

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

Emerson, J. P., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7347-7352 6 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxidation-Reduction
Metals
Oxygen
Enzymes
345 Citations (Scopus)

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

Kovaleva, E. G. & Lipscomb, J. D., Jan 1 2008, In : Nature Chemical Biology. 4, 3, p. 186-193 8 p.

Research output: Contribution to journalReview article

Metals
Oxygen
Oxygenases
Enzymes
Histidine
2010
45 Citations (Scopus)

A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

Makris, T. M., Chakrabarti, M., Münck, E. & Lipscomb, J. D., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15391-15396 6 p.

Research output: Contribution to journalArticle

Hydroxylation
Mixed Function Oxygenases
Peptide Synthases
Anti-Bacterial Agents
Amino Acids
105 Citations (Scopus)

Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Bominaar, E. L., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16788-16793 6 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Iron
Enzymes
Heme
Catalytic Domain
2011
13 Citations (Scopus)

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Vu, V. V., Makris, T. M., Lipscomb, J. D. & Que, L., May 11 2011, In : Journal of the American Chemical Society. 133, 18, p. 6938-6941 4 p.

Research output: Contribution to journalArticle

Biosynthesis
methane monooxygenase
Antibiotics
Mixed Function Oxygenases
Catalytic Domain
58 Citations (Scopus)

A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., Feb 1 2011, In : Journal of Biological Inorganic Chemistry. 16, 2, p. 341-355 15 p.

Research output: Contribution to journalArticle

Dioxygenases
Cobalt
Metals
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Kinetics
37 Citations (Scopus)

Oxy intermediates of homoprotocatechuate 2,3-dioxygenase: Facile electron transfer between substrates

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Meier, K. K., Dalluge, J. J., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Nov 29 2011, In : Biochemistry. 50, 47, p. 10262-10274 13 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Electrons
Substrates
Iron
Electron Spin Resonance Spectroscopy
2012
29 Citations (Scopus)

Characterization of an O 2 adduct of an active cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 796-799 4 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Dioxygenases
Cobalt
Substrates
Oxygenases
41 Citations (Scopus)

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

Hemerythrin
Iron
Iron Regulatory Protein 2
Ubiquitin-Protein Ligases
Regulator Genes
21 Citations (Scopus)

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Tyrosine
Chemical activation
Oxygen
Substrates
26 Citations (Scopus)

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Tyrosine
Chemical activation
Electrons
Chromophores
2013
33 Citations (Scopus)

Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n - 1 aldehydes and alcohols in addition to alkanes

Aukema, K. G., Makris, T. M., Stoian, S. A., Richman, J. E., Münck, E., Lipscomb, J. D. & Wackett, L. P., Oct 4 2013, In : ACS Catalysis. 3, 10, p. 2228-2238 11 p.

Research output: Contribution to journalArticle

Alkanes
Oxygenation
Aldehydes
Paraffins
Alcohols
28 Citations (Scopus)

Intermediate P* from soluble methane monooxygenase contains a diferrous cluster

Banerjee, R., Meier, K. K., Münck, E. & Lipscomb, J. D., Jun 25 2013, In : Biochemistry. 52, 25, p. 4331-4342 12 p.

Research output: Contribution to journalArticle

methane monooxygenase
Rate constants
Oxidation
Kinetics
Paramagnetic resonance
5 Citations (Scopus)

NO binding to Mn-substituted homoprotocatechuate 2,3-dioxygenase: Relationship to O2 reactivity

Hayden, J. A., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Oct 1 2013, In : Journal of Biological Inorganic Chemistry. 18, 7, p. 717-728 12 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Nitric Oxide
Enzymes
Electrons
Ligands
20 Citations (Scopus)

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Hydroxylation
Biosynthesis
Viperidae
Mixed Function Oxygenases
2014
24 Citations (Scopus)
Dioxygenases
Catalytic Domain
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Metals
Electrons
21 Citations (Scopus)

Catalase (KatA) Plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa

Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C., Lipscomb, J. D., Irvin, R. T., Schurr, M. J., Lancaster, J. R., Kovall, R. A. & Hassett, D. J., Mar 24 2014, In : PloS one. 9, 3, e91813.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Catalase
nitric oxide
catalase
Nitric Oxide
2 Citations (Scopus)

Life in a Sea of Oxygen

Lipscomb, J. D., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

Biochemistry
Heme
Cytochrome P-450 Enzyme System
Iron
Oxygen
2015
10 Citations (Scopus)

A long-lived FeIII-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: Characterization by mössbauer, electron paramagnetic resonance, and density functional theory methods

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Mbughuni, M. M., Bominaar, E. L., Lipscomb, J. D. & Münck, E., Nov 2 2015, In : Inorganic Chemistry. 54, 21, p. 10269-10280 12 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Density functional theory
Paramagnetic resonance
electron paramagnetic resonance
density functional theory
33 Citations (Scopus)

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Makris, T. M., Vu, V. V., Meier, K. K., Komor, A. J., Rivard, B. S., Münck, E., Que, L. & Lipscomb, J. D., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1608-1617 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Oxygenases
Biosynthetic Pathways
Chloramphenicol
Peptides
17 Citations (Scopus)
Dioxygenases
Anhydrides
Protocatechuate-3,4-Dioxygenase
Catalytic Domain
X-Rays
20 Citations (Scopus)

Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase

Rivard, B. S., Rogers, M., Marell, D. J., Neibergall, M. B., Chakrabarty, S., Cramer, C. & Lipscomb, J. D., Aug 4 2015, In : Biochemistry. 54, 30, p. 4652-4664 13 p.

Research output: Contribution to journalArticle

Dioxygenases
Benzoates
Electrons
Oxidation
Substrates
13 Citations (Scopus)

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Histidine
Protons
Catalytic Domain
Chemical activation
100 Citations (Scopus)

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methane
Methanol
Oxygen
Raman Spectrum Analysis
2016
4 Citations (Scopus)

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

Jasniewski, A. J., Knoot, C., Lipscomb, J. D. & Que, L., Oct 18 2016, In : Biochemistry. 55, 41, p. 5818-5831 14 p.

Research output: Contribution to journalArticle

Peptide Synthases
Mixed Function Oxygenases
Chemical activation
Oxygen
Substrates
21 Citations (Scopus)

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

Knoot, C. J., Kovaleva, E. G. & Lipscomb, J. D., Sep 1 2016, In : Journal of Biological Inorganic Chemistry. 21, 5-6, p. 589-603 15 p.

Research output: Contribution to journalArticle

Oxygenases
Biosynthetic Pathways
Chloramphenicol
Crystal structure
Catalytic Domain
1 Citation (Scopus)

Enzyme Substrate Complex of the H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Mössbauer and Computational Studies

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Lipscomb, J. D., Bominaar, E. L. & Münck, E., Jun 20 2016, In : Inorganic Chemistry. 55, 12, p. 5862-5870 9 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Tensors
enzymes
tensors
Electric fields
16 Citations (Scopus)

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Jun 15 2016, In : Journal of the American Chemical Society. 138, 23, p. 7411-7421 11 p.

Research output: Contribution to journalArticle

Oxygenation
Chloramphenicol
Enzymes
Electrons
Oxidation
2017
3 Citations (Scopus)

CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4940-4950 11 p.

Research output: Contribution to journalArticle

Open Access
Oxygenases
Biosynthesis
Chloramphenicol
Catalytic Domain
Electrons
1 Citation (Scopus)

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

Crystallography
corrigendum
39 Citations (Scopus)

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific reports. 7, 44628.

Research output: Contribution to journalArticle

Open Access
Crystallography
Dioxygenases
Temperature
RNA Polymerase II
Lasers