1971 …2021

Research output per year

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Research Output

2006

Methane monooxygenase hydroxylase and B component interactions

Zhang, J., Wallar, B. J., Popescu, C. V., Renner, D. B., Thomas, D. D. & Lipscomb, J. D., Mar 7 2006, In : Biochemistry. 45, 9, p. 2913-2926 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling

Zheng, H. & Lipscomb, J. D., Feb 14 2006, In : Biochemistry. 45, 6, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
16 Scopus citations
2007

Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates

Kovaleva, E. G. & Lipscomb, J. D., Apr 20 2007, In : Science. 316, 5823, p. 453-457 5 p.

Research output: Contribution to journalArticle

260 Scopus citations

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

Yan, F., Moon, S. J., Liu, P., Zhao, Z., Lipscomb, J. D., Liu, A. & Liu, H. W., Nov 6 2007, In : Biochemistry. 46, 44, p. 12628-12638 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Finding intermediates in the O2 activation pathways of non-heme iron oxygenases

Kovaleva, E. G., Neibergall, M. B., Chakrabarty, S. & Lipscomb, J. D., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 475-483 9 p.

Research output: Contribution to journalArticle

174 Scopus citations

Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase

Neibergall, M. B., Stubna, A., Mekmouche, Y., Münck, E. & Lipscomb, J. D., Jul 10 2007, In : Biochemistry. 46, 27, p. 8004-8016 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Radical intermediates in monooxygenase reactions of Rieske dioxygenases

Chakrabarty, S., Austin, R. N., Deng, D., Groves, J. T. & Lipscomb, J. D., Mar 28 2007, In : Journal of the American Chemical Society. 129, 12, p. 3514-3515 2 p.

Research output: Contribution to journalArticle

78 Scopus citations

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Substrate activation for O2 reactions by oxidized metal centers in biology

Pau, M. Y. M., Lipscomb, J. D. & Solomon, E. I., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18355-18362 8 p.

Research output: Contribution to journalReview article

71 Scopus citations

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

81 Scopus citations
2008

CD and MCD studies of the effects of component B variant binding on the biferrous active site of methane monooxygenase

Mitić, N., Schwartz, J. K., Brazeau, B. J., Lipscomb, J. D. & Solomon, E. I., Aug 12 2008, In : Biochemistry. 47, 32, p. 8386-8397 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Electron paramagnetic resonance detection of intermediates in the enzymatic cycle of an extradiol dioxygenase

Gunderson, W. A., Zatsman, A. I., Emerson, J. P., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Nov 5 2008, In : Journal of the American Chemical Society. 130, 44, p. 14465-14467 3 p.

Research output: Contribution to journalArticle

62 Scopus citations

Intermediate in the O-O bond cleavage reaction of an extradiol dioxygenase

Kovaleva, E. G. & Lipscomb, J. D., Oct 28 2008, In : Biochemistry. 47, 43, p. 11168-11170 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

Intermediates in the reaction cycle of methane monooxygenase: Structure and chemistry

Lipscomb, J. D., Lee, S. K., Nesheim, J. C., Jin, Y., Wallar, B. J. & Zhang, X. Y., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. Wiley, p. 323-339 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mechanism of extradiol aromatic ring-cleaving dioxygenases

Lipscomb, J. D., Dec 1 2008, In : Current Opinion in Structural Biology. 18, 6, p. 644-649 6 p.

Research output: Contribution to journalReview article

112 Scopus citations
23 Scopus citations

Swapping metals in Fe- and Mn-dependent dioxygenases: Evidence for oxygen activation without a change in metal redox state

Emerson, J. P., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., May 27 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 21, p. 7347-7352 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

Kovaleva, E. G. & Lipscomb, J. D., Mar 2008, In : Nature Chemical Biology. 4, 3, p. 186-193 8 p.

Research output: Contribution to journalReview article

358 Scopus citations
2010

A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

Makris, T. M., Chakrabarti, M., Münck, E. & Lipscomb, J. D., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15391-15396 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Trapping and spectroscopic characterization of an FeIII-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Bominaar, E. L., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16788-16793 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
2011

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Vu, V. V., Makris, T. M., Lipscomb, J. D. & Que, L., May 11 2011, In : Journal of the American Chemical Society. 133, 18, p. 6938-6941 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., Feb 1 2011, In : Journal of Biological Inorganic Chemistry. 16, 2, p. 341-355 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

Oxy intermediates of homoprotocatechuate 2,3-dioxygenase: Facile electron transfer between substrates

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Meier, K. K., Dalluge, J. J., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Nov 29 2011, In : Biochemistry. 50, 47, p. 10262-10274 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Characterization of an O 2 adduct of an active cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 796-799 4 p.

Research output: Contribution to journalArticle

31 Scopus citations

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n - 1 aldehydes and alcohols in addition to alkanes

Aukema, K. G., Makris, T. M., Stoian, S. A., Richman, J. E., Münck, E., Lipscomb, J. D. & Wackett, L. P., Oct 4 2013, In : ACS Catalysis. 3, 10, p. 2228-2238 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Intermediate P* from soluble methane monooxygenase contains a diferrous cluster

Banerjee, R., Meier, K. K., Münck, E. & Lipscomb, J. D., Jun 25 2013, In : Biochemistry. 52, 25, p. 4331-4342 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

NO binding to Mn-substituted homoprotocatechuate 2,3-dioxygenase: Relationship to O2 reactivity

Hayden, J. A., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Oct 1 2013, In : Journal of Biological Inorganic Chemistry. 18, 7, p. 717-728 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014
28 Scopus citations

Catalase (KatA) Plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa

Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C., Lipscomb, J. D., Irvin, R. T., Schurr, M. J., Lancaster, J. R., Kovall, R. A. & Hassett, D. J., Mar 24 2014, In : PloS one. 9, 3, e91813.

Research output: Contribution to journalArticle

21 Scopus citations

Life in a Sea of Oxygen

Lipscomb, J. D., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

A long-lived FeIII-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: Characterization by mössbauer, electron paramagnetic resonance, and density functional theory methods

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Mbughuni, M. M., Bominaar, E. L., Lipscomb, J. D. & Münck, E., Nov 2 2015, In : Inorganic Chemistry. 54, 21, p. 10269-10280 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Makris, T. M., Vu, V. V., Meier, K. K., Komor, A. J., Rivard, B. S., Münck, E., Que, L. & Lipscomb, J. D., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1608-1617 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
17 Scopus citations

Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase

Rivard, B. S., Rogers, M., Marell, D. J., Neibergall, M. B., Chakrabarty, S., Cramer, C. & Lipscomb, J. D., Aug 4 2015, In : Biochemistry. 54, 30, p. 4652-4664 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

107 Scopus citations
2016

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

Jasniewski, A. J., Knoot, C., Lipscomb, J. D. & Que, L., Oct 18 2016, In : Biochemistry. 55, 41, p. 5818-5831 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

Knoot, C. J., Kovaleva, E. G. & Lipscomb, J. D., Sep 1 2016, In : Journal of Biological Inorganic Chemistry. 21, 5-6, p. 589-603 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Enzyme Substrate Complex of the H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Mössbauer and Computational Studies

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Lipscomb, J. D., Bominaar, E. L. & Münck, E., Jun 20 2016, In : Inorganic chemistry. 55, 12, p. 5862-5870 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Jun 15 2016, In : Journal of the American Chemical Society. 138, 23, p. 7411-7421 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017

CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4940-4950 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific reports. 7, 44628.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations