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Research Output 1971 2019

1999
43 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
Chemical activation
Oxidation
Hydroxylation
91 Citations (Scopus)

Role of the nonheme Fe(II) center in the biosynthesis of the plant hormone ethylene

Rocklin, A. M., Tierney, D. L., Kofman, V., Brunhuber, N. M. W., Hoffman, B. M., Christoffersen, R. E., Reich, N. O., Lipscomb, J. D. & Que, L., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 7905-7909 5 p.

Research output: Contribution to journalArticle

Plant Growth Regulators
Iron
Enzymes
Persea
Electron Spin Resonance Spectroscopy
55 Citations (Scopus)

Solution structure of component B from methane monooxygenase derived through heteronuclear NMR and molecular modeling

Chang, S. L., Wallar, B. J., Lipscomb, J. D. & Mayo, K. H., May 4 1999, In : Biochemistry. 38, 18, p. 5799-5812 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Biomolecular Nuclear Magnetic Resonance
Molecular modeling
Nuclear magnetic resonance
Proteins
15 Citations (Scopus)

Spectroscopic investigation of reduced protocatechuate 3,4-dioxygenase: Charge-induced alterations in the active site iron coordination environment

Davis, M. I., Wasinger, E. C., Westre, T. E., Zaleski, J. M., Orville, A. M., Lipscomb, J. D., Hedman, B., Hodgson, K. O. & Solomon, E. I., Dec 1 1999, In : Inorganic Chemistry. 38, 16, p. 3676-3683 8 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
dichroism
X ray absorption
Iron
Ligands
1998
2 Citations (Scopus)

Intermediates in Non-Heme Iron Intradiol Dioxygenase Catalysis

Lispscomb, J. D., Orville, A. M., Frazee, R. W., Dolbeare, K. B., Elango, N. & Ohlendorf, D. H., Dec 1 1998, In : ACS Symposium Series. 692, p. 387-402 16 p.

Research output: Contribution to journalArticle

Dioxygenases
Catalysis
Iron
Ligands
Protocatechuate-3,4-Dioxygenase
60 Citations (Scopus)

MMO: P450 in wolf's clothing?

Lipscomb, J. D. & Que, L., Jun 1 1998, In : Journal of Biological Inorganic Chemistry. 3, 3, p. 331-336 6 p.

Research output: Contribution to journalReview article

methane monooxygenase
Clothing
Hydrocarbons
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
30 Citations (Scopus)

Mossbauer evidence for antisymmetric exchange in a diferric synthetic complex and diferric methane monooxygenase

Kauffmann, K. E., Popescu, C. V., Dong, Y., Lipscomb, J. D., Que, L. & Münck, E., Sep 2 1998, In : Journal of the American Chemical Society. 120, 34, p. 8739-8746 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Magnetization
Methane
Iron
Mossbauer Spectroscopy
51 Citations (Scopus)

The axial tyrosinate Fe3+ ligand in protocatechuate 3,4-dioxygenase influences substrate binding and product release: Evidence for new reaction cycle intermediates

Frazee, R. W., Orville, A. M., Dolbeare, K. B., Yu, H., Ohlendorf, D. H. & Lipscomb, J. D., Feb 24 1998, In : Biochemistry. 37, 8, p. 2131-2144 14 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Dioxygenases
Catalytic Domain
Ligands
R388
1997
484 Citations (Scopus)

An Fe2/(IV)O2 diamond core structure for the key intermediate Q of methane monooxygenase

Shu, L., Nesheim, J. C., Kauffmann, K., Münck, E., Lipscomb, J. D. & Que, L., Jan 24 1997, In : Science. 275, 5299, p. 515-518 4 p.

Research output: Contribution to journalArticle

methane monooxygenase
Diamond
Fatty Acid Desaturases
Ribonucleotide Reductases
Porphyrins
29 Citations (Scopus)
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Brevibacterium
Mutagenesis
Organism Cloning
Genes
73 Citations (Scopus)

Crystal structure and resonance Raman studies of protocatechuate 3,4- dioxygenase complexed with 3,4-dihydroxyphenylacetate

Elgren, T. E., Orville, A. M., Kelly, K. A., Lipscomb, J. D., Ohlendorf, D. H. & Que, L., Sep 23 1997, In : Biochemistry. 36, 38, p. 11504-11513 10 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Catalytic Domain
Crystal structure
Brevibacterium
Electrons
258 Citations (Scopus)

Crystal structure of the hydroxylase component of methane monooxygenase from Methylosinus trichosporium OB3b

Elango, N., Radhakrishnan, R., Froland, W. A., Wallar, B. J., Earhart, C. A., Lipscomb, J. D. & Ohlendorf, D. H., Jan 1 1997, In : Protein Science. 6, 3, p. 556-568 13 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methylosinus trichosporium
Mixed Function Oxygenases
Baths
Crystal structure
153 Citations (Scopus)
Protocatechuate-3,4-Dioxygenase
Passive Cutaneous Anaphylaxis
R388
Iron
Crystal structure
23 Citations (Scopus)
Protocatechuate-3,4-Dioxygenase
Dioxygenases
Cyanides
Paramagnetic resonance
Nitric Oxide
61 Citations (Scopus)
methane monooxygenase
Dichroism
Circular Dichroism
Mixed Function Oxygenases
Methane

Methane monooxygenase and compound Q P450 chemistry without heme

Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
heme
Heme
active sites

Probing the interactions between component B and the hydroxylase of methane monooxygenase

Wallar, B. J. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

methane monooxygenase
Cysteine
cysteine
Labels
Gene Components
33 Citations (Scopus)

Radiolytic reduction of methane monooxygenase dinuclear iron cluster at 77 K. EPR evidence for conformational change upon reduction or binding of component B to the diferric state

Davydov, A., Davydov, R., Gräslund, A., Lipscomb, J. D. & Andersson, K. K., Mar 14 1997, In : Journal of Biological Chemistry. 272, 11, p. 7022-7026 5 p.

Research output: Contribution to journalArticle

methane monooxygenase
Diamond
Paramagnetic resonance
Iron
Oxygen

Reaction of methylcubane with methane monooxygenase from.U. trichosrokil'm

Jin, V. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

methane monooxygenase
methane
Hydroxylation
hydroxylation
Clocks
48 Citations (Scopus)

Roles of the methane monooxygenase reductase component in the regulation of catalysis

Liu, Y., Nesheim, J. C., Paulsen, K. E., Stankovich, M. T. & Lipscomb, J. D., Apr 29 1997, In : Biochemistry. 36, 17, p. 5223-5233 11 p.

Research output: Contribution to journalArticle

methane monooxygenase
Catalysis
Oxidation-Reduction
Oxidoreductases
Electrons

Spectroscopic characterization of substrate binding to the oxygenase component of benzoate 1,2-dioxygenase

Wolfe, M. D., Altier, D. J. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Oxygenases
benzoates
oxygenases
nitric oxide
Nitric Oxide

Structure, reactivity, and regulation of methane monooxygenase catalytic cycle intermediates

Nesheim, J. C. & Lipscomb, J. D., Dec 1 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

methane monooxygenase
methane
iron
Oxygen
oxygen
71 Citations (Scopus)

Structures of competitive inhibitor complexes of protocatechuate 3,4- Dioxygenase: Multiple exogenous ligand binding orientations within the active site

Orville, A. M., Elango, N., Lipscomb, J. D. & Ohlendorf, D. H., Aug 19 1997, In : Biochemistry. 36, 33, p. 10039-10051 13 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Catalytic Domain
Ligands
Iron
R388
1996
1039 Citations (Scopus)

Dioxygen activation by enzymes containing binuclear non-heme iron clusters

Wallar, B. J. & Lipscomb, J. D., Nov 1 1996, In : Chemical Reviews. 96, 7, p. 2625-2657 33 p.

Research output: Contribution to journalArticle

Iron
Chemical activation
Oxygen
Enzymes
Dioxygenases
Oxygen
63 Citations (Scopus)

Homoprotocatechuate 2,3-Dioxygenase from Brevibacterium fuscum: A dioxygenase with catalase activity

Miller, M. A. & Lipscomb, J. D., Mar 8 1996, In : Journal of Biological Chemistry. 271, 10, p. 5524-5535 12 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Brevibacterium
Dioxygenases
Catalase
Substrates
206 Citations (Scopus)
methane monooxygenase
Methane
Isotopes
Oxidation
Kinetics
43 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
X ray absorption
Mixed Function Oxygenases
X-Rays
1995
133 Citations (Scopus)

Gating effects of component B on oxygen activation by the methane monooxygenase hydroxylase component

Liu, Y., Nesheim, J. C., Lee, S. K. & Lipscomb, J. D., Jan 1 1995, In : Journal of Biological Chemistry. 270, 42, p. 24662-24665 4 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Catalysis
Chemical activation
Oxygen
152 Citations (Scopus)

X-ray Absorption Spectroscopic Studies of the Fe(II) Active Site of Catechol 2,3-Dioxygenase. Implications for the Extradiol Cleavage Mechanism

Shu, L., Chiou, Y. M., Orville, A. M., Miller, M. A., Lipscomb, J. D. & Que, L., May 1 1995, In : Biochemistry. 34, 20, p. 6649-6659 11 p.

Research output: Contribution to journalArticle

Catechol 2,3-Dioxygenase
X ray absorption
Catalytic Domain
X-Rays
Ligands
1994
317 Citations (Scopus)

Biochemistry of the soluble methane monooxygenase

Lipscomb, J. D., Jan 1 1994, In : Annual Review of Microbiology. 48, p. 371-399 29 p.

Research output: Contribution to journalReview article

methane monooxygenase
Catalysis
Biochemistry
NAD
Diagnostic Uses of Chemicals
92 Citations (Scopus)

Oxidation-Reduction Potentials of the Methane Monooxygenase Hydroxylase Component from Methylosinus trichosporium OB3b

Paulsen, K. E., Stankovich, M. T., Liu, Y., Lipscomb, J. D., Fox, B. G. & Münck, E., Jan 1 1994, In : Biochemistry. 33, 3, p. 713-722 10 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methylosinus trichosporium
Oxidation-Reduction
Oxidoreductases
Hydrocarbons
5 Citations (Scopus)

Preliminary crystallographic analysis of methane mono-oxygenase hydroxylase from Methylosinus trichosporium OB3b

Froland, W. A., Dyer, D. H., Radhakrishnan, R., Earhart, C. A., Lipscomb, J. D. & Ohlendorf, D. H., Feb 10 1994, In : Journal of Molecular Biology. 236, 1, p. 379-381 3 p.

Research output: Contribution to journalArticle

Methylosinus trichosporium
Oxygenases
Methane
Mixed Function Oxygenases
Enzymes
14 Citations (Scopus)

Preliminary crystallographic study of protocatechuate 3,4-Dioxygenase from Brevibacterium fuscum

Earhart, C. A., Radhakrishnan, R., Orville, A. M., Lipscomb, J. D. & Ohlendorf, D. H., Feb 10 1994, In : Journal of Molecular Biology. 236, 1, p. 374-376 3 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Brevibacterium
Protein Subunits
Enzymes
5 Citations (Scopus)
methane monooxygenase
Hemerythrin
Azides
Mixed Function Oxygenases
Iron
158 Citations (Scopus)

Structure of protocatechuate 3,4-dioxygenase from Pseudomonas aeruginosa at 2.15 Å resolution

Ohlendorf, D. H., Orville, A. M. & Lipscomb, J. D., Dec 15 1994, In : Journal of Molecular Biology. 244, 5, p. 586-608 23 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Pseudomonas aeruginosa
Catalytic Domain
R388
Iron
40 Citations (Scopus)

The Active Site of Hydroxylamine Oxidoreductase from Nitrosomonas: Evidence for a New Metal Cluster in Enzymes

Hendrich, M. P., Logan, M., Andersson, K. K., Arriero, D. M., Hooper, A. B. & Lipscomb, J. D., Dec 1 1994, In : Journal of the American Chemical Society. 116, 26, p. 11961-11968 8 p.

Research output: Contribution to journalArticle

hydroxylamine dehydrogenase
Nitrosomonas
Heme
Catalytic Domain
Enzymes
1993
286 Citations (Scopus)

A Transient Intermediate of the Methane Monooxygenase Catalytic Cycle Containing an FeIVFeIV Cluster

Lee, S. K., Froland, W. A., Lipscomb, J. D., Fox, B. G. & Münck, E., Jul 1 1993, In : Journal of the American Chemical Society. 115, 14, p. 6450-6451 2 p.

Research output: Contribution to journalEditorial

methane monooxygenase
48 Citations (Scopus)

Cloning, sequencing, and expression of the Pseudomonas putida protocatechuate 3,4-dioxygenase genes

Frazee, R. W., Livingston, D. M., Laporte, D. C. & Lipscomb, J. D., Jan 1 1993, In : Journal of bacteriology. 175, 19, p. 6194-6202 9 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Pseudomonas putida
Organism Cloning
Proteus mirabilis
Enzymes
165 Citations (Scopus)

Mössbauer, EPR, and ENDOR Studies of the Hydroxylase and Reductase Components of Methane Monooxygenase from Methylosinus trichosporium OB3b

Fox, B. G., Surerus, K. K., Münck, E., Hendrick, M. P., Andersson, K. K., Froland, W. A. & Lipscomb, J. D., May 1 1993, In : Journal of the American Chemical Society. 115, 9, p. 3688-3701 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methylosinus trichosporium
Electron Spin Resonance Spectroscopy
Mixed Function Oxygenases
Exchange coupling
61 Citations (Scopus)

Pulsed EPR Studies of Mixed Valent [Fe(II)Fe(III)] Forms of Hemerythrin and Methane Monooxygenase: Evidence for a Hydroxide Bridge

Thomann, H., Bernardo, M., McCormick, J. M., Pulver, S., Solomon, E. I., Andersson, K. K. & Lipscomb, J. D., Sep 1 1993, In : Journal of the American Chemical Society. 115, 19, p. 8881-8882 2 p.

Research output: Contribution to journalArticle

methane monooxygenase
Hemerythrin
Paramagnetic resonance
Methane
hydroxide ion
50 Citations (Scopus)

Purification and characterization of protocatechuate 2,3-dioxygenase from Bacillus macerans: A new extradiol catecholic dioxygenase

Wolgel, S. A., Dege, J. E., Perkins-Olson, P. E., Juarez-Garcia, C. H., Crawford, R. L., Munck, E. & Lipscomb, J. D., Jan 1 1993, In : Journal of Bacteriology. 175, 14, p. 4414-4426 13 p.

Research output: Contribution to journalArticle

Bacillus
Enzymes
Dioxygenases
Electron Spin Resonance Spectroscopy
Iron
52 Citations (Scopus)
Protocatechuate-3,4-Dioxygenase
Nitric Oxide
Substrates
Paramagnetic resonance
Iron
83 Citations (Scopus)
methane monooxygenase
Hemerythrin
Azides
Dichroism
Circular Dichroism
293 Citations (Scopus)

Transient intermediates of the methane monooxygenase catalytic cycle

Lee, S. K., Nesheim, J. C. & Lipscomb, J. D., Oct 15 1993, In : Journal of Biological Chemistry. 268, 29, p. 21569-21577 9 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Rate constants
Substrates
Paramagnetic resonance
1992
30 Citations (Scopus)

Accessibility to the Active Site of Methane Monooxygenase: The First Demonstration of Exogenous Ligand Binding to the Diiron Cluster

Andersson, K. K., Elgren, T. E., Que, L. & Lipscomb, J. D., Oct 1 1992, In : Journal of the American Chemical Society. 114, 22, p. 8711-8713 3 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Cryptic Stereospecificity of Methane Monooxygenase

Priestley, N. D., Floss, H. G., Froland, W. A., Lipscomb, J. D., Williams, P. G. & Morimoto, H., Sep 1 1992, In : Journal of the American Chemical Society. 114, 19, p. 7561-7562 2 p.

Research output: Contribution to journalArticle

EPR-spectroelectrochemistry of mammalian electron-transfer flavoprotein-ubiquinone oxidoreductase.

Paulsen, K. E., Orville, A. M., Frerman, F. E., Stankovich, M. T. & Lipscomb, J. D., Jan 1 1992, In : Progress in Clinical and Biological Research. 375, p. 69-73 5 p.

Research output: Contribution to journalArticle

Fatty Acid Desaturases
Multienzyme Complexes
Electrochemistry
Electron Spin Resonance Spectroscopy
Swine
48 Citations (Scopus)

Ligation of the diiron site of the hydroxylase component of methane monooxygenase. An electron nuclear double resonance study

Hendrich, M. P., Fox, B. G., Andersson, K. K., Debrunner, P. G. & Lipscomb, J. D., Jan 1 1992, In : Journal of Biological Chemistry. 267, 1, p. 261-269 9 p.

Research output: Contribution to journalArticle

methane monooxygenase
Electron Spin Resonance Spectroscopy
Mixed Function Oxygenases
Ligation
Nitrogen
139 Citations (Scopus)
methane monooxygenase
Regioselectivity
Oxygenases
Mixed Function Oxygenases
Catalysis