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Research Output 1971 2019

2008
342 Citations (Scopus)

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

Kovaleva, E. G. & Lipscomb, J. D., Jan 1 2008, In : Nature Chemical Biology. 4, 3, p. 186-193 8 p.

Research output: Contribution to journalReview article

Metals
Oxygen
Oxygenases
Enzymes
Histidine
2007
256 Citations (Scopus)

Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates

Kovaleva, E. G. & Lipscomb, J. D., Apr 20 2007, In : Science. 316, 5823, p. 453-457 5 p.

Research output: Contribution to journalArticle

Dioxygenases
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Oxygenases
Enzymes
Atmosphere
25 Citations (Scopus)

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

Yan, F., Moon, S. J., Liu, P., Zhao, Z., Lipscomb, J. D., Liu, A. & Liu, H. W., Nov 6 2007, In : Biochemistry. 46, 44, p. 12628-12638 11 p.

Research output: Contribution to journalArticle

Organophosphonates
Catalytic Domain
Hydroxyl Radical
Iron
Epoxy Compounds
172 Citations (Scopus)

Finding intermediates in the O2 activation pathways of non-heme iron oxygenases

Kovaleva, E. G., Neibergall, M. B., Chakrabarty, S. & Lipscomb, J. D., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 475-483 9 p.

Research output: Contribution to journalArticle

Oxygenases
methane monooxygenase
Iron
Chemical activation
Dioxygenases
55 Citations (Scopus)

Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase

Neibergall, M. B., Stubna, A., Mekmouche, Y., Münck, E. & Lipscomb, J. D., Jul 10 2007, In : Biochemistry. 46, 27, p. 8004-8016 13 p.

Research output: Contribution to journalArticle

Benzoates
Oxygenases
Hydrogen Peroxide
Peroxides
Iron
77 Citations (Scopus)

Radical intermediates in monooxygenase reactions of Rieske dioxygenases

Chakrabarty, S., Austin, R. N., Deng, D., Groves, J. T. & Lipscomb, J. D., Mar 28 2007, In : Journal of the American Chemical Society. 129, 12, p. 3514-3515 2 p.

Research output: Contribution to journalArticle

Dioxygenases
Naphthalene
Mixed Function Oxygenases
Substrates
Molecules
60 Citations (Scopus)

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

Dioxygenases
Electronic structure
Iron
Enzymes
Chemical activation
69 Citations (Scopus)

Substrate activation for O2 reactions by oxidized metal centers in biology

Pau, M. Y. M., Lipscomb, J. D. & Solomon, E. I., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18355-18362 8 p.

Research output: Contribution to journalReview article

Metals
Enzymes
Dioxygenases
Iron
Electrons
51 Citations (Scopus)

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

Pathogens
Cystic Fibrosis
Pseudomonas aeruginosa
Nitric Oxide
Respiration
78 Citations (Scopus)

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

Oxygenases
Probability density function
Charge transfer
Oxidoreductases
Enzymes
2006
14 Citations (Scopus)

Basis for specificity in methane monooxygenase and related non-heme iron-containing biological oxidation catalysts

Zhang, J., Zheng, H., Groce, S. L. & Lipscomb, J. D., May 17 2006, In : Journal of Molecular Catalysis A: Chemical. 251, 1-2, p. 54-65 12 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methane
methane
Iron
cleavage
14 Citations (Scopus)

Methane monooxygenase hydroxylase and B component interactions

Zhang, J., Wallar, B. J., Popescu, C. V., Renner, D. B., Thomas, D. D. & Lipscomb, J. D., Mar 7 2006, In : Biochemistry. 45, 9, p. 2913-2926 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Catalytic Domain
Fluorescent Dyes
Detergents
Cysteine
35 Citations (Scopus)

Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling

Zheng, H. & Lipscomb, J. D., Feb 14 2006, In : Biochemistry. 45, 6, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Ethane
Catalysis
Methane
Oxidation
16 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
Chemical activation
Oxygen
Rate constants
2005
2 Citations (Scopus)

Allosteric control of O2 reactivity in Rieske oxygenases

Lipscomb, J. D. & Hoffman, B. M., May 1 2005, In : Structure. 13, 5, p. 684-685 2 p.

Research output: Contribution to journalShort survey

Oxygenases
Electrons
Oxidants
Oxidoreductases
Oxygen
60 Citations (Scopus)
3,4-dihydroxyphenylacetate 2,3-dioxygenase
Rate constants
Kinetics
Catalytic Domain
Substrates
2 Citations (Scopus)

Catalysis and regulation in the soluble methane monooxygenase system: Applications of isotopes and isotope effects

Lipscomb, J. D., Jan 1 2005, Isotope Effects in Chemistry and Biology. CRC Press, p. 931-953 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

methane monooxygenase
Methane
Catalysis
Isotopes
Bacteria
50 Citations (Scopus)

ENDOR studies of the ligation and structure of the non-heme iron site in ACC oxidase

Tierney, D. L., Rocklin, A. M., Lipscomb, J. D., Que, L. & Hoffman, B. M., May 18 2005, In : Journal of the American Chemical Society. 127, 19, p. 7005-7013 9 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Carboxylic acids
Ligation
Iron
Substrates
41 Citations (Scopus)

Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis

Valley, M. P., Brown, C. K., Burk, D. L., Vetting, M. W., Ohlendorf, D. H. & Lipscomb, J. D., Aug 23 2005, In : Biochemistry. 44, 33, p. 11024-11039 16 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Passive Cutaneous Anaphylaxis
Catalysis
Iron
Ligands
12 Citations (Scopus)

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase

Yan, F., Li, T., Lipscomb, J. D., Liu, A. & Liu, H. W., Oct 1 2005, In : Archives of Biochemistry and Biophysics. 442, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Site-Directed Mutagenesis
Iron
Binding Sites
Fosfomycin
34 Citations (Scopus)

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

Horsman, G. P., Jirasek, A., Vaillancourt, F. H., Barbosa, C. J., Jarzecki, A. A., Xu, C., Mekmouche, Y., Spiro, T. G., Lipscomb, J. D., Blades, M. W., Turner, R. F. B. & Eltis, L. D., Dec 7 2005, In : Journal of the American Chemical Society. 127, 48, p. 16882-16891 10 p.

Research output: Contribution to journalArticle

Catechol 1,2-Dioxygenase
Enzymes
Ligands
Substrates
Protonation
9 Citations (Scopus)

Substrate radical intermediates in soluble methane monooxygenase

Liu, A., Jin, Y., Zhang, J., Brazeau, B. J. & Lipscomb, J. D., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 254-261 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Substrates
Oxides
NAD
Paramagnetic resonance
2004
116 Citations (Scopus)

Crystallographic Comparison of Manganese- and Iron-Dependent Homoprotocatechuate 2,3-Dioxygenases

Vetting, M. W., Wackett, L. P., Que, L., Lipscomb, J. D. & Ohlendorf, D. H., Apr 1 2004, In : Journal of bacteriology. 186, 7, p. 1945-1958 14 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Manganese
Iron
Metals
Catalytic Domain
64 Citations (Scopus)

Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Single turnover reaction

Rocklin, A. M., Kato, K., Liu, H. W., Que, L. & Lipscomb, J. D., Mar 1 2004, In : Journal of Biological Inorganic Chemistry. 9, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

Iron
Chemical activation
Electrons
Oxidation
Proton transfer
methane monooxygenase
Mutagenesis
Methane
Mixed Function Oxygenases
Catalysis
44 Citations (Scopus)

Single-turnover kinetics of homoprotocatechuate 2,3-dioxygenase

Groce, S. L., Miller-Rodeberg, M. A. & Lipscomb, J. D., Dec 7 2004, In : Biochemistry. 43, 48, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Kinetics
Substrates
Catalytic Domain
Iron
2003
42 Citations (Scopus)

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: A novel mononuclear non-heme iron enzyme

Liu, P., Liu, A., Yan, F., Wolfe, M. D., Lipscomb, J. D. & Liu, H. W., Oct 14 2003, In : Biochemistry. 42, 40, p. 11577-11586 10 p.

Research output: Contribution to journalArticle

Fosfomycin
Iron
Enzymes
Paramagnetic resonance
Dehydrogenation
44 Citations (Scopus)

Conversion of extradiol aromatic ring-cleaving homoprotocatechuate 2,3-dioxygenase into an intradiol cleaving enzyme

Groce, S. L. & Lipscomb, J. D., Oct 1 2003, In : Journal of the American Chemical Society. 125, 39, p. 11780-11781 2 p.

Research output: Contribution to journalArticle

3,4-dihydroxyphenylacetate 2,3-dioxygenase
Dioxygenases
Iron
Enzymes
Substrates
28 Citations (Scopus)

Effector proteins from P450cam and methane monooxygenase: Lessons in tuning nature's powerful reagents

Brazeau, B. J., Wallar, B. J. & Lipscomb, J. D., Dec 5 2003, In : Biochemical and Biophysical Research Communications. 312, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

methane monooxygenase
Camphor 5-Monooxygenase
Oxygenases
Tuning
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
86 Citations (Scopus)

Hydrogen peroxide-coupled cis-diol formation catalyzed by naphthalene 1,2-dioxygenase

Wolfe, M. D. & Lipscomb, J. D., Jan 10 2003, In : Journal of Biological Chemistry. 278, 2, p. 829-835 7 p.

Research output: Contribution to journalArticle

Dioxygenases
Hydrogen Peroxide
Peroxides
Iron
Metals
37 Citations (Scopus)

Key amino acid residues in the regulation of soluble methane monooxygenase catalysis by component B

Brazeau, B. J. & Lipscomb, J. D., May 20 2003, In : Biochemistry. 42, 19, p. 5618-5631 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Catalysis
Methane
Ethane
Amino Acids
22 Citations (Scopus)

Modulation of substrate binding to naphthalene 1,2-dioxygenase by Rieske cluster reduction/oxidation

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Feb 26 2003, In : Journal of the American Chemical Society. 125, 8, p. 2034-2035 2 p.

Research output: Contribution to journalArticle

Dioxygenases
Naphthalene
Modulation
Electron Spin Resonance Spectroscopy
Oxidation
20 Citations (Scopus)

Spectroscopic studies of the effect of ligand donor strength on the Fe-NO bond in intradiol dioxygenases

Wasinger, E. C., Davis, M. I., Pau, M. Y. M., Orville, A. M., Zaleski, J. M., Hedman, B., Lipscomb, J. D., Hodgson, K. O. & Solomon, E. I., Jan 27 2003, In : Inorganic Chemistry. 42, 2, p. 365-376 12 p.

Research output: Contribution to journalArticle

Dioxygenases
X ray absorption
dichroism
Ligands
ligands
41 Citations (Scopus)

Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7056-7066 11 p.

Research output: Contribution to journalArticle

Dioxygenases
Electron Spin Resonance Spectroscopy
Naphthalene
Spectrum Analysis
Spectroscopy
2002
62 Citations (Scopus)

Benzoate 1,2-dioxygenase from Pseudomonas putida: Single turnover kinetics and regulation of a two-component rieske dioxygenase

Wolfe, M. D., Altier, D. J., Stubna, A., Popescu, C. V., Münck, E. & Lipscomb, J. D., Jul 30 2002, In : Biochemistry. 41, 30, p. 9611-9626 16 p.

Research output: Contribution to journalArticle

Dioxygenases
Pseudomonas putida
Iron
Oxygenases
Kinetics
1 Citation (Scopus)

Methane monooxygenase and compound Q: Lessons in oxygen activation

Lipscomb, J. D., Brazeau, B. J. & Wallar, B. J., Nov 1 2002, In : International Congress Series. 1233, C, p. 205-212 8 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methane
Catalytic Domain
Oxygen
Ethane
87 Citations (Scopus)

Spectroscopic and electronic structure studies of protocatechuate 3,4-dioxygenase: Nature of tyrosinate-Fe(III) bonds and their contribution to reactivity

Davis, M. I., Orville, A. M., Neese, F., Zaleski, J. M., Lipscomb, J. D. & Solomon, E. I., Jan 30 2002, In : Journal of the American Chemical Society. 124, 4, p. 602-614 13 p.

Research output: Contribution to journalArticle

Protocatechuate-3,4-Dioxygenase
Electronic structure
Dichroism
Circular Dichroism
Metals
53 Citations (Scopus)

Spectroscopic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Molecular mechanism and CO2 activation in the biosynthesis of ethylene

Zhou, J., Rocklin, A. M., Lipscomb, J. D., Que, L. & Solomon, E. I., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

Biosynthesis
Carboxylic acids
Ethylene
Chemical activation
Enzymes
3 Citations (Scopus)

Thermodynamic and kinetic evidence for a two-step reaction between methane monooxygenase compound Q and substrates

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2002, In : International Congress Series. 1233, C, p. 229-233 5 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Methane
Thermodynamics
Activation Analysis
2001
51 Citations (Scopus)

Desaturation reactions catalyzed by soluble methane monooxygenase

Jin, Y. & Lipscomb, J. D., Oct 17 2001, In : Journal of Biological Inorganic Chemistry. 6, 7, p. 717-725 9 p.

Research output: Contribution to journalArticle

methane monooxygenase
Hydroxylation
Substrates
Cyclohexenes
Alcohols
87 Citations (Scopus)

Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: Evidence for a stepwise reaction

Brazeau, B. J., Austin, R. N., Tarr, C., Groves, J. T. & Lipscomb, J. D., Dec 5 2001, In : Journal of the American Chemical Society. 123, 48, p. 11831-11837 7 p.

Research output: Contribution to journalArticle

methane monooxygenase
Methane
Oxidation
Substrates
Methylosinus trichosporium
67 Citations (Scopus)

Methane monooxygenase component B mutants alter the kinetics of steps throughout the catalytic cycle

Wallar, B. J. & Lipscomb, J. D., Feb 20 2001, In : Biochemistry. 40, 7, p. 2220-2233 14 p.

Research output: Contribution to journalArticle

methane monooxygenase
Rate constants
Methane
Kinetics
Diethyl Pyrocarbonate
39 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
Molecular interactions
Mixed Function Oxygenases
Peptides
148 Citations (Scopus)

Single turnover chemistry and regulation of O2 activation by the oxygenase component of naphthalene 1,2-dioxygenase

Wolfe, M. D., Parales, J. V., Gibson, D. T. & Lipscomb, J. D., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

Dioxygenases
Oxygenases
Chemical activation
Ferredoxins
Iron
55 Citations (Scopus)
methane monooxygenase
Trichosanthin
Oxygenases
Mutagenesis
Deuterium
2000
13 Citations (Scopus)

Electron transfer and radical forming reactions of methane monooxygenase.

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2000, In : Sub-Cellular Biochemistry. 35, p. 233-277 45 p.

Research output: Contribution to journalReview article

methane monooxygenase
Oxygenases
X ray crystallography
Oxygen
Electrons
21 Citations (Scopus)

Hydrogen peroxide sensitivity of catechol-2,3-dioxygenase: A cautionary note on use of xylE reporter fusions under aerobic conditions

Hassett, D. J., Ochsner, U. A., Groce, S. L., Parvatiyar, K., Ma, J. F. & Lipscomb, J. D., Sep 25 2000, In : Applied and environmental microbiology. 66, 9, p. 4119-4123 5 p.

Research output: Contribution to journalArticle

Catechol 2,3-Dioxygenase
catechol
Galactosidases
aerobic conditions
oxic conditions
112 Citations (Scopus)

Kinetics and activation thermodynamics of methane monooxygenase compound Q formation and reaction with substrates

Brazeau, B. J. & Lipscomb, J. D., Nov 7 2000, In : Biochemistry. 39, 44, p. 13503-13515 13 p.

Research output: Contribution to journalArticle

methane monooxygenase
Trichosanthin
Methane
Thermodynamics
Chemical activation
27 Citations (Scopus)
methane monooxygenase
Methylosinus trichosporium
Clocks
Chemical activation
Oxidation
1999
151 Citations (Scopus)

Oxygen activation catalyzed by methane monooxygenase hydroxylase component: Proton delivery during the O-O bond cleavage steps

Sang-Kyu, L. & Lipscomb, J. D., Apr 6 1999, In : Biochemistry. 38, 14, p. 4423-4432 10 p.

Research output: Contribution to journalArticle

methane monooxygenase
Protons
Deprotonation
Chemical activation
Oxygen