1971 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2008

Versatility of biological non-heme Fe(II) centers in oxygen activation reactions

Kovaleva, E. G. & Lipscomb, J. D., Mar 2008, In : Nature Chemical Biology. 4, 3, p. 186-193 8 p.

Research output: Contribution to journalReview article

358 Scopus citations
2007

Crystal structures of Fe2+ dioxygenase superoxo, alkylperoxo, and bound product intermediates

Kovaleva, E. G. & Lipscomb, J. D., Apr 20 2007, In : Science. 316, 5823, p. 453-457 5 p.

Research output: Contribution to journalArticle

260 Scopus citations

Determination of the substrate binding mode to the active site iron of (S)-2-hydroxypropylphosphonic acid epoxidase using 17O-enriched substrates and substrate analogues

Yan, F., Moon, S. J., Liu, P., Zhao, Z., Lipscomb, J. D., Liu, A. & Liu, H. W., Nov 6 2007, In : Biochemistry. 46, 44, p. 12628-12638 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Finding intermediates in the O2 activation pathways of non-heme iron oxygenases

Kovaleva, E. G., Neibergall, M. B., Chakrabarty, S. & Lipscomb, J. D., Jul 1 2007, In : Accounts of Chemical Research. 40, 7, p. 475-483 9 p.

Research output: Contribution to journalArticle

174 Scopus citations

Hydrogen peroxide dependent cis-dihydroxylation of benzoate by fully oxidized benzoate 1,2-dioxygenase

Neibergall, M. B., Stubna, A., Mekmouche, Y., Münck, E. & Lipscomb, J. D., Jul 10 2007, In : Biochemistry. 46, 27, p. 8004-8016 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Radical intermediates in monooxygenase reactions of Rieske dioxygenases

Chakrabarty, S., Austin, R. N., Deng, D., Groves, J. T. & Lipscomb, J. D., Mar 28 2007, In : Journal of the American Chemical Society. 129, 12, p. 3514-3515 2 p.

Research output: Contribution to journalArticle

78 Scopus citations

Spectroscopic and electronic structure study of the enzyme-substrate complex of intradiol dioxygenases: Substrate activation by a high-spin ferric non-heme iron site

Pau, M. Y. M., Davis, M. I., Orville, A. M., Lipscomb, J. D. & Solomon, E. I., Feb 21 2007, In : Journal of the American Chemical Society. 129, 7, p. 1944-1958 15 p.

Research output: Contribution to journalArticle

62 Scopus citations

Substrate activation for O2 reactions by oxidized metal centers in biology

Pau, M. Y. M., Lipscomb, J. D. & Solomon, E. I., Nov 20 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18355-18362 8 p.

Research output: Contribution to journalReview article

71 Scopus citations

Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K. H., Schweizer, H. P. & Hassett, D. J., Aug 8 2007, In : EMBO Journal. 26, 15, p. 3662-3672 11 p.

Research output: Contribution to journalArticle

51 Scopus citations

VTVH-MCD and DFT studies of thiolate bonding to {FeNO}7/ {FeO2}8 complexes of isopenicillin N synthase: Substrate determination of oxidase versus oxygenase activity in nonheme Fe enzymes

Brown, C. D., Neidig, M. L., Neibergall, M. B., Lipscomb, J. D. & Solomon, E. I., Jun 13 2007, In : Journal of the American Chemical Society. 129, 23, p. 7427-7438 12 p.

Research output: Contribution to journalArticle

81 Scopus citations
2006

Basis for specificity in methane monooxygenase and related non-heme iron-containing biological oxidation catalysts

Zhang, J., Zheng, H., Groce, S. L. & Lipscomb, J. D., May 17 2006, In : Journal of Molecular Catalysis A: Chemical. 251, 1-2, p. 54-65 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Methane monooxygenase hydroxylase and B component interactions

Zhang, J., Wallar, B. J., Popescu, C. V., Renner, D. B., Thomas, D. D. & Lipscomb, J. D., Mar 7 2006, In : Biochemistry. 45, 9, p. 2913-2926 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of methane monooxygenase catalysis based on size exclusion and quantum tunneling

Zheng, H. & Lipscomb, J. D., Feb 14 2006, In : Biochemistry. 45, 6, p. 1685-1692 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
16 Scopus citations
2005

Allosteric control of O2 reactivity in Rieske oxygenases

Lipscomb, J. D. & Hoffman, B. M., May 1 2005, In : Structure. 13, 5, p. 684-685 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations
62 Scopus citations

Catalysis and regulation in the soluble methane monooxygenase system: Applications of isotopes and isotope effects

Lipscomb, J. D., Jan 1 2005, Isotope Effects in Chemistry and Biology. CRC Press, p. 931-953 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

ENDOR studies of the ligation and structure of the non-heme iron site in ACC oxidase

Tierney, D. L., Rocklin, A. M., Lipscomb, J. D., Que, L. & Hoffman, B. M., May 18 2005, In : Journal of the American Chemical Society. 127, 19, p. 7005-7013 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Roles of the equatorial tyrosyl iron ligand of protocatechuate 3,4-dioxygenase in catalysis

Valley, M. P., Brown, C. K., Burk, D. L., Vetting, M. W., Ohlendorf, D. H. & Lipscomb, J. D., Aug 23 2005, In : Biochemistry. 44, 33, p. 11024-11039 16 p.

Research output: Contribution to journalArticle

45 Scopus citations

Site-directed mutagenesis and spectroscopic studies of the iron-binding site of (S)-2-hydroxypropylphosphonic acid epoxidase

Yan, F., Li, T., Lipscomb, J. D., Liu, A. & Liu, H. W., Oct 1 2005, In : Archives of Biochemistry and Biophysics. 442, 1, p. 82-91 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

Horsman, G. P., Jirasek, A., Vaillancourt, F. H., Barbosa, C. J., Jarzecki, A. A., Xu, C., Mekmouche, Y., Spiro, T. G., Lipscomb, J. D., Blades, M. W., Turner, R. F. B. & Eltis, L. D., Dec 7 2005, In : Journal of the American Chemical Society. 127, 48, p. 16882-16891 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Substrate radical intermediates in soluble methane monooxygenase

Liu, A., Jin, Y., Zhang, J., Brazeau, B. J. & Lipscomb, J. D., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 254-261 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004

Crystallographic Comparison of Manganese- and Iron-Dependent Homoprotocatechuate 2,3-Dioxygenases

Vetting, M. W., Wackett, L. P., Que, L., Lipscomb, J. D. & Ohlendorf, D. H., Apr 1 2004, In : Journal of bacteriology. 186, 7, p. 1945-1958 14 p.

Research output: Contribution to journalArticle

117 Scopus citations

Mechanistic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Single turnover reaction

Rocklin, A. M., Kato, K., Liu, H. W., Que, L. & Lipscomb, J. D., Mar 1 2004, In : Journal of Biological Inorganic Chemistry. 9, 2, p. 171-182 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Role of the B component of methylosinus trichosporium OB3B methane monooxygenase

Zhang, J. & Lipscomb, J. D., Oct 20 2004, In : ACS National Meeting Book of Abstracts. 228, 1, p. AEI-103

Research output: Contribution to journalConference article

Single-turnover kinetics of homoprotocatechuate 2,3-dioxygenase

Groce, S. L., Miller-Rodeberg, M. A. & Lipscomb, J. D., Dec 7 2004, In : Biochemistry. 43, 48, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

45 Scopus citations
2003

Biochemical and spectroscopic studies on (S)-2-hydroxypropylphosphonic acid epoxidase: A novel mononuclear non-heme iron enzyme

Liu, P., Liu, A., Yan, F., Wolfe, M. D., Lipscomb, J. D. & Liu, H. W., Oct 14 2003, In : Biochemistry. 42, 40, p. 11577-11586 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Conversion of extradiol aromatic ring-cleaving homoprotocatechuate 2,3-dioxygenase into an intradiol cleaving enzyme

Groce, S. L. & Lipscomb, J. D., Oct 1 2003, In : Journal of the American Chemical Society. 125, 39, p. 11780-11781 2 p.

Research output: Contribution to journalArticle

45 Scopus citations

Effector proteins from P450cam and methane monooxygenase: Lessons in tuning nature's powerful reagents

Brazeau, B. J., Wallar, B. J. & Lipscomb, J. D., Dec 5 2003, In : Biochemical and Biophysical Research Communications. 312, 1, p. 143-148 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Hydrogen peroxide-coupled cis-diol formation catalyzed by naphthalene 1,2-dioxygenase

Wolfe, M. D. & Lipscomb, J. D., Jan 10 2003, In : Journal of Biological Chemistry. 278, 2, p. 829-835 7 p.

Research output: Contribution to journalArticle

89 Scopus citations

Key amino acid residues in the regulation of soluble methane monooxygenase catalysis by component B

Brazeau, B. J. & Lipscomb, J. D., May 20 2003, In : Biochemistry. 42, 19, p. 5618-5631 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Modulation of substrate binding to naphthalene 1,2-dioxygenase by Rieske cluster reduction/oxidation

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Feb 26 2003, In : Journal of the American Chemical Society. 125, 8, p. 2034-2035 2 p.

Research output: Contribution to journalArticle

22 Scopus citations

Spectroscopic studies of the effect of ligand donor strength on the Fe-NO bond in intradiol dioxygenases

Wasinger, E. C., Davis, M. I., Pau, M. Y. M., Orville, A. M., Zaleski, J. M., Hedman, B., Lipscomb, J. D., Hodgson, K. O. & Solomon, E. I., Jan 27 2003, In : Inorganic Chemistry. 42, 2, p. 365-376 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Substrate binding to NO-ferro-naphthalene 1,2-dioxygenase studied by high-resolution Q-band pulsed 2H-ENDOR spectroscopy

Yang, T. C., Wolfe, M. D., Neibergall, M. B., Mekmouche, Y., Lipscomb, J. D. & Hoffman, B. M., Jun 11 2003, In : Journal of the American Chemical Society. 125, 23, p. 7056-7066 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2002

Benzoate 1,2-dioxygenase from Pseudomonas putida: Single turnover kinetics and regulation of a two-component rieske dioxygenase

Wolfe, M. D., Altier, D. J., Stubna, A., Popescu, C. V., Münck, E. & Lipscomb, J. D., Jul 30 2002, In : Biochemistry. 41, 30, p. 9611-9626 16 p.

Research output: Contribution to journalArticle

62 Scopus citations

Methane monooxygenase and compound Q: Lessons in oxygen activation

Lipscomb, J. D., Brazeau, B. J. & Wallar, B. J., Nov 1 2002, In : International Congress Series. 1233, C, p. 205-212 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Spectroscopic and electronic structure studies of protocatechuate 3,4-dioxygenase: Nature of tyrosinate-Fe(III) bonds and their contribution to reactivity

Davis, M. I., Orville, A. M., Neese, F., Zaleski, J. M., Lipscomb, J. D. & Solomon, E. I., Jan 30 2002, In : Journal of the American Chemical Society. 124, 4, p. 602-614 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Spectroscopic studies of 1-aminocyclopropane-1-carboxylic acid oxidase: Molecular mechanism and CO2 activation in the biosynthesis of ethylene

Zhou, J., Rocklin, A. M., Lipscomb, J. D., Que, L. & Solomon, E. I., May 1 2002, In : Journal of the American Chemical Society. 124, 17, p. 4602-4609 8 p.

Research output: Contribution to journalArticle

54 Scopus citations

Thermodynamic and kinetic evidence for a two-step reaction between methane monooxygenase compound Q and substrates

Brazeau, B. J. & Lipscomb, J. D., Jan 1 2002, In : International Congress Series. 1233, C, p. 229-233 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2001

Desaturation reactions catalyzed by soluble methane monooxygenase

Jin, Y. & Lipscomb, J. D., Oct 17 2001, In : Journal of Biological Inorganic Chemistry. 6, 7, p. 717-725 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: Evidence for a stepwise reaction

Brazeau, B. J., Austin, R. N., Tarr, C., Groves, J. T. & Lipscomb, J. D., Dec 5 2001, In : Journal of the American Chemical Society. 123, 48, p. 11831-11837 7 p.

Research output: Contribution to journalArticle

88 Scopus citations

Methane monooxygenase component B mutants alter the kinetics of steps throughout the catalytic cycle

Wallar, B. J. & Lipscomb, J. D., Feb 20 2001, In : Biochemistry. 40, 7, p. 2220-2233 14 p.

Research output: Contribution to journalArticle

67 Scopus citations
39 Scopus citations

Single turnover chemistry and regulation of O2 activation by the oxygenase component of naphthalene 1,2-dioxygenase

Wolfe, M. D., Parales, J. V., Gibson, D. T. & Lipscomb, J. D., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 1945-1953 9 p.

Research output: Contribution to journalArticle

150 Scopus citations
57 Scopus citations
2000

Electron transfer and radical forming reactions of methane monooxygenase.

Brazeau, B. J. & Lipscomb, J. D., 2000, In : Sub-Cellular Biochemistry. 35, p. 233-277 45 p.

Research output: Contribution to journalReview article

13 Scopus citations

Hydrogen peroxide sensitivity of catechol-2,3-dioxygenase: A cautionary note on use of xylE reporter fusions under aerobic conditions

Hassett, D. J., Ochsner, U. A., Groce, S. L., Parvatiyar, K., Ma, J. F. & Lipscomb, J. D., Sep 25 2000, In : Applied and environmental microbiology. 66, 9, p. 4119-4123 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Kinetics and activation thermodynamics of methane monooxygenase compound Q formation and reaction with substrates

Brazeau, B. J. & Lipscomb, J. D., Nov 7 2000, In : Biochemistry. 39, 44, p. 13503-13515 13 p.

Research output: Contribution to journalArticle

113 Scopus citations
27 Scopus citations
1999

Oxygen activation catalyzed by methane monooxygenase hydroxylase component: Proton delivery during the O-O bond cleavage steps

Sang-Kyu, L. & Lipscomb, J. D., Apr 6 1999, In : Biochemistry. 38, 14, p. 4423-4432 10 p.

Research output: Contribution to journalArticle

155 Scopus citations