John D Lipscomb – Research Output

2019

Salicylate 5-Hydroxylase: Intermediates in Aromatic Hydroxylation by a Rieske Monooxygenase

Rogers, M. & Lipscomb, J. D., Jan 1 2019, In : Biochemistry.

Research output: Contribution to journal › Article

Electron spin resonance spectroscopy

Reaction intermediates

Hydroxylation

Aromatic compounds

Electron Spin Resonance Spectroscopy

2018

4 Citations (Scopus)

Diiron monooxygenases in natural product biosynthesis

Komor, A. J., Jasniewski, A. J., Que, L. & Lipscomb, J. D., Jul 1 2018, In : Natural Product Reports. 35, 7, p. 646-659 14 p.

Research output: Contribution to journal › Review article

Biosynthesis

Mixed Function Oxygenases

Biological Products

Amines

Hydroxylation

3 Citations (Scopus)

High-Resolution Extended X-ray Absorption Fine Structure Analysis Provides Evidence for a Longer Fe···Fe Distance in the Q Intermediate of Methane Monooxygenase

Cutsail, G. E., Banerjee, R., Zhou, A., Que, L., Lipscomb, J. D. & Debeer, S., Dec 5 2018, In : Journal of the American Chemical Society. 140, 48, p. 16807-16820 14 p.

Research output: Contribution to journal › Article

methane monooxygenase

X ray absorption

Methane

X-Rays

Iron

3 Citations (Scopus)

NRVS Studies of the Peroxide Shunt Intermediate in a Rieske Dioxygenase and Its Relation to the Native Fe^II O₂ Reaction

Sutherlin, K. D., Rivard, B. S., Böttger, L. H., Liu, L. V., Rogers, M., Srnec, M., Park, K., Yoda, Y., Kitao, S., Kobayashi, Y., Saito, M., Seto, M., Hu, M., Zhao, J., Lipscomb, J. D. & Solomon, E. I., Apr 25 2018, In : Journal of the American Chemical Society. 140, 16, p. 5544-5559 16 p.

Research output: Contribution to journal › Article

Dioxygenases

Vibrational spectroscopy

Peroxides

Spectrum Analysis

Enzymes

Nuclear Resonance Vibrational Spectroscopy Definition of O ₂ Intermediates in an Extradiol Dioxygenase: Correlation to Crystallography and Reactivity

Sutherlin, K. D., Wasada-Tsutsui, Y., Mbughuni, M. M., Rogers, M., Park, K., Liu, L. V., Kwak, Y., Srnec, M., Böttger, L. H., Frenette, M., Yoda, Y., Kobayashi, Y., Kurokuzu, M., Saito, M., Seto, M., Hu, M., Zhao, J., Alp, E. E., Lipscomb, J. D. & Solomon, E. I., Dec 5 2018, In : Journal of the American Chemical Society. 140, 48, p. 16495-16513 19 p.

Research output: Contribution to journal › Article

Vibrational spectroscopy

Crystallography

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Spectrum Analysis

Enzymes

2017

2 Citations (Scopus)

CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4940-4950 11 p.

Research output: Contribution to journal › Article

Oxygenases

Biosynthesis

Chloramphenicol

Catalytic Domain

Electrons

1 Citation (Scopus)

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 othersWang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, 1 p.

Research output: Contribution to journal › Comment/debate

Crystallography

corrigendum

28 Citations (Scopus)

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 othersWang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific reports. 7, 44628.

Research output: Contribution to journal › Article

Crystallography

Dioxygenases

Temperature

RNA Polymerase II

Lasers

14 Citations (Scopus)

Equilibrating (L)Fe^III-OOAc and (L)Fe^V(O) Species in Hydrocarbon Oxidations by Bio-Inspired Nonheme Iron Catalysts Using H₂O₂ and AcOH

Oloo, W. N., Banerjee, R., Lipscomb, J. D. & Que, L., Dec 6 2017, In : Journal of the American Chemical Society. 139, 48, p. 17313-17326 14 p.

Research output: Contribution to journal › Article

Hydrocarbons

Oxygenases

Iron

Ligands

Oxidants

2 Citations (Scopus)

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 othersFlory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journal › Comment/debate

Biguanides

Mitochondria

Heme

Cytochrome P-450 Enzyme System

Cell Biology

2 Citations (Scopus)

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 othersFlory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journal › Article

Biguanides

Cytochrome P-450 CYP3A

Mitochondria

Heme

Cytochrome P-450 Enzyme System

14 Citations (Scopus)

High-Energy-Resolution Fluorescence-Detected X-ray Absorption of the Q Intermediate of Soluble Methane Monooxygenase

Castillo, R. G., Banerjee, R., Allpress, C. J., Rohde, G. T., Bill, E., Que, L., Lipscomb, J. D. & DeBeer, S., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 18024-18033 10 p.

Research output: Contribution to journal › Article

Open Access

methane monooxygenase

X-Ray Absorption Spectroscopy

X ray absorption spectroscopy

X ray absorption

Catalytic Domain

1 Citation (Scopus)

Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation

Eiden, C. G., Maize, K. M., Finzel, B. C., Lipscomb, J. D. & Aldrich, C., May 31 2017, In : Journal of the American Chemical Society. 139, 21, p. 7132-7135 4 p.

Research output: Contribution to journal › Article

Open Access

Kinetic parameters

Scaffolds

Medicine

Rate constants

Enzymes

7 Citations (Scopus)

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

Jasniewski, A. J., Komor, A. J., Lipscomb, J. D. & Que, L., Aug 2 2017, In : Journal of the American Chemical Society. 139, 30, p. 10472-10485 14 p.

Research output: Contribution to journal › Article

X-Ray Absorption Spectroscopy

Oxygenases

X ray absorption spectroscopy

Oxidants

Catalytic Domain

3 Citations (Scopus)

Use of Isotopes and Isotope Effects for Investigations of Diiron Oxygenase Mechanisms

Banerjee, R., Komor, A. J. & Lipscomb, J. D., Jan 1 2017, Methods in Enzymology. Academic Press Inc., p. 239-290 52 p. (Methods in Enzymology; vol. 596).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Oxygenases

Isotopes

methane monooxygenase

Vibrational spectroscopy

Biosynthetic Pathways

2016

4 Citations (Scopus)

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

Jasniewski, A. J., Knoot, C. J., Lipscomb, J. D. & Que, L., Oct 18 2016, In : Biochemistry. 55, 41, p. 5818-5831 14 p.

Research output: Contribution to journal › Article

Peptide Synthases

Mixed Function Oxygenases

Chemical activation

Oxygen

Substrates

19 Citations (Scopus)

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

Knoot, C. J., Kovaleva, E. G. & Lipscomb, J. D., Sep 1 2016, In : Journal of Biological Inorganic Chemistry. 21, 5-6, p. 589-603 15 p.

Research output: Contribution to journal › Article

Oxygenases

Biosynthetic Pathways

Chloramphenicol

Crystal structure

Catalytic Domain

1 Citation (Scopus)

Enzyme Substrate Complex of the H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Mössbauer and Computational Studies

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Lipscomb, J. D., Bominaar, E. L. & Münck, E., Jun 20 2016, In : Inorganic Chemistry. 55, 12, p. 5862-5870 9 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Tensors

enzymes

tensors

Electric fields

15 Citations (Scopus)

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Jun 15 2016, In : Journal of the American Chemical Society. 138, 23, p. 7411-7421 11 p.

Research output: Contribution to journal › Article

Oxygenation

Chloramphenicol

Enzymes

Electrons

Oxidation

2015

10 Citations (Scopus)

A long-lived Fe^III-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: Characterization by mössbauer, electron paramagnetic resonance, and density functional theory methods

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Mbughuni, M. M., Bominaar, E. L., Lipscomb, J. D. & Münck, E., Nov 2 2015, In : Inorganic Chemistry. 54, 21, p. 10269-10280 12 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Density functional theory

Paramagnetic resonance

electron paramagnetic resonance

density functional theory

29 Citations (Scopus)

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Makris, T. M., Vu, V. V., Meier, K. K., Komor, A. J., Rivard, B. S., Münck, E., Que, L. & Lipscomb, J. D., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1608-1617 10 p.

Research output: Contribution to journal › Article

Peptide Synthases

Oxygenases

Biosynthetic Pathways

Chloramphenicol

Peptides

14 Citations (Scopus)

Crystal structures of alkylperoxo and anhydride intermediates in an intradiol ring-cleaving dioxygenase

Knoot, C. J., Purpero, V. M. & Lipscomb, J. D., Jan 13 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 2, p. 388-393 6 p.

Research output: Contribution to journal › Article

Dioxygenases

Anhydrides

Protocatechuate-3,4-Dioxygenase

Catalytic Domain

X-Rays

18 Citations (Scopus)

Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase

Rivard, B. S., Rogers, M., Marell, D. J., Neibergall, M. B., Chakrabarty, S., Cramer, C. & Lipscomb, J. D., Aug 4 2015, In : Biochemistry. 54, 30, p. 4652-4664 13 p.

Research output: Contribution to journal › Article

Dioxygenases

Benzoates

Electrons

Oxidation

Substrates

12 Citations (Scopus)

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Histidine

Protons

Catalytic Domain

Chemical activation

89 Citations (Scopus)

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journal › Article

methane monooxygenase

Methane

Methanol

Oxygen

Raman Spectrum Analysis

2014

22 Citations (Scopus)

A two-electron-shell game: Intermediates of the extradiol-cleaving catechol dioxygenases Topical Issue in honor of Ivano Bertini. Guest editors: Lucia Banci, Claudio Luchinat

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 1 2014, In : Journal of Biological Inorganic Chemistry. 19, 4-5, p. 491-504 14 p.

Research output: Contribution to journal › Review article

Dioxygenases

Catalytic Domain

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Metals

Electrons

16 Citations (Scopus)

Catalase (KatA) Plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa

Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C., Lipscomb, J. D., Irvin, R. T., Schurr, M. J., Lancaster, J. R., Kovall, R. A. & Hassett, D. J., Mar 24 2014, In : PLoS One. 9, 3, e91813.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Catalase

nitric oxide

catalase

Nitric Oxide

2 Citations (Scopus)

Life in a Sea of Oxygen

Lipscomb, J. D., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15141-15153 13 p.

Research output: Contribution to journal › Article

Biochemistry

Heme

Cytochrome P-450 Enzyme System

Iron

Oxygen

2013

33 Citations (Scopus)

Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n - 1 aldehydes and alcohols in addition to alkanes

Aukema, K. G., Makris, T. M., Stoian, S. A., Richman, J. E., Münck, E., Lipscomb, J. D. & Wackett, L. P., Oct 4 2013, In : ACS Catalysis. 3, 10, p. 2228-2238 11 p.

Research output: Contribution to journal › Article

Alkanes

Oxygenation

Aldehydes

Paraffins

Alcohols

27 Citations (Scopus)

Intermediate P* from soluble methane monooxygenase contains a diferrous cluster

Banerjee, R., Meier, K. K., Münck, E. & Lipscomb, J. D., Jun 25 2013, In : Biochemistry. 52, 25, p. 4331-4342 12 p.

Research output: Contribution to journal › Article

methane monooxygenase

Rate constants

Oxidation

Kinetics

Paramagnetic resonance

5 Citations (Scopus)

NO binding to Mn-substituted homoprotocatechuate 2,3-dioxygenase: Relationship to O₂ reactivity

Hayden, J. A., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Oct 1 2013, In : Journal of Biological Inorganic Chemistry. 18, 7, p. 717-728 12 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Nitric Oxide

Enzymes

Electrons

Ligands

19 Citations (Scopus)

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journal › Article

Peptide Synthases

Hydroxylation

Biosynthesis

Viperidae

Mixed Function Oxygenases

2012

27 Citations (Scopus)

Characterization of an O ₂ adduct of an active cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 796-799 4 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Dioxygenases

Cobalt

Substrates

Oxygenases

40 Citations (Scopus)

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journal › Article

Hemerythrin

Iron

Iron Regulatory Protein 2

Ubiquitin-Protein Ligases

Regulator Genes

20 Citations (Scopus)

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Tyrosine

Chemical activation

Oxygen

Substrates

26 Citations (Scopus)

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Tyrosine

Chemical activation

Electrons

Chromophores

2011

13 Citations (Scopus)

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Vu, V. V., Makris, T. M., Lipscomb, J. D. & Que, L., May 11 2011, In : Journal of the American Chemical Society. 133, 18, p. 6938-6941 4 p.

Research output: Contribution to journal › Article

Biosynthesis

methane monooxygenase

Antibiotics

Mixed Function Oxygenases

Catalytic Domain

55 Citations (Scopus)

A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., Feb 1 2011, In : Journal of Biological Inorganic Chemistry. 16, 2, p. 341-355 15 p.

Research output: Contribution to journal › Article

Dioxygenases

Cobalt

Metals

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Kinetics

38 Citations (Scopus)

Oxy intermediates of homoprotocatechuate 2,3-dioxygenase: Facile electron transfer between substrates

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Meier, K. K., Dalluge, J. J., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Nov 29 2011, In : Biochemistry. 50, 47, p. 10262-10274 13 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Electrons

Substrates

Iron

Electron Spin Resonance Spectroscopy

2010

42 Citations (Scopus)

A family of diiron monooxygenases catalyzing amino acid beta-hydroxylation in antibiotic biosynthesis

Makris, T. M., Chakrabarti, M., Münck, E. & Lipscomb, J. D., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15391-15396 6 p.

Research output: Contribution to journal › Article

Hydroxylation

Mixed Function Oxygenases

Peptide Synthases

Anti-Bacterial Agents

Amino Acids

102 Citations (Scopus)

Trapping and spectroscopic characterization of an Fe^III-superoxo intermediate from a nonheme mononuclear iron-containing enzyme

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Bominaar, E. L., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Sep 28 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16788-16793 6 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Iron

Enzymes

Heme

Catalytic Domain

2008

22 Citations (Scopus)

CD and MCD studies of the effects of component B variant binding on the biferrous active site of methane monooxygenase

Mitić, N., Schwartz, J. K., Brazeau, B. J., Lipscomb, J. D. & Solomon, E. I., Aug 12 2008, In : Biochemistry. 47, 32, p. 8386-8397 12 p.

Research output: Contribution to journal › Article

methane monooxygenase

Catalytic Domain

Ligands

Methane

Mixed Function Oxygenases

59 Citations (Scopus)

Electron paramagnetic resonance detection of intermediates in the enzymatic cycle of an extradiol dioxygenase

Gunderson, W. A., Zatsman, A. I., Emerson, J. P., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Nov 5 2008, In : Journal of the American Chemical Society. 130, 44, p. 14465-14467 3 p.

Research output: Contribution to journal › Article

Electron Spin Resonance Spectroscopy

Paramagnetic resonance

Enzymes

Substrates

Metalloids

44 Citations (Scopus)

Intermediate in the O-O bond cleavage reaction of an extradiol dioxygenase

Kovaleva, E. G. & Lipscomb, J. D., Oct 28 2008, In : Biochemistry. 47, 43, p. 11168-11170 3 p.

Research output: Contribution to journal › Article

3,4-dihydroxyphenylacetate 2,3-dioxygenase

Dioxygenases

Crystals

Substrates

Gems

Intermediates in the reaction cycle of methane monooxygenase: Structure and chemistry

Lipscomb, J. D., Lee, S. K., Nesheim, J. C., Jin, Y., Wallar, B. J. & Zhang, X. Y., Jan 2 2008, Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms. Wiley, p. 323-339 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

methane monooxygenase

Mossbauer spectroscopy

Greenhouse gases

103 Citations (Scopus)