20092019
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 5 Similar Profiles
Phosphodiesterase Inhibitors Medicine & Life Sciences
Poisons Medicine & Life Sciences
Type II DNA Topoisomerase Medicine & Life Sciences
Benzamides Medicine & Life Sciences
Thiones Medicine & Life Sciences
Cytotoxicity Chemical Compounds
Puromycin Medicine & Life Sciences
Inosine Monophosphate Medicine & Life Sciences

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Research Output 2009 2019

Discovery of Irreversible p97 Inhibitors

Ding, R., Zhang, T., Wilson, D. J., Xie, J., Williams, J., Xu, Y., Ye, Y. & Chen, L., Mar 14 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2814-2829 16 p.

Research output: Contribution to journalArticle

Amides
Mutagenesis
Cysteine
Mass Spectrometry
Neoplasms

Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide

Kankanala, J., Ribeiro, C. J. A., Kiselev, E., Ravji, A., Williams, J., Xie, J., Aihara, H., Pommier, Y. & Wang, Z., May 9 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4669-4682 14 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
Poisons
Etoposide
Phosphodiesterase Inhibitors
Permeability
2 Citations (Scopus)

Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors

Ribeiro, C. J. A., Kankanala, J., Xie, J., Williams, J., Aihara, H. & Wang, Z., Jan 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 2, p. 257-261 5 p.

Research output: Contribution to journalArticle

Phosphodiesterase Inhibitors
Scaffolds
Poisons
Type II DNA Topoisomerase
Cytotoxicity
4 Citations (Scopus)

N-(1-Benzyl-3,5-dimethyl‑1H‑pyrazol-4-yl)benzamides: Antiproliferative activity and effects on mTORC1 and autophagy

Ai, T., Willett, R., Williams, J., Ding, R., Wilson, D., Xie, J., Kim, D-H., Puertollano, R. & Chen, L., Jan 1 2017, In : ACS Medicinal Chemistry Letters. 8, 1, p. 90-95 6 p.

Research output: Contribution to journalArticle

Open Access
Benzamides
Autophagy
Starvation
Modulators
Fluxes
2 Citations (Scopus)
Puromycin
Aminopeptidases
Hematologic Neoplasms
Peptide Hydrolases
Cells