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Article
2018

A role for monomethylation of histone H3-K27 in gene activity in Drosophila

Wang, L., Joshi, P., Miller, E. L., Higgins, L., Slattery, M. & Simon, J. A., Mar 2018, In : Genetics. 208, 3, p. 1023-1036 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2014

A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element

Herzog, V. A., Lempradl, A., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., Ruf, M., Pospisilik, A., Dimond, A., Senergin, H. B., Vargas, M. L., Simon, J. A. & Ringrose, L., Jan 1 2014, In : Nature Genetics. 46, 9, p. 973-981 9 p.

Research output: Contribution to journalArticle

63 Scopus citations
2013

Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function

Rai, A. N., Vargas, M. L., Wang, L., Andersen, E. F., Miller, E. L. & Simon, J. A., Dec 2013, In : Molecular and cellular biology. 33, 24, p. 4844-4856 13 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Epigenetics: Stopping a chromatin enzyme

Simon, J. A., Nov 2012, In : Nature Chemical Biology. 8, 11, p. 875-876 2 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Small ubiquitin-like modifier (SUMO) conjugation impedes transcriptional silencing by the Polycomb group repressor sex comb on midleg

Smith, M., Mallin, D. R., Simon, J. A. & Courey, A. J., Apr 1 2011, In : Journal of Biological Chemistry. 286, 13, p. 11391-11400 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene

Wang, L., Jahren, N., Miller, E. L., Ketel, C. S., Mallin, D. R. & Simon, J. A., Jun 2010, In : Molecular and cellular biology. 30, 11, p. 2584-2593 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

Chen, S., Bohrer, L. R., Rai, A. N., Pan, Y., Gan, L., Zhou, X., Bagchi, A., Simon, J. A. & Huang, H., Nov 1 2010, In : Nature Cell Biology. 12, 11, p. 1108-1114 7 p.

Research output: Contribution to journalArticle

165 Scopus citations
2008

Dominant alleles identify SET domain residues required for histone methyltransferase of polycomb repressive complex 2

Joshi, P., Carrington, E. A., Wang, L., Ketel, C. S., Miller, E. L., Jones, R. S. & Simon, J. A., Oct 10 2008, In : Journal of Biological Chemistry. 283, 41, p. 27757-27766 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis

Zhu, C. C., Bornemann, D. J., Zhitomirsky, D., Miller, E. L., O'Connor, M. B. & Simon, J. A., Feb 1 2008, In : PLoS genetics. 4, 2

Research output: Contribution to journalArticle

17 Scopus citations
2006

Alternative ESC and ESC-like subunits of a polycomb group histone methyltransferase complex are differentially deployed during Drosophila development

Wang, L., Jahren, N., Vargas, M. L., Andersen, E. F., Benes, J., Zhang, J., Miller, E. L., Jones, R. S. & Simon, J. A., Apr 1 2006, In : Molecular and cellular biology. 26, 7, p. 2637-2647 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes

Ketel, C. S., Andersen, E. F., Vargas, M. L., Suh, J., Strome, S. & Simon, J. A., Aug 1 2005, In : Molecular and cellular biology. 25, 16, p. 6857-6868 12 p.

Research output: Contribution to journalArticle

128 Scopus citations
2004

Requirement for Sex Comb on Midleg protein interactions in Drosophila Polycomb group repression

Peterson, A. J., Mallin, D. R., Francis, N. J., Ketel, C. S., Stamm, J., Voeller, R. K., Kingston, R. E. & Simon, J. A., Jul 1 2004, In : Genetics. 167, 3, p. 1225-1239 15 p.

Research output: Contribution to journalArticle

52 Scopus citations
2003

Polycomb group proteins.

Simon, J. A., Feb 4 2003, In : Current biology : CB. 13, 3

Research output: Contribution to journalArticle

12 Scopus citations
2002

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

Müller, J., Hart, C. M., Francis, N. J., Vargas, M. L., Sengupta, A., Wild, B., Miller, E. L., O'Connor, M. B., Kingston, R. E. & Simon, J. A., Oct 18 2002, In : Cell. 111, 2, p. 197-208 12 p.

Research output: Contribution to journalArticle

1072 Scopus citations

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

Fang, J., Feng, Q., Ketel, C. S., Wang, H., Cao, R., Xia, L., Erdjument-Bromage, H., Tempst, P., Simon, J. A. & Zhang, Y., Jul 9 2002, In : Current Biology. 12, 13, p. 1086-1099 14 p.

Research output: Contribution to journalArticle

229 Scopus citations
2001

Interactions of Exo1p with components of MutLα in Saccharomyces cerevisiae

Tran, P. T., Simon, J. A. & Liskay, R. M., Aug 14 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 17, p. 9760-9765 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Long-range repression by multiple Polycomb group (PcG) proteins targeted by fusion to a defined DNA-binding domain in drosophila

Roseman, R. R., Morgan, K., Mallin, D. R., Roberson, R., Parnell, T. J., Bornemann, D. J., Simon, J. A. & Geyer, P. K., May 22 2001, In : Genetics. 158, 1, p. 291-307 17 p.

Research output: Contribution to journalArticle

25 Scopus citations
2000

A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC

Ng, J., Hart, C. M., Morgan, K. & Simon, J. A., May 1 2000, In : Molecular and cellular biology. 20, 9, p. 3069-3078 10 p.

Research output: Contribution to journalArticle

132 Scopus citations

Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene

Shimell, M. J., Peterson, A. J., Burr, J., Simon, J. A. & O'Connor, M. B., Feb 1 2000, In : Developmental Biology. 218, 1, p. 38-52 15 p.

Research output: Contribution to journalArticle

70 Scopus citations
1999

A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with RAE28/mph1 in vitro

Tomotsune, D., Takihara, Y., Berger, J., Duhl, D., Sunghae, J., Kyba, M., Shirai, M., Ohta, H., Matsuda, Y., Honda, B. M., Simon, J., Shimada, K., Brock, H. W. & Randazzo, F., Jan 1 1999, In : Differentiation. 65, 4, p. 229-239 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
1998

Expression and properties of wild-type and mutant forms of the drosophila sex comb on midleg (SCM) repressor protein

Bornemann, D., Miller, E. & Simon, J., Oct 20 1998, In : Genetics. 150, 2, p. 675-686 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression

Jones, C. A., Ng, J., Peterson, A. J., Morgan, K., Simon, J. & Jones, R. S., May 1 1998, In : Molecular and cellular biology. 18, 5, p. 2825-2834 10 p.

Research output: Contribution to journalArticle

102 Scopus citations
1997

A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions

Peterson, A. J., Kyba, M., Bornemann, D., Morgan, K., Brock, H. W. & Simon, J., Nov 1997, In : Molecular and cellular biology. 17, 11, p. 6683-6692 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein

Ng, J., Li, R., Morgan, K. & Simon, J., Nov 1997, In : Molecular and cellular biology. 17, 11, p. 6663-6672 10 p.

Research output: Contribution to journalArticle

43 Scopus citations
1996

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

Umar, A., Buermeyer, A. B., Simon, J. A., Thomas, D. C., Clark, A. B., Liskay, R. M. & Kunkel, T. A., Oct 1996, In : Cell. 87, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

464 Scopus citations

Sunlight and sunburn in human skin cancer: P53, apoptosis, and tumor promotion

Brash, D. E., Ziegler, A., Jonason, A. S., Simon, J. A., Kunala, S. & Leffell, D. J., Dec 1 1996, In : Journal of Investigative Dermatology Symposium Proceedings. 1, 2, p. 136-142 7 p.

Research output: Contribution to journalArticle

395 Scopus citations

The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein

Bornemann, D., Miller, E. & Simon, J., Jun 5 1996, In : Development. 122, 5, p. 1621-1630 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Tumor suppressor gene mutations and photocarcinogenesis

Ziegler, A., Jonason, A., Simon, J., Leffell, D. & Brash, D. E., Apr 1996, In : Photochemistry and Photobiology. 63, 4, p. 432-435 4 p.

Research output: Contribution to journalArticle

42 Scopus citations
1995

Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex

Chiang, A., O'Connor, M. B., Paro, R., Simon, J. & Bender, W., Jan 1 1995, In : Development. 121, 6, p. 1681-1689 9 p.

Research output: Contribution to journalArticle

100 Scopus citations
266 Scopus citations

The extra sex combs product contains WD40 repeats and its time of action implies a role distinct from other Polycomb group products

Simon, J., Bornemann, D., Lunde, K. & Schwartz, C., Oct 1995, In : Mechanisms of Development. 53, 2, p. 197-208 12 p.

Research output: Contribution to journalArticle

58 Scopus citations
1994

Enhancer point mutation results in a homeotic transformation in drosophila

Shimell, M. J., Simon, J., Bender, W. & O'Connor, M. B., Jan 1 1994, In : Science. 264, 5161, p. 968-971 4 p.

Research output: Contribution to journalArticle

69 Scopus citations

Sunburn and p53 in the onset of skin cancer

Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T. & Brash, D. E., Jan 1 1994, In : Nature. 372, 6508, p. 773-776 4 p.

Research output: Contribution to journalArticle

1251 Scopus citations
1993

Elements of the Drosophila bithorax complex that mediate repression by polycomb group products

Simon, J., Chiang, A., Bender, W., Shimell, M. J. & O’connor, M., Jul 1993, In : Developmental Biology. 158, 1, p. 131-144 14 p.

Research output: Contribution to journalArticle

222 Scopus citations

Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers

Ziegler, A., Leffell, D. J., Kunala, S., Sharma, H. W., Gailani, M., Simon, J. A., Halperin, A. J., Baden, H. P., Shapiro, P. E., Bale, A. E. & Brash, D. E., May 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 9, p. 4216-4220 5 p.

Research output: Contribution to journalArticle

616 Scopus citations
1992

Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines

Reiss, M., Brash, D. E., Muñoz-Antonia, T., Simon, J. A., Ziegler, A., Vellucci, V. F. & Zhou, Z. L., Dec 1 1992, In : Oncology Research. 4, 8-9, p. 349-357 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic products

Simon, J., Chiang, A. & Bender, W., Jan 1 1992, In : Development. 114, 2, p. 493-505 13 p.

Research output: Contribution to journalArticle

228 Scopus citations
1991

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., Mckenna, G. J., Baden, H. P., Halperin, A. J. & Pontén, J., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 22, p. 10124-10128 5 p.

Research output: Contribution to journalArticle

1549 Scopus citations
1990

Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis

Simon, J., Peifer, M., Bender, W. & O'Connor, M., Nov 29 1990, In : EMBO Journal. 9, 12, p. 3945-3956 12 p.

Research output: Contribution to journalArticle

107 Scopus citations
1988

Structure and expression of ubiquitin genes of Drosophila melanogaster.

Lee, H. S., Simon, J. A. & Lis, J. T., Nov 1988, In : Molecular and Cellular Biology. 8, 11, p. 4727-4735 9 p.

Research output: Contribution to journalArticle

146 Scopus citations
1987

A germline transformation analysis reveals flexibility in the organization of beat shock consensus elements

Simon, J. A. & Lis, J. T., Apr 10 1987, In : Nucleic acids research. 15, 7, p. 2971-2988 18 p.

Research output: Contribution to journalArticle

101 Scopus citations
1985

A hypersensitive site in hsp70 chromatin requires adjacent not internal DNA sequence

Costlow, N. A., Simon, J. A. & Lis, J. T., Dec 1 1985, In : Nature. 313, 5998, p. 147-149 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Determinants of heat shock-induced chromosome puffing

Simon, J. A., Sutton, C. A., Lobell, R. B., Glaser, R. L. & Lis, J. T., Apr 1985, In : Cell. 40, 4, p. 805-817 13 p.

Research output: Contribution to journalArticle

164 Scopus citations

Localization and expression of transformed DNA sequences within heat shock puffs of Drosophila melanogaster

Simon, J. A., Sutton, C. A. & Lis, J. T., Jan 1 1985, In : Chromosoma. 93, 1, p. 26-30 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
1983

New heat shock puffs and β=galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene

Lis, J. T., Simon, J. A. & Sutton, C. A., Dec 1983, In : Cell. 35, 2 PART 1, p. 403-410 8 p.

Research output: Contribution to journalArticle

219 Scopus citations