Jayanth Panyam

Professor and Head

Accepting PhD Students

19992020
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Research Output 1999 2019

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Article
2019

Combination of Sunitinib and PD-L1 Blockade Enhances Anticancer Efficacy of TLR7/8 Agonist-Based Nanovaccine

Kim, H., Khanna, V., Kucaba, T. A., Zhang, W., Ferguson, D. M., Griffith, T. S. & Panyam, J., Mar 4 2019, In : Molecular pharmaceutics. 16, 3, p. 1200-1210 11 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Ligands
T-Lymphocytes
Tumor Microenvironment
Nanoparticles
1 Citation (Scopus)

Improving payload capacity and anti-tumor efficacy of mesenchymal stem cells using tat peptide functionalized polymeric nanoparticles

Moku, G., Layek, B., Trautman, L., Putnam, S., Panyam, J. & Prabha, S., Apr 1 2019, In : Cancers. 11, 4, 491.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Nanoparticles
Peptides
Trans-Activators
Neoplasms
3 Citations (Scopus)

Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response

Niu, L., Chu, L. Y., Burton, S. A., Hansen, K. J. & Panyam, J., Jan 28 2019, In : Journal of Controlled Release. 294, p. 268-278 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Vaccines
Ovalbumin
Antigens
imiquimod
2018
2 Citations (Scopus)

Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy

Kim, H., Sehgal, D., Kucaba, T. A., Ferguson, D. M., Griffith, T. S. & Panyam, J., Nov 28 2018, In : Nanoscale. 10, 44, p. 20851-20862 12 p.

Research output: Contribution to journalArticle

Polymers
Nanoparticles
T-cells
Gases
Antigens
6 Citations (Scopus)

Chemopreventive efficacy of curcumin-loaded PLGA microparticles in a transgenic mouse model of HER-2-positive breast cancer

Grill, A. E., Shahani, K., Koniar, B. & Panyam, J., Apr 1 2018, In : Drug Delivery and Translational Research. 8, 2, p. 329-341 13 p.

Research output: Contribution to journalArticle

Open Access
Curcumin
Transgenic Mice
Breast Neoplasms
Neoplasms
Chemoprevention
9 Citations (Scopus)
Mesenchymal Stromal Cells
Paclitaxel
Pharmaceutical Preparations
Neoplasms
Nanoparticles
13 Citations (Scopus)

Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy

Kim, H., Niu, L., Larson, P., Kucaba, T. A., Murphy, K. A., James, B. R., Ferguson, D. M., Griffith, T. S. & Panyam, J., May 1 2018, In : Biomaterials. 164, p. 38-53 16 p.

Research output: Contribution to journalArticle

T-cells
Immunotherapy
Nanoparticles
Vaccines
Tumors
2017
3 Citations (Scopus)

Assessing the Benefits of Drug Delivery by Nanocarriers: A Partico/Pharmacokinetic Framework

Siegel, R. A., Kirtane, A. R. & Panyam, J., Sep 1 2017, In : IEEE Transactions on Biomedical Engineering. 64, 9, p. 2176-2185 10 p., 7762087.

Research output: Contribution to journalArticle

Pharmacokinetics
Drug delivery
Tissue
Toxicity
Kinetics
14 Citations (Scopus)
Antibody-Dependent Cell Cytotoxicity
Natural Killer Cells
Interleukin-15
Neoplastic Stem Cells
Interferons
1 Citation (Scopus)

Evaluation of Vaginal Drug Levels and Safety of a Locally Administered Glycerol Monolaurate Cream in Rhesus Macaques

Kirtane, A. R., Rothenberger, M. K., Frieberg, A., Nephew, K., Schultz-Darken, N., Schmidt, T., Reimann, T., Haase, A. T. & Panyam, J., Jul 1 2017, In : Journal of Pharmaceutical Sciences. 106, 7, p. 1821-1827 7 p.

Research output: Contribution to journalArticle

Open Access
Drug Evaluation
Macaca mulatta
Safety
Foams and Jellies Vaginal Creams
Intravaginal Administration
5 Citations (Scopus)

Fibrinolytic enzyme cotherapy improves tumor perfusion and therapeutic efficacy of anticancer nanomedicine

Kirtane, A. R., Sadhukha, T., Kim, H., Khanna, V., Koniar, B. & Panyam, J., Mar 15 2017, In : Cancer Research. 77, 6, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

Open Access
Nanomedicine
Tissue Plasminogen Activator
Fibrin
Perfusion
Enzymes
10 Citations (Scopus)
Polystyrenes
Ice
Nanoparticles
Freezing
Freeze Drying
6 Citations (Scopus)

Polymer-surfactant nanoparticles for improving oral bioavailability of doxorubicin

Kirtane, A. R., Narayan, P., Liu, G. & Panyam, J., Jan 1 2017, In : Journal of Pharmaceutical Investigation. 47, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Surface-Active Agents
Nanoparticles
Doxorubicin
Biological Availability
3 Citations (Scopus)

The effects of collagen-rich extracellular matrix on the intracellular delivery of glycol chitosan nanoparticles in human lung fibroblasts

Yhee, J. Y., Yoon, H. Y., Kim, H., Jeon, S., Hergert, P., Im, J., Panyam, J., Kim, K. & Nho, R. S., Aug 21 2017, In : International Journal of Nanomedicine. 12, p. 6089-6105 17 p.

Research output: Contribution to journalArticle

Open Access
Fibroblasts
Glycols
Chitosan
Collagen
Nanoparticles
14 Citations (Scopus)

Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling

Song, J. M., Molla, K., Anandharaj, A., Cornax, I., Gerard O'Sullivan, M., Kirtane, A. R., Panyam, J. & Kassie, F., Jan 1 2017, In : Oncotarget. 8, 16, p. 26927-26940 14 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Lung Neoplasms
Lung
Growth
Non-Small Cell Lung Carcinoma
2016
9 Citations (Scopus)

Honokiol suppresses lung tumorigenesis by targeting EGFR and its downstream effectors

Song, J. M., Anandharaj, A., Upadhyaya, P., Kirtane, A. R., Kim, J. H., Hong, K. H., Panyam, J. & Kassie, F., Jan 1 2016, In : Oncotarget. 7, 36, p. 57752-57769 18 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Lung
Magnolia
Neoplasms
2015
11 Citations (Scopus)
Nanomedicine
Drug Carriers
Capillary Permeability
Pharmacokinetics
Blood Vessels
3 Citations (Scopus)

Attenuated Salmonella enterica Typhimurium reduces tumor burden in an autochthonous breast cancer model

Drees, J., Mertensotto, M., Liu, G., Panyam, J., Leonard, A., Augustin, L. B., Schottel, J. L. & Saltzman, D. A., Feb 1 2015, In : Anticancer Research. 35, 2, p. 843-849 7 p.

Research output: Contribution to journalArticle

Salmonella enterica
Salmonella typhimurium
Tumor Burden
Breast Neoplasms
Neoplasms
12 Citations (Scopus)

Nanoparticles Containing High Loads of Paclitaxel-Silicate Prodrugs: Formulation, Drug Release, and Anticancer Efficacy

Han, J., Michel, A. R., Lee, H., Kalscheuer, S., Wohl, A., Hoye, T. R., McCormick, A. V., Panyam, J. & Macosko, C., Oct 27 2015, In : Molecular pharmaceutics. 12, 12, p. 4329-4335 7 p.

Research output: Contribution to journalArticle

Silicates
Prodrugs
Paclitaxel
Nanoparticles
Hydrophobic and Hydrophilic Interactions
4 Citations (Scopus)

Reformulating Tylocrebrine in Epidermal Growth Factor Receptor Targeted Polymeric Nanoparticles Improves Its Therapeutic Index

Kirtane, A. R., Wong, H. L., Guru, B. R., Lis, L. G., Georg, G. I., Gurvich, V. J. & Panyam, J., Aug 3 2015, In : Molecular Pharmaceutics. 12, 8, p. 2912-2923 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Nanoparticles
Neoplasms
Pharmaceutical Preparations
Costs and Cost Analysis
2014
24 Citations (Scopus)
Curcumin
Drug Delivery Systems
Biological Availability
piperine
Quercetin
23 Citations (Scopus)

Enhanced photodynamic therapy and effective elimination of cancer stem cells using surfactant-polymer nanoparticles

Usacheva, M., Swaminathan, S. K., Kirtane, A. R. & Panyam, J., Sep 2 2014, In : Molecular Pharmaceutics. 11, 9, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

Photosensitizing Agents
Neoplastic Stem Cells
Methylene Blue
Photochemotherapy
Surface-Active Agents
22 Citations (Scopus)

Enhancing therapeutic efficacy through designed aggregation of nanoparticles

Sadhukha, T., Wiedmann, T. S. & Panyam, J., Jan 1 2014, In : Biomaterials. 35, 27, p. 7860-7869 10 p.

Research output: Contribution to journalArticle

Nanoparticles
Agglomeration
Induced Hyperthermia
Iron oxides
Particle Size
7 Citations (Scopus)

Intranasal delivery of liposomal indole-3-carbinol improves its pulmonary bioavailability

Song, J. M., Kirtane, A. R., Upadhyaya, P., Qian, X., Balbo, S., Teferi, F., Panyam, J. & Kassie, F., Dec 30 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 96-101 6 p.

Research output: Contribution to journalArticle

Biological Availability
Lung
Intranasal Administration
Carcinogens
Cytochrome P-450 Enzyme System
16 Citations (Scopus)

Silicate esters of paclitaxel and docetaxel: Synthesis, hydrophobicity, hydrolytic stability, cytotoxicity, and prodrug potential

Wohl, A. R., Michel, A. R., Kalscheuer, S., Macosko, C., Panyam, J. & Hoye, T. R., Mar 27 2014, In : Journal of Medicinal Chemistry. 57, 6, p. 2368-2379 12 p.

Research output: Contribution to journalArticle

docetaxel
Silicates
Prodrugs
Paclitaxel
Hydrophobic and Hydrophilic Interactions
37 Citations (Scopus)

Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: Potential implications for pancreatic cancer therapy

Arora, S., Swaminathan, S. K., Kirtane, A. R., Srivastava, S. K., Bhardwaj, A., Singh, S., Panyam, J. & Singh, A. P., Jun 18 2014, In : International Journal of Nanomedicine. 9, 1, p. 2933-2942 10 p.

Research output: Contribution to journalArticle

MicroRNAs
Pancreatic Neoplasms
Tumors
Cells
Encapsulation
2013
83 Citations (Scopus)

CD133-targeted paclitaxel delivery inhibits local tumor recurrence in amousemodel of breast cancer

Swaminathan, S. K., Roger, E., Toti, U., Niu, L., Ohlfest, J. R. & Panyam, J., Nov 10 2013, In : Journal of Controlled Release. 171, 3, p. 280-287 8 p.

Research output: Contribution to journalArticle

Paclitaxel
Nanoparticles
Breast Neoplasms
Recurrence
Neoplastic Stem Cells
49 Citations (Scopus)

Effective elimination of cancer stem cells by magnetic hyperthermia

Sadhukha, T., Niu, L., Wiedmann, T. S. & Panyam, J., Apr 1 2013, In : Molecular Pharmaceutics. 10, 4, p. 1432-1441 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Fever
Neoplasms
Recurrence
Ferrosoferric Oxide
59 Citations (Scopus)

Flash nanoprecipitation: Particle structure and stability

Pustulka, K. M., Wohl, A. R., Lee, H., Michel, A. R., Han, J., Hoye, T. R., McCormick, A. V., Panyam, J. & Macosko, C., Nov 4 2013, In : Molecular pharmaceutics. 10, 11, p. 4367-4377 11 p.

Research output: Contribution to journalArticle

Particle Size
Nanoparticles
Polymers
Octanols
Ethylene Glycol
6 Citations (Scopus)

Identification and characterization of a novel scFv recognizing human and mouse CD133

Swaminathan, S. K., Niu, L., Waldron, N., Kalscheuer, S., Zellmer, D. M., Olin, M. R., Ohlfest, J. R., Vallera, D. A. & Panyam, J., Mar 14 2013, In : Drug Delivery and Translational Research. 3, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

Clone Cells
Single-Chain Antibodies
Caco-2 Cells
Molecular Pathology
Neoplastic Stem Cells
14 Citations (Scopus)

Immunotoxin targeting CD133+ breast carcinoma cells

Ohlfest, J. R., Zellmer, D. M., Panyam, J., Swaminathan, S. K., Oh, S. U., Waldron, N. N., Toma, S. & Vallera, D. A., Mar 14 2013, In : Drug Delivery and Translational Research. 3, 2, p. 195-204 10 p.

Research output: Contribution to journalArticle

Immunotoxins
Breast Neoplasms
Neoplasms
Neoplastic Stem Cells
Carcinoma, Ductal, Breast
101 Citations (Scopus)

Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy

Sadhukha, T., Wiedmann, T. S. & Panyam, J., Jul 1 2013, In : Biomaterials. 34, 21, p. 5163-5171 9 p.

Research output: Contribution to journalArticle

Nanoparticles
Tumors
Lung Neoplasms
Iron oxides
Fever
2012
14 Citations (Scopus)

Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1

Schaefers, M. M., Breshears, L. M., Anderson, M. J., Lin, Y. C., Grill, A. E., Panyam, J., Southern, P., Schlievert, P. M. & Peterson, M. L., Mar 14 2012, In : PLoS One. 7, 3, e32813.

Research output: Contribution to journalArticle

septic shock
Curcumin
curcumin
toxins
Poisons
97 Citations (Scopus)

Folic acid functionalized nanoparticles for enhanced oral drug delivery

Roger, E., Kalscheuer, S., Kirtane, A. R., Guru, B. R., Grill, A. E., Whittum-Hudson, J. & Panyam, J., Jul 2 2012, In : Molecular pharmaceutics. 9, 7, p. 2103-2110 8 p.

Research output: Contribution to journalArticle

Folic Acid
Nanoparticles
Pharmaceutical Preparations
Paclitaxel
Transcytosis
2011
52 Citations (Scopus)

Highly loaded, sustained-release microparticles of curcumin for chemoprevention

Shahani, K. & Panyam, J., Jan 1 2011, In : Journal of Pharmaceutical Sciences. 100, 7, p. 2599-2609 11 p.

Research output: Contribution to journalArticle

Curcumin
Chemoprevention
Polymers
Liver
Dosage Forms
22 Citations (Scopus)

Nanoparticle-mediated p53 gene therapy for tumor inhibition

Sharma, B., Ma, W., Adjei, I. M., Panyam, J., Dimitrijevic, S. & Labhasetwar, V., Feb 1 2011, In : Drug Delivery and Translational Research. 1, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

p53 Genes
Genetic Therapy
Nanoparticles
Neoplasms
Injections
64 Citations (Scopus)

Targeted delivery of antibiotics to intracellular chlamydial infections using PLGA nanoparticles

Toti, U. S., Guru, B. R., Hali, M., McPharlin, C. M., Wykes, S. M., Panyam, J. & Whittum-Hudson, J. A., Sep 1 2011, In : Biomaterials. 32, 27, p. 6606-6613 8 p.

Research output: Contribution to journalArticle

Antibiotics
Nanoparticles
Anti-Bacterial Agents
Infection
Chlamydia
2010
24 Citations (Scopus)

Identification of a novel monoclonal antibody recognizing CD133

Swaminathan, S. K., Olin, M. R., Forster, C. L., Cruz, K. S. S., Panyam, J. & Ohlfest, J. R., Sep 1 2010, In : Journal of Immunological Methods. 361, 1-2, p. 110-115 6 p.

Research output: Contribution to journalArticle

Clone Cells
Monoclonal Antibodies
Antibodies
Epitopes
Neural Stem Cells
87 Citations (Scopus)

Injectable sustained release microparticles of curcumin: A new concept for cancer chemoprevention

Shahani, K., Swaminathan, S. K., Freeman, D., Blum, A., Ma, L. & Panyam, J., Jun 1 2010, In : Cancer Research. 70, 11, p. 4443-4452 10 p.

Research output: Contribution to journalArticle

Curcumin
Chemoprevention
Injections
Neoplasms
Breast Neoplasms
30 Citations (Scopus)
Nanoparticles
Pharmaceutical Preparations
Neoplasms
maleimide
cyclic arginine-glycine-aspartic acid peptide
156 Citations (Scopus)

Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance

Khdair, A., Di Chen, C., Patil, Y., Ma, L., Dou, Q. P., Shekhar, M. P. V. & Panyam, J., Jan 25 2010, In : Journal of Controlled Release. 141, 2, p. 137-144 8 p.

Research output: Contribution to journalArticle

Photochemotherapy
Combination Drug Therapy
Drug Resistance
Nanoparticles
Neoplasms
233 Citations (Scopus)

The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance

Patil, Y. B., Swaminathan, S. K., Sadhukha, T., Ma, L. & Panyam, J., Jan 1 2010, In : Biomaterials. 31, 2, p. 358-365 8 p.

Research output: Contribution to journalArticle

Glycoproteins
P-Glycoprotein
Gene Silencing
Drug delivery
Drug Resistance
2009
89 Citations (Scopus)

Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance in vitro

Khdair, A., Handa, H., Mao, G. & Panyam, J., Feb 1 2009, In : European Journal of Pharmaceutics and Biopharmaceutics. 71, 2, p. 214-222 9 p.

Research output: Contribution to journalArticle

Photochemotherapy
Combination Drug Therapy
Drug Resistance
Nanoparticles
Methylene Blue
228 Citations (Scopus)

Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance

Patil, Y., Sadhukha, T., Ma, L. & Panyam, J., May 21 2009, In : Journal of Controlled Release. 136, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

Paclitaxel
Drug Resistance
Nanoparticles
P-Glycoprotein
Neoplasms
161 Citations (Scopus)

Polymeric nanoparticles for siRNA delivery and gene silencing

Patil, Y. & Panyam, J., Feb 9 2009, In : International Journal of Pharmaceutics. 367, 1-2, p. 195-203 9 p.

Research output: Contribution to journalArticle

Gene Silencing
Polyethyleneimine
RNA Interference
Nanoparticles
Small Interfering RNA
161 Citations (Scopus)

Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery

Patil, Y. B., Toti, U. S., Khdair, A., Ma, L. & Panyam, J., Feb 1 2009, In : Biomaterials. 30, 5, p. 859-866 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Ligands
Polyethylene glycols
Pharmaceutical Preparations
Tumors
2008
26 Citations (Scopus)

Core-shell particles for the dispersion of small polar drugs and biomolecules in hydrofluoroalkane propellants

Wu, L., Bharatwaj, B., Panyam, J. & Da Rocha, S. R. P., Feb 1 2008, In : Pharmaceutical research. 25, 2, p. 289-301 13 p.

Research output: Contribution to journalArticle

HFA 134a
Biomolecules
Propellants
Metered Dose Inhalers
Pharmaceutical Preparations
10 Citations (Scopus)

Fe3O4 incorporated AOT-alginate nanoparticles for drug delivery

Sudakar, C., Dixit, A., Regmi, R., Naik, R., Lawes, G., Naik, V. M., Vaishnava, P. P., Toti, U. & Panyam, J., Nov 1 2008, In : IEEE Transactions on Magnetics. 44, 11 PART 2, p. 2800-2803 4 p.

Research output: Contribution to journalArticle

Alginate
Drug delivery
Nanoparticles
Rhodamines
Dioctyl Sulfosuccinic Acid
81 Citations (Scopus)

Surfactant - Polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy

Khdair, A., Gerard, B., Handa, H., Mao, G., Shekhar, M. P. V. & Panyam, J., Sep 1 2008, In : Molecular Pharmaceutics. 5, 5, p. 795-807 13 p.

Research output: Contribution to journalArticle

Photochemotherapy
Methylene Blue
Surface-Active Agents
Nanoparticles
Polymers
2007
6 Citations (Scopus)

Incorporation of phospholipids enhances cellular uptake and retention of surfactant-polymer nanoparticles

Chavanpatil, M. D., Handa, H., Mao, G. & Panyam, J., Sep 1 2007, In : Journal of Biomedical Nanotechnology. 3, 3, p. 291-296 6 p.

Research output: Contribution to journalArticle

Phospholipids
Surface-Active Agents
Nanoparticles
Polymers
Surface active agents