Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 8 Similar Profiles
Ribonuclease H Medicine & Life Sciences
Antiviral Agents Medicine & Life Sciences
Human Immunodeficiency Virus Ribonuclease H Medicine & Life Sciences
HIV Reverse Transcriptase Medicine & Life Sciences
Receptor Protein-Tyrosine Kinases Medicine & Life Sciences
Vascular Endothelial Growth Factor Receptor-2 Medicine & Life Sciences
Integrases Medicine & Life Sciences
spleen exonuclease Medicine & Life Sciences

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Research Output 2012 2017

1 Citations

Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

Kankanala, J., Kirby, K. A., Huber, A. D., Casey, M. C., Wilson, D. J., Sarafianos, S. G. & Wang, Z. Dec 1 2017 In : European Journal of Medicinal Chemistry. 141, p. 149-161 13 p.

Research output: Contribution to journalArticle

Ribonuclease H
HIV Reverse Transcriptase
Antiviral Agents
Human Immunodeficiency Virus Ribonuclease H
Viruses
4 Citations

Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

Vernekar, S. K. V., Tang, J., Wu, B., Huber, A. D., Casey, M. C., Myshakina, N., Wilson, D. J., Kankanala, J., Kirby, K. A., Parniak, M. A., Sarafianos, S. G. & Wang, Z. Jun 22 2017 In : Journal of Medicinal Chemistry. 60, 12, p. 5045-5056 12 p.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus Ribonuclease H
Ribonuclease H
Antiviral Agents
HIV-1
HIV Reverse Transcriptase
5 Citations

Inhibition of human cytomegalovirus pUL89 terminase subunit blocks virus replication and genome cleavage

Wang, Y., Mao, L., Kankanala, J., Wang, Z. & Geraghty, R. J. Jan 1 2017 In : Journal of virology. 91, 3, e02152-16

Research output: Contribution to journalArticle

Human herpesvirus 5
Endonucleases
Virus Replication
virus replication
Ribonuclease H
10 Citations

3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H

Wu, B., Tang, J., Wilson, D. J., Huber, A. D., Casey, M. C., Ji, J., Kankanala, J., Xie, J., Sarafianos, S. G. & Wang, Z. Jul 14 2016 In : Journal of Medicinal Chemistry. 59, 13, p. 6136-6148 13 p.

Research output: Contribution to journalArticle

Ribonuclease H
Integrases
Antiviral Agents
HIV-1
RNA-Directed DNA Polymerase
9 Citations

Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2

Marchand, C., Abdelmalak, M., Kankanala, J., Huang, S. Y., Kiselev, E., Fesen, K., Kurahashi, K., Sasanuma, H., Takeda, S., Aihara, H., Wang, Z. & Pommier, Y. Jul 15 2016 In : ACS Chemical Biology. 11, 7, p. 1925-1933 9 p.

Research output: Contribution to journalArticle

Enzymes
Phosphodiesterase Inhibitors
Derivatives
Drug Residues
Topoisomerase II Inhibitors