James Robinson

20052018

Research output per year

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Research Output

2018

Mutant IDH1 Promotes Glioma Formation In Vivo

Philip, B., Yu, D. X., Silvis, M. R., Shin, C. H., Robinson, J. P., Robinson, G. L., Welker, A. E., Angel, S. N., Tripp, S. R., Sonnen, J. A., VanBrocklin, M. W., Gibbons, R. J., Looper, R. E., Colman, H. & Holmen, S. L., May 1 2018, In : Cell Reports. 23, 5, p. 1553-1564 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations
2017

Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma

Yang, H., Kircher, D. A., Kim, K. H., Grossmann, A. H., VanBrocklin, M. W., Holmen, S. L. & Robinson, J. P., Jul 2017, In : Oncogene. 36, 27, p. 3842-3851 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss

Shin, C. H., Robinson, J. P., Sonnen, J. A., Welker, A. E., Yu, D. X., VanBrocklin, M. W. & Holmen, S. L., Aug 10 2017, In : Oncogene. 36, 32, p. 4610-4618 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Resistance mechanisms to genetic suppression of mutant NRAS in melanoma

Robinson, J. P., Rebecca, V. W., Kircher, D. A., Silvis, M. R., Smalley, I., Gibney, G. T., Lastwika, K. J., Chen, G., Davies, M. A., Grossman, D., Smalley, K. S. M., Holmen, S. L. & VanBrocklin, M. W., Jan 1 2017, In : Melanoma research. 27, 6, p. 545-557 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

AKT1 Activation Promotes Development of Melanoma Metastases

Cho, J. H., Robinson, J. P., Arave, R. A., Burnett, W. J., Kircher, D. A., Chen, G., Davies, M. A., Grossmann, A. H., VanBrocklin, M. W., McMahon, M. & Holmen, S. L., Nov 3 2015, In : Cell reports. 13, 5, p. 898-905 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

The BRAF kinase domain promotes the development of gliomas in vivo

Shin, C. H., Grossmann, A. H., Holmen, S. L. & Robinson, J. P., Jan 1 2015, In : Genes and Cancer. 6, 1-2, p. 9-18 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2013

Akt Signaling Accelerates Tumor Recurrence Following Ras Inhibition in the Context of Ink4a/Arf Loss

Robinson, G. L., Robinson, J. P., Lastwika, K. J., Holmen, S. L. & VanBrocklin, M. W., Nov 1 2013, In : Genes and Cancer. 4, 11-12, p. 476-485 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Ink4a/Arf loss promotes tumor recurrence following Ras inhibition

Van Brocklin, M. W., Robinson, J. P., Lastwika, K. J., McKinney, A. J., Gach, H. M. & Holmen, S. L., Jan 1 2012, In : Neuro-Oncology. 14, 1, p. 34-42 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Activated MEK cooperates with Ink4a/Arf loss or Akt activation to induce gliomas in vivo

Robinson, J. P., Vanbrocklin, M. W., Lastwika, K. J., McKinney, A. J., Brandner, S. & Holmen, S. L., Mar 17 2011, In : Oncogene. 30, 11, p. 1341-1350 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome

Lai, C., Robinson, J., Clark, S., Stamp, G., Poulsom, R. & Silver, A., Apr 1 2011, In : Journal of Pathology. 223, 5, p. 584-592 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2010

Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation

Robinson, J. P., Vanbrocklin, M. W., Guilbeault, A. R., Signorelli, D. L., Brandner, S. & Holmen, S. L., Jan 1 2010, In : Oncogene. 29, 3, p. 335-344 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Targeted delivery of NRASQ61R and Cre-recombinase to post-natal melanocytes induces melanoma in Ink4a/Arflox/lox mice

Vanbrocklin, M. W., Robinson, J. P., Lastwika, K. J., Khoury, J. D. & Holmen, S. L., Aug 1 2010, In : Pigment Cell and Melanoma Research. 23, 4, p. 531-541 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2009

Met amplification and tumor progression in Cdkn2a-deficient melanocytes

VanBrocklin, M. W., Robinson, J. P., Whitwam, T., Guilbeault, A. R., Koeman, J., Swiatek, P. J., Vande Woude, G. F., Khoury, J. D. & Holmen, S. L., Aug 1 2009, In : Pigment Cell and Melanoma Research. 22, 4, p. 454-460 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Oral rapamycin reduces tumour burden and vascularization in Lkb1 +/- mice

Robinson, J., Lai, C., Martin, A., Nye, E., Tomlinson, I. & Silver, A., Sep 1 2009, In : Journal of Pathology. 219, 1, p. 35-40 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
2008

APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps

Will, O. C. C., Robinson, J., Günther, T., Phillips, R. K. S., Clark, S. K. & Tomlinson, I., Jun 1 2008, In : British Journal of Surgery. 95, 6, p. 765-769 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Osteogenic tumours in Lkb1-deficient mice

Robinson, J., Nye, E., Stamp, G. & Silver, A., Dec 1 2008, In : Experimental and Molecular Pathology. 85, 3, p. 223-226 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Unregulated smooth-muscle myosin in human intestinal neoplasia

Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L. Q., Orntoft, T., Mecklin, J. P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 others, Arango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., Apr 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

Research output: Contribution to journalArticle

45 Scopus citations
2006

Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation

Sieber, O. M., Segditsas, S., Knudsen, A. L., Zhang, J., Luz, J., Rowan, A. J., Spain, S. L., Thirlwell, C., Howarth, K. M., Jaeger, E. E. M., Robinson, J., Volikos, E., Silver, A., Kelly, G., Aretz, S., Frayling, I., Hutter, P., Dunlop, M., Guenther, T., Neale, K. & 3 others, Phillips, R., Heinimann, K. & Tomlinson, I. P. M., Oct 1 2006, In : Gut. 55, 10, p. 1440-1448 9 p.

Research output: Contribution to journalArticle

72 Scopus citations

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.

Volikos, E., Robinson, J., Aittomäki, K., Mecklin, J. P., Järvinen, H., Westerman, A. M., de Rooji, F. W., Vogel, T., Moeslein, G., Launonen, V., Tomlinson, I. P., Silver, A. R. & Aaltonen, L. A., May 1 2006, In : Journal of Medical Genetics. 43, 5, p. e18

Research output: Contribution to journalLetter

111 Scopus citations

Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines

Suraweera, N., Robinson, J., Volikos, E., Guenther, T., Talbot, I., Tomlinson, I. & Silver, A., Oct 15 2006, In : International Journal of Cancer. 119, 8, p. 1837-1842 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
2005

Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer

Robinson, J. P., Johnson, V. L., Rogers, P. A., Houlston, R. S., Maher, E. R., Bishop, D. T., Evans, D. G. R., Thomas, H. J. W., Tomlinson, I. P. M., Silver, A. R. J., Hodgson, S., Izatt, L. & Lucassen, A., Jun 1 2005, In : Cancer Epidemiology Biomarkers and Prevention. 14, 6, p. 1460-1463 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population

Rasinperä, H., Forsblom, C., Enattah, N. S., Halonen, P., Salo, K., Victorzon, M., Mecklin, J. P., Järvinen, H., Enholm, S., Sellick, G., Alazzouzi, H., Houlston, R., Robinson, J., Groop, P. H., Tomlinson, I., Schwartz, S., Aaltonen, L. A. & Järvelä, I., May 1 2005, In : Gut. 54, 5, p. 643-647 5 p.

Research output: Contribution to journalArticle

27 Scopus citations