1993 …2022

Research output per year

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Research Output

2020
Open Access
2019

Interspecies Organogenesis for Human Transplantation

Crane, A. T., Aravalli, R. N., Asakura, A., Grande, A. W., Krishna, V. D., Carlson, D. F., Cheeran, M. C. J., Danczyk, G., Dutton, J. R., Hackett, P. B., Hu, W. S., Li, L., Lu, W. C., Miller, Z. D., O’Brien, T. D., Panoskaltsis-Mortari, A., Parr, A. M., Pearce, C., Ruiz-Estevez, M., Shiao, M. & 6 others, Sipe, C. J., Toman, N. G., Voth, J., Xie, H., Steer, C. J. & Low, W. C., Sep 1 2019, In : Cell transplantation. 28, 9-10, p. 1091-1105 15 p.

Research output: Contribution to journalReview article

Open Access
2018

3D Printed Stem-Cell Derived Neural Progenitors Generate Spinal Cord Scaffolds

Joung, D., Truong, V., Neitzke, C. C., Guo, S. Z., Walsh, P. J., Monat, J. R., Meng, F., Park, S. H., Dutton, J. R., Parr, A. M. & McAlpine, M. C., Sep 26 2018, In : Advanced Functional Materials. 28, 39, 1801850.

Research output: Contribution to journalArticle

33 Scopus citations

Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury

Patil, N., Truong, V., Holmberg, M. H., Lavoie, N. S., McCoy, M. R., Dutton, J. R., Holmberg, E. G. & Parr, A. M., Aug 1 2018, In : Journal of neurotrauma. 35, 15, p. 1745-1754 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways 06 Biological Sciences 0601 Biochemistry and Cell Biology

Su, L., Kong, X., Lim, S., Loo, S., Tan, S., Poh, K., Dutton, J., Stewart, C., Cook, S., Su, X., Ma, J., Zhang, J. & Ye, L., Nov 15 2018, In : Stem Cell Research and Therapy. 9, 1, 313.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration

Ferrington, D. A., Ebeling, M. C., Kapphahn, R. J., Terluk, M. R., Fisher, C. R., Polanco, J. R., Roehrich, H., Leary, M. M., Geng, Z., Dutton, J. R. & Montezuma, S. R., Oct 2017, In : Redox Biology. 13, p. 255-265 11 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Defined Culture Conditions Accelerate Small-molecule-assisted Neural Induction for the Production of Neural Progenitors from Human-induced Pluripotent Stem Cells

Walsh, P., Truong, V., Hill, C., Stoflet, N. D., Baden, J., Low, W. C., Keirstead, S. A., Dutton, J. R. & Parr, A. M., Dec 1 2017, In : Cell transplantation. 26, 12, p. 1890-1902 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Establishing a Large-Animal Model for in Vivo Reprogramming of Bile Duct Cells into Insulin-Secreting Cells to Treat Diabetes

Hill, C. M., Banga, A., Abrahante, J. E., Yuan, C., Mutch, L. A., Janecek, J., O'Brien, T., Graham, M. L. & Dutton, J. R., Jun 2017, In : Human Gene Therapy Clinical Development. 28, 2, p. 87-95 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts

Pei, H., Fu, H. Y., Cho, D. S., Cho, D. S., Dutton, J., Hu, W. S., Hirai, H., Verfaillie, C. M. & O'Brien, T. D., May 1 2017, In : Stem Cell Research. 21, p. 132-136 5 p.

Research output: Contribution to journalArticle

Open Access

Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration

Geng, Z., Walsh, P. J., Truong, V., Hill, C., Ebeling, M., Kapphahn, R. J., Montezuma, S. R., Yuan, C., Roehrich, H., Ferrington, D. A. & Dutton, J. R., Mar 2017, In : PloS one. 12, 3, e0173575.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Instructive role of the microenvironment in preventing renal fibrosis

Matsumoto, K., Xavier, S., Chen, J., Kida, Y., Lipphardt, M., Ikeda, R., Gevertz, A., Caviris, M., Hatzopoulos, A. K., Kalajzic, I., Dutton, J., Ratliff, B. B., Zhao, H., Darzynkiewicz, Z., Rose-John, S. & Goligorsky, M. S., Mar 2017, In : Stem Cells Translational Medicine. 6, 3, p. 992-1005 14 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2016

cGMP-compliant expansion of human iPSC cultures as adherent monolayers

Parr, A. M., Walsh, P. J., Truong, V. & Dutton, J. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 221-229 9 p. (Methods in Molecular Biology; vol. 1357).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Differentiation of human induced-pluripotent stem cells into smooth-muscle cells: Two novel protocols

Yang, L., Geng, Z., Nickel, T., Johnson, C., Gao, L., Dutton, J. R., Hou, C. & Zhang, J. J., Jan 1 2016, In : PloS one. 11, 1, 0147155.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Directed differentiation of oligodendrocyte progenitor cells from mouse induced pluripotent stem cells

Terzic, D., Maxon, J. R., Krevitt, L., Dibartolomeo, C., Goyal, T., Low, W. C., Dutton, J. R. & Parr, A. M., Jan 1 2016, In : Cell transplantation. 25, 2, p. 411-424 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Rapid induction of cerebral organoids from human induced pluripotent stem cells using a chemically defined hydrogel and defined cell culture medium

Lindborg, B. A., Brekke, J. H., Vegoe, A. L., Ulrich, C. B., Haider, K. T., Subramaniam, S., Venhuizen, S. L., Eide, C. R., Orchard, P. J., Chen, W., Wang, Q., Pelaez, F., Scott, C. M., Kokkoli, E., Keirstead, S. A., Dutton, J. R., Tolar, J. & O’Brien, T. D., Jan 1 2016, In : Stem Cells Translational Medicine. 5, 7, p. 970-979 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Reprogramming cell fate with a genome-scale library of artificial transcription factors

Eguchi, A., Wleklinski, M. J., Spurgat, M. C., Heiderscheit, E. A., Kropornicka, A. S., Vu, C. K., Bhimsaria, D., Swanson, S. A., Stewart, R., Ramanathan, P., Kamp, T. J., Slukvin, I., Thomson, J. A., Dutton, J. R. & Ansari, A. Z., Dec 20 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 51, p. E8257-E8266

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Using Oct4:MerCreMer lineage tracing to monitor endogenous Oct4 expression during the reprogramming of fibroblasts into induced pluripotent stem cells (iPSCs)

Greder, L. V., Post, J. & Dutton, J. R., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 97-110 14 p. (Methods in Molecular Biology; vol. 1357).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2015

Erratum: Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells (Cell Stem Cell (2014) 15 (750-761))

Ye, L., Chang, Y. H., Xiong, Q., Zhang, P., Zhang, L., Somasundaram, P., Lepley, M., Swingen, C., Su, L., Wendel, J. S., Guo, J., Jang, A., Rosenbush, D., Greder, L., Dutton, J. R., Zhang, J., Kamp, T. J., Kaufman, D. S., Ge, Y. & Zhang, J., Jan 8 2015, In : Cell Stem Cell. 16, 1, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

T cell deficiency in spinal cord injury: Altered locomotor recovery and whole-genome transcriptional analysis

Satzer, D., Miller, C., Maxon, J., Voth, J., DiBartolomeo, C., Mahoney, R., Dutton, J. R., Low, W. C. & Parr, A. M., Nov 6 2015, In : BMC neuroscience. 16, 1, 74.

Research output: Contribution to journalArticle

6 Scopus citations

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

Maza, I., Caspi, I., Zviran, A., Chomsky, E., Rais, Y., Viukov, S., Geula, S., Buenrostro, J. D., Weinberger, L., Krupalnik, V., Hanna, S., Zerbib, M., Dutton, J. R., Greenleaf, W. J., Massarwa, R., Novershtern, N. & Hanna, J. H., Jul 13 2015, In : Nature biotechnology. 33, 7, p. 769-774 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2014

Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells

Ye, L., Chang, Y. H., Xiong, Q., Zhang, P., Zhang, L., Somasundaram, P., Lepley, M., Swingen, C., Su, L., Wendel, J. S., Guo, J., Jang, A., Rosenbush, D., Greder, L., Dutton, J. R., Zhang, J., Kamp, T. J., Kaufman, D. S., Ge, Y. & Zhang, J., Dec 4 2014, In : Cell Stem Cell. 15, 6, p. 750-761 12 p.

Research output: Contribution to journalArticle

196 Scopus citations

Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα

O'Neill, K. E., Thowfeequ, S., Li, W. C., Eberhard, D., Dutton, J. R., Tosh, D. & Slack, J. M. W., Oct 1 2014, In : Cellular Reprogramming. 16, 5, p. 314-323 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist

Banga, A., Greder, L. V., Dutton, J. R. & Slack, J. M. W., Jan 1 2014, In : Gene therapy. 21, 1, p. 19-27 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The influence of a spatiotemporal 3D environment on endothelial cell differentiation of human induced pluripotent stem cells

Zhang, S., Dutton, J. R., Su, L., Zhang, J. & Ye, L., Apr 1 2014, In : Biomaterials. 35, 12, p. 3786-3793 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2013

Corrigendum to "Loss of Oct4 expression during the development of murine embryoid bodies" [Dev. Biol. 371 (2012) 170-179]

Sajini, A. A., Greder, L. V., Dutton, J. R. & Slack, J. M. W., Jan 1 2013, In : Developmental Biology. 373, 1, 1 p.

Research output: Contribution to journalComment/debate

Effective Cardiac Myocyte Differentiation of Human Induced Pluripotent Stem Cells Requires VEGF

Ye, L., Zhang, S., Greder, L., Dutton, J., Keirstead, S. A., Lepley, M., Zhang, L., Kaufman, D. & Zhang, J., Jan 17 2013, In : PloS one. 8, 1, e53764.

Research output: Contribution to journalArticle

42 Scopus citations

Induced pluripotential stem cells and the prospects for cardiac cell therapy

Slack, J. M. W. & Dutton, J. R., Jun 1 2013, Coronary Heart Disease: Clinical, Pathological, Imaging, and Molecular Profiles: Clinical, Pathological, Imaging, and Molecular Profiles. Springer US, Vol. 9781461414759. p. 249-260 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Reprogramming of various cell types to a beta-like state by Pdx1, Ngn3 and MafA

Akinci, E., Banga, A., Tungatt, K., Segal, J., Eberhard, D., Dutton, J. R. & Slack, J. M. W., Nov 29 2013, In : PloS one. 8, 11, e82424.

Research output: Contribution to journalArticle

18 Scopus citations

Stage specific reprogramming of mouse embryo liver cells to a beta cell-like phenotype

Yang, Y., Akinci, E., Dutton, J. R., Banga, A. & Slack, J. M. W., Nov 1 2013, In : Mechanisms of Development. 130, 11-12, p. 602-612 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2012

Brief report: Analysis of endogenous Oct4 activation during induced pluripotent stem cell reprogramming using an inducible Oct4 lineage label

Greder, L. V., Gupta, S., Li, S., Abedin, M. J., Sajini, A., Segal, Y., Slack, J. M. W. & Dutton, J. R., Nov 1 2012, In : STEM CELLS. 30, 11, p. 2596-2601 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts

Banga, A., Akinci, E., Greder, L. V., Dutton, J. R. & Slack, J. M. W., Sep 18 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15336-15341 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Loss of Oct4 expression during the development of murine embryoid bodies

Sajini, A. A., Greder, L. V., Dutton, J. R. & Slack, J. M. W., Nov 15 2012, In : Developmental Biology. 371, 2, p. 170-179 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1, Ngn3 and MafA

Akinci, E., Banga, A., Greder, L. V., Dutton, J. R. & Slack, J. M. W., Mar 15 2012, In : Biochemical Journal. 442, 3, p. 539-550 12 p.

Research output: Contribution to journalArticle

71 Scopus citations

Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes

Kudva, Y. C., Ohmine, S., Greder, L. V., Dutton, J. R., Armstrong, A., De Lamo, J. G., Khan, Y. K., Thatava, T., Hasegawa, M., Fusaki, N., Slack, J. M. W. & Ikeda, Y., Jan 1 2012, In : Stem Cells Translational Medicine. 1, 6, p. 451-461 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2011

MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells

Watanabe, S., Hirai, H., Asakura, Y., Tastad, C., Verma, M., Keller, C., Dutton, J. R. & Asakura, A., Mar 1 2011, In : STEM CELLS. 29, 3, p. 505-516 12 p.

Research output: Contribution to journalArticle

31 Scopus citations
2009

Inhibition of Hes1 activity in gall bladder epithelial cells promotes insulin expression and glucose responsiveness

Coad, R. A., Dutton, J. R., Tosh, D. & Slack, J. M. W., Dec 1 2009, In : Biochemistry and Cell Biology. 87, 6, p. 975-987 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Use of adenovirus for ectopic gene expression in Xenopus

Dutton, J. R., Daughters, R. S., Chen, Y., O'Neill, K. E. & Slack, J. M. W., Jun 1 2009, In : Developmental Dynamics. 238, 6, p. 1412-1421 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10

Dutton, J. R., Antonellis, A., Carney, T. J., Rodrigues, F. S. L. M., Pavan, W. J., Ward, A. & Kelsh, R. N., Dec 19 2008, In : BMC Developmental Biology. 8, 105.

Research output: Contribution to journalArticle

65 Scopus citations
2007

Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele

Lahiri, D., Button, J. R., Duarte, A., Moorwood, K., Graham, C. F. & Ward, A., Mar 1 2007, In : Molecular Reproduction and Development. 74, 3, p. 300-311 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

β cells occur naturally in extrahepatic bile ducts of mice

Dutton, J. R., Chillingworth, N. L., Eberhard, D., Brannon, C. R., Hornsey, M. A., Tosh, D. & Slack, J. M. W., Jan 15 2007, In : Journal of cell science. 120, 2, p. 239-245 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2006

Different isoforms of the Wilms' tumour protein WT1 have distinct patterns of distribution and trafficking within the nucleus

Dutton, J. R., Lahiri, D. & Ward, A., Dec 1 2006, In : Cell Proliferation. 39, 6, p. 519-535 17 p.

Research output: Contribution to journalArticle

15 Scopus citations
2001

A morpholino phenocopy of the colourless mutant

Dutton, K., Dutton, J. R., Pauliny, A. & Kelsh, R. N., Aug 20 2001, In : Genesis. 30, 3, p. 188-189 2 p.

Research output: Contribution to journalArticle

39 Scopus citations
1998

Regulation of the Wilms' tumour suppressor (WT1) gene by an antisense RNA: A link with genomic imprinting?

Ward, A. & Dutton, J. R., Aug 11 1998, In : Journal of Pathology. 185, 4, p. 342-344 3 p.

Research output: Contribution to journalEditorial

8 Scopus citations
1997

StuAp is a sequence-specific transcription factor that regulates developmental complexity in Aspergillus nidulans

Dutton, J. R., Johns, S. & Miller, B. L., Sep 15 1997, In : EMBO Journal. 16, 18, p. 5710-5721 12 p.

Research output: Contribution to journalArticle

115 Scopus citations
1995
8 Scopus citations
1993

Characterization of a Flavobacterium glutathione S-transferase gene involved in reductive dechlorination

Orser, C. S., Dutton, J., Lange, C., Jablonski, P., Xun, L. & Hargis, M., Jan 1 1993, In : Journal of bacteriology. 175, 9, p. 2640-2644 5 p.

Research output: Contribution to journalArticle

91 Scopus citations