Personal profile

Education / Academic qualification

PhD, University of Minnesota

Sep 1 1992Dec 31 1996

MD, Charles University

Sep 1 1984Sep 27 1990

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Epidermolysis Bullosa Dystrophica Medicine & Life Sciences
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Mesenchymal Stromal Cells Medicine & Life Sciences
Bone Marrow Medicine & Life Sciences
Epidermolysis Bullosa Medicine & Life Sciences
Adrenoleukodystrophy Medicine & Life Sciences

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Projects 1994 2023

Research Output 1996 2018

A multitask clustering approach for single-cell RNA-seq analysis in Recessive Dystrophic Epidermolysis Bullosa

Zhang, H., Lee, C. A. A., Li, Z., Garbe, J. R., Eide, C. R., Petegrosso, R., Kuang, R. & Tolar, J. Apr 1 2018 In : PLoS computational biology. 14, 4, e1006053

Research output: Contribution to journalArticle

epidermolysis bullosa
Epidermolysis Bullosa Dystrophica
RNA
Cluster Analysis
Clustering

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Rousseaux, M. W. C. , Tschumperlin, T. , Lu, H. C. , Lackey, E. P. , Bondar, V. V. , Wan, Y. W. , Tan, Q. , Adamski, C. J. , Friedrich, J. , Twaroski, K. , Chen, W. , Tolar, J. , Henzler, C. , Sharma, A. , Bajić, A. , Lin, T. , Duvick, L. , Liu, Z. , Sillitoe, R. V. , Zoghbi, H. Y. & 1 others Orr, H. T. Jan 1 2018 (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Ataxia
Cerebellum
Pathology
Neurons

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., McElmury, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J. Apr 1 2018 In : International Journal of Molecular Sciences. 19, 4, 946

Research output: Contribution to journalArticle

Cell Engineering
genes
Genes
engineering
T-cells
Stellite
gene therapy
Gene therapy
Antigen Receptors
T-cells

Inside out: Regenerative medicine for recessive dystrophic epidermolysis bullosa

Vanden Oever, M., Twaroski, K., Osborn, M. J., Wagner, J. E. & Tolar, J. Jan 1 2018 In : Pediatric Research. 83, 1-2, p. 318-324 7 p.

Research output: Contribution to journalReview article

Epidermolysis Bullosa Dystrophica
Epidermolysis Bullosa
Regenerative Medicine
Mesenchymal Stromal Cells
Induced Pluripotent Stem Cells