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Jakub Tolar

 https://orcid.org/0000-0002-0957-4380
1994 …2023
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Personal profile

Education/Academic qualification

PhD, University of Minnesota Twin Cities

Sep 1 1992 → Dec 31 1996

MD, Charles University

Sep 1 1984 → Sep 27 1990

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Mucopolysaccharidosis I Medicine & Life Sciences
Cell Transplantation Medicine & Life Sciences
Epidermolysis Bullosa Dystrophica Medicine & Life Sciences
Transplants Medicine & Life Sciences
Bone Marrow Medicine & Life Sciences
Stem cells Chemical Compounds
Epidermolysis Bullosa Medicine & Life Sciences
Mesenchymal Stromal Cells Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 1994 2023

Genetic mapping of cellular trait variation in single human individuals

Albert, F. W. & Tolar, J.

NIH NHGRI NATL HUMAN GENOME RE

9/17/18 → 8/31/20

Project: Research project

Asan Minnesota Institute for Innovating Transplantation (AMIT)

Tolar, J.

Asan Medical Center

9/1/18 → 8/31/21

Project: Research project

Transplantation

Mayo / UMN Partnership in Regenerative Medicine

Tolar, J.

State of Minnesota

7/1/18 → 6/30/23

Project: Research project

Regenerative Medicine

Mayo Partnership in Regenerative Medicine

Tolar, J.

MINNESOTA REGENERATIVE MEDICINE

7/1/17 → 6/30/22

Project: Research project

Regenerative Medicine

Center for Modeling Tumor Cell Migration Mechanics

Odde, D. J., Alford, P. W., Barocas, V. H., Largaespada, D. A., Olin, M. R., Othmer, H. G., Provenzano, P., Schwertfeger, K., Tolar, J., Tranquillo, R. T. & Wood, D. K.

NIH NATIONAL CANCER INSTITUTE (NCI)

8/17/16 → 7/31/21

Project: Research project

Mechanics
Cell Movement
Neoplasms

Research Output 1996 2019

A homozygous frameshift variant in the KRT5 gene is compatible with life and results in severe recessive epidermolysis bullosa simplex

Tryon, R. K., Tolar, J., Preusser, S. M., Riddle, M. J., Keene, D. R., Bower, M., Thyagarajan, B. & Ebens, C., Jul 1 2019, In : JAAD Case Reports. 5, 7, p. 576-579 4 p.

Research output: Contribution to journal › Article

Open Access
Epidermolysis Bullosa Simplex
Keratin-5
Keratins
Genes
Autosomal Recessive Epidermolysis Bullosa Simplex
1 Citation (Scopus)

Bone marrow transplant with post-transplant cyclophosphamide for recessive dystrophic epidermolysis bullosa expands the related donor pool and permits tolerance of nonhaematopoietic cellular grafts

Ebens, C., McGrath, J. A., Tamai, K., Hovnanian, A., Wagner, J. E., Riddle, M. J., Keene, D. R., De For, T. E., Tryon, R., Chen, M., Woodley, D. T., Hook, K. P. & Tolar, J., Jan 1 2019, In : British Journal of Dermatology.

Research output: Contribution to journal › Article

Epidermolysis Bullosa Dystrophica
Cyclophosphamide
Bone Marrow
Tissue Donors
Transplants

Erratum: Correction: Rapid DNA replication origin licensing protects stem cell pluripotency (eLife (2017) 6 PII: e49040)

Matson, J. P., Dumitru, R., Coryell, P., Baxley, R. M., Chen, W., Twaroski, K., Webber, B. R., Tolar, J., Bielinsky, A. K., Purvis, J. E. & Cook, J. G., Jun 5 2019, In : eLife. 8

Research output: Contribution to journal › Comment/debate

Open Access
Replication Origin
Licensure
Chromosomes
Stem cells
DNA Replication

Intrathecal enzyme replacement for Hurler syndrome: biomarker association with neurocognitive outcomes

Eisengart, J., Pierpont, R., Kaizer, A. M., Rudser, K., King, K. E., Pasquali, M., Polgreen, L. E., Dickson, P. I., Le, S. Q., Miller, W. P., Tolar, J., Orchard, P. J. & Lund, T. C., Jan 1 2019, In : Genetics in Medicine.

Research output: Contribution to journal › Article

Open Access
Mucopolysaccharidosis I
Enzyme Replacement Therapy
Biomarkers
Cerebrospinal Fluid
Enzymes
1 Citation (Scopus)

Molecular Additives Significantly Enhance Glycopolymer-Mediated Transfection of Large Plasmids and Functional CRISPR-Cas9 Transcription Activation Ex Vivo in Primary Human Fibroblasts and Induced Pluripotent Stem Cells

Boyle, W. S., Twaroski, K. R., Woska, E. C., Tolar, J. & Reineke, T. M., Feb 20 2019, In : Bioconjugate Chemistry. 30, 2, p. 418-431 14 p.

Research output: Contribution to journal › Article

Clustered Regularly Interspaced Short Palindromic Repeats
Induced Pluripotent Stem Cells
Transcription
Fibroblasts
Stem cells