If you made any changes in Pure, your changes will be visible here soon.

Research Output 1988 2019

2003
37 Citations (Scopus)

Enhancing antimelanoma immune responses through apoptosis

Bianco, S. R., Sun, J., Fosmire, S. P., Hance, K., Padilla, M. L., Ritt, M. G., Getzy, D. M., Duke, R. C., Withrow, S. J., Lana, S., Matthiesen, D. T., Dow, S. W., Bellgrau, D., Cutter, G. R., Helfand, S. C. & Modiano, J. F., Sep 1 2003, In : Cancer Gene Therapy. 10, 9, p. 726-736 11 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Apoptosis
Melanoma
Neoplasms
Dogs
37 Citations (Scopus)

Hydroquinone and catechol interfere with T cell cycle entry and progression through the G1 phase

McCue, J. M., Lazis, S., Cohen, J. J., Modiano, J. F. & Freed, B. M., Jan 1 2003, In : Molecular Immunology. 39, 16, p. 995-1001 7 p.

Research output: Contribution to journalArticle

G1 Phase
Cell Cycle
T-Lymphocytes
Smoke
Tobacco Products
2002
Interleukin-2 Receptors
Hematologic Neoplasms
Canidae
Neoplasms
77 Citations (Scopus)

Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma.

Koenig, A., Bianco, S. R., Fosmire, S., Wojcieszyn, J. & Modiano, J. F., Jan 1 2002, In : Veterinary pathology. 39, 4, p. 458-472 15 p.

Research output: Contribution to journalArticle

Ink
melanoma
Canidae
Melanoma
cell lines
137 Citations (Scopus)

NFATc2-mediated repression of cyclin-dependent kinase 4 expression

Baksh, S., Widlund, H. R., Frazer-Abel, A. A., Du, J., Fosmire, S., Fisher, D. E., DeCaprio, J. A., Modiano, J. F. & Burakoff, S. J., Nov 1 2002, In : Molecular Cell. 10, 5, p. 1071-1081 11 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 4
NFATC Transcription Factors
Calcineurin
Histone Deacetylases
Transcription Factor AP-1
19 Citations (Scopus)

Potential to target dysregulated interleukin-2 receptor expression in canine lymphoid and hematopoietic malignancies as a model for human cancer

Dickerson, E. B., Fosmire, S., Padilla, M. L., Modiano, J. F. & Helfand, S. C., Jan 21 2002, In : Journal of Immunotherapy. 25, 1, p. 36-45 10 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptors
Hematologic Neoplasms
Canidae
Dogs
Neoplasms
11 Citations (Scopus)

Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and cats

Fernandes, P. J., Modiano, J. F., Wojcieszyn, J., Thomas, J. S., Benson, P. A., Smith, R., Avery, A. C., Burnett, R. C., Boone, L. I., Johnson, M. C. & Pierce, K. R., Jan 1 2002, In : Veterinary Clinical Pathology. 31, 4, p. 167-182 16 p.

Research output: Contribution to journalArticle

Cell Lineage
leukemia
Cats
Dogs
lymphocytic leukemia
2001
53 Citations (Scopus)

Expression of S100a, Vimentin, NSE, and Melan A/MART-1 in Seven Canine Melanoma Cell Lines and Twenty-nine Retrospective Cases of Canine Melanoma

Koenig, A., Wojcieszyn, J., Weeks, B. R. & Modiano, J., Jul 1 2001, In : Veterinary pathology. 38, 4, p. 427-435 9 p.

Research output: Contribution to journalArticle

MART-1 Antigen
phosphopyruvate hydratase
Phosphopyruvate Hydratase
vimentin
Vimentin
2000
24 Citations (Scopus)

CDK4 expression and activity are required for cytokine responsiveness in T cells

Modiano, J. F., Mayor, J., Ball, C., Fuentes, M. K. & Linthicum, D. S., Dec 15 2000, In : Journal of Immunology. 165, 12, p. 6693-6702 10 p.

Research output: Contribution to journalArticle

Interleukin-2
Cytokines
T-Lymphocytes
Staurosporine
Mitogens
35 Citations (Scopus)

Sustained nuclear localization of p21/Waf-1 upon growth arrest induced by contact inhibition

Ritt, M. G., Mayor, J., Wojcieszyn, J., Smith, R., Barton, C. L. & Modiano, J., Sep 29 2000, In : Cancer Letters. 158, 1, p. 73-84 12 p.

Research output: Contribution to journalArticle

Contact Inhibition
Growth
Melanoma
Apoptosis
Cell Cycle
1999
28 Citations (Scopus)

Growth arrest of melanoma cells is differentially regulated by contact inhibition and serum deprivation

Modiano, J. F., Ritt, M. G., Wojcieszyn, J. & Smith, R., May 1 1999, In : DNA and Cell Biology. 18, 5, p. 357-367 11 p.

Research output: Contribution to journalArticle

Contact Inhibition
Melanoma
Cyclin-Dependent Kinases
Apoptosis
Growth
26 Citations (Scopus)

Quantitative and qualitative signals determine T-cell cycle entry and progression

Modiano, J., Mayor, J., Ball, C., Chitko-McKown, C. G., Sakata, N., Domenico-Hahn, J., Lucas, J. J. & Gelfand, E. W., Oct 10 1999, In : Cellular Immunology. 197, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Cell Cycle
T-Lymphocytes
Transcription Factor AP-1
G1 Phase
Phytohemagglutinins
53 Citations (Scopus)

The molecular basis of canine melanoma: pathogenesis and trends in diagnosis and therapy.

Modiano, J. F., Ritt, M. G. & Wojcieszyn, J., Jan 1 1999, In : Journal of veterinary internal medicine / American College of Veterinary Internal Medicine. 13, 3, p. 163-174 12 p.

Research output: Contribution to journalReview article

melanoma
Canidae
Melanoma
pathogenesis
therapeutics
1998
18 Citations (Scopus)

Functional loss of p21/Waf-1 in a case of benign canine multicentric melanoma

Ritt, M. G., Wojcieszyn, J. & Modiano, J., Jan 1 1998, In : Veterinary pathology. 35, 2, p. 94-101 8 p.

Research output: Contribution to journalArticle

melanoma
Canidae
Cysts
Melanoma
p53 Genes
3 Citations (Scopus)

Mammary Mass Aspirate from a Yorkshire Terrier

Fernandes, P. J., Guyer, C. & Modiano, J., Jan 1 1998, In : Veterinary Clinical Pathology. 27, 3

Research output: Contribution to journalArticle

27 Citations (Scopus)

The Use of Cytochemistry, Immunophenotyping, Flow Cytometry, and in Vitro Differentiation to Determine the Ontogeny of a Canine Monoblastic Leukemia

Modiano, J. F., Smith, R., Wojcieszyn, J., Thomas, J. S., Rosenbaum, B. A., Ball, C., Nicholds, E. A., Anthony, M. A. & Barton, C. L., Jan 1 1998, In : Veterinary Clinical Pathology. 27, 2, p. 40-49 10 p.

Research output: Contribution to journalArticle

cytochemistry
Immunophenotyping
Histocytochemistry
leukemia
flow cytometry
16 Citations (Scopus)

Use of human recombinant erythropoietin and prednisone for treatment of myelodysplastic syndrome with erythroid predominance in a dog

Boone, L. I., Knauer, K. W., Rapp, S. W., Stewart, J. F. & Modiano, J. F., Oct 1 1998, In : Journal of the American Veterinary Medical Association. 213, 7, p. 999-1001 3 p.

Research output: Contribution to journalArticle

prednisone
erythropoietin
Myelodysplastic Syndromes
Erythropoietin
Prednisone
1997
5 Citations (Scopus)

Clues to immune function and oncogenesis provided by events that activate the cell cycle machinery in normal human T cells

Chitko-McKown, C. G. & Modiano, J. F., Oct 1 1997, In : Journal of Leukocyte Biology. 62, 4, p. 430-437 8 p.

Research output: Contribution to journalReview article

Cell Cycle
Carcinogenesis
Cytokines
T-Lymphocytes
Cell Proliferation
56 Citations (Scopus)

Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin

Modiano, J. F., Amran, D., Lack, G., Bradley, K., Ball, C., Domenico, J. & Gelfand, E. W., Jan 1 1997, In : Clinical Immunology and Immunopathology. 83, 1, p. 77-85 9 p.

Research output: Contribution to journalArticle

Interleukin-2
T-Lymphocytes
Firefly Luciferases
Monensin
Jurkat Cells
1996
38 Citations (Scopus)

Bone marrow cytological findings in 4 dogs and a cat with hemophagocytic syndrome

Walton, R. M., Modiano, J., Thrall, M. A. & Wheeler, S. L., Jan 1 1996, In : Journal of veterinary internal medicine. 10, 1, p. 7-14 8 p.

Research output: Contribution to journalArticle

Hemophagocytic Lymphohistiocytosis
bone marrow
Cats
Bone Marrow
Dogs
1995
22 Citations (Scopus)

Functional interleukin-2 receptors are expressed on natural killer-like leukemic cells from a dog with cutaneous lymphoma

Helfand, S. C., Modiano, J. F., Moore, P. F., Soergel, S. A., MacWilliams, P. S., Dubielzig, R. D., Hank, J. A., Gelfand, E. W. & Sondel, P. M., Jan 1 1995, In : Blood. 86, 2, p. 636-645 10 p.

Research output: Contribution to journalArticle

Interleukin-2 Receptors
Interleukin-2
Lymphoma
Dogs
Skin
51 Citations (Scopus)

Regulation of synthesis and activity of the PLSTIRE protein (cyclin-dependent kinase 6 (cdk6)), a major cyclin D-associated cdk4 homologue in normal human T lymphocytes

Lucas, J. J., Szepesi, A., Modiano, J. F., Domenico, J. & Gelfand, E. W., Dec 1 1995, In : Journal of Immunology. 154, 12, p. 6275-6284 10 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin D
T-Lymphocytes
Interleukin-2
Cyclin D2
8 Citations (Scopus)

Retrovirus-like activity in an immunosuppressed dog: Pathological and immunological findings

Modiano, J. F., Getzy, D. M., Akol, K. G., Van Winkle, T. J. & Cockerell, G. L., Jan 1 1995, In : Journal of Comparative Pathology. 112, 2, p. 165-183 19 p.

Research output: Contribution to journalArticle

Retroviridae
Dogs
Canidae
dogs
Small Intestine
13 Citations (Scopus)

Symmetry of the Activation of Cyclin‐dependent Kinases in Mitogen and Growth Factor‐stimulated T Lymphocytes

MODIANO, JAIME. F., DOMENICO, JOANNE., SZEPESI, AGOTA., TERADA, NAOHIRO., LUCAS, JOSEPH. J. & GELFAND, ERWIN. W., Jan 1 1995, In : Annals of the New York Academy of Sciences. 766, 1, p. 134-148 15 p.

Research output: Contribution to journalArticle

T-cells
Cyclin-Dependent Kinases
Mitogens
Intercellular Signaling Peptides and Proteins
Phosphorylation
1994
59 Citations (Scopus)

Differential requirements for interleukin-2 distinguish the expression and activity of the cyclin-dependent kinases Cdk4 and Cdk2 in human T cells

Modiano, J. F., Domenico, J., Szepesi, A., Lucas, J. J. & Gelfand, E. W., Dec 1 1994, In : Journal of Biological Chemistry. 269, 52, p. 32972-32978 7 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 4
T-cells
Cyclin D2
Interleukin-2
T-Lymphocytes
20 Citations (Scopus)

Induction of lymphokine-activated killer (LAK) activity in canine lymphocytes with low dose human recombinant interleukin-2 in vitro

Helfand, S. C., Soergel, S. A., Modiano, J. F., Hank, J. A. & Sondel, P. M., Jan 1 1994, In : Cancer Biotherapy. 9, 3, p. 237-244 8 p.

Research output: Contribution to journalArticle

Lymphokines
Interleukin-2
Canidae
Lymphocytes
Lymphokine-Activated Killer Cells
1992
27 Citations (Scopus)

Immunophysiological studies of interleukin-2 and canine lymphocytes

Helfand, S. C., Modiano, J. F. & Nowell, P. C., Jan 1 1992, In : Veterinary Immunology and Immunopathology. 33, 1-2, p. 1-16 16 p.

Research output: Contribution to journalArticle

interleukin-2
Interleukin-2
Canidae
lymphocytes
Lymphocytes
1991
23 Citations (Scopus)

Progesterone augments proliferation induced by epidermal growth factor in a feline mammary adenocarcinoma cell line

Modiano, J. F., Kokai, Y., Weiner, D. B., Pykett, M. J., Nowell, P. C. & Lyttle, C. R., Jan 1 1991, In : Journal of Cellular Biochemistry. 45, 2, p. 196-206 11 p.

Research output: Contribution to journalArticle

Felidae
Promegestone
Epidermal Growth Factor
Progesterone
Adenocarcinoma
20 Citations (Scopus)

Protein kinase C regulates both production and secretion of interleukin 2

Modiano, J. F., Kolp, R., Lamb, R. J. & Nowell, P. C., Aug 16 1991, In : Journal of Biological Chemistry. 266, 16, p. 10552-10561 10 p.

Research output: Contribution to journalArticle

Protein Kinase C
Interleukin-2
Gene expression
T-cells
Gene Expression
1988
22 Citations (Scopus)

Requirement for extracellular calcium or magnesium in mitogen‐induced activation of human peripheral blood lymphocytes

Modiano, J. F., Kelepouris, E., Kern, J. A. & Nowell, P. C., Jan 1 1988, In : Journal of Cellular Physiology. 135, 3, p. 451-458 8 p.

Research output: Contribution to journalArticle

Lymphocytes
Ionomycin
Interleukin-2 Receptors
Magnesium
Interleukin-2