1966 …2019

Research output per year

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Research Output

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Article
2011
44 Scopus citations

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

Liu, X. Y., Liu, Z. C., Sun, Y. G., Ross, M., Kim, S., Tsai, F. F., Li, Q. F., Jeffry, J., Kim, J. Y., Loh, H. H. & Chen, Z. F., Oct 14 2011, In : Cell. 147, 2, p. 447-458 12 p.

Research output: Contribution to journalArticle

160 Scopus citations
2010

Agonist-dependent μ-opioid receptor signaling can lead to heterologous desensitization

Chu, J., Zheng, H., Zhang, Y., Loh, H. H. & Law, P-Y., Apr 1 2010, In : Cellular Signalling. 22, 4, p. 684-696 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A gene.

Chen, S. L., Ma, H. I., Han, J. M., Lu, R. B., Tao, P. L., Law, P. Y. & Loh, H. H., 2010, In : Journal of biomedical science. 17, 1 p.

Research output: Contribution to journalArticle

12 Scopus citations
11 Scopus citations

Intrathecal delivery of a mutant μ-opioid receptor activated by naloxone as a possible antinociceptive paradigm

Kao, J. H., Chen, S. L., Ma, H. I., Law, P-Y., Tao, P. L. & Loh, H. H., Sep 2010, In : Journal of Pharmacology and Experimental Therapeutics. 334, 3, p. 739-745 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Kappa opioid receptor contributes to EGF-stimulated neurite extension in development

Tsai, N. P., Tsui, Y. C., Pintar, J. E., Loh, H. H. & Wei, L-N., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3216-3221 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability

Zheng, H., Zeng, Y., Chu, J., Kam, A. Y. F., Loh, H. H. & Law, P-Y., Jun 16 2010, In : Journal of Neuroscience. 30, 24, p. 8102-8110 9 p.

Research output: Contribution to journalArticle

47 Scopus citations
37 Scopus citations

Morphine regulates dopaminergic neuron differentiation via miR-133b

Sanchez-Simon, F. M., Zhang, X. X., Loh, H. H., Law, P-Y. & Rodriguez, R. E., Nov 1 2010, In : Molecular Pharmacology. 78, 5, p. 935-942 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

uAUG-mediated translational initiations are responsible for human mu opioid receptor gene expression

Song, K. Y., Kim, C. S., Hwang, C. K., Choi, H. S., Law, P. Y., Wei, L. N. & Loh, H. H., Jul 23 2010, In : Journal of Cellular and Molecular Medicine. 14, 5, p. 1113-1124 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Up-regulation of the μ-opioid receptor gene is mediated through chromatin remodeling and transcriptional factors in differentiated neuronal cells

Hwang, C. K., Kim, C. S., Kim, D. K., Law, P. Y., Wei, L. N. & Loh, H. H., Jul 1 2010, In : Molecular Pharmacology. 78, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Yin Yang 1 phosphorylation contributes to the differential effects of μ-opioid receptor agonists on microRNA-190 expression

Zheng, H., Chu, J., Zeng, Y., Loh, H. H. & Law, P-Y., Jul 16 2010, In : Journal of Biological Chemistry. 285, 29, p. 21994-22002 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

μ-opioid receptor agonists differentially regulate the expression of miR-190 and NeuroD

Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H. & Law, P-Y., Jan 1 2010, In : Molecular Pharmacology. 77, 1, p. 102-109 8 p.

Research output: Contribution to journalArticle

71 Scopus citations

μ-opioid receptor knockout mice are insensitive to methamphetamine- induced behavioral sensitization

Shen, X., Purser, C., Tien, L. T., Chiu, C. T., Paul, I. A., Baker, R., Loh, H. H., Ho, I. K. & Ma, T., Aug 1 2010, In : Journal of Neuroscience Research. 88, 10, p. 2294-2302 9 p.

Research output: Contribution to journalArticle

40 Scopus citations
2009

Bidirectional Effects of Fentanyl on Dendritic Spines and AMPA Receptors Depend Upon the Internalization of Mu Opioid Receptors

Lin, H., Higgins, P., Loh, H. H., Law, P. Y. & Liao, D., Aug 1 2009, In : Neuropsychopharmacology. 34, 9, p. 2097-2111 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Differential use of an in-frame translation initiation codon regulates human mu opioid receptor (OPRM1)

Song, K. Y., Choi, H. S., Hwang, C. K. T., Kim, C. S., Law, P-Y., Wei, L-N. & Loh, H. H., Sep 1 2009, In : Cellular and Molecular Life Sciences. 66, 17, p. 2933-2942 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Epigenetic programming of μ-opioid receptor gene in mouse brain is regulated by MeCP2 and brg1 chromatin remodelling factor

Hwang, C. K., Song, K. Y., Kim, C. S., Choi, H. S., Guo, X. H., Law, P. Y., Wei, L. N. & Loh, H. H., Sep 1 2009, In : Journal of Cellular and Molecular Medicine. 13, 9 B, p. 3591-3615 25 p.

Research output: Contribution to journalArticle

55 Scopus citations

GRIN1 regulates μ-opioid receptor activities by tethering the receptor and G protein in the lipid raft

Ge, X., Qiu, Y., Loh, H. H. & Law, P-Y., Dec 25 2009, In : Journal of Biological Chemistry. 284, 52, p. 36521-36534 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Long-term morphine treatment decreases the association of μ-opioid receptor (MOR1) mRNA with polysomes through miRNA23b

Wu, Q., Zhang, L., Law, P-Y., Wei, L-N. & Loh, H. H., Apr 1 2009, In : Molecular Pharmacology. 75, 4, p. 744-750 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Neurite outgrowth is dependent on the association of c-Src and lipid rafts

Zhao, H., Cao, X., Wu, G., Loh, H. H. & Law, P. Y., Dec 1 2009, In : Neurochemical Research. 34, 12, p. 2197-2205 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Src phosphorylation of μ-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal

Zhang, L., Zhao, H., Qiu, Y., Loh, H. H. & Law, P-Y., Jan 23 2009, In : Journal of Biological Chemistry. 284, 4, p. 1990-2000 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

μ-opioid receptor cell surface expression is regulated by its direct interaction with Ribophorin I

Ge, X., Loh, H. H. & Law, P-Y., Jun 1 2009, In : Molecular Pharmacology. 75, 6, p. 1307-1316 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Agonist-selective signaling is determined by the receptor location within the membrane domains

Zheng, H., Chu, J., Qiu, Y., Loh, H. H. & Law, P-Y., Jul 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 27, p. 9421-9426 6 p.

Research output: Contribution to journalArticle

72 Scopus citations
25 Scopus citations

Effects of trichostatin A on neuronal mu-opioid receptor gene expression

Lin, Y. C., Flock, K. E., Cook, R. J., Hunkele, A. J., Loh, H. H. & Ko, J. L., Dec 30 2008, In : Brain Research. 1246, p. 1-10 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Epigenetic regulation of kappa opioid receptor gene in neuronal differentiation

Park, S. W., He, Y., Ha, S. G., Loh, H. H. & Wei, L-N., Feb 19 2008, In : Neuroscience. 151, 4, p. 1034-1041 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Gender differences in the antinociceptive effect of tramadol, alone or in combination with gabapentin, in mice

Dai, X., Brunson, C. D., Rockhold, R. W., Loh, H. H., Ho, I. K. & Ma, T., Sep 1 2008, In : Journal of Biomedical Science. 15, 5, p. 645-651 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Morphine-induced μ-opioid receptor rapid desensitization is independent of receptor phosphorylation and β-arrestins

Chu, J., Zheng, H., Loh, H. H. & Law, P-Y., Sep 1 2008, In : Cellular Signalling. 20, 9, p. 1616-1624 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression

Chen, Y. L., Law, P-Y. & Loh, H. H., Apr 11 2008, In : Biochemical and Biophysical Research Communications. 368, 3, p. 755-760 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation

Kim, C. S., Hwang, C. K., Song, K. Y., Choi, H. S., Kim, D. K., Law, P. Y., Wei, L. N. & Loh, H. H., Oct 1 2008, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1783, 10, p. 1835-1846 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Post-transcriptional regulation of mouse μ opioid receptor (MOR1) via its 3′ untranslated region: A role for microRNA23b

Wu, Q., Law, P-Y., Wei, L-N. & Loh, H. H., Dec 1 2008, In : FASEB Journal. 22, 12, p. 4085-4095 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by Poly(ADP-ribose) polymerase-1

Choi, H. S., Hwang, C. K., Kim, C. S., Song, K. Y., Law, P. Y., Loh, H. H. & Wei, L. N., Dec 1 2008, In : Journal of Cellular and Molecular Medicine. 12, 6A, p. 2319-2333 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
115 Scopus citations
2007

Action of NF-κB on the delta opioid receptor gene promoter

Chen, Y. L., Law, P-Y. & Loh, H. H., Jan 19 2007, In : Biochemical and Biophysical Research Communications. 352, 3, p. 818-822 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Agonist-dependent postsynaptic effects of opioids on miniature excitatory postsynaptic currents in cultured hippocampal neurons

Liao, D., Grigoriants, O. O., Loh, H. H. & Law, P. Y., Feb 1 2007, In : Journal of neurophysiology. 97, 2, p. 1485-1494 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Autoradiographic analysis of GABAA receptors in μ-opioid receptor knockout mice

Tien, L. T., Ma, T., Fan, L. W., Loh, H. H. & Ho, I. K., Nov 1 2007, In : Neurochemical Research. 32, 11, p. 1891-1897 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Copb1-facilitated axonal transport and translation of κ opioid-receptor mRNA

Bi, J., Tsai, N. P., Lu, H. Y., Loh, H. H. & Wei, L-N., Aug 21 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 34, p. 13810-13815 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Distinct effects of individual opioids on the morphology of spines depend upon the internalization of mu opioid receptors

Liao, D., Grigoriants, O. O., Wang, W., Wiens, K., Loh, H. H. & Law, P. Y., Jul 1 2007, In : Molecular and Cellular Neuroscience. 35, 3, p. 456-469 14 p.

Research output: Contribution to journalArticle

40 Scopus citations

dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm

Chen, S. L., Ma, H. I., Han, J. M., Tao, P. L., Law, P. Y. & Loh, H. H., Dec 11 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 50, p. 20096-20101 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters

Cheol, K. H., Kyu, Y. S., Chun, S. K., Hack, S. C., Guo, X. H., Law, P. Y., Wei, L. N. & Loh, H. H., Jul 1 2007, In : Molecular and cellular biology. 27, 13, p. 4720-4736 17 p.

Research output: Contribution to journalArticle

73 Scopus citations

Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: Role of inducible nitric oxide synthase

Kiang, J. G., Bowman, P. D., Lu, X., Li, Y., Wu, B. W., Loh, H. H., Tsen, K. T. & Tsokos, G. C., Sep 1 2007, In : Journal of applied physiology. 103, 3, p. 1045-1055 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Novel function of the poly(C)-binding protein αCP3 as a transcriptional repressor of the mu opioid receptor gene

Hack, S. C., Chun, S. K., Cheol, K. H., Kyu, Y. S., Law, P. Y., Wei, L. N. & Loh, H. H., Dec 1 2007, In : FASEB Journal. 21, 14, p. 3963-3973 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
37 Scopus citations
24 Scopus citations

Translational repression of mouse mu opioid receptor expression via leaky scanning

Song, K. Y., Hwang, C. K., Kim, C. S., Choi, H. S., Law, P. Y., Wei, L. N. & Loh, H. H., Mar 1 2007, In : Nucleic acids research. 35, 5, p. 1501-1513 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2006
63 Scopus citations
59 Scopus citations

Differential effects of morphine- and cocaine-induced nNOS immunoreactivity in the dentate gyrus of hippocampus of mice lacking μ-opioid receptors

Yoo, J. H., Cho, J. H., Lee, S. Y., Lee, S., Loh, H. H., Ho, I. K. & Jang, C. G., Mar 6 2006, In : Neuroscience Letters. 395, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene

Kim, C. S., Choi, H. S., Hwang, C. K., Song, K. Y., Lee, B. K., Law, P. Y., Wei, L. N. & Loh, H. H., Dec 1 2006, In : Nucleic acids research. 34, 22, p. 6392-6403 12 p.

Research output: Contribution to journalArticle

40 Scopus citations