1966 …2019
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Research Output 1966 2019

2019

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 2405.

Research output: Contribution to journalArticle

Open Access
mu Opioid Receptor
Endocytosis
Morphine
Ligands
Morphine Dependence
1 Citation (Scopus)

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Lin, S. Y., Kuo, Y. H., Tien, Y. W., Ke, Y. Y., Chang, W. T., Chang, H. F., Ou, L. C., Law, P-Y., Xi, J. H., Tao, P. L., Loh, H. H., Chao, Y. S., Shih, C., Chen, C. T., Yeh, S. H. & Ueng, S. H., Apr 1 2019, In : European Journal of Medicinal Chemistry. 167, p. 312-323 12 p.

Research output: Contribution to journalArticle

Opioid Receptors
Naloxone
Amines
Chemical activation
Analgesics
2018
2 Citations (Scopus)

Morphine regulates adult neurogenesis and contextual memory extinction via the PKCε/Prox1 pathway

Fan, W., Wang, H., Zhang, Y., Loh, H. H., Law, P. Y. & Xu, C., Oct 2018, In : Neuropharmacology. 141, p. 126-138 13 p.

Research output: Contribution to journalArticle

Open Access
Neural Stem Cells
Neurogenesis
Morphine
Fentanyl
Stem Cells
2017
5 Citations (Scopus)

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

Opioid Receptors
Morphine
Opioid Analgesics
Charcoal
Surgical Instruments
6 Citations (Scopus)

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists

Chen, S. R., Ke, Y. Y., Yeh, T. K., Lin, S. Y., Ou, L. C., Chen, S. C., Chang, W. T., Chang, H. F., Wu, Z. H., Hsieh, C. C., Law, P. Y., Loh, H. H., Shih, C., Lai, Y. K., Yeh, S. H. & Ueng, S. H., Jan 1 2017, In : European Journal of Medicinal Chemistry. 126, p. 202-217 16 p.

Research output: Contribution to journalArticle

Benzamides
Opioid Receptors
Structure-Activity Relationship
Pain
Constipation
3 Citations (Scopus)
Opioid Receptors
Epigenomics
Genes
Opioid Analgesics
Protein Kinases
3 Citations (Scopus)

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Naloxone
Binding Sites
Morphine
Amber
3 Citations (Scopus)
Open Access
Poly(A)-Binding Proteins
AU Rich Elements
Untranslated Regions
RNA-Binding Proteins
mu Opioid Receptor
7 Citations (Scopus)
Open Access
Heterogeneous-Nuclear Ribonucleoprotein K
Poly C
RNA-Binding Proteins
mu Opioid Receptor
Protein Binding
3 Citations (Scopus)

Spinal or supraspinal phosphorylation deficiency at the MOR C-terminus does not affect morphine tolerance in vivo

Kibaly, C., Lin, H. Y., Loh, H. H. & Law, P. Y., May 1 2017, In : Pharmacological Research. 119, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
Morphine
Phosphorylation
Knockout Mice
Fentanyl
Spinal Cord
7 Citations (Scopus)

Src-dependent phosphorylation of μ-opioid receptor at Tyr 336 modulates opiate withdrawal

Zhang, L., Kibaly, C., Wang, Y. J., Xu, C., Song, K. Y., McGarrah, P. W., Loh, H. H., Liu, J. G. & Law, P. Y., Nov 2017, In : EMBO Molecular Medicine. 9, 11, p. 1521-1536 16 p.

Research output: Contribution to journalArticle

Open Access
Opiate Alkaloids
Opioid Receptors
Phosphorylation
Addictive Behavior
Opioid-Related Disorders
6 Citations (Scopus)

Temporal effect of manipulating NeuroD1 expression with the synthetic small molecule KHS101 on morphine contextual memory

Zhang, Y., Kibaly, C., Xu, C., Loh, H. H. & Law, P-Y., Nov 2017, In : Neuropharmacology. 126, p. 58-69 12 p.

Research output: Contribution to journalArticle

Morphine
Opioid Analgesics
Neurogenesis
Pharmaceutical Preparations
Recurrence
2016
11 Citations (Scopus)

Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice

Yang, P. P., Yeh, G. C., Yeh, T. K., Xi, J., Loh, H. H., Law, P. Y. & Tao, P. L., Sep 1 2016, In : Pharmacological Research. 111, p. 867-876 10 p.

Research output: Contribution to journalArticle

Oxycodone
delta Opioid Receptor
mu Opioid Receptor
Oxymorphone
naltrindole
2 Citations (Scopus)

A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain

Kibaly, C., Loh, H. H. & Law, P. Y., Jan 1 2016, International Review of Cell and Molecular Biology. Elsevier Inc., p. 89-161 73 p. (International Review of Cell and Molecular Biology; vol. 327).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene therapy
Chronic Pain
Genetic Therapy
Viruses
Drug therapy
11 Citations (Scopus)

Effect of Opioid on Adult Hippocampal Neurogenesis

Zhang, Y., Loh, H. H. & Law, P-Y., Jan 1 2016, In : Scientific World Journal. 2016, 2601264.

Research output: Contribution to journalReview article

Neurogenesis
Opioid Analgesics
Opiate Alkaloids
drug
Pharmaceutical Preparations
11 Citations (Scopus)

Effects of addictive drugs on adult neural stem/progenitor cells

Xu, C., Loh, H. H. & Law, P. Y., Jan 1 2016, In : Cellular and Molecular Life Sciences. 73, 2, p. 327-348 22 p.

Research output: Contribution to journalReview article

Adult Stem Cells
Neural Stem Cells
Stem Cells
Neurogenesis
Pharmaceutical Preparations
11 Citations (Scopus)

Morphine modulates adult neurogenesis and contextual memory by impeding the maturation of neural progenitors

Zhang, Y., Xu, C., Zheng, H., Loh, H. H. & Law, P. Y., Apr 2016, In : PloS one. 11, 4, e0153628.

Research output: Contribution to journalArticle

neurogenesis
morphine
Neurogenesis
Morphine
Data storage equipment
14 Citations (Scopus)

Naltrexone Facilitates Learning and Delays Extinction by Increasing AMPA Receptor Phosphorylation and Membrane Insertion

Kibaly, C., Kam, A. Y. F., Loh, H. H. & Law, P-Y., Jun 1 2016, In : Biological Psychiatry. 79, 11, p. 906-916 11 p.

Research output: Contribution to journalArticle

Naltrexone
AMPA Receptors
Phosphorylation
Learning
Membranes
5 Citations (Scopus)

Opioid doses required for pain management in lung cancer patients with different cholesterol levels: Negative correlation between opioid doses and cholesterol levels

Huang, Z., Liang, L., Li, L., Xu, M., Li, X., Sun, H., He, S., Lin, L., Zhang, Y., Song, Y., Yang, M., Luo, Y., Loh, H. H., Law, P. Y., Zheng, D. & Zheng, H., Jan 1 2016, In : Lipids in Health and Disease. 15, 1, 47.

Research output: Contribution to journalArticle

Pain Management
Opioid Analgesics
Lung Neoplasms
Cholesterol
Oxycodone
3 Citations (Scopus)

Possible role of β-endorphin in heat adaptation

Holaday, J. W., Loh, H. H., Wei, E. & Li, C. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 473-483 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

beta-Endorphin
Thermotolerance
1 Citation (Scopus)

β-endorphin: Stimulation of DNA-dependent RNA formation

Catlin, D. H., Hui, K. K., Loh, H. H. & Li, C. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 254-259 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

beta-Endorphin
RNA
DNA
2015
3 Citations (Scopus)

Analysis of epigenetic mechanisms regulating opioid receptor gene transcription

Hwang, C. K., Wagley, Y., Law, P. Y., Wei, L. N. & Loh, H. H., Jan 1 2015, In : Methods in Molecular Biology. 1230, p. 39-51 13 p.

Research output: Contribution to journalArticle

Opioid Receptors
Epigenomics
DNA Methylation
Genes
Untranslated RNA
7 Citations (Scopus)

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord

Kao, J. H., Gao, M. J., Yang, P. P., Law, P. Y., Loh, H. H. & Tao, P. L., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 630-641 12 p.

Research output: Contribution to journalArticle

Naltrexone
Opioid Receptors
Neuralgia
Spinal Cord
Morphine
12 Citations (Scopus)

Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice

Yang, P. P., Yeh, G. C., Huang, E. Y. K., Law, P. Y., Loh, H. H. & Tao, P. L., Sep 22 2015, In : Journal of biomedical science. 22, 1, 81.

Research output: Contribution to journalArticle

Oxycodone
Dextromethorphan
Neuralgia
Neuroglia
Therapeutics
4 Citations (Scopus)

Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12

Wang, Y., Ge, Y. H., Wang, Y. X., Liu, T., Law, P-Y., Loh, H. H., Chen, H. Z. & Qiu, Y., Jul 1 2015, In : CNS Neuroscience and Therapeutics. 21, 7, p. 591-598 8 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Opioid Receptors
Sirolimus
Morphine
Physiological Phenomena
13 Citations (Scopus)
Astrocytes
Morphine
Stem Cells
Phosphorylation
Fentanyl
19 Citations (Scopus)

μ-Opioid Receptor Attenuates Aβ Oligomers-Induced Neurotoxicity Through mTOR Signaling

Wang, Y., Wang, Y. X., Liu, T., Law, P. Y., Loh, H. H., Qiu, Y. & Chen, H. Z., Jan 1 2015, In : CNS Neuroscience and Therapeutics. 21, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

Opioid Receptors
Sirolimus
Morphine
70-kDa Ribosomal Protein S6 Kinases
TOR Serine-Threonine Kinases
2014
9 Citations (Scopus)

Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists

Cheng, M. F., Ou, L. C., Chen, S. C., Chang, W. T., Law, P-Y., Loh, H. H., Chao, Y. S., Shih, C., Yeh, S. H. & Ueng, S. H., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4694-4703 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
Structure-Activity Relationship
Analgesics
Adenylyl Cyclases
Inhibitory Concentration 50
7 Citations (Scopus)

FK506-Binding protein 12 modulates m-opioid receptor phosphorylation and protein kinase σ-dependent signaling by its direct interaction with the receptor

Qiu, Y., Zhao, W., Wang, Y., Xu, J. R., Huie, E., Jiang, S., Yan, Y. H., Loh, H. H., Chen, H. Z. & Law, P. Y., Jan 1 2014, In : Molecular Pharmacology. 85, 1, p. 37-49 13 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Opioid Receptors
Protein Kinases
Phosphorylation
Protein Kinase C
13 Citations (Scopus)

Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling

Lee, P. T., Chao, P. K., Ou, L. C., Chuang, J. Y., Lin, Y. C., Chen, S. C., Chang, H. F., Law, P. Y., Loh, H. H., Chao, Y. S., Su, T. P. & Yeh, S. H., Dec 1 2014, In : Nucleic acids research. 42, 21, p. 13012-13025 14 p.

Research output: Contribution to journalArticle

Heterogeneous-Nuclear Ribonucleoprotein K
Opioid Receptors
Morphine
Neurons
mu Opioid Receptor
21 Citations (Scopus)

Morphine modulates mouse hippocampal progenitor cell lineages by upregulating miR-181a level

Xu, C., Zhang, Y., Zheng, H., Loh, H. H. & Law, P. Y., Nov 1 2014, In : STEM CELLS. 32, 11, p. 2961-2972 12 p.

Research output: Contribution to journalArticle

Cell Lineage
Morphine
Stem Cells
Astrocytes
Neurogenesis
8 Citations (Scopus)

Neurod1 modulates opioid antinociceptive tolerance via two distinct mechanisms

Li, W., He, S., Zhou, Y., Li, Y., Hao, J., Zhou, X., Wang, F., Zhang, Y., Huang, Z., Li, Z., Loh, H. H., Law, P. Y. & Zheng, H., Jan 1 2014, In : Biological Psychiatry. 76, 10, p. 775-784 10 p.

Research output: Contribution to journalArticle

Morphine
Opioid Analgesics
Fentanyl
MicroRNAs
Hippocampus
5 Citations (Scopus)

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization

Yan, Y. H., Wang, Y., Zhao, L. X., Jiang, S., Loh, H. H., Law, P-Y., Chen, H. Z. & Qiu, Y., Apr 30 2014, In : Neuroscience Letters. 566, p. 231-235 5 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Opioid Receptors
Morphine
Phosphorylation
Adenylyl Cyclases
11 Citations (Scopus)

β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia

Feng, X., Wu, C-Y., Burton, F. H., Loh, H. H. & Wei, L-N., Mar 1 2014, In : Cell Death and Differentiation. 21, 3, p. 397-406 10 p.

Research output: Contribution to journalArticle

Arrestin
kappa Opioid Receptor
Microglia
Opioid Analgesics
Neurons
2013
18 Citations (Scopus)

A novel noncanonical signaling pathway for the μ-opioid receptor

Zhang, L., Loh, H. H. & Law, P-Y., Dec 1 2013, In : Molecular Pharmacology. 84, 6, p. 844-853 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
Adenylyl Cyclases
src-Family Kinases
Phosphorylation
Receptor Protein-Tyrosine Kinases
20 Citations (Scopus)
JNK Mitogen-Activated Protein Kinases
NF-kappa B
mu Opioid Receptor
p38 Mitogen-Activated Protein Kinases
Morphine
37 Citations (Scopus)

MicroRNA 339 down-regulates μ-opioid μeceptor at the post-transcriptional level in response to opioid treatment

Wu, Q., Hwang, C. K. T., Zheng, H., Wagley, Y., Lin, H. Y., Kim, D. K., Law, P-Y., Loh, H. H. & Wei, L-N., Feb 1 2013, In : FASEB Journal. 27, 2, p. 522-535 14 p.

Research output: Contribution to journalArticle

Fentanyl
MicroRNAs
Morphine
Opioid Analgesics
Down-Regulation
20 Citations (Scopus)

NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction

Zheng, H., Zhang, Y., Li, W., Loh, H. H. & Law, P. Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 770-777 8 p.

Research output: Contribution to journalArticle

Neurogenesis
Morphine
Opioid Analgesics
Fentanyl
Lentivirus
2 Citations (Scopus)
Single-Stranded DNA
Carrier Proteins
RNA-Binding Proteins
Protein Folding
Electrophoretic Mobility Shift Assay
34 Citations (Scopus)

Opioid receptors: Toward separation of analgesic from undesirable effects

Law, P. Y., Reggio, P. H. & Loh, H. H., Jun 1 2013, In : Trends in Biochemical Sciences. 38, 6, p. 275-282 8 p.

Research output: Contribution to journalReview article

Opioid Receptors
Opioid Analgesics
Analgesics
Oligomers
Pain Management

Opioid Receptors

Law, P. Y. & Loh, H. H., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 354-358 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Opioid Receptors
Alkaloids
Chemical activation
Ligands
Heterotrimeric GTP-Binding Proteins
11 Citations (Scopus)

Posttranslation modification of G protein-coupled receptor in relationship to biased agonism

Zheng, H., Loh, H. H. & Law, P-Y., 2013, G Protein Coupled ReceptorsModeling, Activation, Interactions and Virtual Screening. Academic Press Inc., p. 391-408 18 p. (Methods in Enzymology; vol. 522).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lipoylation
G-Protein-Coupled Receptors
CCR10 Receptors
Phosphorylation
Opioid Receptors
5 Citations (Scopus)
mu Opioid Receptor
5' Untranslated Regions
Vimentin
Opioid Receptors
RNA
2012
11 Citations (Scopus)
Respiratory Insufficiency
Morphine
Protein Kinase C
Opioid Analgesics
Periaqueductal Gray
19 Citations (Scopus)

Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans

Zheng, H., Zou, H., Liu, X., Chu, J., Zhou, Y., Loh, H. H. & Law, P-Y., Jun 1 2012, In : Journal of Lipid Research. 53, 6, p. 1153-1162 10 p.

Research output: Contribution to journalArticle

Analgesia
Opioid Analgesics
Cholesterol
Opioid Receptors
Lipids
20 Citations (Scopus)

Differential modulation of drug-induced structural and functional plasticity of dendritic spines

Miller, E. C., Zhang, L., Dummer, B. W., Cariveau, D. R., Loh, H. H., Law, P-Y. & Liao, D., Aug 1 2012, In : Molecular Pharmacology. 82, 2, p. 333-343 11 p.

Research output: Contribution to journalArticle

Dendritic Spines
KN 62
Neuronal Plasticity
Tacrolimus
Pharmaceutical Preparations
28 Citations (Scopus)

MicroRNAs in opioid pharmacology

Hwang, C. K. T., Wagley, Y., Law, P-Y., Wei, L-N. & Loh, H. H., Dec 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 4, p. 808-819 12 p.

Research output: Contribution to journalReview article

MicroRNAs
Opioid Analgesics
Pharmacology
Drug Receptors
Messenger RNA
7 Citations (Scopus)

Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway

Chou, S. H., Kao, J. H., Tao, P. L., Law, P-Y. & Loh, H. H., Aug 1 2012, In : Synapse. 66, 8, p. 694-704 11 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Naloxone
Analgesics
Periaqueductal Gray
Pain
17 Citations (Scopus)

Non-coding RNAs regulating morphine function: With emphasis on the in vivo and in vitro functions of miR-190

Zheng, H., Law, P. Y. & Loh, H. H., Dec 1 2012, In : Frontiers in Genetics. 3, JUN, Article 113.

Research output: Contribution to journalReview article

Untranslated RNA
Morphine
Opioid Analgesics
Biological Phenomena
Neurogenesis