1990 …2024

Research output per year

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Research Output

2020

Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila

Takemura, M., Noborn, F., Nilsson, J., Bowden, N., Nakato, E., Baker, S., Su, T. Y., Larson, G. & Nakato, H., Apr 1 2020, In : Molecular biology of the cell. 31, 8, p. 813-824 12 p.

Research output: Contribution to journalArticle

Open Access
2019

Establishment and characterization of Drosophila cell lines mutant for heparan sulfate modifying enzymes

Nakato, E., Liu, X., Eriksson, I., Yamamoto, M., Kinoshita-Toyoda, A., Toyoda, H., Kjellén, L., Li, J. P. & Nakato, H., Jun 1 2019, In : Glycobiology. 29, 6, p. 479-489 11 p.

Research output: Contribution to journalArticle

2018

Drosophila glypicans regulate follicle stem cell maintenance and niche competition

Su, T. Y., Nakato, E., Choi, P. Y. & Nakato, H., Jun 2018, In : Genetics. 209, 2, p. 537-549 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Loss of heparan sulfate in the niche leads to tumor-like germ cell growth in the Drosophila testis

Levings, D. C. & Nakato, H., Jan 1 2018, In : Glycobiology. 28, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Regulation of neuroblast proliferation by surface glia in the Drosophila larval brain

Kanai, M. I., Kim, M. J., Akiyama, T., Takemura, M., Wharton, K., O'Connor, M. B. & Nakato, H., Dec 1 2018, In : Scientific reports. 8, 1, 3730.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2017

Drosophila Sulf1 is required for the termination of intestinal stem cell division during regeneration

Takemura, M. & Nakato, H., Jan 1 2017, In : Journal of cell science. 130, 2, p. 332-343 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2016
21 Scopus citations

Heparan sulfate regulates the number and centrosome positioning of Drosophila male germline stem cells

Levings, D. C., Arashiro, T. & Nakato, H., Mar 15 2016, In : Molecular biology of the cell. 27, 6, p. 888-896 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2015

Genetic approaches in the study of heparan sulfate functions in drosophila

Takemura, M. & Nakato, H., Jan 1 2015, In : Methods in Molecular Biology. 1229, p. 497-505 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Heparan sulfate proteoglycans in drosophila ovarian germline stem cell niche

Nakato, H., Jan 1 2015, Glycoscience: Biology and Medicine. Springer Japan, p. 825-832 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Preface. Glycosaminoglycans

Balagurunathan, K., Nakato, H. & Desai, U. R., Jan 1 2015, In : Methods in molecular biology (Clifton, N.J.). 1229, p. v

Research output: Contribution to journalEditorial

1 Scopus citations
2013

Analysis of drosophila glucuronyl C5-epimerase: Implications for developmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid

Dejima, K., Takemura, M., Nakato, E., Peterson, J., Hayashi, Y., Kinoshita-Toyoda, A., Toyoda, H. & Nakato, H., Nov 29 2013, In : Journal of Biological Chemistry. 288, 48, p. 34384-34393 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

Kleinschmit, A., Takemura, M., Dejima, K., Choi, P. Y. & Nakato, H., Feb 15 2013, In : Journal of Biological Chemistry. 288, 7, p. 5081-5089 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

Kleinschmit, A., Takemura, M., Dejima, K., Choi, P. Y. & Nakato, H., Feb 15 2013, Journal of Biological Chemistry. p. 5081-5089 9 p. (Journal of Biological Chemistry; vol. 288).

Research output: Chapter in Book/Report/Conference proceedingChapter

The role of drosophila heparan sulfate 6-O-endosulfatase in sulfation compensation

Dejima, K., Kleinschmit, A., Takemura, M., Choi, P. Y., Kinoshita-Toyoda, A., Toyoda, H. & Nakato, H., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6574-6582 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2012

Glypicans regulate JAK/STAT signaling and distribution of the unpaired morphogen

Hayashi, Y., Sexton, T. R., Dejima, K., Perry, D. W., Takemura, M., Kobayashi, S., Nakato, H. & Harrison, D. A., Nov 15 2012, In : Development (Cambridge). 139, 22, p. 4162-4171 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop

Wojcinski, A., Nakato, H., Soula, C. & Glise, B., Oct 1 2011, In : Developmental Biology. 358, 1, p. 168-180 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

In vivo manipulation of heparan sulfate structure and its effect on Drosophila development

Kamimura, K., Maeda, N. & Nakato, H., May 1 2011, In : Glycobiology. 21, 5, p. 607-618 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans

Dejima, K., Kanai, M. I., Akiyama, T., Levings, D. C. & Nakato, H., May 13 2011, In : Journal of Biological Chemistry. 286, 19, p. 17103-17111 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
2010

Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation

Kleinschmit, A., Koyama, T., Dejima, K., Hayashi, Y., Kamimura, K. & Nakato, H., Sep 2010, In : Developmental Biology. 345, 2, p. 204-214 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2009

Drosophila glypicans regulate the germline stem cell niche

Hayashi, Y., Kobayashi, S. & Nakato, H., Nov 16 2009, In : Journal of Cell Biology. 187, 4, p. 473-480 8 p.

Research output: Contribution to journalArticle

94 Scopus citations
2008

Dally regulates Dpp morphogen gradient formation by stabilizing Dpp on the cell surface

Akiyama, T., Kamimura, K., Firkus, C., Takeo, S., Shimmi, O. & Nakato, H., Jan 1 2008, In : Developmental Biology. 313, 1, p. 408-419 12 p.

Research output: Contribution to journalArticle

120 Scopus citations
2006

Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling

Kamimura, K., Koyama, T., Habuchi, H., Ueda, R., Masu, M., Kimata, K. & Nakato, H., Sep 11 2006, In : Journal of Cell Biology. 174, 6, p. 773-778 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2005

A Myxococcus xanthus CbpB containing two cAMP-binding domains is involved in temperature and osmotic tolerances

Kimura, Y., Nakato, H., Ishibashi, K. & Kobayashi, S., Mar 1 2005, In : FEMS Microbiology Letters. 244, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of Drosophila aspartic proteases that induce the secretion of a golgi-resident transferase, heparan sulfate 6-O-sulfotransferase

Kotani, N., Kitazume, S., Kamimura, K., Takeo, S., Aigaki, T., Nakato, H. & Hashimoto, Y., Mar 1 2005, In : Journal of Biochemistry. 137, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog

Takeo, S., Akiyama, T., Firkus, C., Aigaki, T. & Nakato, H., Aug 1 2005, In : Developmental Biology. 284, 1, p. 204-218 15 p.

Research output: Contribution to journalArticle

47 Scopus citations

Wing-to-leg homeosis by spineless causes apoptosis regulated by fish-lips, a novel leucine-rich repeat transmembrane protein

Adachi-Yamada, T., Harumoto, T., Sakurai, K., Ueda, R., Saigo, K., O'Connor, M. B. & Nakato, H., Apr 1 2005, In : Molecular and cellular biology. 25, 8, p. 3140-3150 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2004

Analysis of the chitin recognition mechanism of cuticle proteins from the soft cuticle of the silkworm, Bombyx mori

Togawa, T., Nakato, H. & Izumi, S., Oct 1 2004, In : Insect Biochemistry and Molecular Biology. 34, 10, p. 1059-1067 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

Functional dissection of glycoconjugates during development: Lessons from the fruitfly

Selleck, S. B. & Nakato, H., Mar 2004, In : Trends in Glycoscience and Glycotechnology. 16, 88, p. 95-108 14 p.

Research output: Contribution to journalShort survey

3 Scopus citations

Glycosyltransferases as substrates for Alzheimer's beta-secretase

Kitazume, S., Kotani, N., Nakato, H., Saido, T. & Hashimoto, Y., Nov 2004, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 49, 15 Suppl, p. 2468-2472 5 p.

Research output: Contribution to journalReview article

In Vivo Hyaluronan Synthesis upon Expression of the Mammalian Hyaluronan Synthase Gene in Drosophila

Takeo, S., Fujise, M., Akiyama, T., Habuchi, H., Itano, N., Matsuo, T., Aigaki, T., Kimata, K. & Nakato, H., Apr 30 2004, In : Journal of Biological Chemistry. 279, 18, p. 18920-18925 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase

Kamimura, K., Rhodes, J. M., Ueda, R., McNeely, M., Shukla, D., Kimata, K., Spear, P. G., Shworak, N. W. & Nakato, H., Sep 27 2004, In : Journal of Cell Biology. 166, 7, p. 1069-1079 11 p.

Research output: Contribution to journalArticle

2003

Dally regulates Dpp morphogen gradient formation in the Drosophila wing

Fujise, M., Takeo, S., Kamimura, K., Matsuo, T., Aigaki, T., Izumi, S. & Nakato, H., Apr 1 2003, In : Development. 130, 8, p. 1515-1522 8 p.

Research output: Contribution to journalReview article

167 Scopus citations

Molecular cloning and characterization of a cDNA encoding a novel cuticle protein in the silkworm, Bombyx mori

Sawada, H., Nakato, H., Togawa, T., Nakagoshi, M., Takikawa, S. I., Dohke, K., Iino, T., Mase, K., Yamamoto, T. & Izumi, S., Mar 1 2003, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 134, 3, p. 519-527 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Non-mammalian model systems for functional studies of heparan sulfate proteoglycans

Nakato, H., Takeo, S. & Kamimura, K., Jun 2003, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 48, 8 Suppl, p. 1072-1078 7 p.

Research output: Contribution to journalReview article

Proteoglycan UDP-galactose:β-xylose β1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster

Takemae, H., Ueda, R., Okubo, R., Nakato, H., Izumi, S., Saigo, K. & Nishihara, S., May 2 2003, In : Journal of Biological Chemistry. 278, 18, p. 15571-15578 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2002
13 Scopus citations

Heparan sulfate fine structure and specificity of proteoglycan functions

Nakato, H. & Kimata, K., Dec 19 2002, In : Biochimica et Biophysica Acta - General Subjects. 1573, 3, p. 312-318 7 p.

Research output: Contribution to journalReview article

121 Scopus citations

Heparan sulfate proteoglycans in Drosophila morphogenesis

Nakato, H., Sep 1 2002, In : Connective Tissue. 34, 3, p. 267-275 9 p.

Research output: Contribution to journalReview article

2001

Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal system

Kamimura, K., Fujise, M., Villa, F., Izumi, S., Habuchi, H., Kimata, K. & Nakato, H., May 18 2001, In : Journal of Biological Chemistry. 276, 20, p. 17014-17021 8 p.

Research output: Contribution to journalArticle

106 Scopus citations

Glycosaminoglycans: a view from developmental genetics

Nakato, H. & Kamimura, K., Sep 2001, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 46, 12, p. 1849-1854 6 p.

Research output: Contribution to journalReview article

Heparan sulfate proteoglycans: Drosophila genetics and biochemistry provide a new insight into the regulation of their functions

Nakato, H. & Toyoda, H., Dec 1 2001, In : Seikagaku. 73, 6, p. 449-457 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of dally, an integral membrane proteoglycan, and its function during adult sensory organ formation of Drosophila

Fujise, M., Izumi, S., Selleck, S. B. & Nakato, H., Jul 15 2001, In : Developmental Biology. 235, 2, p. 433-448 16 p.

Research output: Contribution to journalArticle

54 Scopus citations

Structural analysis of gene encoding cuticle protein BMCP18, and characterization of its putative transcription factor in the silkworm, Bombyx mori

Togawa, T., Shofuda, K. I., Yaginuma, T., Tomino, S., Nakato, H. & Izumi, S., Apr 27 2001, In : Insect Biochemistry and Molecular Biology. 31, 6-7, p. 611-620 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Transcriptional and posttranscriptional regulation of the gene for Dally, a Drosophila integral membrane proteoglycan

Tsuda, M., Izumi, S. & Nakato, H., Apr 13 2001, In : FEBS Letters. 494, 3, p. 241-245 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2000

Gentic analysis of the function of a Drosophila integral membrane proteoglycan

Nakato, H., Dec 1 2000, In : Seikagaku. 72, 2, p. 109-113 5 p.

Research output: Contribution to journalArticle

1999

Biosynthesis of major plasma proteins in the primary culture of fat body cells from the silkworm, Bombyx mori

Kishimoto, A., Nakato, H., Izumi, S. & Tomino, S., Aug 15 1999, In : Cell and Tissue Research. 297, 2, p. 329-335 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Molecular cloning and characterization of a cDNA encoding a larval cuticle protein of Bombyx mori

Shofuda, K. I., Togawa, T., Nakato, H., Tomino, S. & Izumi, S., Mar 17 1999, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 122, 1, p. 105-109 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila

Tsuda, M., Kamimura, K., Nakato, H., Archer, M., Staatz, W., Fox, B., Humphrey, M., Olson, S., Futch, T., Kaluza, V., Siegfried, E., Stam, L. & Selleck, S. B., Jul 15 1999, In : Nature. 400, 6741, p. 276-280 5 p.

Research output: Contribution to journalArticle

341 Scopus citations
1998

Structure and expression of a cyst specific protein of Acanthamoeba castellanii

Hirukawa, Y., Nakato, H., Izumi, S., Tsuruhara, T. & Tomino, S., May 29 1998, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1398, 1, p. 47-56 10 p.

Research output: Contribution to journalArticle

47 Scopus citations