1986 …2018
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 3 Similar Profiles
DNA Topoisomerase IV Medicine & Life Sciences
DNA Gyrase Medicine & Life Sciences
Quinolones Medicine & Life Sciences
Type I DNA Topoisomerase Medicine & Life Sciences
DNA Chemical Compounds
Type II DNA Topoisomerase Medicine & Life Sciences
DNA Replication Medicine & Life Sciences
DNA Primase Medicine & Life Sciences

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Projects 2010 2016

fluoroquinolones

Research Output 1986 2018

1 Citations

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

Towle, T. R., Kulkarni, C. A., Oppegard, L. M., Williams, B. P., Picha, T. A., Hiasa, H. & Kerns, R. J., Jun 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 10, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

DNA Gyrase
Fluoroquinolones
Tyrosine
Catalytic Domain
Derivatives
2 Citations

DNA topoisomerases as targets for antibacterial agents

Hiasa, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 47-62 16 p. (Methods in Molecular Biology; vol. 1703).

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Topoisomerases
Fluoroquinolones
Topoisomerase Inhibitors
Anti-Bacterial Agents
Topoisomerase I Inhibitors

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B. J., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Jan 1 2018, (Accepted/In press) In : Investigational New Drugs.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Fluoroquinolones
Heterografts
Human Activities
Poisoning
7 Citations

Topoisomerases as anticancer targets

Delgado, J. L., Hsieh, C. M., Chan, N. L. & Hiasa, H., Jan 31 2018, In : Biochemical Journal. 475, 2, p. 373-398 26 p.

Research output: Contribution to journalReview article

Topoisomerase Inhibitors
Antineoplastic Agents
Poisons
Pharmaceutical Preparations
Neoplasms
2 Citations

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site

Oppegard, L. M., Schwanz, H. A., Towle, T. R., Kerns, R. J. & Hiasa, H., Mar 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 3, p. 569-575 7 p.

Research output: Contribution to journalArticle

DNA Topoisomerase IV
DNA Cleavage
Fluoroquinolones
Metals
Binding Sites