1986 …2018
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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 3 Similar Profiles
DNA Topoisomerase IV Medicine & Life Sciences
DNA Gyrase Medicine & Life Sciences
Quinolones Medicine & Life Sciences
DNA Chemical Compounds
Type I DNA Topoisomerase Medicine & Life Sciences
Type II DNA Topoisomerase Medicine & Life Sciences
DNA Replication Medicine & Life Sciences
DNA Primase Medicine & Life Sciences

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Projects 2010 2016

fluoroquinolones

Research Output 1986 2018

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

Towle, T. R., Kulkarni, C. A., Oppegard, L. M., Williams, B. P., Picha, T. A., Hiasa, H. & Kerns, R. J. Jan 1 2018 (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

DNA Gyrase
Fluoroquinolones
Tyrosine
Catalytic Domain
Type II DNA Topoisomerase
1 Citations

DNA topoisomerases as targets for antibacterial agents

Hiasa, H. Jan 1 2018 Methods in Molecular Biology. Humana Press Inc., p. 47-62 16 p. (Methods in Molecular Biology; vol. 1703)

Research output: Chapter in Book/Report/Conference proceedingChapter

DNA Topoisomerases
Fluoroquinolones
Topoisomerase Inhibitors
Anti-Bacterial Agents
Topoisomerase I Inhibitors
3 Citations

Topoisomerases as anticancer targets

Delgado, J. L., Hsieh, C. M., Chan, N. L. & Hiasa, H. Jan 31 2018 In : Biochemical Journal. 475, 2, p. 373-398 26 p.

Research output: Contribution to journalReview article

Slip forming
Gasohol
Topoisomerase Inhibitors
Antineoplastic Agents
Neoplasms
2 Citations

Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg2+ to the second metal binding site

Oppegard, L. M., Schwanz, H. A., Towle, T. R., Kerns, R. J. & Hiasa, H. Mar 1 2016 In : Biochimica et Biophysica Acta - General Subjects. 1860, 3, p. 569-575 7 p.

Research output: Contribution to journalArticle

DNA Topoisomerase IV
DNA Cleavage
Fluoroquinolones
Metals
Binding Sites
7 Citations

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

Malik, M., Mustaev, A., Schwanz, H. A., Luan, G., Shah, N., Oppegard, L. M., De Souza, E. C., Hiasa, H., Zhao, X., Kerns, R. J. & Drlica, K. Mar 16 2016 In : Nucleic acids research. 44, 7, p. 3304-3316 13 p.

Research output: Contribution to journalArticle

Quinolones
Fluoroquinolones
DNA Topoisomerase IV
Type I DNA Topoisomerase
Pharmaceutical Preparations