Hiroshi Hiasa

1986 …2019
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  • 3 Similar Profiles
DNA Topoisomerase IV Medicine & Life Sciences
DNA Gyrase Medicine & Life Sciences
Quinolones Medicine & Life Sciences
Type I DNA Topoisomerase Medicine & Life Sciences
DNA Chemical Compounds
Type II DNA Topoisomerase Medicine & Life Sciences
DNA Replication Medicine & Life Sciences
Fluoroquinolones Medicine & Life Sciences

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Projects 2010 2016

fluoroquinolones

Research Output 1986 2019

2 Citations (Scopus)
Quinolones
Fluoroquinolones
DNA Topoisomerase IV
Mutation
Staphylococcus haemolyticus
1 Citation (Scopus)

Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity

Oppegard, L. M., Delgado, J. L., Kulkarni, C. A., Towle, T. R., Hart, D. E., Williams, B. P., Lentz, S. R. C., Norris, B., Flory, C. M., Schumacher, R. J., Murry, D. J., Kerns, R. J. & Hiasa, H., Apr 15 2019, In : Investigational New Drugs. 37, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

Open Access
Type I DNA Topoisomerase
Fluoroquinolones
Heterografts
Human Activities
Poisoning

Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone

Delgado, J. L., Lentz, S. R. C., Kulkarni, C. A., Chheda, P. R., Held, H. A., Hiasa, H. & Kerns, R. J., Jun 15 2019, In : European Journal of Medicinal Chemistry. 172, p. 109-130 22 p.

Research output: Contribution to journalArticle

Type I DNA Topoisomerase
Fluoroquinolones
Quinolones
Functional groups
DNA
1 Citation (Scopus)

The C7-aminomethylpyrrolidine group rescues the activity of a thio-fluoroquinolone

Lentz, S. R. C., Chheda, P. R., Oppegard, L. M., Towle, T. R., Kerns, R. J. & Hiasa, H., May 1 2019, In : Biochimie. 160, p. 24-27 4 p.

Research output: Contribution to journalArticle

Fluoroquinolones
DNA Gyrase
Quinolones
Type I DNA Topoisomerase
Pathogens
6 Citations (Scopus)

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

Towle, T. R., Kulkarni, C. A., Oppegard, L. M., Williams, B. P., Picha, T. A., Hiasa, H. & Kerns, R. J., Jun 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 10, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

DNA Gyrase
Fluoroquinolones
Tyrosine
Catalytic Domain
Derivatives