19992022

Research output per year

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Research Output

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2019
2018

Arenaviral nucleoproteins suppress PACT-induced augmentation of RIG-I function to inhibit type I interferon production

Shao, J., Huang, Q., Liu, X., Di, D., Liang, Y. & Ly, H., Jul 1 2018, In : Journal of virology. 92, 13, e00482-18.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site

Chen, J., Zhang, J., Zhu, W., Zhang, Y., Tan, H., Liu, M., Cai, M., Shen, J., Ly, H. & Chen, J., Dec 1 2017, In : Scientific reports. 7, 1, 9972.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2016

A novel live Pichinde virus-based vaccine vector induces enhanced humoral and cellular immunity after a booster dose

Dhanwani, R., Zhou, Y., Huang, Q., Verma, V., Dileepan, M., Ly, H. & Liang, Y., Jan 1 2016, In : Journal of virology. 90, 5, p. 2551-2560 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Characterization of the glycoprotein stable signal peptide in mediating Pichinde virus replication and virulence

Shao, J., Liu, X., Ly, H. & Liang, Y., Jan 1 2016, In : Journal of virology. 90, 22, p. 10390-10397 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Inhibition of innate immune responses is key to pathogenesis by arenaviruses

Meyer, B. & Ly, H., Apr 1 2016, In : Journal of virology. 90, 8, p. 3810-3818 9 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2015

Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: A cohort study in China

Lu, Q. B., Cui, N., Hu, J. G., Chen, W. W., Xu, W., Li, H., Zhang, X. A., Ly, H., Liu, W. & Cao, W. C., Mar 3 2015, In : Vaccine. 33, 10, p. 1250-1255 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
9 Scopus citations

In Vitro and In Vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions

Huang, Q., Shao, J., Lan, S., Zhou, Y., Xing, J., Dong, C., Liang, Y. & Ly, H., Jan 1 2015, In : Journal of virology. 89, 13, p. 6595-6607 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-i-like receptor-dependent interferon production

Xing, J., Ly, H. & Liang, Y., Jan 1 2015, In : Journal of virology. 89, 5, p. 2944-2955 12 p.

Research output: Contribution to journalArticle

52 Scopus citations
2014

Characterization of chikungunya virus induced host response in a mouse model of viral myositis

Dhanwani, R., Khan, M., Lomash, V., Rao, P. V. L., Ly, H. & Parida, M., Mar 25 2014, In : PloS one. 9, 3, e92813.

Research output: Contribution to journalArticle

14 Scopus citations

High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions

Wallat, G. D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y. & Dong, C., Feb 7 2014, In : PloS one. 9, 2, e87577.

Research output: Contribution to journalArticle

18 Scopus citations

PLC-γ1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus

Zhu, L., Ly, H. & Liang, Y., Jan 1 2014, In : Journal of virology. 88, 1, p. 417-424 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Identification of virulence determinants within the L genomic segment of the pichinde arenavirus

McLay, L., Lan, S., Ansari, A., Liang, Y. & Ly, H., Jun 1 2013, In : Journal of virology. 87, 12, p. 6635-6643 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression

Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y. & Dong, C., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 16949-16959 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Biological roles and functional mechanisms of arenavirus Z protein in viral replication

Wang, J., Danzy, S., Kumar, N., Ly, H. & Liang, Y., Sep 1 2012, In : Journal of virology. 86, 18, p. 9794-9801 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus

Kumar, N., Wang, J., Lan, S., Danzy, S., McLay Schelde, L., Seladi-Schulman, J., Ly, H. & Liang, Y., Nov 10 2012, In : Virology. 433, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model

Makarova, N., Zhao, C., Zhang, Y., Bhosle, S., Suppiah, S., Rhea, J. M., Kozyr, N., Arnold, R. S., Ly, H., Molinaro, R. J., Parslow, T. G., Hunter, E., Liotta, D., Petros, J. & Blackwell, J. L., Apr 12 2011, In : PloS one. 6, 4, e18272.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations

Receptor tyrosine kinase inhibitors that block replication of influenza A and other viruses

Kumar, N., Sharma, N. R., Ly, H., Parslow, T. G. & Liang, Y., Dec 1 2011, In : Antimicrobial agents and chemotherapy. 55, 12, p. 5553-5559 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors

Xin, Z. T., Carroll, K. A., Kumar, N., Song, K. & Ly, H., Jun 29 2011, In : PloS one. 6, 6, e21333.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

Qi, X., Lan, S., Wang, W., Schelde, L. M., Dong, H., Wallat, G. D., Ly, H., Liang, Y. & Dong, C., Dec 9 2010, In : Nature. 468, 7325, p. 779-785 7 p.

Research output: Contribution to journalArticle

172 Scopus citations

Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells

Bhosle, S., Suppiah, S., Molinaro, R., Liang, Y., Arnold, R., Diehl, W., Makarova, N., Blackwell, J., Petros, J., Liotta, D., Hunter, E. & Ly, H., Jul 1 2010, In : Journal of virology. 84, 13, p. 6288-6296 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

XMRV Infection in Patients With Prostate Cancer: Novel Serologic Assay and Correlation With PCR and FISH

Arnold, R. S., Makarova, N. V., Osunkoya, A. O., Suppiah, S., Scott, T. A., Johnson, N. A., Bhosle, S. M., Liotta, D., Hunter, E., Marshall, F. F., Ly, H., Molinaro, R. J., Blackwell, J. L. & Petros, J. A., Apr 1 2010, In : Urology. 75, 4, p. 755-761 7 p.

Research output: Contribution to journalArticle

93 Scopus citations
2009

Development of infectious clones for virulent and avirulent pichinde viruses: A model virus to study arenavirus-induced hemorrhagic fevers

Lan, S., Schelde, L. M., Wang, J., Kumar, N., Ly, H. & Liang, Y., Jul 1 2009, In : Journal of virology. 83, 13, p. 6357-6362 6 p.

Research output: Contribution to journalArticle

41 Scopus citations
2008

Genome comparison of virulent and avirulent strains of the Pichinde arenavirus

Lan, S., McLay, L., Aronson, J., Ly, H. & Liang, Y., Jul 1 2008, In : Archives of Virology. 153, 7, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Identification and functional characterization of novel telomerase variant alleles in Japanese patients with bone-marrow failure syndromes

Takeuchi, J., Ly, H., Yamaguchi, H., Carroll, K. A., Kosaka, F., Sawaguchi, K., Mitamura, Y., Watanabe, A., Gomi, S., Inokuchi, K. & Dan, K., Mar 1 2008, In : Blood Cells, Molecules, and Diseases. 40, 2, p. 185-191 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

IL-12 RB1 genetic variants contribute to human susceptibility to severe acute respiratory syndrome infection among Chinese

Tang, F., Liu, W., Zhang, F., Xin, Z. T., Wei, M. T., Zhang, P. H., Yang, H., Ly, H. & Cao, W. C., May 14 2008, In : PloS one. 3, 5, e2183.

Research output: Contribution to journalArticle

8 Scopus citations

Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments

Liang, Y., Huang, T., Ly, H., Parslow, T. G. & Liang, Y., Jan 1 2008, In : Journal of virology. 82, 1, p. 229-236 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

NF-κB signaling differentially regulates influenza virus RNA synthesis

Kumar, N., Xin, Z. T., Liang, Y., Ly, H. & Liang, Y., Oct 1 2008, In : Journal of virology. 82, 20, p. 9880-9889 10 p.

Research output: Contribution to journalArticle

111 Scopus citations

Short report: Failure of Japanese encephalitis vaccine and infection in inducing neutralizing antibodies against West Nile Virus, People's Republic of China

Tang, F., Zhang, J. S., Liu, W., Zhao, Q. M., Zhang, F., Wu, X. M., Yang, H., Ly, H. & Cao, W. C., Jun 1 2008, In : American Journal of Tropical Medicine and Hygiene. 78, 6, p. 999-1001 3 p.

Research output: Contribution to journalArticle

11 Scopus citations

Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells

Tomlinson, R. L., Abreu, E. B., Ziegler, T., Ly, H., Counter, C. M., Terns, R. M. & Terns, M. P., Sep 1 2008, In : Molecular biology of the cell. 19, 9, p. 3793-3800 8 p.

Research output: Contribution to journalArticle

53 Scopus citations
2007

Functional characterization of natural telomerase mutations found in patients with hematologic disorders

Xin, H. T., Beauchamp, A. D., Calado, R. T., Bradford, J. W., Regal, J. A., Shenoy, A., Liang, Y., Lansdorp, P. M., Young, N. S. & Ly, H., Jan 15 2007, In : Blood. 109, 2, p. 524-532 9 p.

Research output: Contribution to journalArticle

78 Scopus citations

Functional characterization of yeast telomerase RNA dimerization

Gipson, C. L., Xin, Z. T., Danzy, S. C., Parslow, T. G. & Ly, H., Jun 29 2007, In : Journal of Biological Chemistry. 282, 26, p. 18857-18863 7 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

Genetic variation in telomeric repeat binding factors 1 and 2 in aplastic anemia

Savage, S. A., Calado, R. T., Xin, Z. T., Ly, H., Young, N. S. & Chanock, S. J., May 1 2006, In : Experimental Hematology. 34, 5, p. 664-671 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Functional characterization of telomerase RNA variants found in patients with hematologic disorders

Ly, H., Calado, R. T., Allard, P., Baerlocher, G. M., Lansdorp, P. M., Young, N. S. & Parslow, T. G., Mar 15 2005, In : Blood. 105, 6, p. 2332-2339 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita

Ly, H., Schertzer, M., Jastaniah, W., Davis, J., Yong, S. L., Ouyang, Q., Blackburn, E. H., Parslow, T. G. & Lansdorp, P. M., Aug 15 2005, In : Blood. 106, 4, p. 1246-1252 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia

Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M. & Young, N. S., Apr 7 2005, In : New England Journal of Medicine. 352, 14, p. 1413-1424 12 p.

Research output: Contribution to journalArticle

504 Scopus citations

Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes

Khan, M. A., Kao, S., Miyagi, E., Takeuchi, H., Goila-Gaur, R., Opi, S., Gipson, C. L., Parslow, T. G., Ly, H. & Strebel, K., May 1 2005, In : Journal of virology. 79, 9, p. 5870-5874 5 p.

Research output: Contribution to journalArticle

143 Scopus citations
2004

A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein

Lin, J., Ly, H., Hussain, A., Abraham, M., Pearl, S., Tzfati, Y., Parslow, T. G. & Blackburn, E. H., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14713-14718 6 p.

Research output: Contribution to journalArticle

84 Scopus citations

The RNA-binding protein SUP-12 controls muscle-specific splicing of the ADF/cofilin pre-mRNA in C. elegans

Anyanful, A., Ono, K., Johnsen, R. C., Ly, H., Jensen, V., Baillie, D. L. & Ono, S., Nov 22 2004, In : Journal of Cell Biology. 167, 4, p. 639-647 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase

Ly, H., Xu, L., Rivera, M. A., Parslow, T. G. & Blackburn, E. H., May 1 2003, In : Genes and Development. 17, 9, p. 1078-1083 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

Comprehensive structure-function analysis of the core domain of human telomerase RNA

Ly, H., Blackburn, E. H. & Parslow, T. G., Oct 1 2003, In : Molecular and cellular biology. 23, 19, p. 6849-6856 8 p.

Research output: Contribution to journalArticle

78 Scopus citations
2002

Bipartite signal for genomic RNA dimerization in Moloney murine leukemia virus

Ly, H. & Parslow, T. G., Mar 25 2002, In : Journal of virology. 76, 7, p. 3135-3144 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2000

Functional characterization of the dimer linkage structure RNA of Moloney murine sarcoma virus

Ly, H., Nierlich, D. P., Olsen, J. C. & Kaplan, A. H., Jan 1 2000, In : Journal of virology. 74, 21, p. 9937-9945 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
1999

Moloney murine sarcoma virus genomic RNAs dimerize via a two-step process: A concentration-dependent kissing-loop interaction is driven by initial contact between consecutive guanines

Ly, H., Nierlich, D. P., Olsen, J. C. & Kaplan, A. H., Aug 23 1999, In : Journal of virology. 73, 9, p. 7255-7261 7 p.

Research output: Contribution to journalArticle

22 Scopus citations