19992022

Research output per year

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Research Output

2020

Animal models of lassa fever

Sattler, R. A., Paessler, S., Ly, H. & Huang, C., Mar 2020, In : Pathogens. 9, 3, 197.

Research output: Contribution to journalReview article

Open Access

Host-Directed Antiviral Therapy

Kumar, N., Sharma, S., Kumar, R., Tripathi, B. N., Barua, S., Ly, H. & Rouse, B. T., Jun 17 2020, In : Clinical microbiology reviews. 33, 3

Research output: Contribution to journalReview article

2019

Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5

Brisse, M. & Ly, H., Jan 1 2019, In : Frontiers in immunology. 10, JULY, 1586.

Research output: Contribution to journalReview article

Open Access
14 Scopus citations

Hemorrhagic fever-causing arenaviruses: Lethal pathogens and potent immune suppressors

Brisse, M. E. & Ly, H., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 372.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations
2018

Arenaviral nucleoproteins suppress PACT-induced augmentation of RIG-I function to inhibit type I interferon production

Shao, J., Huang, Q., Liu, X., Di, D., Liang, Y. & Ly, H., Jul 1 2018, In : Journal of virology. 92, 13, e00482-18.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Assays to assess arenaviral glycoprotein function

Shao, J., Liu, X., Liang, Y. & Ly, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 169-178 10 p. (Methods in Molecular Biology; vol. 1604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Assays to demonstrate the roles of arenaviral nucleoproteins (NPs) in viral RNA synthesis and in suppressing type I interferon

Huang, Q., Shao, J., Liang, Y. & Ly, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 189-200 12 p. (Methods in Molecular Biology; vol. 1604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Establishment of bisegmented and trisegmented reverse genetics systems to generate recombinant pichindé viruses

Dhanwani, R., Huang, Q., Lan, S., Zhou, Y., Shao, J., Liang, Y. & Ly, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 247-253 7 p. (Methods in Molecular Biology; vol. 1604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
1 Scopus citations

Expression and x-ray structural determination of the nucleoprotein of lassa fever virus

Qi, X., Wang, W., Dong, H., Liang, Y., Dong, C. & Ly, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 179-188 10 p. (Methods in Molecular Biology; vol. 1604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Roles of Arenavirus Z Protein in Mediating Virion Budding, Viral Transcription-Inhibition and Interferon-Beta Suppression

Shao, J., Liang, Y. & Ly, H., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 217-227 11 p. (Methods in Molecular Biology; vol. 1604).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
2 Scopus citations
2017

Differential immune responses to new world and old world mammalian arenaviruses

Ly, H., May 12 2017, In : International journal of molecular sciences. 18, 5, 1040.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

First genome report and analysis of chicken H7N9 influenza viruses with poly-basic amino acids insertion in the hemagglutinin cleavage site

Chen, J., Zhang, J., Zhu, W., Zhang, Y., Tan, H., Liu, M., Cai, M., Shen, J., Ly, H. & Chen, J., Dec 1 2017, In : Scientific reports. 7, 1, 9972.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Immunosuppression by viral N proteins

Chen, J. & Ly, H., Feb 7 2017, In : Oncotarget. 8, 31, p. 50331-50332 2 p.

Research output: Contribution to journalEditorial

Open Access

Recombinant tri-segmented Pichinde virus as a novel live viral vaccine platform

Dhanwani, R., Ly, H. & Liang, Y., Jan 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 169-179 11 p. (Methods in Molecular Biology; vol. 1581).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
1 Scopus citations

Uniquely conserved immunosuppressive viral exoribonucleases

Meyer, B. & Ly, H., Jan 1 2017, In : Oncotarget. 8, 4, p. 5650-5651 2 p.

Research output: Contribution to journalEditorial

Open Access

Viral inhibitions of PACT-induced RIG-I activation

Brisse, M. & Ly, H., Sep 1 2017, In : Oncotarget. 8, 37, p. 60725-60726 2 p.

Research output: Contribution to journalEditorial

Open Access
2 Scopus citations
2016

A novel live Pichinde virus-based vaccine vector induces enhanced humoral and cellular immunity after a booster dose

Dhanwani, R., Zhou, Y., Huang, Q., Verma, V., Dileepan, M., Ly, H. & Liang, Y., Jan 1 2016, In : Journal of virology. 90, 5, p. 2551-2560 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Arenaviral vaccine vectors to combat infectious diseases

Dhanwani, R. & Ly, H., Jan 1 2016, In : Oncotarget. 7, 29, 1 p.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Characterization of the glycoprotein stable signal peptide in mediating Pichinde virus replication and virulence

Shao, J., Liu, X., Ly, H. & Liang, Y., Jan 1 2016, In : Journal of virology. 90, 22, p. 10390-10397 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Inhibition of innate immune responses is key to pathogenesis by arenaviruses

Meyer, B. & Ly, H., Apr 1 2016, In : Journal of virology. 90, 8, p. 3810-3818 9 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Virulence profile: Hinh Ly

Ly, H., Nov 16 2016, In : Virulence. 7, 8, p. 895-897 3 p.

Research output: Contribution to journalComment/debate

Open Access
2015

Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: A cohort study in China

Lu, Q. B., Cui, N., Hu, J. G., Chen, W. W., Xu, W., Li, H., Zhang, X. A., Ly, H., Liu, W. & Cao, W. C., Mar 3 2015, In : Vaccine. 33, 10, p. 1250-1255 6 p.

Research output: Contribution to journalArticle

16 Scopus citations
9 Scopus citations

Human hemorrhagic fever causing arenaviruses: Molecular mechanisms contributing to virus virulence and disease pathogenesis

Shao, J., Liang, Y. & Ly, H., May 21 2015, In : Pathogens. 4, 2, p. 283-306 24 p.

Research output: Contribution to journalReview article

23 Scopus citations

Immune evasion mechanisms of arenaviruses

Ly, H. & Liang, Y., Jan 1 2015, In : Oncotarget. 6, 38, p. 40386-40387 2 p.

Research output: Contribution to journalEditorial

Immunosuppression by hemorrhagic fever-causing viruses

Ly, H., Jan 1 2015, In : Oncotarget. 6, 42, p. 44057-44058 2 p.

Research output: Contribution to journalEditorial

Immunosuppressive arenaviral exoribonuclease

Meyer, B. & Ly, H., Jan 1 2015, In : Oncotarget. 6, 32, p. 32315-32316 2 p.

Research output: Contribution to journalEditorial

In Vitro and In Vivo characterizations of pichinde viral nucleoprotein exoribonuclease functions

Huang, Q., Shao, J., Lan, S., Zhou, Y., Xing, J., Dong, C., Liang, Y. & Ly, H., Jan 1 2015, In : Journal of virology. 89, 13, p. 6595-6607 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

The Z proteins of pathogenic but not nonpathogenic arenaviruses inhibit RIG-i-like receptor-dependent interferon production

Xing, J., Ly, H. & Liang, Y., Jan 1 2015, In : Journal of virology. 89, 5, p. 2944-2955 12 p.

Research output: Contribution to journalArticle

52 Scopus citations
2014

Characterization of chikungunya virus induced host response in a mouse model of viral myositis

Dhanwani, R., Khan, M., Lomash, V., Rao, P. V. L., Ly, H. & Parida, M., Mar 25 2014, In : PloS one. 9, 3, e92813.

Research output: Contribution to journalArticle

14 Scopus citations

Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections

McLay, L., Liang, Y. & Ly, H., Jan 1 2014, In : Journal of General Virology. 95, PART 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

34 Scopus citations

High-resolution structure of the N-terminal endonuclease domain of the Lassa virus L polymerase in complex with magnesium ions

Wallat, G. D., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y. & Dong, C., Feb 7 2014, In : PloS one. 9, 2, e87577.

Research output: Contribution to journalArticle

18 Scopus citations

Peste des petits ruminants virus infection of small ruminants: A comprehensive review

Kumar, N., Maherchandani, S., Kashyap, S. K., Singh, S. V., Sharma, S., Chaubey, K. K. & Ly, H., Jun 6 2014, In : Viruses. 6, 6, p. 2287-2327 41 p.

Research output: Contribution to journalReview article

72 Scopus citations

PLC-γ1 signaling plays a subtype-specific role in postbinding cell entry of influenza A virus

Zhu, L., Ly, H. & Liang, Y., Jan 1 2014, In : Journal of virology. 88, 1, p. 417-424 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Identification of virulence determinants within the L genomic segment of the pichinde arenavirus

McLay, L., Lan, S., Ansari, A., Liang, Y. & Ly, H., Jun 1 2013, In : Journal of virology. 87, 12, p. 6635-6643 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Structures of arenaviral nucleoproteins with triphosphate dsRNA reveal a unique mechanism of immune suppression

Jiang, X., Huang, Q., Wang, W., Dong, H., Ly, H., Liang, Y. & Dong, C., Jun 7 2013, In : Journal of Biological Chemistry. 288, 23, p. 16949-16959 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever

McLay, L., Ansari, A., Liang, Y. & Ly, H., Feb 1 2013, In : Antiviral Research. 97, 2, p. 81-92 12 p.

Research output: Contribution to journalReview article

17 Scopus citations
2012

Biological roles and functional mechanisms of arenavirus Z protein in viral replication

Wang, J., Danzy, S., Kumar, N., Ly, H. & Liang, Y., Sep 1 2012, In : Journal of virology. 86, 18, p. 9794-9801 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
6 Scopus citations

Characterization of virulence-associated determinants in the envelope glycoprotein of Pichinde virus

Kumar, N., Wang, J., Lan, S., Danzy, S., McLay Schelde, L., Seladi-Schulman, J., Ly, H. & Liang, Y., Nov 10 2012, In : Virology. 433, 1, p. 97-103 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model

Makarova, N., Zhao, C., Zhang, Y., Bhosle, S., Suppiah, S., Rhea, J. M., Kozyr, N., Arnold, R. S., Ly, H., Molinaro, R. J., Parslow, T. G., Hunter, E., Liotta, D., Petros, J. & Blackwell, J. L., Apr 12 2011, In : PloS one. 6, 4, e18272.

Research output: Contribution to journalArticle

6 Scopus citations
1 Scopus citations

Receptor tyrosine kinase inhibitors that block replication of influenza A and other viruses

Kumar, N., Sharma, N. R., Ly, H., Parslow, T. G. & Liang, Y., Dec 1 2011, In : Antimicrobial agents and chemotherapy. 55, 12, p. 5553-5559 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors

Xin, Z. T., Carroll, K. A., Kumar, N., Song, K. & Ly, H., Jun 29 2011, In : PloS one. 6, 6, e21333.

Research output: Contribution to journalArticle

3 Scopus citations
2010

Cap binding and immune evasion revealed by Lassa nucleoprotein structure

Qi, X., Lan, S., Wang, W., Schelde, L. M., Dong, H., Wallat, G. D., Ly, H., Liang, Y. & Dong, C., Dec 9 2010, In : Nature. 468, 7325, p. 779-785 7 p.

Research output: Contribution to journalArticle

172 Scopus citations

Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells

Bhosle, S., Suppiah, S., Molinaro, R., Liang, Y., Arnold, R., Diehl, W., Makarova, N., Blackwell, J., Petros, J., Liotta, D., Hunter, E. & Ly, H., Jul 1 2010, In : Journal of virology. 84, 13, p. 6288-6296 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of TINF2 gene mutations in adult Japanese patients with acquired bone marrow failure syndromes: Correspondence

Yamaguchi, H., Inokuchi, K., Takeuchi, J., Tamai, H., Mitamura, Y., Kosaka, F., Ly, H. & Dan, K., Sep 1 2010, In : British Journal of Haematology. 150, 6, p. 725-727 3 p.

Research output: Contribution to journalLetter

5 Scopus citations