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Research Output 1972 2019

1989
19 Citations (Scopus)

Regulation of HLA class I transcription in T cells

Zachow, K. R. & Orr, H. T., Jan 1 1989, In : Journal of Immunology. 143, 10, p. 3385-3389 5 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Cell Line
Thymocytes
DNA
HLA-A2 Antigen
1988
122 Citations (Scopus)

cDNA cloning and characterization of three genes uniquely expressed in cerebellum by Purkinje neurons

Nordquist, D. T., Kozak, C. A. & Orr, H. T., Dec 1 1988, In : Journal of Neuroscience. 8, 12, p. 4780-4789 10 p.

Research output: Contribution to journalArticle

Purkinje Cells
Cerebellum
Organism Cloning
Complementary DNA
Clone Cells

Cystic Fibrosis: Chromosome 7 DNA Genotyping: An Aide in Resolving Ambiguous Diagnoses in Siblings of Known Patients

Orr, H. T., Parker, T., Wielinski, C. L., Clawson, C. C. & Warwick, W. J., Dec 1988, In : Clinical Pediatrics. 27, 12, p. 591-595 5 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 7
Sweat
Genetic Markers
Cystic Fibrosis
Siblings
13 Citations (Scopus)

Diagnosis of classical steroid 21-hydroxylase deficiency using an HLA-B locus-specific DNA-probe

Killeen, A. A., Seelig, S., Ulstrom, R. A. & Orr, H. T., Jan 1 1988, In : American Journal of Medical Genetics. 29, 3, p. 703-712 10 p.

Research output: Contribution to journalArticle

Steroid 21-Hydroxylase
HLA-B Antigens
DNA Probes
Serotyping
Genotype
192 Citations (Scopus)

HLA-E: A novel HLA class I gene expressed in resting T lymphocytes

Koller, B. H., Geraghty, D. E., Shimizu, Y., DeMars, R. & Orr, H. T., Jan 1 1988, In : Journal of Immunology. 141, 3, p. 897-904 8 p.

Research output: Contribution to journalArticle

MHC Class I Genes
T-Lymphocytes
RNA
HLA-C Antigens
Genes
39 Citations (Scopus)

Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution

Sung Yoon Choo, Y. C., Thomas, S. J., Orr, H. T. & Hansen, J. A., Jan 1 1988, In : Human Immunology. 21, 3, p. 209-219 11 p.

Research output: Contribution to journalArticle

HLA-B27 Antigen
HLA-B Antigens
Isoantigens
Cytotoxic T-Lymphocytes
Amino Acid Substitution
176 Citations (Scopus)
MHC Class I Genes
Major Histocompatibility Complex
HLA-A Antigens
HLA-B Antigens
beta 2-Microglobulin
1987
423 Citations (Scopus)
MHC Class I Genes
Major Histocompatibility Complex
HLA-A Antigens
HLA-B Antigens
Genetic Promoter Regions
8 Citations (Scopus)

Failure to detect human cytomegalovirus dna in igm-seropositive blood donors by spot hybridization

Brooks Jackson, J., Orr, H. T., Jeffrey McCullough, J. & Colin Jordan, M., Jan 1 1987, In : Journal of Infectious Diseases. 156, 6, p. 1013-1016 4 p.

Research output: Contribution to journalArticle

Viral Antibodies
Nucleic Acid Hybridization
Carrier State
Viral Genes
Viral DNA
283 Citations (Scopus)

Linkage map of the human major histocompatibility complex including the tumor necrosis factor genes

Carroll, M. C., Katzman, P., Alicot, E. M., Koller, B. H., Geraghty, D. E., Orr, H. T., Strominger, J. L. & Spies, T., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 23, p. 8535-8539 5 p.

Research output: Contribution to journalArticle

HLA-B Antigens
Major Histocompatibility Complex
Tumor Necrosis Factor-alpha
HLA-C Antigens
Steroid 21-Hydroxylase
39 Citations (Scopus)

Organization of the human class I major histocompatibility complex genes

Koller, B. H., Geraghty, D., Orr, H. T., Shimizu, Y. & DeMars, R., Mar 1 1987, In : Immunologic Research. 6, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

Nucleic Acid Sequence Homology
Molecular Cloning
Multigene Family
HLA Antigens
Major Histocompatibility Complex
38 Citations (Scopus)

Spinocerebellar ataxia: Localization of an autosomal dominant locus between two markers on human chromosome 6

Rich, S. S., Wilkie, P., Schut, L., Vance, G. & Orr, H. T., Dec 1 1987, In : American Journal of Human Genetics. 41, 4, p. 524-531 8 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Chromosomes, Human, Pair 6
Human Chromosomes
Cerebellar Cortex
HLA-A Antigens
1986
3 Citations (Scopus)

Comparison of enzymatic activity with evidence of engraftment in patients with inborn errors of metabolism receiving allogeneic marrow transplantation

Blazar, B. R., Whitley, C. B., Desnick, R. J., Pierpont, M. E., Filipovich, A. H., Ramsay, N. K., Kersey, J. H., Orr, H. T., Yasmineh, W. G. & Tsai, M. Y., Sep 18 1986, In : Birth Defects: Original Article Series. 22, 1, p. 135-152 18 p.

Research output: Contribution to journalArticle

Chondro-4-Sulfatase
Iduronidase
Mucopolysaccharidosis VI
Cerebroside-Sulfatase
Metachromatic Leukodystrophy
18 Citations (Scopus)

Successful donor cell engraftment in a recipient of bone marrow from a cadaveric donor

Blazar, B. R., Lasky, L. C., Perentesis, J. P., Watson, K. V., Steinberg, S. E., Filipovich, A. H., Orr, H. T. & Ramsay, N. K., Oct 8 1986, In : Blood. 67, 6, p. 1655-1660 6 p.

Research output: Contribution to journalArticle

Transplantation (surgical)
Trypan Blue
Liquid nitrogen
Grafts
Assays
47 Citations (Scopus)

Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoid cells

Shimizu, Y., Koller, B., Geraghty, D., Orr, H., Shaw, S., Kavathas, P. & DeMars, R., Jan 1 1986, In : Molecular and cellular biology. 6, 4, p. 1074-1087 14 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
MHC Class I Genes
HLA-A2 Antigen
Genes
Human Herpesvirus 4
9 Citations (Scopus)

Use of DNA probes from the 5′ flanking region of the HLA-B gene to examine polymorphism at the HLA-B locus

Steere, K., Sidwell, B., Leach, R., Ward, F. E., Taurog, J. D. & Orr, H. T., Jan 1 1986, In : Human Immunology. 16, 2, p. 137-147 11 p.

Research output: Contribution to journalArticle

HLA-B Antigens
5' Flanking Region
DNA Probes
HLA-C Antigens
Genes
1985
200 Citations (Scopus)

Cloning and complete sequence of an HLA-A2 gene: Analysis of two HLA-A alleles at the nucleotide level

Koller, B. H. & Orr, H. T., Jan 1 1985, In : Journal of Immunology. 134, 4, p. 2727-2733 7 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
HLA-A Antigens
Organism Cloning
Nucleotides
HLA-A3 Antigen
15 Citations (Scopus)

Comparison of multiple HLA-A alleles at the DNA level by using southern blotting and HLA-A-specific probes

Koller, B. H., Ward, F. E., DeMars, R. & Orr, H. T., Dec 1 1985, In : Journal of Immunology. 135, 6, p. 4229-4234 6 p.

Research output: Contribution to journalArticle

HLA-A Antigens
Southern Blotting
Alleles
DNA
HLA DNA Probes
154 Citations (Scopus)

Mutations that impair a posttranscriptional step in expression of HLA-A and -B antigens

DeMars, R., Rudersdorf, R., Chang, C., Petersen, J., Strandtmann, J., Korn, N., Sidwell, B. & Orr, H. T., Dec 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 23, p. 8183-8187 5 p.

Research output: Contribution to journalArticle

HLA-A Antigens
HLA-B Antigens
Mutation
Major Histocompatibility Complex
Genes
99 Citations (Scopus)

Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation

Blazar, B. R., Orr, H. T., Arthur, D. C., Kersey, J. H. & Filipovich, A. H., Dec 1 1985, In : Blood. 66, 6, p. 1436-1444 9 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Polymorphism
Restriction Fragment Length Polymorphisms
Bone Marrow
Tissue Donors
1984
94 Citations (Scopus)

Isolation of HLA locus-specific DNA probes from the 3'-untranslated region

Koller, B. H., Sidwell, B., DeMars, R. & Orr, H. T., Jan 1 1984, In : Proceedings of the National Academy of Sciences of the United States of America. 81, 16 I, p. 5175-5178 4 p.

Research output: Contribution to journalArticle

HLA-A Antigens
HLA-B Antigens
DNA Probes
3' Untranslated Regions
MHC Class I Genes
Bone Marrow Transplantation
Genetic Markers
1983
40 Citations (Scopus)

Class I-like HLA genes map telomeric to the HLA-A2 locus in human cells

Orr, H. T. & Demars, R., Dec 1 1983, In : Nature. 302, 5908, p. 534-536 3 p.

Research output: Contribution to journalArticle

MHC Class I Genes
HLA-A2 Antigen
Major Histocompatibility Complex
DNA
HLA-C Antigens
33 Citations (Scopus)

Mapping of class I DNA sequences within the human major histocompatibility complex

Orr, H. T. & DeMars, R., Jan 1 1983, In : Immunogenetics. 18, 5, p. 489-502 14 p.

Research output: Contribution to journalArticle

Major Histocompatibility Complex
DNA
MHC Class I Genes
HLA-B8 Antigen
Lymphocytes
11 Citations (Scopus)
HLA-A Antigens
HLA-B Antigens
Southern Blotting
DNA
Population
1982
65 Citations (Scopus)

Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: Possible implications for the generation of HLA polymorphism

Lopez de Castro, J. A., Strominger, J. L., Strong, D. M. & Orr, H. T., Jan 1 1982, In : Proceedings of the National Academy of Sciences of the United States of America. 79, 12 I, p. 3813-3817 5 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
Histocompatibility Antigens
HLA-B7 Antigen
Antigenic Variation
Gene Conversion
43 Citations (Scopus)

Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex

Orr, H. T., Bach, F. H., Ploegh, H. L., Strominger, J. L., Kavathas, P. & Demars, R., Dec 1 1982, In : Nature. 296, 5856, p. 454-456 3 p.

Research output: Contribution to journalArticle

HLA-B8 Antigen
Major Histocompatibility Complex
Clone Cells
MHC Class I Genes
Recombinant DNA
1981
86 Citations (Scopus)

Biosynthesis and cell surface localization of nonglycosylated human histocompatibility antigens

Ploegh, H. L., Orr, H. T. & Strominger, J. L., Jan 1 1981, In : Journal of Immunology. 126, 1, p. 270-275 6 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
HLA-A Antigens
HLA-B Antigens
Tunicamycin
Carbohydrates
341 Citations (Scopus)

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

Ploegh, H. L., Orr, H. T. & Strominger, J. L., Jan 1 1981, In : Cell. 24, 2, p. 287-299 13 p.

Research output: Contribution to journalReview article

H-2 Antigens
beta 2-Microglobulin
Histocompatibility Antigens
HLA-A Antigens
Histocompatibility Antigens Class II
1980
29 Citations (Scopus)

An Evaluation of the Significance of Amino Acid Sequence Homologies in Human Histocompatibility Antigens (HLA‐A and HLA‐B) with Immunoglobulins and Other Proteins, Using Relatively Short Sequences

STROMINGER, J. L., ORR, H. T., PARHAM, P., PLOEGH, H. L., MANN, D. L., BILOFSKY, H., SAROFF, H. A., WU, T. T. & KABAT, E. A., Jan 1 1980, In : Scandinavian Journal of Immunology. 11, 6, p. 573-592 20 p.

Research output: Contribution to journalArticle

Immunoglobulin Constant Regions
Amino Acid Sequence Homology
Histocompatibility Antigens
Immunoglobulins
Peptides

Complete primary structure of human histocompatibility antigen hla-b7: Evolutionary and functional implications

Strominger, J. L., Engelhard, V. H., Guild, B. C., Kostyk, T. G., Lancet, D., Lopez de Castro, J. A., Orr, H. T., Parham, P., Ploegh, H. L. & Pober, J. S., Jan 1 1980, In : Current Topics in Developmental Biology. 14, C, p. 97-113 17 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
Genes
Immunoglobulins
HLA-B7 Antigen
Gene Duplication
73 Citations (Scopus)

Molecular cloning of a human histocompatibility antigen cDNA fragment

Ploegh, H. L., Orr, H. T. & Strominger, J. L., Dec 1 1980, In : Proceedings of the National Academy of Sciences of the United States of America. 77, 10 II, p. 6081-6085 5 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens
Molecular Cloning
Complementary DNA
Messenger RNA
HLA-A Antigens

Structural studies of the membrane-associated products of the human major histocompatibility complex.

Orr, H., Fuks, A., Kaufman, J., Lancet, D., Ploegh, H., Robb, R., Strominger, J. & Parham, P., Jan 1 1980, In : Advances in pathobiology. 7, p. 318-330 13 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Structure, Function, and Biosynthesis of the Major Human Histocompatibility Antigens (HLA‐A and HLA‐B)

Krangel, M. S., Orr, H. T. & Strominger, J. L., Jan 1 1980, In : Scandinavian Journal of Immunology. 11, 6, p. 561-571 11 p.

Research output: Contribution to journalEditorial

Histocompatibility Antigens
Antigens
Human Chromosomes
HLA Antigens
Liposomes
1979
173 Citations (Scopus)

Assembly and maturation of HLA-A and HLA-B antigens in vivo

Krangel, M. S., Orr, H. T. & Strominger, J. L., Jan 1 1979, In : Cell. 18, 4, p. 979-991 13 p.

Research output: Contribution to journalArticle

HLA-A Antigens
HLA-B Antigens
Oligosaccharides
Mannose
Antigens
91 Citations (Scopus)

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: Location of putative alloantigenic sites

Orr, H. T., Lopez De Castro, J. A., Parham, P., Ploegh, H. L. & Strominger, J. L., Jan 1 1979, In : Unknown Journal. 76, 9, p. 4395-4399 5 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Papain
HLA-A2 Antigen
Histocompatibility Antigens
Antigens
27 Citations (Scopus)

Complete Amino Acid Sequence of a Papain-Solubilized Human Histocompatibility Antigen, HLA-B7. 1. Isolation and Amino Acid Composition of Fragments and of Tryptic and Chymotryptic Peptides

Castro, J. A. L. D., Orr, H. T., Robb, R. J., Kostyk, T. G., Strominger, J. L. & Mann, D. L., Jan 1 1979, In : Biochemistry. 18, 25, p. 5704-5711 8 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Histocompatibility Antigens
Papain
Amino Acid Sequence
Amino Acids
86 Citations (Scopus)

Complete Amino Acid Sequence of a Papain-Solubilized Human Histocompatibility Antigen, HLA-B7. 2. Sequence Determination and Search for Homologies

Orr, H. T., Castro, J. A. L. D., Lancet, D. & Strominger, J. L., Jan 1 1979, In : Biochemistry. 18, 25, p. 5711-5720 10 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Histocompatibility Antigens
Papain
Sequence Alignment
Disulfides
13 Citations (Scopus)

Serologic and structural studies of DR-related antigens

Mann, D. L., Kaufman, J., Orr, H., Robb, R. & Strominger, J., Dec 27 1979, In : Transplantation Proceedings. 11, 1, p. 668-673 6 p.

Research output: Contribution to journalArticle

Antigens
Genes
Immunoprecipitation
Sequence Analysis
Epitopes
1 Citation (Scopus)

Structural and sequence homologies between HLA-A and HLA-B antigens and immunoglobulins

Strominger, J. L., Kabat, E. A., Bilofsky, H., Mann, D., Orr, H., Parham, P., Ploegh, H., Robb, R., Terhorst, C. & Wu, T. T., Nov 19 1979, In : Transplantation proceedings. 11, 2, 1 p.

Research output: Contribution to journalArticle

HLA-A Antigens
HLA-B Antigens
Sequence Homology
HLA Antigens
Immunoglobulins
92 Citations (Scopus)

The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region

Orr, H. T., Lancet, D., Robb, R. J., De Castro, J. A. L. & Strominger, J. L., Dec 1 1979, In : Nature. 282, 5736, p. 266-270 5 p.

Research output: Contribution to journalArticle

HLA-B7 Antigen
Histocompatibility Antigens
HLA Antigens
Disulfides
Immunoglobulins
1978
4 Citations (Scopus)

Isolation and structure of HLA antigens

Strominger, J. L., Ferguson, W., Fuks, A., Giphart, M., Kaufman, J., Mann, D., Orr, H., Parham, P., Robb, R. & Terhorst, C., Dec 1 1978, In : Birth Defects: Original Article Series. 14, 2, p. 235-246 12 p.

Research output: Contribution to journalArticle

HLA Antigens
HLA-A Antigens
HLA-B Antigens
Lymphocytes
Genes
1977
102 Citations (Scopus)

Carbohydrate moeity of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation

Parham, P., Alpert, B. N., Orr, H. T. & Strominger, J. L., Jan 1 1977, In : Journal of Biological Chemistry. 252, 21, p. 7555-7567 13 p.

Research output: Contribution to journalArticle

Glycosylation
Glycopeptides
HLA Antigens
Amino Acid Sequence
Carbohydrates
16 Citations (Scopus)

Measurement of cyclic nucleotides in histologically defined samples of brain and retina

Ferrendelli, J. A., Rubin, E. H., Orr, H. T., Kinscherf, D. A. & Lowry, O. H., Jan 1 1977, In : Analytical Biochemistry. 78, 1, p. 252-259 8 p.

Research output: Contribution to journalArticle

Cyclic Nucleotides
Retina
Assays
Brain
Cyclic GMP
3 Citations (Scopus)

Structural aspects of the products of the human major histocompatibility complex

Fuks, A., Kaufman, J. F., Orr, H. T., Parham, P., Robb, R. R., Terhorst, C. & Strominger, J. L., Dec 1 1977, In : Transplantation Proceedings. 9, 4, p. 1685-1689 5 p.

Research output: Contribution to journalArticle

Histocompatibility Antigens Class II
Sequence Homology
Major Histocompatibility Complex
B-Lymphocytes
1976
111 Citations (Scopus)
Ocular Adaptation
Guanosine Monophosphate
Dark Adaptation
Photoreceptor Cells
Cyclic GMP
168 Citations (Scopus)

The distribution of taurine in the vertebrate retina

Orr, H. T., Cohen, A. I. & Lowry, O. H., Jan 1 1976, In : Journal of Neurochemistry. 26, 3, p. 609-611 3 p.

Research output: Contribution to journalArticle

Taurine
Macaca mulatta
Haplorhini
Vertebrates
Retina
37 Citations (Scopus)
Butyric Acid
Taurine
Glycine
Retina
Glutamic Acid
1973
82 Citations (Scopus)

Absolute levels of some free amino acids in normal and biologically fractionated retinas

Cohen, A. I., McDaniel, M. & Orr, H., Dec 1 1973, In : Investigative Ophthalmology. 12, 9, p. 686-693 8 p.

Research output: Contribution to journalArticle

Retina
Amino Acids
gamma-Aminobutyric Acid
Glutamine
Aspartic Acid
1972
3 Citations (Scopus)

Synthetic activity of corneal endothelium.

Riley, M. V., Hodson, S. A. & Orr, H. T., Aug 1 1972, In : Israel Journal of Medical Sciences. 8, 8, p. 1519-1522 4 p.

Research output: Contribution to journalArticle

Phosphorus Isotopes
Sodium Isotopes
Trichloroacetic acid
Carbon Isotopes
Paper Electrophoresis