Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Astrocyte dysfunction in Spinocerebellar ataxia type 1 (SCA1)
Cvetanovic, M. (PI), Zhang, Y. (PI), Kofuji, P. (Other Role), Orr, H. T. (Other Role) & Selimovic, A. (Other Role)
NIH NAT INST OF NEURO DISORDERS & STROKE
7/1/24 → 5/31/29
Project: Research project
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Understanding degeneration in neurons of the inferior olivary nucleus
Orr, H. T. (PI)
UT SOUTHWESTERN MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
7/1/24 → 5/31/29
Project: Research project
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Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspective
Cvetanovic, M. (PI), Orr, H. T. (PI) & Walters, M. A. (PI)
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/22 → 4/30/30
Project: Research project
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Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
Orr, H. T. (PI)
UT SOUTHWESTERN MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
4/20/21 → 3/31/24
Project: Research project
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Assessing AAV-siRNA as a treatment for SCA1
Orr, H. T. (PI)
3/1/21 → 12/31/22
Project: Research project
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Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1
Soles, A., Grittner, J., Douglas, K., Yang, P., Duvick, L., O'Callaghan, B., Barnett, R., Chau, C., Cosiquien, R., Rainwater, O., Serres, S., Dougherty, B., Orr, H. T. & Cvetanovic, M., May 2026, In: Neurobiology of Disease. 222, 107356.Research output: Contribution to journal › Article › peer-review
Open Access -
Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias
Banez-Coronel, M., Zu, T., Aldridge, M., Guo, S., Ajredini, R., Morrison, D., Tays, A. B., Duvick, L. A., Pletnikova, O., Yachnis, A. T., Troncoso, J. C., Paulson, H. L., McLoughlin, H. S., Ashizawa, T., Subramony, S. H., Orr, H. T. & Ranum, L. P. W., Jan 27 2026, In: Cell reports. 45, 1, 116741.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model
Talukdar, G., Duvick, L., Yang, P., O’Callaghan, B., Fuchs, G. J., Cvetanovic, M. & Orr, H. T., Dec 2025, In: Journal of Neuroinflammation. 22, 1, 127.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients
Bartelt, L. C., Switonski, P. M., Adamek, G., Longo, F., Carvalho, J., Duvick, L. A., Jarrah, S. I., McLoughlin, H. S., Scoles, D. R., Pulst, S. M., Orr, H. T., Hull, C., Lowe, C. B. & La Spada, A. R., Nov 6 2024, In: Science Translational Medicine. 16, 772, eadn5449.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells
Sheeler, C., Labrada, E., Duvick, L., Thompson, L. M., Zhang, Y., Orr, H. T. & Cvetanovic, M., Oct 15 2024, In: Neurobiology of Disease. 201, 106673.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations