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Harry T Orr

1972 …2020

Research output per year

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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Projects

Label-free Optical Imaging of Atrophy in SCA1 Mouse Models

Akkin, T. & Orr, H. T.

National Ataxia Foundation, Inc.

3/1/20 → 2/28/21

Project: Research project

    • Intraperitoneal (i.p.) injection of CCK receptor agonists

    Orr, H. T.

    CYDAN DEVELOPMENT, INC.

    10/1/19 → 4/1/21

    Project: Research project

    • Identifying symptomatic and neuroprotective strategies for cerebellar ataxia

    Orr, H. T.

    University of Michigan

    4/15/19 → 3/31/24

    Project: Research project

    • Understanding cell specificity of Ataxin-1 toxicity in human neurons

    Cvetanovic, M. & Orr, H. T.

    National Ataxia Foundation, Inc.

    3/1/19 → 8/31/20

    Project: Research project

    • Cell signaling and neurodegeneration

    Orr, H. T. & Walters, M. A.

    NIH NAT INST OF NEURO DISORDERS & STROKE

    5/1/18 → 4/30/23

    Project: Research project

    Research Output

    Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism

    Chao, O. Y., Marron Fernandez de Velasco, E., Pathak, S. S., Maitra, S., Zhang, H., Duvick, L., Wickman, K., Orr, H. T., Hirai, H. & Yang, Y. M., Jun 1 2020, In : Neuropsychopharmacology. 45, 7, p. 1159-1170 12 p.

    Research output: Contribution to journal › Article

    Open Access

    • The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

    Zhang, S., Williamson, N. A., Duvick, L., Lee, A., Orr, H. T., Korlin-Downs, A., Yang, P., Mok, Y. F., Jans, D. A. & Bogoyevitch, M. A., Dec 1 2020, In : Nature communications. 11, 1, 3343.

    Research output: Contribution to journal › Article

    Open Access

    • Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse model of spinocerebellar ataxia type 1

    Chuang, C. S., Chang, J. C., Soong, B. W., Chuang, S. F., Lin, T. T., Cheng, W. L., Orr, H. T. & Liu, C. S., Nov 1 2019, In : Kaohsiung Journal of Medical Sciences. 35, 11, p. 679-685 7 p.

    Research output: Contribution to journal › Article

    Open Access

    • Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

    Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI Insight. 3, 21

    Research output: Contribution to journal › Article

    Open Access
    • 12 Scopus citations

    ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

    Rousseaux, M. W. C., Tschumperlin, T., Lu, H. C., Lackey, E. P., Bondar, V. V., Wan, Y. W., Tan, Q., Adamski, C. J., Friedrich, J., Twaroski, K., Chen, W., Tolar, J., Henzler, C., Sharma, A., Bajić, A., Lin, T., Duvick, L., Liu, Z., Sillitoe, R. V., Zoghbi, H. Y. & 1 others, Orr, H. T., Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5

    Research output: Contribution to journal › Article

    Open Access
    • 16 Scopus citations