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Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

  • 9 Similar Profiles
Spinocerebellar Ataxias Medicine & Life Sciences
Purkinje Cells Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Genes Medicine & Life Sciences
Ataxia Medicine & Life Sciences
HLA-A Antigens Medicine & Life Sciences
MHC Class I Genes Medicine & Life Sciences

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Projects 1996 2024

Cell signaling and neurodegeneration

Orr, H. T. & Walters, M. A.

NIH NAT INST OF NEURO DISORDERS & STROKE

5/1/184/30/23

Project: Research project

cells
Spinocerebellar Ataxias
Molecular Biology

Research Output 1972 2019

Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse model of spinocerebellar ataxia type 1

Chuang, C. S., Chang, J. C., Soong, B. W., Chuang, S. F., Lin, T. T., Cheng, W. L., Orr, H. T. & Liu, C. S., Nov 1 2019, In : Kaohsiung Journal of Medical Sciences. 35, 11, p. 679-685 7 p.

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Motor Neurons
Cerebellum
Motor Activity
Exercise
5 Citations (Scopus)

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI Insight. 3, 21

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Antisense Oligonucleotides
Transcriptome
Neurological Models
RNA
7 Citations (Scopus)

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Rousseaux, M. W. C., Tschumperlin, T., Lu, H. C., Lackey, E. P., Bondar, V. V., Wan, Y. W., Tan, Q., Adamski, C. J., Friedrich, J., Twaroski, K., Chen, W., Tolar, J., Henzler, C., Sharma, A., Bajić, A., Lin, T., Duvick, L., Liu, Z., Sillitoe, R. V., Zoghbi, H. Y. & 1 others, Orr, H. T., Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Pathology
Cerebellum
Neurons
Purkinje Cells
3 Citations (Scopus)

Motor neuron degeneration correlates with respiratory dysfunction in SCA1

Orengo, J. P., van der Heijden, M. E., Hao, S., Tang, J., Orr, H. T. & Zoghbi, H. Y., Feb 26 2018, In : Disease models & mechanisms. 11, 2

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Nerve Degeneration
Motor Neurons
Neurons
Diaphragm
2 Citations (Scopus)

PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1

Bondar, V. V., Adamski, C. J., Onur, T. S., Tan, Q., Wang, L., Diaz-Garcia, J., Park, J., Orr, H. T., Botas, J. & Zoghbi, H. Y., Jan 1 2018, In : Human molecular genetics. 27, 16, p. 2863-2873 11 p.

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
p21-Activated Kinases
Pharmacology
Ataxin-1
Drosophila