Projects per year
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
- 4 Similar Profiles
Spinocerebellar Ataxias
Medicine & Life Sciences
Purkinje Cells
Medicine & Life Sciences
Neurodegenerative Diseases
Medicine & Life Sciences
Transgenic Mice
Medicine & Life Sciences
Genes
Medicine & Life Sciences
Ataxia
Medicine & Life Sciences
HLA-A Antigens
Medicine & Life Sciences
MHC Class I Genes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1996 2023
Understanding cell specificity of Ataxin-1 toxicity in human neurons
National Ataxia Foundation, Inc.
3/1/19 → 2/29/20
Project: Research project
Neurons
Ataxin-1
Cell signaling and neurodegeneration
Orr, H. T. & Walters, M. A.
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/18 → 4/30/23
Project: Research project
cells
Molecular Genetics of SCA1
NIH NAT INST OF NEURO DISORDERS & STROKE
3/1/18 → 2/28/23
Project: Research project
Spinocerebellar Ataxias
Molecular Biology
scanning
Spinocerebellar Ataxias
Research Output 1972 2018
Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles
Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI insight. 3, 21Research output: Contribution to journal › Article
Open Access
Spinocerebellar Ataxias
Antisense Oligonucleotides
Transcriptome
Neurological Models
RNA
5
Citations
(Scopus)
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism
Rousseaux, M. W. C., Tschumperlin, T., Lu, H. C., Lackey, E. P., Bondar, V. V., Wan, Y. W., Tan, Q., Adamski, C. J., Friedrich, J., Twaroski, K., Chen, W., Tolar, J., Henzler, C., Sharma, A., Bajić, A., Lin, T., Duvick, L., Liu, Z., Sillitoe, R. V., Zoghbi, H. Y. & 1 others, Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Pathology
Cerebellum
Neurons
Purkinje Cells
3
Citations
(Scopus)
Motor neuron degeneration correlates with respiratory dysfunction in SCA1
Orengo, J. P., van der Heijden, M. E., Hao, S., Tang, J., Orr, H. T. & Zoghbi, H. Y., Feb 26 2018, In : Disease models & mechanisms. 11, 2Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Nerve Degeneration
Motor Neurons
Neurons
Diaphragm
PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1
Bondar, V. V., Adamski, C. J., Onur, T. S., Tan, Q., Wang, L., Diaz-Garcia, J., Park, J., Orr, H. T., Botas, J. & Zoghbi, H. Y., Jan 1 2018, In : Human molecular genetics. 27, 16, p. 2863-2873 11 p.Research output: Contribution to journal › Article
Open Access
Spinocerebellar Ataxias
p21-Activated Kinases
Pharmacology
Ataxin-1
Drosophila
Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models
Liu, C. J., Rainwater, O., Clark, H. B., Orr, H. T. & Akkin, T., Aug 1 2018, In : Neurobiology of Disease. 116, p. 69-77 9 p.Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Optical Coherence Tomography
Atrophy
Neurodegenerative Diseases
Birefringence