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  • 4 Similar Profiles
Spinocerebellar Ataxias Medicine & Life Sciences
Purkinje Cells Medicine & Life Sciences
Neurodegenerative Diseases Medicine & Life Sciences
Transgenic Mice Medicine & Life Sciences
Genes Medicine & Life Sciences
HLA-A Antigens Medicine & Life Sciences
Ataxia Medicine & Life Sciences
MHC Class I Genes Medicine & Life Sciences

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Projects 1996 2023

cells
Spinocerebellar Ataxias
Molecular Biology
Spinocerebellar Ataxias
Spinocerebellar Ataxias
Therapeutics

Research Output 1972 2018

1 Citations

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Rousseaux, M. W. C. , Tschumperlin, T. , Lu, H. C. , Lackey, E. P. , Bondar, V. V. , Wan, Y. W. , Tan, Q. , Adamski, C. J. , Friedrich, J. , Twaroski, K. , Chen, W. , Tolar, J. , Henzler, C. , Sharma, A. , Bajić, A. , Lin, T. , Duvick, L. , Liu, Z. , Sillitoe, R. V. , Zoghbi, H. Y. & 1 others Orr, H. T., Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Ataxia
Cerebellum
Pathology
Neurons

Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

Liu, C. J., Rainwater, O., Clark, H. B., Orr, H. T. & Akkin, T., Aug 1 2018, In : Neurobiology of Disease. 116, p. 69-77 9 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Optical Coherence Tomography
Atrophy
Neurodegenerative Diseases
Birefringence

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

Pérez Ortiz, J. M., Mollema, N., Toker, N., Adamski, C. J., O'Callaghan, B., Duvick, L., Friedrich, J., Walters, M. A., Strasser, J., Hawkinson, J. E., Zoghbi, H. Y., Henzler, C., Orr, H. T. & Lagalwar, S., Aug 1 2018, In : Neurobiology of Disease. 116, p. 93-105 13 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Purkinje Cells
Ataxia
Cyclic AMP-Dependent Protein Kinases
Phosphorylation

Serial optical coherence scanner for imaging neurodegenerative diseases

Liu, C. J., Rainwater, O., Orr, H. T. & Akkin, T., Jan 1 2018, Clinical and Translational Biophotonics, TRANSLATIONAL 2018. OSA - The Optical Society, Vol. Part F91-TRANSLATIONAL 2018

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Neurodegenerative diseases
Optical tomography
Brain
Visualization
Tissue

Spinocerebellar ataxia type 1: Molecular mechanisms of neurodegeneration and preclinical studies

Pérez Ortiz, J. M. & Orr, H. T., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 135-145 11 p. (Advances in Experimental Medicine and Biology; vol. 1049)

Research output: Chapter in Book/Report/Conference proceedingChapter

Spinocerebellar Ataxias
Phosphorylation
Purkinje Cells
Proteins
RNA Splicing