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Harry T Orr

1972 …2023
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  • 6 Similar Profiles
Spinocerebellar Ataxias Medicine & Life Sciences
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Genes Medicine & Life Sciences
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Ataxia Medicine & Life Sciences
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Projects 1996 2023

Cell signaling and neurodegeneration

Orr, H. T. & Walters, M.

NIH NAT INST OF NEURO DISORDERS & STROKE

5/1/18 → 4/30/23

Project: Research project

cells

Molecular Genetics of SCA1

Orr, H. T. & Clark, H. B.

NIH NAT INST OF NEURO DISORDERS & STROKE

3/1/18 → 2/28/23

Project: Research project

Spinocerebellar Ataxias
Molecular Biology

Developing serial optical coherence scanning to reveal w

Akkin, T. & Orr, H. T.

National Science Foundation

7/1/15 → 6/30/19

Project: Research project

scanning

Takeda SCA1 trial

Oz, G. & Orr, H. T.

TAKEDA DEVELOPMENT CENTER AMERICAS, INC.

4/1/17 → 3/31/18

Project: Research project

Spinocerebellar Ataxias

Development of an ASO-based Therapy for Spinocerebellar

Orr, H. T.

Winston & Maxine Wallin Neuro Disc Fund

1/1/17 → 12/31/17

Project: Research project

Spinocerebellar Ataxias
Therapeutics

Research Output 1972 2018

2 Citations

ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

Rousseaux, M. W. C., Tschumperlin, T., Lu, H. C., Lackey, E. P., Bondar, V. V., Wan, Y. W., Tan, Q., Adamski, C. J., Friedrich, J., Twaroski, K., Chen, W., Tolar, J., Henzler, C., Sharma, A., Bajić, A., Lin, T., Duvick, L., Liu, Z., Sillitoe, R. V., Zoghbi, H. Y. & 1 othersOrr, H. T., Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Pathology
Cerebellum
Neurons
Purkinje Cells
1 Citations

Motor neuron degeneration correlates with respiratory dysfunction in SCA1

Orengo, J. P., van der Heijden, M. E., Hao, S., Tang, J., Orr, H. T. & Zoghbi, H. Y., Feb 26 2018, In : Disease models & mechanisms. 11, 2

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Nerve Degeneration
Motor Neurons
Neurons
Diaphragm

PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1

Bondar, V. V., Adamski, C. J., Onur, T. S., Tan, Q., Wang, L., Diaz-Garcia, J., Park, J., Orr, H. T., Botas, J. & Zoghbi, H. Y., Jan 1 2018, In : Human molecular genetics. 27, 16, p. 2863-2873 11 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
p21-Activated Kinases
Pharmacology
Ataxin-1
Drosophila

Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models

Liu, C. J., Rainwater, O., Clark, H. B., Orr, H. T. & Akkin, T., Aug 1 2018, In : Neurobiology of Disease. 116, p. 69-77 9 p.

Research output: Contribution to journal › Article

Spinocerebellar Ataxias
Optical Coherence Tomography
Atrophy
Neurodegenerative Diseases
Birefringence

RBM17 Interacts with U2SURP and CHERP to Regulate Expression and Splicing of RNA-Processing Proteins

De Maio, A., Yalamanchili, H. K., Adamski, C. J., Gennarino, V. A., Liu, Z., Qin, J., Jung, S. Y., Richman, R., Orr, H. T. & Zoghbi, H. Y., Oct 16 2018, In : Cell Reports. 25, 3, p. 726-736.e7

Research output: Contribution to journal › Article

RNA Splicing
RNA-Binding Proteins
Spliceosomes
RNA
Processing