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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Collaborations and top research areas from the last five years
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Astrocyte dysfunction in Spinocerebellar ataxia type 1 (SCA1)
Cvetanovic, M. (PI), Kofuji, P. (Other Role), Orr, H. T. (Other Role) & Selimovic, A. (Other Role)
NIH NAT INST OF NEURO DISORDERS & STROKE
7/1/24 → 5/31/29
Project: Research project
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Understanding degeneration in neurons of the inferior olivary nucleus
Orr, H. T. (PI)
UT SOUTHWESTERN MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
7/1/24 → 5/31/29
Project: Research project
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Molecular genetics of neurodegenerative pathogenic and protective pathways: The SCA1 perspective
Orr, H. T. (PI), Cvetanovic, M. (CoI) & Walters, M. A. (CoI)
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/22 → 4/30/30
Project: Research project
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Etiology of cognitive decline in Spinocerebellar ataxia type 1
Cvetanovic, M. (PI), Araque, A. (CoI) & Orr, H. T. (CoI)
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/20 → 6/30/25
Project: Research project
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Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
Orr, H. T. (PI)
UT SOUTHWESTERN MEDICAL CENTER, NATIONAL INSTITUTES OF HEALTH (NIH)
4/20/21 → 3/31/24
Project: Research project
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Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients
Bartelt, L. C., Switonski, P. M., Adamek, G., Longo, F., Carvalho, J., Duvick, L. A., Jarrah, S. I., McLoughlin, H. S., Scoles, D. R., Pulst, S. M., Orr, H. T., Hull, C., Lowe, C. B. & La Spada, A. R., Nov 6 2024, In: Science Translational Medicine. 16, 772, eadn5449.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells
Sheeler, C. A., Labrada, E., Duvick, L. A., Thompson, L. M., Zhang, Y., Orr, H. T. & Cvetanovic, M., Oct 15 2024, In: Neurobiology of Disease. 201, 106673.Research output: Contribution to journal › Article › peer-review
Open Access -
Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1
Morrison, L. M., Huang, H., Handler, H. P., Fu, M., Jones, D. M., Bushart, D. D., Pappas, S. S., Orr, H. T. & Shakkottai, V. G., Dec 15 2024, In: Human molecular genetics. 33, 24, p. 2159-2176 18 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Tejwani, L., Ravindra, N. G., Lee, C., Cheng, Y., Nguyen, B., Luttik, K., Ni, L., Zhang, S., Morrison, L. M., Gionco, J., Xiang, Y., Yoon, J., Ro, H., Haidery, F., Grijalva, R. M., Bae, E., Kim, K., Martuscello, R. T., Orr, H. T. & Zoghbi, H. Y. & 7 others, , Feb 7 2024, In: Neuron. 112, 3, p. 362-383.e15Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease
Duvick, L., Southern, W. M., Benzow, K. A., Burch, Z. N., Handler, H. P., Mitchell, J. S., Kuivinen, H., Gadiparthi, U., Yang, P., Soles, A., Sheeler, C. A., Rainwater, O., Serres, S., Lind, E. B., Nichols-Meade, T., You, Y., O'Callaghan, B., Zoghbi, H. Y., Cvetanovic, M. & Wheeler, V. C. & 3 others, , May 8 2024, In: JCI Insight. 9, 9, e176057.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations