Projects per year
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
- 4 Similar Profiles
Spinocerebellar Ataxias
Medicine & Life Sciences
Purkinje Cells
Medicine & Life Sciences
Neurodegenerative Diseases
Medicine & Life Sciences
Transgenic Mice
Medicine & Life Sciences
Genes
Medicine & Life Sciences
HLA-A Antigens
Medicine & Life Sciences
Ataxia
Medicine & Life Sciences
MHC Class I Genes
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 1996 2023
Cell signaling and neurodegeneration
Orr, H. T. & Walters, M.
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/18 → 4/30/23
Project: Research project
cells
Molecular Genetics of SCA1
NIH NAT INST OF NEURO DISORDERS & STROKE
3/1/18 → 2/28/23
Project: Research project
Spinocerebellar Ataxias
Molecular Biology
scanning
Spinocerebellar Ataxias
Towards an ASO Therapy for Spinocerebellar Ataxia Type 1
Orr, H. T., Oz, G. & Henzler, C.
National Ataxia Foundation, Inc.
1/1/17 → 12/31/17
Project: Research project
Spinocerebellar Ataxias
Therapeutics
Research Output 1972 2018
ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism
Rousseaux, M. W. C. , Tschumperlin, T. , Lu, H. C. , Lackey, E. P. , Bondar, V. V. , Wan, Y. W. , Tan, Q. , Adamski, C. J. , Friedrich, J. , Twaroski, K. , Chen, W. , Tolar, J. , Henzler, C. , Sharma, A. , Bajić, A. , Lin, T. , Duvick, L. , Liu, Z. , Sillitoe, R. V. , Zoghbi, H. Y. & 1 others , Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Ataxia
Cerebellum
Pathology
Neurons
Polarization-sensitive optical coherence tomography reveals gray matter and white matter atrophy in SCA1 mouse models
Liu, C. J., Rainwater, O., Clark, H. B., Orr, H. T. & Akkin, T., Aug 1 2018, In : Neurobiology of Disease. 116, p. 69-77 9 p.Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Optical Coherence Tomography
Atrophy
Neurodegenerative Diseases
Birefringence
Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model
Pérez Ortiz, J. M., Mollema, N., Toker, N., Adamski, C. J., O'Callaghan, B., Duvick, L., Friedrich, J., Walters, M. A., Strasser, J., Hawkinson, J. E., Zoghbi, H. Y., Henzler, C., Orr, H. T. & Lagalwar, S., Aug 1 2018, In : Neurobiology of Disease. 116, p. 93-105 13 p.Research output: Contribution to journal › Article
Spinocerebellar Ataxias
Purkinje Cells
Ataxia
Cyclic AMP-Dependent Protein Kinases
Phosphorylation
Serial optical coherence scanner for imaging neurodegenerative diseases
Liu, C. J., Rainwater, O., Orr, H. T. & Akkin, T., Jan 1 2018, Clinical and Translational Biophotonics, TRANSLATIONAL 2018. OSA - The Optical Society, Vol. Part F91-TRANSLATIONAL 2018Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Neurodegenerative diseases
Optical tomography
Brain
Visualization
Tissue
Spinocerebellar ataxia type 1: Molecular mechanisms of neurodegeneration and preclinical studies
Pérez Ortiz, J. M. & Orr, H. T., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 135-145 11 p. (Advances in Experimental Medicine and Biology; vol. 1049)Research output: Chapter in Book/Report/Conference proceeding › Chapter
Spinocerebellar Ataxias
Phosphorylation
Purkinje Cells
Proteins
RNA Splicing