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Harry T Orr

1972 …2024

Research output per year

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Projects

Identifying symptomatic and neuroprotective strategies for cerebellar ataxia

Orr, H. T.

University of Michigan

4/15/19 → 3/31/24

Project: Research project

    • Understanding cell specificity of Ataxin-1 toxicity in human neurons

    Cvetanovic, M. & Orr, H. T.

    National Ataxia Foundation, Inc.

    3/1/19 → 8/31/20

    Project: Research project

    • Cell signaling and neurodegeneration

    Orr, H. T. & Walters, M. A.

    NIH NAT INST OF NEURO DISORDERS & STROKE

    5/1/18 → 4/30/23

    Project: Research project

    Molecular Genetics of SCA1

    Orr, H. T. & Clark, H. B.

    NIH NAT INST OF NEURO DISORDERS & STROKE

    3/1/18 → 2/28/23

    Project: Research project

    • Developing serial optical coherence scanning to reveal w

    Akkin, T. & Orr, H. T.

    National Science Foundation

    7/1/15 → 5/31/20

    Project: Research project

    Research Output

    Treadmill training increases the motor activity and neuron survival of the cerebellum in a mouse model of spinocerebellar ataxia type 1

    Chuang, C. S., Chang, J. C., Soong, B. W., Chuang, S. F., Lin, T. T., Cheng, W. L., Orr, H. T. & Liu, C. S., Nov 1 2019, In : Kaohsiung Journal of Medical Sciences. 35, 11, p. 679-685 7 p.

    Research output: Contribution to journal › Article

    Open Access

    • Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

    Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI Insight. 3, 21

    Research output: Contribution to journal › Article

    Open Access
    • 6 Scopus citations

    ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

    Rousseaux, M. W. C., Tschumperlin, T., Lu, H. C., Lackey, E. P., Bondar, V. V., Wan, Y. W., Tan, Q., Adamski, C. J., Friedrich, J., Twaroski, K., Chen, W., Tolar, J., Henzler, C., Sharma, A., Bajić, A., Lin, T., Duvick, L., Liu, Z., Sillitoe, R. V., Zoghbi, H. Y. & 1 others, Orr, H. T., Mar 21 2018, In : Neuron. 97, 6, p. 1235-1243.e5

    Research output: Contribution to journal › Article

    Open Access
    • 10 Scopus citations

    Motor neuron degeneration correlates with respiratory dysfunction in SCA1

    Orengo, J. P., van der Heijden, M. E., Hao, S., Tang, J., Orr, H. T. & Zoghbi, H. Y., Feb 26 2018, In : Disease models & mechanisms. 11, 2

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations

    PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1

    Bondar, V. V., Adamski, C. J., Onur, T. S., Tan, Q., Wang, L., Diaz-Garcia, J., Park, J., Orr, H. T., Botas, J. & Zoghbi, H. Y., Jan 1 2018, In : Human molecular genetics. 27, 16, p. 2863-2873 11 p.

    Research output: Contribution to journal › Article

    Open Access
    • 3 Scopus citations