Projects per year
Personal profile
Expertise related to UN SDGs
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Projects
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Etiology of cognitive decline in Spinocerebellar ataxia type 1
Cvetanovic, M., Araque, A. & Orr, H. T.
NIH NAT INST OF NEURO DISORDERS & STROKE
9/15/20 → 6/30/25
Project: Research project
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Label-free Optical Imaging of Atrophy in SCA1 Mouse Models
National Ataxia Foundation, Inc.
3/1/20 → 7/1/21
Project: Research project
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Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
4/15/19 → 3/31/24
Project: Research project
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Cell signaling and neurodegeneration
Orr, H. T. & Walters, M. A.
NIH NAT INST OF NEURO DISORDERS & STROKE
5/1/18 → 4/30/23
Project: Research project
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Molecular Genetics of SCA1
NIH NAT INST OF NEURO DISORDERS & STROKE
3/1/18 → 2/28/23
Project: Research project
Research output
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Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1
Lee, W. S., Lavery, L., Rousseaux, M. W. C., Rutledge, E. B., Jang, Y., Wan, Y. W., Wu, S. R., Kim, W., Al-Ramahi, I., Rath, S., Adamski, C. J., Bondar, V. V., Tewari, A., Soleimani, S., Mota, S., Yalamanchili, H. K., Orr, H. T., Liu, Z., Botas, J. & Zoghbi, H. Y., Apr 1 2021, In: EMBO Journal. 40, 7, e106106.Research output: Contribution to journal › Article › peer-review
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Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1
Nitschke, L., Coffin, S. L., Xhako, E., El-Najjar, D. B., Orengo, J. P., Alcala, E., Dai, Y., Wan, Y. W., Liu, Z., Orr, H. T. & Zoghbi, H. Y., Feb 8 2021, In: JCI Insight. 6, 3, e144955.Research output: Contribution to journal › Article › peer-review
Open Access -
Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1
Chopra, R., Bushart, D. D., Cooper, J. P., Yellajoshyula, D., Morrison, L. M., Huang, H., Handler, H. P., Man, L. J., Dansithong, W., Scoles, D. R., Pulst, S. M., Orr, H. T. & Shakkottai, V. G., Oct 1 2020, In: Human molecular genetics. 29, 19, p. 3249-3265 17 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Antisense Oligonucleotide Therapeutic Approach for Suppression of Ataxin-1 Expression: A Safety Assessment
O'Callaghan, B., Hofstra, B., Handler, H. P., Kordasiewicz, H. B., Cole, T., Duvick, L., Friedrich, J., Rainwater, O., Yang, P., Benneyworth, M., Nichols-Meade, T., Heal, W., Ter Haar, R., Henzler, C. & Orr, H. T., Sep 4 2020, In: Molecular Therapy - Nucleic Acids. 21, p. 1006-1016 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Patterns of CAG repeat instability in the central nervous system and periphery in Huntington's disease and in spinocerebellar ataxia type 1
Pinto, R. M., Arning, L., Giordano, J. V., Razghandi, P., Andrew, M. A., Gillis, T., Correia, K., Mysore, J. S., Grote Urtubey, D. M., Parwez, C. R., von Hein, S. M., Brent Clark, H., Nguyen, H. P., Förster, E., Beller, A., Jayadaev, S., Dirk Keene, C., Bird, T. D., Lucente, D., Vonsattel, J. P. & 4 others, , Aug 29 2020, In: Human molecular genetics. 29, 15, p. 2551-2567 17 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations