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Projects 2007 2021

Drug Discovery
Pharmaceutical Preparations
Male Contraceptive Agents
Cell Cycle
Phosphotransferases
Pharmaceutical Preparations

Maintenance and Operation of a Medicinal Chemistry Facil

Georg, G., Gurvich, V., Hawkinson, J. & Walters, M.

NIH NAT'L INST OF CHILD HEALTH/HUMAN DEV

9/30/139/29/18

Project: Research project

Pharmaceutical Chemistry
Maintenance

Research Output 1983 2017

1 Citations

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen

Ayoub, A. M., Hawk, L. M. L., Herzig, R. J., Jiang, J., Wisniewski, A. J., Gee, C. T., Zhao, P., Zhu, J. Y., Berndt, N., Offei-Addo, N. K., Scott, T. G., Qi, J., Bradner, J. E., Ward, T. R., Schönbrunn, E., Georg, G. I. & Pomerantz, W. C. K. Jun 22 2017 In : Journal of Medicinal Chemistry. 60, 12, p. 4805-4817 13 p.

Research output: Research - peer-reviewArticle

Ligands
Fluorescence Polarization
Uracil
Structure-Activity Relationship
Contraception

Current Medicinal Chemistry Research in India: Progress and Opportunities

Georg, G. I. & Wang, S. Mar 9 2017 In : Journal of Medicinal Chemistry. 60, 5, p. 1619 1 p.

Research output: Research - peer-reviewEditorial

Pharmaceutical Chemistry
India
Research

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z. , Sevrioukova, I. F. , Denisov, I. G. , Zhang, X. , Chiu, T. L. , Thomas, D. G. , Hanse, E. A. , Cuellar, R. A. D. , Grinkova, Y. V. , Langenfeld, V. W. , Swedien, D. S. , Stamschror, J. D. , Alvarez, J. , Luna, F. , Galván, A. , Bae, Y. K. , Wulfkuhle, J. D. , Gallagher, R. I. , Petricoin, E. F. , Norris, B. & 17 others Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A. Oct 19 2017 In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Research - peer-reviewArticle

Biguanides
Cytochrome P-450 CYP3A
Heme
Cytochrome P-450 Enzyme System
Mitochondria

Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2)

Hawkinson, J. E., Sinville, R., Mudaliar, D., Shetty, J., Ward, T., Herr, J. C. & Georg, G. I. Nov 22 2017 In : ChemMedChem. 12, 22, p. 1857-1865 9 p.

Research output: Research - peer-reviewArticle

Protein-Serine-Threonine Kinases
Testis
pyrimidine
pyrrolopyrimidine
Staurosporine
1 Citations

Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors

Zhu, J. Y., Cuellar, R. A., Berndt, N., Lee, H. E., Olesen, S. H., Martin, M. P., Jensen, J. T., Georg, G. I. & Schönbrunn, E. 2017 In : Journal of Medicinal Chemistry. 60, 18, p. 7863-7875 13 p.

Research output: Research - peer-reviewArticle

Phosphotransferases
Phosphorylation
MK 1775
Protein Kinases
Cell Cycle