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Research Output

2020

Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

The Experts' Working Group on Advanced Single Voxel H MRS, Jan 1 2020, (Accepted/In press) In : NMR in biomedicine. e4236.

Research output: Contribution to journalReview article

3 Scopus citations
Open Access
2019

Across-vendor standardization of semi-LASER for single-voxel MRS at 3T

Deelchand, D. K., Berrington, A., Noeske, R., Joers, J. M., Arani, A., Gillen, J., Schär, M., Nielsen, J. F., Peltier, S., Seraji-Bozorgzad, N., Landheer, K., Juchem, C., Soher, B. J., Noll, D. C., Kantarci, K., Ratai, E. M., Mareci, T. H., Barker, P. B. & Öz, G., Jan 1 2019, (Accepted/In press) In : NMR in biomedicine. e4218.

Research output: Contribution to journalArticle

4 Scopus citations

Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Wilson, M., Andronesi, O., Barker, P. B., Bartha, R., Bizzi, A., Bolan, P. J., Brindle, K. M., Choi, I. Y., Cudalbu, C., Dydak, U., Emir, U. E., Gonzalez, R. G., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P., Huppi, P. S., Hurd, R. E. & 29 others, Kantarci, K., Kauppinen, R. A., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjanska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Mullins, P. G., Murdoch, J. B., Nelson, S. J., Noeske, R., Oz, G., Pan, J. W., Peet, A. C., Poptani, H., Posse, S., Ratai, E. M., Salibi, N., Scheenen, T. W. J., Smith, I. C. P., Soher, B. J., Tkáč, I., Vigneron, D. B. & Howe, F. A., Aug 2019, In : Magnetic resonance in medicine. 82, 2, p. 527-550 24 p.

Research output: Contribution to journalReview article

Open Access
31 Scopus citations

Neurochemical abnormalities in patients with type 1 Gaucher disease on standard of care therapy

Kartha, R. V., Joers, J., Terluk, M. R., Travis, A., Rudser, K., Tuite, P. J., Weinreb, N. J., Jarnes, J. R., Cloyd, J. C. & Öz, G., Jan 1 2019, (Accepted/In press) In : Journal of Inherited Metabolic Disease.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
3 Scopus citations

Sensitivity of Volumetric Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy to Progression of Spinocerebellar Ataxia Type 1

Deelchand, D. K., Joers, J. M., Ravishankar, A., Lyu, T., Emir, U. E., Hutter, D., Gomez, C. M., Bushara, K. O., Lenglet, C., Eberly, L. E. & Oz, G., Sep 1 2019, In : Movement Disorders Clinical Practice. 6, 7, p. 549-558 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

State-Dependent Changes in Brain Glycogen Metabolism

DiNuzzo, M., Walls, A. B., Öz, G., Seaquist, E. R., Waagepetersen, H. S., Bak, L. K., Nedergaard, M. & Schousboe, A., Jan 1 2019, Advances in Neurobiology. Springer New York LLC, p. 269-309 41 p. (Advances in Neurobiology; vol. 23).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI Insight. 3, 21

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy

Park, Y. W., Deelchand, D. K., Joers, J. M., Hanna, B., Berrington, A., Gillen, J. S., Kantarci, K., Soher, B. J., Barker, P. B., Park, H., Öz, G. & Lenglet, C., Nov 2018, In : Magnetic resonance in medicine. 80, 5, p. 1787-1798 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
Open Access
1 Scopus citations

Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting

Deelchand, D. K., Kantarci, K. & Öz, G., Mar 2018, In : Magnetic resonance in medicine. 79, 3, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Neurochemical abnormalities in premanifest and early spinocerebellar ataxias

Joers, J. M., Deelchand, D. K., Lyu, T., Emir, U. E., Hutter, D., Gomez, C. M., Bushara, K. O., Eberly, L. E. & Öz, G., Apr 2018, In : Annals of Neurology. 83, 4, p. 816-829 14 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
Open Access
33 Scopus citations

Spinocerebellar ataxias: prospects and challenges for therapy development

Ashizawa, T., Öz, G. & Paulson, H. L., Oct 1 2018, In : Nature Reviews Neurology. 14, 10, p. 590-605 16 p.

Research output: Contribution to journalReview article

33 Scopus citations
2017

Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness

Oz, G., DiNuzzo, M., Kumar, A., Moheet, A., Khowaja, A., Kubisiak, K., Eberly, L. E. & Seaquist, E. R., Aug 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 8, p. 2883-2893 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study

Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., Öz, G. & Kantarci, K., Nov 1 2017, In : Journal of Neuroimaging. 27, 6, p. 630-636 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Maliszewski-Hall, A. M., Alexander, M., Tkáč, I., Öz, G. & Rao, R., Jan 1 2017, In : Neurochemical Research. 42, 1, p. 133-140 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
Open Access
7 Scopus citations

Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T

Joers, J. M., Deelchand, D. K., Kumar, A., Moheet, A., Seaquist, E., Henry, P. G. & Öz, G., Mar 1 2017, In : Journal of magnetic resonance imaging : JMRI. 45, 3, p. 681-691 11 p., doi: 10.1002/jmri.25383.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis

Cheong, I., Marjańska, M., Deelchand, D. K., Eberly, L. E., Walk, D. & Öz, G., Jun 1 2017, In : Neurochemical Research. 42, 6, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress

Lou, S., Lepak, V. C., Eberly, L. E., Roth, B., Cui, W., Zhu, X. H., Öz, G. & Dubinsky, J. M., Jan 1 2016, In : Human molecular genetics. 25, 13, p. 2813-2826 14 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Test-retest reproducibility of neurochemical profiles with short-echo, single-voxel MR spectroscopy at 3T and 7T

Terpstra, M., Cheong, I., Lyu, T., Deelchand, D. K., Emir, U. E., Bednarik, P., Eberly, L. E. & Oz, G., Oct 1 2016, In : Magnetic resonance in medicine. 76, 4, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations
2015
10 Scopus citations

Cerebrospinal fluid biomarkers in spinocerebellar ataxia: A pilot study

Brouillette, A. M., Öz, G. & Gomez, C. M., 2015, In : Disease Markers. 2015, 413098.

Research output: Contribution to journalArticle

9 Scopus citations

Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3T

Bednařík, P., Moheet, A., Deelchand, D. K., Emir, U. E., Eberly, L. E., Bareš, M., Seaquist, E. R. & Öz, G., Jun 1 2015, In : NMR in biomedicine. 28, 6, p. 685-693 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans

Khowaja, A., Choi, I. Y., Seaquist, E. R. & Öz, G., Feb 1 2015, In : Metabolic Brain Disease. 30, 1, p. 255-261 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7

Adanyeguh, I. M., Henry, P. G., Nguyen, T. M., Rinaldi, D., Jauffret, C., Valabregue, R., Emir, U. E., Deelchand, D. K., Brice, A., Eberly, L. E., Öz, G., Durr, A. & Mochel, F., Apr 15 2015, In : Movement Disorders. 30, 5, p. 662-670 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

MR Spectroscopy: A Longitudinal Biomarker for Substantia Nigra Pathology in Parkinson's Disease?

Öz, G., Sep 1 2015, In : Movement Disorders. 30, 10, p. 1304-1305 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Multi-center reproducibility of neurochemical profiles in the human brain at 7T

van de Bank, B. L., Emir, U. E., Boer, V. O., van Asten, J. J. A., Maas, M. C., Wijnen, J. P., Kan, H. E., Oz, G., Klomp, D. W. J. & Scheenen, T. W. J., Mar 1 2015, In : NMR in biomedicine. 28, 3, p. 306-316 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

Proceedings of the workshop on Cerebellum, Basal Ganglia and Cortical Connections Unmasked in Health and Disorder Held in Brno, Czech Republic, October 17th, 2013

Bareš, M., Apps, R., Kikinis, Z., Timmann, D., Oz, G., Ashe, J. J., Loft, M., Koutsikou, S., Cerminara, N., Bushara, K. O. & Kašpárek, T., Jan 1 2015, In : Cerebellum. 14, 2, p. 142-150 9 p.

Research output: Contribution to journalReview article

3 Scopus citations

Revisiting Glycogen Content in the Human Brain

Oz, G., DiNuzzo, M., Kumar, A., Moheet, A. & Seaquist, E. R., Dec 1 2015, In : Neurochemical Research. 40, 12, p. 2473-2481 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T

Deelchand, D. K., Adanyeguh, I. M., Emir, U. E., Nguyen, T. M., Valabregue, R., Henry, P. G., Mochel, F. & Öz, G., May 1 2015, In : Magnetic resonance in medicine. 73, 5, p. 1718-1725 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2014
17 Scopus citations

Clinical proton MR spectroscopy in central nervous system disorders

Öz, G., Alger, J. R., Barker, P. B., Bartha, R., Bizzi, A., Boesch, C., Bolan, P. J., Brindle, K. M., Cudalbu, C., Dinçer, A., Dydak, U., Emir, U. E., Frahm, J., Gilberto González, R., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P. & 30 others, Howe, F. A., Hüppi, P. S., Hurd, R. E., Kantarci, K., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjańska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Nelson, S. J., Pamir, N., Pan, J. W., Peet, A. C., Poptani, H., Poptani, H., Posse, S., Pouwels, P. J. W., Ratai, E. M., Ross, B. D., Scheenen, T. W. J., Schuster, C., Smith, I. C. P., Soher, B. J., Tkáč, I. & Vigneron, D. B., Mar 5 2014, In : Radiology. 270, 3, p. 658-679 22 p.

Research output: Contribution to journalReview article

240 Scopus citations
13 Scopus citations

Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5

Armbrust, K. R., Wang, X., Hathorn, T. J., Cramer, S. W., Chen, G., Zu, T., Kangas, T., Zink, A. N., Öz, G., Ebner, T. J. & Ranum, L. P. W., Jan 1 2014, In : Journal of Neuroscience. 34, 30, p. 9891-9904 14 p.

Research output: Contribution to journalArticle

35 Scopus citations
2013

Animal models and high field imaging and spectroscopy

Öz, G., Tkáč, I. & Uǧurbil, K., Sep 1 2013, In : Dialogues in Clinical Neuroscience. 15, 3, p. 263-278 16 p.

Research output: Contribution to journalArticle

12 Scopus citations

Diabetes: Does lactate sustain brain metabolism during hypoglycaemia?

Seaquist, E. R. & Öz, G., Jul 1 2013, In : Nature Reviews Endocrinology. 9, 7, p. 386-387 2 p.

Research output: Contribution to journalShort survey

2 Scopus citations

Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey

Rao, R., Ennis, K., Oz, G., Lubach, G. R., Georgieff, M. K. & Coe, C. L., Mar 1 2013, In : Neurochemical Research. 38, 3, p. 573-580 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

MR spectroscopy in health and disease

Öz, G., Jan 1 2013, Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands, p. 713-734 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C. & Tuite, P. J., Jul 1 2013, In : Clinical Neuropharmacology. 36, 4, p. 103-106 4 p.

Research output: Contribution to journalArticle

88 Scopus citations

Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1

Emir, U. E., Brent Clark, H., Vollmers, M. L., Eberly, L. E. & Öz, G., Dec 2013, In : Journal of Neurochemistry. 127, 5, p. 660-668 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field 17O MR spectroscopy

Cui, W., Zhu, X. H., Vollmers, M. L., Colonna, E. T., Adriany, G., Tramm, B., Dubinsky, J. M. & Öz, G., Dec 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 12, p. 1846-1849 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012
42 Scopus citations

Elevated pontine and putamenal gaba levels in mild-moderate parkinson disease detected by 7 tesla proton mrs

Emir, U. E., Tuite, P. J. & Öz, G., Jan 25 2012, In : PloS one. 7, 1, e30918.

Research output: Contribution to journalArticle

103 Scopus citations
75 Scopus citations

Sweet and low: Measuring brain glucose during hypoglycemia

Seaquist, E. R. & Öz, G., Aug 1 2012, In : Diabetes. 61, 8, p. 1918-1919 2 p.

Research output: Contribution to journalComment/debate

2 Scopus citations
2011

Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy

Oz, G., Iltis, I., Hutter, D., Thomas, W., Bushara, K. O. & Gomez, C. M., Jun 1 2011, In : Cerebellum. 10, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

45 Scopus citations