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Research Output 1998 2019

2019
6 Citations (Scopus)

Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Wilson, M., Andronesi, O., Barker, P. B., Bartha, R., Bizzi, A., Bolan, P. J., Brindle, K. M., Choi, I. Y., Cudalbu, C., Dydak, U., Emir, U. E., Gonzalez, R. G., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P., Huppi, P. S., Hurd, R. E. & 29 others, Kantarci, K., Kauppinen, R. A., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjanska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Mullins, P. G., Murdoch, J. B., Nelson, S. J., Noeske, R., Oz, G., Pan, J. W., Peet, A. C., Poptani, H., Posse, S., Ratai, E. M., Salibi, N., Scheenen, T. W. J., Smith, I. C. P., Soher, B. J., Tkáč, I., Vigneron, D. B. & Howe, F. A., Aug 2019, In : Magnetic resonance in medicine. 82, 2, p. 527-550 24 p.

Research output: Contribution to journalReview article

Open Access
Protons
Brain
Brain Diseases
Magnetic Fields
Research
1 Citation (Scopus)
Amyotrophic Lateral Sclerosis
Motor Cortex
Upper Extremity
Pons
Disease Progression

Sensitivity of Volumetric Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy to Progression of Spinocerebellar Ataxia Type 1

Deelchand, D. K., Joers, J. M., Ravishankar, A., Lyu, T., Emir, U. E., Hutter, D., Gomez, C. M., Bushara, K. O., Lenglet, C., Eberly, L. E. & Oz, G., Sep 1 2019, In : Movement Disorders Clinical Practice. 6, 7, p. 549-558 10 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Ataxia
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Disease Progression

State-Dependent Changes in Brain Glycogen Metabolism

DiNuzzo, M., Walls, A. B., Öz, G., Seaquist, E. R., Waagepetersen, H. S., Bak, L. K., Nedergaard, M. & Schousboe, A., Jan 1 2019, Advances in Neurobiology. Springer New York LLC, p. 269-309 41 p. (Advances in Neurobiology; vol. 23).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycogen
Metabolism
Brain
Neurophysiology
Polydispersity
2018
5 Citations (Scopus)

Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles

Friedrich, J., Kordasiewicz, H. B., O'Callaghan, B., Handler, H. P., Wagener, C., Duvick, L., Swayze, E. E., Rainwater, O., Hofstra, B., Benneyworth, M., Nichols-Meade, T., Yang, P., Chen, Z., Ortiz, J. P., Clark, H. B., Oz, G., Larson, S., Zoghbi, H. Y., Henzler, C. & Orr, H. T., Nov 2 2018, In : JCI Insight. 3, 21

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Antisense Oligonucleotides
Transcriptome
Neurological Models
RNA
2 Citations (Scopus)

AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy

Park, Y. W., Deelchand, D. K., Joers, J. M., Hanna, B., Berrington, A., Gillen, J. S., Kantarci, K., Soher, B. J., Barker, P. B., Park, H., Öz, G. & Lenglet, C., Nov 2018, In : Magnetic resonance in medicine. 80, 5, p. 1787-1798 12 p.

Research output: Contribution to journalArticle

Open Access
Prescriptions
Spectrum Analysis
Atlases
Brain
Cerebrum
1 Citation (Scopus)
Spinocerebellar Ataxias
Neurology
Animal Models
Therapeutics
6 Citations (Scopus)

Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting

Deelchand, D. K., Kantarci, K. & Oz, G., Mar 1 2018, In : Magnetic resonance in medicine. 79, 3, p. 1241-1250 10 p.

Research output: Contribution to journalArticle

Open Access
Magnetic Resonance Spectroscopy
Spectrum Analysis
Aminobutyrates
Water Quality
Central Nervous System Diseases
8 Citations (Scopus)

Neurochemical abnormalities in premanifest and early spinocerebellar ataxias

Joers, J. M., Deelchand, D. K., Lyu, T., Emir, U. E., Hutter, D., Gomez, C. M., Bushara, K. O., Eberly, L. E. & Oz, G., Apr 1 2018, In : Annals of Neurology. 83, 4, p. 816-829 14 p.

Research output: Contribution to journalArticle

Open Access
Spinocerebellar Ataxias
Ataxia
Magnetic Resonance Spectroscopy
Neurochemistry
Mutation
19 Citations (Scopus)
Open Access
Acetylcysteine
Glutathione
Parkinson Disease
Oxidative Stress
Pharmacokinetics
18 Citations (Scopus)

Spinocerebellar ataxias: prospects and challenges for therapy development

Ashizawa, T., Oz, G. & Paulson, H. L., Oct 1 2018, In : Nature Reviews Neurology. 14, 10, p. 590-605 16 p.

Research output: Contribution to journalReview article

Spinocerebellar Ataxias
Therapeutics
Biomarkers
Research Personnel
Clinical Trials
2017
13 Citations (Scopus)

Cerebral glycogen in humans following acute and recurrent hypoglycemia: Implications on a role in hypoglycemia unawareness

Oz, G., DiNuzzo, M., Kumar, A., Moheet, A., Khowaja, A., Kubisiak, K., Eberly, L. E. & Seaquist, E. R., Aug 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 8, p. 2883-2893 11 p.

Research output: Contribution to journalArticle

Open Access
Glycogen
Hypoglycemia
Hypoglycemic Agents
Brain
Occipital Lobe
5 Citations (Scopus)

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB-PET Study

Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., Oz, G. & Kantarci, K., Nov 1 2017, In : Journal of Neuroimaging. 27, 6, p. 630-636 7 p.

Research output: Contribution to journalArticle

Open Access
Protons
Glutamic Acid
Magnetic Resonance Spectroscopy
Gyrus Cinguli
Inositol
3 Citations (Scopus)

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

Maliszewski Hall, A. M., Curtis, M. A., Tkac, I., Oz, G. & Rao, R., Jan 1 2017, In : Neurochemical Research. 42, 1, p. 133-140 8 p.

Research output: Contribution to journalArticle

Open Access
Rats
Brain
Growth
Hippocampus
Taurine
Amyotrophic Lateral Sclerosis
Protons
Magnetic Resonance Spectroscopy
Spectroscopy
Research
4 Citations (Scopus)
Hypoglycemia
Glucose
Magnetic resonance spectroscopy
Hypothalamus
Medical problems
3 Citations (Scopus)

Measurement of Hypothalamic Glucose Under Euglycemia and Hyperglycemia by MRI at 3T

Joers, J. M., Deelchand, D. K., Kumar, A., Moheet, A., Seaquist, E., Henry, P. G. & Öz, G., Mar 1 2017, In : Journal of magnetic resonance imaging : JMRI. 45, 3, p. 681-691 11 p., doi: 10.1002/jmri.25383.

Research output: Contribution to journalArticle

Open Access
Hyperglycemia
Glucose
Hypothalamus
Magnetic Resonance Spectroscopy
Cerebrospinal Fluid
10 Citations (Scopus)

Ultra-High Field Proton MR Spectroscopy in Early-Stage Amyotrophic Lateral Sclerosis

Cheong, I., Marjanska, M., Deelchand, D. K., Eberly, L. E., Walk, D. & Oz, G., Jun 1 2017, In : Neurochemical Research. 42, 6, p. 1833-1844 12 p.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Inositol
Protons
Magnetic Resonance Spectroscopy
Spectroscopy
2016
13 Citations (Scopus)

Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress

Lou, S., Lepak, V. C., Eberly, L. E., Roth, B., Cui, W., Zhu, X-H., Oz, G. & Dubinsky, J. M., Jan 1 2016, In : Human molecular genetics. 25, 13, p. 2813-2826 14 p.

Research output: Contribution to journalArticle

Physiological Stress
Huntington Disease
Oxygen Consumption
Brain
Dinitrophenols
47 Citations (Scopus)

Test-retest reproducibility of neurochemical profiles with short-echo, single-voxel MR spectroscopy at 3T and 7T

Terpstra, M., Cheong, I., Lyu, T., Deelchand, D. K., Emir, U. E., Bednarik, P., Eberly, L. E. & Oz, G., Oct 1 2016, In : Magnetic resonance in medicine. 76, 4, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Gyrus Cinguli
Signal-To-Noise Ratio
Cerebellum
Protons
2015
8 Citations (Scopus)
Spinocerebellar Ataxias
Transgenes
Histology
Magnetic Resonance Spectroscopy
Gene Expression
8 Citations (Scopus)

Cerebrospinal fluid biomarkers in spinocerebellar ataxia: A pilot study

Brouillette, A. M., Öz, G. & Gomez, C. M., Jan 1 2015, In : Disease Markers. 2015, 413098.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Spinocerebellar Ataxias
Biomarkers
Synucleins
Multiple System Atrophy
24 Citations (Scopus)

Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3T

Bednařík, P., Moheet, A., Deelchand, D. K., Emir, U. E., Eberly, L. E., Bareš, M., Seaquist, E. R. & Öz, G., Jun 1 2015, In : NMR in biomedicine. 28, 6, p. 685-693 9 p.

Research output: Contribution to journalArticle

Metabolites
Hippocampus
Neurochemistry
Creatine
Signal-To-Noise Ratio
8 Citations (Scopus)

In vivo Magnetic Resonance Spectroscopy of cerebral glycogen metabolism in animals and humans

Khowaja, A., Choi, I. Y., Seaquist, E. R. & Öz, G., Feb 1 2015, In : Metabolic Brain Disease. 30, 1, p. 255-261 7 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Glycogen
Metabolism
Animals
Magnetic Resonance Spectroscopy
23 Citations (Scopus)

In vivo neurometabolic profiling in patients with spinocerebellar ataxia types 1, 2, 3, and 7

Adanyeguh, I. M., Henry, P. G., Nguyen, T. M., Rinaldi, D., Jauffret, C., Valabregue, R., Emir, U. E., Deelchand, D. K., Brice, A., Eberly, L. E., Öz, G., Durr, A. & Mochel, F., Apr 15 2015, In : Movement Disorders. 30, 5, p. 662-670 9 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Pons
Creatine
Inositol
Neuroglia
1 Citation (Scopus)

MR Spectroscopy: A Longitudinal Biomarker for Substantia Nigra Pathology in Parkinson's Disease?

Oz, G., Sep 1 2015, In : Movement Disorders. 30, 10, p. 1304-1305 2 p.

Research output: Contribution to journalEditorial

Creatine
Substantia Nigra
Aspartic Acid
Parkinson Disease
Magnetic Resonance Spectroscopy
34 Citations (Scopus)

Multi-center reproducibility of neurochemical profiles in the human brain at 7T

van de Bank, B. L., Emir, U. E., Boer, V. O., van Asten, J. J. A., Maas, M. C., Wijnen, J. P., Kan, H. E., Oz, G., Klomp, D. W. J. & Scheenen, T. W. J., Mar 1 2015, In : NMR in biomedicine. 28, 3, p. 306-316 11 p.

Research output: Contribution to journalArticle

Metabolites
Brain
Ethics Committees
Creatine
Gyrus Cinguli
3 Citations (Scopus)

Proceedings of the workshop on Cerebellum, Basal Ganglia and Cortical Connections Unmasked in Health and Disorder Held in Brno, Czech Republic, October 17th, 2013

Bareš, M., Apps, R., Kikinis, Z., Timmann, D., Oz, G., Ashe, J., Loft, M., Koutsikou, S., Cerminara, N., Bushara, K. O. & Kašpárek, T., Jan 1 2015, In : Cerebellum. 14, 2, p. 142-150 9 p.

Research output: Contribution to journalReview article

Czech Republic
Basal Ganglia
Cerebellum
Parkinsonian Disorders
Education
19 Citations (Scopus)

Revisiting Glycogen Content in the Human Brain

Oz, G., DiNuzzo, M., Kumar, A., Moheet, A. & Seaquist, E. R., Dec 1 2015, In : Neurochemical Research. 40, 12, p. 2473-2481 9 p.

Research output: Contribution to journalArticle

Glycogen
Brain
Glucose
Magnetic resonance spectroscopy
Blood Glucose
37 Citations (Scopus)

Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T

Deelchand, D. K., Adanyeguh, I. M., Emir, U. E., Nguyen, T. M., Valabregue, R., Henry, P-G., Mochel, F. & Oz, G., May 1 2015, In : Magnetic resonance in medicine. 73, 5, p. 1718-1725 8 p.

Research output: Contribution to journalArticle

Pons
Calibration
Brain Stem
Matrix Attachment Regions
Brain
2014
13 Citations (Scopus)
Type 1 Diabetes Mellitus
Hypoglycemia
Glutamic Acid
Brain
Control Groups
209 Citations (Scopus)

Clinical proton MR spectroscopy in central nervous system disorders

Öz, G., Alger, J. R., Barker, P. B., Bartha, R., Bizzi, A., Boesch, C., Bolan, P. J., Brindle, K. M., Cudalbu, C., Dinçer, A., Dydak, U., Emir, U. E., Frahm, J., Gilberto González, R., Gruber, S., Gruetter, R., Gupta, R. K., Heerschap, A., Henning, A., Hetherington, H. P. & 30 others, Howe, F. A., Hüppi, P. S., Hurd, R. E., Kantarci, K., Klomp, D. W. J., Kreis, R., Kruiskamp, M. J., Leach, M. O., Lin, A. P., Luijten, P. R., Marjańska, M., Maudsley, A. A., Meyerhoff, D. J., Mountford, C. E., Nelson, S. J., Pamir, N., Pan, J. W., Peet, A. C., Poptani, H., Poptani, H., Posse, S., Pouwels, P. J. W., Ratai, E. M., Ross, B. D., Scheenen, T. W. J., Schuster, C., Smith, I. C. P., Soher, B. J., Tkáč, I. & Vigneron, D. B., Mar 5 2014, In : Radiology. 270, 3, p. 658-679 22 p.

Research output: Contribution to journalReview article

Central Nervous System Diseases
Magnetic Resonance Spectroscopy
Metabolic Diseases
Brain Diseases
Demyelinating Diseases
11 Citations (Scopus)
Hypoglycemia
gamma-Aminobutyric Acid
Magnetic Resonance Spectroscopy
Hypothalamus
Occipital Lobe
31 Citations (Scopus)

Mutant β-III spectrin causes mGluR1α mislocalization and functional deficits in a mouse model of spinocerebellar ataxia type 5

Armbrust, K. R., Wang, X., Hathorn, T. J., Cramer, S. W., Chen, G., Zu, T., Kangas, T., Zink, A. N., Öz, G., Ebner, T. J. & Ranum, L. P. W., Jan 1 2014, In : Journal of Neuroscience. 34, 30, p. 9891-9904 14 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Spectrin
Dendritic Spines
Purkinje Cells
Neurodegenerative Diseases
2013
12 Citations (Scopus)

Animal models and high field imaging and spectroscopy

Oz, G., Tkac, I. & Ugurbil, K., Sep 1 2013, In : Dialogues in Clinical Neuroscience. 15, 3, p. 263-278 16 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Animal Models
Brain
Magnetic Resonance Spectroscopy
Magnetic Fields
2 Citations (Scopus)

Diabetes: Does lactate sustain brain metabolism during hypoglycaemia?

Seaquist, E. R. & Oz, G., Jul 1 2013, In : Nature Reviews Endocrinology. 9, 7, p. 386-387 2 p.

Research output: Contribution to journalShort survey

Lactates
Hypoglycemia
Lactic Acid
Diabetes Mellitus
Glucose
16 Citations (Scopus)

Metabolomic analysis of cerebrospinal fluid indicates iron deficiency compromises cerebral energy metabolism in the infant monkey

Rao, R., Ennis, K., Oz, G., Lubach, G. R., Georgieff, M. K. & Coe, C. L., Mar 1 2013, In : Neurochemical Research. 38, 3, p. 573-580 8 p.

Research output: Contribution to journalArticle

Cerebrospinal fluid
Metabolomics
Energy Metabolism
Haplorhini
Cerebrospinal Fluid
5 Citations (Scopus)

MR spectroscopy in health and disease

Oz, G., Jan 1 2013, Handbook of the Cerebellum and Cerebellar Disorders. Springer Netherlands, p. 713-734 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cerebellar Diseases
Magnetic Resonance Spectroscopy
Neuroglia
Cerebellum
Health
77 Citations (Scopus)

N-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases

Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Oz, G., Cloyd, J. C. & Tuite, P. J., Jul 1 2013, In : Clinical Neuropharmacology. 36, 4, p. 103-106 4 p.

Research output: Contribution to journalArticle

Gaucher Disease
Acetylcysteine
Glutathione
Parkinson Disease
Brain
13 Citations (Scopus)

Non-invasive detection of neurochemical changes prior to overt pathology in a mouse model of spinocerebellar ataxia type 1

Emir, U. E., Clark, H. B., Vollmers, M. L., Eberly, L. E. & Oz, G., Dec 1 2013, In : Journal of Neurochemistry. 127, 5, p. 660-668 9 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Spinocerebellar Ataxias
Pathology
Magnetic Resonance Spectroscopy
Movement Disorders
19 Citations (Scopus)

Non-invasive measurement of cerebral oxygen metabolism in the mouse brain by ultra-high field 17O MR spectroscopy

Cui, W., Zhu, X. H., Vollmers, M. L., Colonna, E. T., Adriany, G., Tramm, B., Dubinsky, J. M. & Öz, G., Dec 1 2013, In : Journal of Cerebral Blood Flow and Metabolism. 33, 12, p. 1846-1849 4 p.

Research output: Contribution to journalArticle

Magnetic Resonance Spectroscopy
Oxygen
Brain
Nervous System Diseases
Intubation
2012
40 Citations (Scopus)
Glycogen
Type 1 Diabetes Mellitus
Hypoglycemia
Brain
Blood Glucose
96 Citations (Scopus)

Elevated pontine and putamenal gaba levels in mild-moderate parkinson disease detected by 7 tesla proton mrs

Emir, U. E., Tuite, P. J. & Oz, G., Jan 25 2012, In : PloS one. 7, 1, e30918.

Research output: Contribution to journalArticle

Parkinson disease
Pons
protons
Parkinson Disease
Protons
72 Citations (Scopus)
Brain
Aminobutyrates
Pons
Chemical shift
Substantia Nigra
2 Citations (Scopus)

Sweet and low: Measuring brain glucose during hypoglycemia

Seaquist, E. R. & Öz, G., Aug 1 2012, In : Diabetes. 61, 8, p. 1918-1919 2 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
Hypoglycemia
Glucose
Brain
2011
39 Citations (Scopus)

Distinct neurochemical profiles of spinocerebellar ataxias 1, 2, 6, and cerebellar multiple system atrophy

Oz, G., Iltis, I., Hutter, D., Thomas, W., Bushara, K. O. & Gomez, C. M., Jun 1 2011, In : Cerebellum. 10, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Multiple System Atrophy
Spinocerebellar Ataxias
Ataxia
Inositol
Biomarkers
19 Citations (Scopus)

In vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice

Öz, G., Vollmers, M. L., Nelson, C. D., Shanley, R., Eberly, L. E., Orr, H. T. & Clark, H. B., Dec 1 2011, In : Experimental Neurology. 232, 2, p. 290-298 9 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Inositol
Doxycycline
Taurine
Pathology
10 Citations (Scopus)
Glycogen
Magnetic Resonance Spectroscopy
Brain
Hypoglycemia
Glucose
65 Citations (Scopus)
Cerebellum
Brain Stem
Brain
Artifacts
Protons
32 Citations (Scopus)

Simultaneous measurement of glucose transport and utilization in the human brain

Shestov, A. A., Emir, U. E., Kumar, A., Henry, P-G., Seaquist, E. R. & Oz, G., Nov 1 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 5, p. E1040-E1049

Research output: Contribution to journalArticle

Glucose
Brain
Radioactive Tracers
Blood-Brain Barrier
Energy Metabolism