1976 …2020

Research output per year

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Research Output

2020

A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease

McArthur, J. G., Svenstrup, N., Chen, C., Fricot, A., Carvalho, C., Nguyen, J., Nguyen, P., Parachikova, A., Abdulla, F., Vercellotti, G. M., Hermine, O., Edwards, D., Ribeil, J. A., Belcher, J. D. & Maciel, T. T., Mar 1 2020, In : Haematologica. 105, 3, p. 623-631 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Antithrombotic effects of heme-degrading and heme-binding proteins

Nath, K. A., Grande, J. P., Belcher, J. D., Garovic, V. D., Croatt, A. J., Hillestad, M. L., Barry, M. A., Nath, M. C., Regan, R. F. & Vercellotti, G. M., Mar 1 2020, In : American journal of physiology. Heart and circulatory physiology. 318, 3, p. H671-H681

Research output: Contribution to journalArticle

Decreased erythrocyte binding of Siglec-9 increases neutrophil activation in sickle cell disease

Kiser, Z. M., Lizcano, A., Nguyen, J., Becker, G. L., Belcher, J. D., Varki, A. P. & Vercellotti, G. M., Mar 2020, In : Blood Cells, Molecules, and Diseases. 81, 102399.

Research output: Contribution to journalArticle

Open Access

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

Belcher, J. D., Zhang, P., Nguyen, J., Kiser, Z. M., Nath, K. A., Hu, J., Trent, J. O. & Vercellotti, G. M., Jun 30 2020, In : Frontiers in immunology. 11, 1370.

Research output: Contribution to journalArticle

Open Access

It’s all in the film

Ebadi, M., Beckman, A. K., Yohe, S. L., Rashidi, A. & Vercellotti, G. M., Apr 1 2020, In : British journal of haematology. 189, 1, 1 p.

Research output: Contribution to journalComment/debate

Renal functional decline in sickle cell disease and trait

Nath, K. A. & Vercellotti, G. M., Jan 1 2020, In : Journal of the American Society of Nephrology. 31, 2, p. 236-238 3 p.

Research output: Contribution to journalEditorial

The multifaceted role of ischemia/reperfusion in sickle cell anemia

Hebbel, R. P., Belcher, J. D. & Vercellotti, G. M., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1062-1072 11 p.

Research output: Contribution to journalArticle

Thrombin-mediated activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Sparkenbaugh, E. M., Chen, C., Brzoska, T., Nguyen, J., Wang, S., Vercellotti, G. M., Key, N. S., Sundd, P., Belcher, J. D. & Pawlinski, R., 2020, In : Blood.

Research output: Contribution to journalArticle

2019

A Simpler Answer – After All This Time

Coetzee, D. J., Vercellotti, G. M. & Olson, A. P., Feb 2019, In : American Journal of Medicine. 132, 2, p. e37-e38

Research output: Contribution to journalArticle

Open Access

Critical role of C5a in sickle cell disease

Vercellotti, G. M., Dalmasso, A. P., Schaid, T. R., Nguyen, J., Chen, C., Ericson, M. E., Abdulla, F., Killeen, T., Lindorfer, M. A., Taylor, R. P. & Belcher, J. D., Mar 2019, In : American Journal of Hematology. 94, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex

Nath, K. A., Garovic, V. D., Grande, J. P., Croatt, A. J., Ackerman, A. W., Farrugia, G., Katusic, Z. S., Belcher, J. D. & Vercellotti, G. M., Sep 1 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F695-F704

Research output: Contribution to journalArticle

1 Scopus citations

Intravenous immunoglobulin for treatment of necrobiotic xanthogranuloma

Goyal, A., O`Leary, D. H., Vercellotti, G. M., Miller, D. D. & Mc Glave, P. B., Jan 1 2019, In : Dermatologic Therapy. 32, 1, e12744.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2 Scopus citations

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

Telen, M. J., Malik, P. & Vercellotti, G. M., Feb 1 2019, In : Nature Reviews Drug Discovery. 18, 2, p. 139-158 20 p.

Research output: Contribution to journalReview article

Open Access
27 Scopus citations
2018
Open Access
6 Scopus citations

Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease

Louie, J. E., Anderson, C. J., Fayaz M. Fomani, K., Henry, A., Killeen, T., Mohandas, N., Yazdanbakhsh, K., Belcher, J. D., Vercellotti, G. M. & Shi, P. A., Feb 1 2018, In : Transfusion. 58, 2, p. 470-479 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation

Hegerova, L., Bachan, A., Cao, Q., Vu, H. X., Rogosheske, J., Reding, M. T., Brunstein, C. G., Arora, M., Ustun, C., Vercellotti, G. M. & Bachanova, V., Dec 2018, In : Biology of Blood and Marrow Transplantation. 24, 12, p. e20-e25

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
5 Scopus citations

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H., Nguyen, P., Killeen, T., Miescher, S. M., Brinkman, N., Nath, K. A., Steer, C. J. & Vercellotti, G. M., Apr 2018, In : PloS one. 13, 4, e0196455.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles

Jana, S., Strader, M. B., Meng, F., Hicks, W., Kassa, T., Tarandovskiy, I., De Paoli, S., Simak, J., Heaven, M. R., Belcher, J. D., Vercellotti, G. M. & Alayash, A. I., Nov 2 2018, In : JCI Insight. 3, 21

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vasoocclusion, inflammation and anemia

Belcher, J. D., Gomperts, E., Nguyen, J., Chen, C., Abdulla, F., Kiser, Z. M., Gallo, D., Levy, H., Otterbein, L. E. & Vercellotti, G. M., Oct 2018, In : PloS one. 13, 10, e0205194.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Role of TLR4 signaling in the nephrotoxicity of Heme and heme proteins

Nath, K. A., Belcher, J. D., Nath, M. C., Grande, J. P., Croatt, A. J., Ackerman, A. W., Katusic, Z. S. & Vercellotti, G. M., Jan 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F906-F914

Research output: Contribution to journalArticle

8 Scopus citations

Romidepsin-associated cardiac toxicity and ECG changes: A case report and review of the literature

Rivers, Z. T., Oostra, D. R., Westholder, J. S. & Vercellotti, G. M., Jan 1 2018, In : Journal of Oncology Pharmacy Practice. 24, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

Santiago, R. P., Guarda, C. C., Figueiredo, C. V. B., Fiuza, L. M., Aleluia, M. M., Adanho, C. S. A., Carvalho, M. O. S., Pitanga, T. N., Zanette, D. L., Lyra, I. M., Nascimento, V. M. L., Vercellotti, G. M., Belcher, J. D. & Goncalves, M. S., Sep 2018, In : Blood Cells, Molecules, and Diseases. 72, p. 34-36 3 p.

Research output: Contribution to journalLetter

Open Access
2 Scopus citations
2017

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

Solovey, A., Somani, A., Belcher, J. D., Milbauer, L., Vincent, L., Pawlinski, R., Nath, K. A., Kelm, R. J., Mackman, N., O'Sullivan, M. G., Gupta, K., Vercellotti, G. M. & Hebbel, R. P., Nov 2017, In : American Journal of Hematology. 92, 11, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Belcher, J. D., Chen, C., Nguyen, J., Zhang, P., Abdulla, F., Nguyen, P., Killeen, T., Xu, P., O'Sullivan, G., Nath, K. A. & Vercellotti, G. M., May 10 2017, In : Antioxidants and Redox Signaling. 26, 14, p. 748-762 15 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Pathobiology of Sickle Cell Disease

Hebbel, R. P. & Vercellotti, G. M., Aug 15 2017, Hematology: Basic Principles and Practice. Hoffman, R. (ed.). 7 ed. Elsevier Inc., p. 571-583 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
3 Scopus citations

The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises

Gomperts, E., Belcher, J. D., Otterbein, L. E., Coates, T. D., Wood, J., Skolnick, B. E., Levy, H. & Vercellotti, G. M., Jun 2017, In : American Journal of Hematology. 92, 6, p. 569-582 14 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations
2016

Clonal lymphoproliferations in a patient with common variable immunodeficiency

Williams, S. J., Moench, L. E., Khan, F., Vercellotti, G. M. & Linden, M. A., Nov 1 2016, In : Lab Medicine. 47, 4, p. 318-325 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
20 Scopus citations

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

Shi, P. A., Choi, E., Chintagari, N. R., Nguyen, J., Guo, X., Yazdanbakhsh, K., Mohandas, N., Alayash, A. I., Manci, E. A., Belcher, J. D. & Vercellotti, G. M., Nov 1 2016, In : British journal of haematology. 175, 4, p. 714-723 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

Shabani, E., Opoka, R. O., Bangirana, P., Park, G. S., Vercellotti, G. M., Guan, W., Hodges, J. S., Lavstsen, T. & John, C. C., Jun 3 2016, In : Scientific reports. 6, 27084.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2015
39 Scopus citations
23 Scopus citations

High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria

Shabani, E., Opoka, R. O., Idro, R., Schmidt, R., Park, G. S., Bangirana, P., Vercellotti, G. M., Hodges, J. S., Widness, J. A. & John, C. C., Jan 1 2015, In : Clinical Infectious Diseases. 60, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
5 Scopus citations

Reply to eisenhut

Shabani, E., Vercellotti, G. M. & John, C. C., Apr 1 2015, In : Clinical Infectious Diseases. 60, 7, p. 1138-1139 2 p.

Research output: Contribution to journalLetter

Special delivery: Microparticles convey heme

Vercellotti, G. M., Jun 11 2015, In : Blood. 125, 24, p. 3677-3678 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-κB activation in transgenic sickle mice

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Nguyen, P., Nguyen, M., Okeley, N. M., Benjamin, D. R., Senter, P. D. & Vercellotti, G. M., Feb 23 2015, In : PloS one. 10, 2, e0117772.

Research output: Contribution to journalArticle

15 Scopus citations
2014
22 Scopus citations

De novo CD5-positive primary cardiac diffuse large B-cell lymphoma diagnosed by pleural fluid cytology

Cioc, A. M., Jessurun, J., Vercellotti, G. M. & Pambuccian, S. E., Mar 1 2014, In : Diagnostic Cytopathology. 42, 3, p. 259-267 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hematopoietic stem-cell transplantation for advanced systemic mastocytosis

Ustun, C., Reiter, A., Scott, B. L., Nakamura, R., Damaj, G., Kreil, S., Shanley, R., Hogan, W. J., Perales, M. A., Shore, T., Baurmann, H., Stuart, R., Gruhn, B., Doubek, M., Hsu, J. W., Tholouli, E., Gromke, T., Godley, L. A., Pagano, L., Gilman, A. & 24 others, Wagner, E. M., Shwayder, T., Bornhäuser, M., Papadopoulos, E. B., Böhm, A., Vercellotti, G., Van Lint, M. T., Schmid, C., Rabitsch, W., Pullarkat, V., Legrand, F., Yakoub-Agha, I., Saber, W., Barrett, J., Hermine, O., Hagglund, H., Sperr, W. R., Popat, U., Alyea, E. P., Devine, S., Deeg, H. J., Weisdorf, D., Akin, C. & Valent, P., Oct 10 2014, In : Journal of Clinical Oncology. 32, 29, p. 3264-3274 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

270 Scopus citations

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

22 Scopus citations

Look out heme, Mac is back in town

Vercellotti, G. M., Aug 28 2014, In : Blood. 124, 9, p. 1388-1389 2 p.

Research output: Contribution to journalArticle

1 Scopus citations