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Research Output 1976 2019

2019

A Simpler Answer – After All This Time

Coetzee, D. J., Vercellotti, G. M. & Olson, A. P., Feb 1 2019, In : American Journal of Medicine. 132, 2, p. e37-e38

Research output: Contribution to journalArticle

4 Citations (Scopus)

Critical role of C5a in sickle cell disease

Vercellotti, G. M., Dalmasso, A. P., Schaid, T. R., Nguyen, J., Chen, C., Ericson, M. E., Abdulla, F., Killeen, T., Lindorfer, M. A., Taylor, R. P. & Belcher, J. D., Mar 1 2019, In : American Journal of Hematology. 94, 3, p. 327-337 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Anaphylatoxin C5a Receptor
P-Selectin
Complement Activation
Immunoglobulin G
2 Citations (Scopus)

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-15
Cell- and Tissue-Based Therapy
Acute Myeloid Leukemia
Natural Killer Cells
Cytokines

Heme oxygenase-2 protects against ischemic acute kidney injury: influence of age and sex

Nath, K. A., Garovic, V. D., Grande, J. P., Croatt, A. J., Ackerman, A. W., Farrugia, G., Katusic, Z. S., Belcher, J. D. & Vercellotti, G. M., Sep 1 2019, In : American journal of physiology. Renal physiology. 317, 3, p. F695-F704

Research output: Contribution to journalArticle

Acute Kidney Injury
Ischemia
Heme Oxygenase-1
Heme Oxygenase (Decyclizing)
Kidney

Intravenous immunoglobulin for treatment of necrobiotic xanthogranuloma

Goyal, A., O`Leary, D. H., Vercellotti, G. M., Miller, D. D. & Mc Glave, P. B., Jan 1 2019, In : Dermatologic Therapy. 32, 1, e12744.

Research output: Contribution to journalLetter

Necrobiotic Xanthogranuloma
Intravenous Immunoglobulins
1 Citation (Scopus)
Open Access
Hematologic Neoplasms
Allografts
Graft vs Host Disease
Cell Transplantation
Transplants
von Willebrand Factor
B-Cell Chronic Lymphocytic Leukemia
Stem Cells
Transplants
Antibodies
10 Citations (Scopus)

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

Telen, M. J., Malik, P. & Vercellotti, G. M., Feb 1 2019, In : Nature Reviews Drug Discovery. 18, 2, p. 139-158 20 p.

Research output: Contribution to journalReview article

Sickle Cell Anemia
Sickle Hemoglobin
Therapeutics
Fetal Hemoglobin
Hydroxyurea
2018
4 Citations (Scopus)
Open Access
Nociception
Sickle Cell Anemia
Ligands
Pain
Morphine
8 Citations (Scopus)

Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease

Louie, J. E., Anderson, C. J., Fayaz M. Fomani, K., Henry, A., Killeen, T., Mohandas, N., Yazdanbakhsh, K., Belcher, J. D., Vercellotti, G. M. & Shi, P. A., Feb 1 2018, In : Transfusion. 58, 2, p. 470-479 10 p.

Research output: Contribution to journalArticle

Hemopexin
Plasma Exchange
Haptoglobins
Sickle Cell Anemia
Heme
1 Citation (Scopus)

Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation

Hegerova, L., Bachan, A., Cao, Q., Vu, H. X., Rogosheske, J., Reding, M. T., Brunstein, C. G., Arora, M., Ustun, C., Vercellotti, G. M. & Bachanova, V., Dec 1 2018, In : Biology of Blood and Marrow Transplantation. 24, 12, p. e20-e25

Research output: Contribution to journalArticle

Stem Cell Transplantation
Lymphoma
Thrombosis
Catheters
Cell Transplantation
5 Citations (Scopus)
Follistatin
Bone Marrow
Tissue Donors
Clinical Trials
Transplants
12 Citations (Scopus)

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H., Nguyen, P., Killeen, T., Miescher, S. M., Brinkman, N., Nath, K. A., Steer, C. J. & Vercellotti, G. M., Apr 2018, In : PloS one. 13, 4, e0196455.

Research output: Contribution to journalArticle

Open Access
heme oxygenase (biliverdin-producing)
Hemopexin
sickle cell anemia
Heme Oxygenase-1
Haptoglobins
5 Citations (Scopus)

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles

Jana, S., Strader, M. B., Meng, F., Hicks, W., Kassa, T., Tarandovskiy, I., De Paoli, S., Simak, J., Heaven, M. R., Belcher, J. D., Vercellotti, G. M. & Alayash, A. I., Nov 2 2018, In : JCI Insight. 3, 21

Research output: Contribution to journalArticle

Open Access
Cell-Derived Microparticles
Hemoglobins
Hydroxyurea
Sickle Cell Anemia
Post Translational Protein Processing
1 Citation (Scopus)

Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vasoocclusion, inflammation and anemia

Belcher, J. D., Gomperts, E., Nguyen, J., Chen, C., Abdulla, F., Kiser, Z. M., Gallo, D., Levy, H., Otterbein, L. E. & Vercellotti, G. M., Oct 2018, In : PloS one. 13, 10, e0205194.

Research output: Contribution to journalArticle

Open Access
sickle cell anemia
carbon monoxide
Sickle Cell Anemia
Carbon Monoxide
anemia
7 Citations (Scopus)

Role of TLR4 signaling in the nephrotoxicity of Heme and heme proteins

Nath, K. A., Belcher, J. D., Nath, M. C., Grande, J. P., Croatt, A. J., Ackerman, A. W., Katusic, Z. S. & Vercellotti, G. M., Jan 1 2018, In : American Journal of Physiology - Renal Physiology. 314, 5, p. F906-F914

Research output: Contribution to journalArticle

Hemeproteins
Toll-Like Receptor 4
Heme
Acute Kidney Injury
Kidney
2 Citations (Scopus)

Romidepsin-associated cardiac toxicity and ECG changes: A case report and review of the literature

Rivers, Z. T., Oostra, D. R., Westholder, J. S. & Vercellotti, G. M., Jan 1 2018, In : Journal of Oncology Pharmacy Practice. 24, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Electrocardiography
Enteropathy-Associated T-Cell Lymphoma
Peripheral T-Cell Lymphoma
Cutaneous T-Cell Lymphoma
2 Citations (Scopus)

Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients

Santiago, R. P., Guarda, C. C., Figueiredo, C. V. B., Fiuza, L. M., Aleluia, M. M., Adanho, C. S. A., Carvalho, M. O. S., Pitanga, T. N., Zanette, D. L., Lyra, I. M., Nascimento, V. M. L., Vercellotti, G. M., Belcher, J. D. & Goncalves, M. S., Sep 1 2018, In : Blood Cells, Molecules, and Diseases. 72, p. 34-36 3 p.

Research output: Contribution to journalLetter

Hemopexin
Haptoglobins
Sickle Cell Anemia
Pediatrics
Serum
2017
9 Citations (Scopus)

A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade

Solovey, A., Somani, A., Belcher, J. D., Milbauer, L., Vincent, L., Pawlinski, R., Nath, K. A., Kelm, R. J., Mackman, N., O'Sullivan, M. G., Gupta, K., Vercellotti, G. M. & Hebbel, R. P., Nov 1 2017, In : American Journal of Hematology. 92, 11, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

Transgenic Mice
Monocytes
Tumor Necrosis Factor-alpha
Sickle Cell Anemia
Blood Cells
20 Citations (Scopus)

Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate

Belcher, J. D., Chen, C., Nguyen, J., Zhang, P., Abdulla, F., Nguyen, P., Killeen, T., Xu, P., O'Sullivan, G., Nath, K. A. & Vercellotti, G. M., May 10 2017, In : Antioxidants and Redox Signaling. 26, 14, p. 748-762 15 p.

Research output: Contribution to journalArticle

Open Access
Oxidative stress
Sickle Cell Anemia
Oxidative Stress
Inflammation
Heme
1 Citation (Scopus)

Pathobiology of Sickle Cell Disease

Hebbel, R. P. & Vercellotti, G. M., Aug 15 2017, Hematology: Basic Principles and Practice. Hoffman, R. (ed.). 7 ed. Elsevier Inc., p. 571-583 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sickle Cell Anemia
Hemolysis
Oxidants
Endothelium
1 Citation (Scopus)
Strongyloides
Strongyloidiasis
Strongyloides stercoralis
T-Cell Leukemia
Human T-lymphotropic virus 1
6 Citations (Scopus)

The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises

Gomperts, E., Belcher, J. D., Otterbein, L. E., Coates, T. D., Wood, J., Skolnick, B. E., Levy, H. & Vercellotti, G. M., Jun 2017, In : American Journal of Hematology. 92, 6, p. 569-582 14 p.

Research output: Contribution to journalReview article

Open Access
Heme Oxygenase (Decyclizing)
Sickle Cell Anemia
Carbon Monoxide
Hemoglobinopathies
beta-Globins
2016
1 Citation (Scopus)

Clonal lymphoproliferations in a patient with common variable immunodeficiency

Williams, S. J., Moench, L. E., Khan, F., Vercellotti, G. M. & Linden, M. A., Nov 1 2016, In : Lab Medicine. 47, 4, p. 318-325 8 p.

Research output: Contribution to journalArticle

Common Variable Immunodeficiency
Immunoglobulins
Cells
Immunocompetence
Lymphoproliferative Disorders
20 Citations (Scopus)
Hemopexin
Sickle Cell Anemia
Blood Vessels
Inflammation
Liver
9 Citations (Scopus)

Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

Shi, P. A., Choi, E., Chintagari, N. R., Nguyen, J., Guo, X., Yazdanbakhsh, K., Mohandas, N., Alayash, A. I., Manci, E. A., Belcher, J. D. & Vercellotti, G. M., Nov 1 2016, In : British Journal of Haematology. 175, 4, p. 714-723 10 p.

Research output: Contribution to journalArticle

Apoferritins
Haptoglobins
Sickle Cell Anemia
Iron
Kidney
5 Citations (Scopus)

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

Shabani, E., Opoka, R. O., Bangirana, P., Park, G. S., Vercellotti, G. M., Guan, W., Hodges, J. S., Lavstsen, T. & John, C. C., Jun 3 2016, In : Scientific reports. 6, 27084.

Research output: Contribution to journalArticle

Protein C
Malaria
Genotype
Communicable Diseases
Immunologic Factors
2015
32 Citations (Scopus)
Angiogenesis Inducing Agents
Graft vs Host Disease
Bone Marrow
Clinical Trials
Transplants
20 Citations (Scopus)
Proximal Kidney Tubule
Heme Oxygenase-1
Haptoglobins
Sickle Cell Anemia
Hemoglobins
7 Citations (Scopus)

High plasma erythropoietin levels are associated with prolonged coma duration and increased mortality in children with cerebral malaria

Shabani, E., Opoka, R. O., Idro, R., Schmidt, R., Park, G. S., Bangirana, P., Vercellotti, G. M., Hodges, J. S., Widness, J. A. & John, C. C., Jan 1 2015, In : Clinical Infectious Diseases. 60, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Cerebral Malaria
Child Mortality
Coma
Erythropoietin
Cerebrospinal Fluid
5 Citations (Scopus)
Melitten
Interleukin-13
L-Lactate Dehydrogenase
Interleukin-4
Permeability

Reply to eisenhut

Shabani, E., Vercellotti, G. M. & John, C. C., Apr 1 2015, In : Clinical Infectious Diseases. 60, 7, p. 1138-1139 2 p.

Research output: Contribution to journalLetter

Cerebral Malaria
Coma
Erythropoietin
1 Citation (Scopus)

Special delivery: Microparticles convey heme

Vercellotti, G. M., Jun 11 2015, In : Blood. 125, 24, p. 3677-3678 2 p.

Research output: Contribution to journalArticle

Endothelial cells
Sickle Cell Anemia
Heme
Blood
Endothelial Cells
13 Citations (Scopus)

The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-κB activation in transgenic sickle mice

Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Nguyen, P., Nguyen, M., Okeley, N. M., Benjamin, D. R., Senter, P. D. & Vercellotti, G. M., Feb 23 2015, In : PloS one. 10, 2, e0117772.

Research output: Contribution to journalArticle

sickle cell anemia
Sickle Cell Anemia
endothelium
Transgenic Mice
Endothelium
2014
21 Citations (Scopus)
Fetal Blood
Transplantation
Tissue Donors
Recurrence
Confidence Intervals
beta-Globins
Blood
Cells
1 Citation (Scopus)

De novo CD5-positive primary cardiac diffuse large B-cell lymphoma diagnosed by pleural fluid cytology

Cioc, A. M., Jessurun, J., Vercellotti, G. M. & Pambuccian, S. E., Mar 1 2014, In : Diagnostic Cytopathology. 42, 3, p. 259-267 9 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
Cell Biology
Pleural Effusion
Pericardial Effusion
Echocardiography
70 Citations (Scopus)

Hematopoietic stem-cell transplantation for advanced systemic mastocytosis

Ustun, C., Reiter, A., Scott, B. L., Nakamura, R., Damaj, G., Kreil, S., Shanley, R., Hogan, W. J., Perales, M. A., Shore, T., Baurmann, H., Stuart, R., Gruhn, B., Doubek, M., Hsu, J. W., Tholouli, E., Gromke, T., Godley, L. A., Pagano, L., Gilman, A. & 24 others, Wagner, E. M., Shwayder, T., Bornhäuser, M., Papadopoulos, E. B., Böhm, A., Vercellotti, G., Van Lint, M. T., Schmid, C., Rabitsch, W., Pullarkat, V., Legrand, F., Yakoub-Agha, I., Saber, W., Barrett, J., Hermine, O., Hagglund, H., Sperr, W. R., Popat, U., Alyea, E. P., Devine, S., Deeg, H. J., Weisdorf, D., Akin, C. & Valent, P., Oct 10 2014, In : Journal of Clinical Oncology. 32, 29, p. 3264-3274 11 p.

Research output: Contribution to journalArticle

Systemic Mastocytosis
Hematopoietic Stem Cell Transplantation
Survival
Transplantation
Mast-Cell Leukemia
241 Citations (Scopus)

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

Belcher, J. D., Chen, C., Nguyen, J., Milbauer, L., Abdulla, F., Alayash, A. I., Smith, A., Nath, K. A., Hebbel, R. P. & Vercellotti, G. M., Jan 16 2014, In : Blood. 123, 3, p. 377-390 14 p.

Research output: Contribution to journalArticle

Endothelial cells
Sickle Cell Anemia
Heme
Endothelial Cells
Chemical activation
21 Citations (Scopus)

H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice

Vercellotti, G. M., Khan, F. B., Nguyen, J., Chen, C., Bruzzone, C. M., Bechtel, H., Brown, G., Nath, K. A., Steer, C. J., Hebbel, R. P. & Belcher, J. D., Jan 1 2014, In : Frontiers in Pharmacology. 5 APR, Article 79.

Research output: Contribution to journalArticle

Apoferritins
Ceruloplasmin
Sickle Cell Anemia
Transgenic Mice
Heme Oxygenase-1
1 Citation (Scopus)

Look out heme, Mac is back in town

Vercellotti, G. M., Aug 28 2014, In : Blood. 124, 9, p. 1388-1389 2 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Heme
Transplants
Anemia
Bone
12 Citations (Scopus)

Not simply misshapen red cells: Multimolecular and cellular events in sickle vaso-occlusion

Vercellotti, G. M. & Belcher, J. D., Apr 1 2014, In : Journal of Clinical Investigation. 124, 4, p. 1462-1465 4 p.

Research output: Contribution to journalComment/debate

Blood Platelets
Sickle Cell Anemia
Blood Proteins
Neutrophils
Endothelial Cells
8 Citations (Scopus)
Pure Red-Cell Aplasia
Boronic Acids
Pyrazines
Blood Group Incompatibility
Hematopoietic Stem Cell Transplantation
2013
18 Citations (Scopus)

Age sensitizes the kidney to heme protein-induced acute kidney injury

Nath, K. A., Grande, J. P., Farrugia, G., Croatt, A. J., Belcher, J. D., Hebbel, R. P., Vercellotti, G. M. & Katusic, Z. S., Feb 8 2013, In : American Journal of Physiology - Renal Physiology. 304, 3, p. F317-F325

Research output: Contribution to journalArticle

Hemeproteins
Acute Kidney Injury
Kidney
Hemoglobins
Messenger RNA
122 Citations (Scopus)

Carbon monoxide expedites metabolic exhaustion to inhibit tumor growth

Wegiel, B., Gallo, D., Csizmadia, E., Harris, C., Belcher, J., Vercellotti, G. M., Penacho, N., Seth, P., Sukhatme, V., Ahmed, A., Pandolfi, P. P., Helczynski, L., Bjartell, A., Persson, J. L. & Otterbein, L. E., Dec 1 2013, In : Cancer Research. 73, 23, p. 7009-7021 13 p.

Research output: Contribution to journalArticle

Carbon Monoxide
Heme Oxygenase-1
Growth
Neoplasms
Prostatic Neoplasms
290 Citations (Scopus)

Hemolysis and free hemoglobin revisited: Exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

Schaer, D. J., Buehler, P. W., Alayash, A. I., Belcher, J. D. & Vercellotti, G. M., Feb 21 2013, In : Blood. 121, 8, p. 1276-1284 9 p.

Research output: Contribution to journalReview article

Hemin
Hemolysis
Hemoglobins
Haptoglobins
Hemopexin
12 Citations (Scopus)
Fetal Blood
Transplantation
Transplants
Multivariate Analysis
Lymphocytes
46 Citations (Scopus)

MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice

Belcher, J. D., Young, M., Chen, C., Nguyen, J., Burhop, K., Tran, P. & Vercellotti, G. M., Jan 1 2013, In : Blood. 122, 15, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Carbon Monoxide
Modulators
Transgenic Mice
Hemoglobins
11 Citations (Scopus)

β-globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34+-based in vitro model

Sjeklocha, L. M., Wong, P. Y. P., Belcher, J. D., Vercellotti, G. M. & Steer, C. J., Nov 18 2013, In : PloS one. 8, 11, e80403.

Research output: Contribution to journalArticle

Beauty
Gene therapy
Globins
transposons
Sickle Hemoglobin
2012
78 Citations (Scopus)

Blood-nanoparticle interactions and in Vivo biodistribution: Impact of surface peg and ligand properties

Shah, N. B., Vercellotti, G. M., White, J. G., Fegan, A., Wagner, C. R. & Bischof, J. C., Aug 6 2012, In : Molecular pharmaceutics. 9, 8, p. 2146-2155 10 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
Ligands
Surface Properties
Blood Proteins