1993 …2022

Research output per year

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Research Output

2020

Intrinsically disordered HAX-1 regulates Ca2+ cycling by interacting with lipid membranes and the phospholamban cytoplasmic region

Larsen, E. K., Weber, D. K., Wang, S., Gopinath, T., Blackwell, D. J., Dalton, M. P., Robia, S. L., Gao, J. & Veglia, G., Jan 1 2020, In : Biochimica et Biophysica Acta - Biomembranes. 1862, 1, 183034.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Multi-receiver solid-state NMR using polarization optimized experiments (POE) at ultrafast magic angle spinning

Gopinath, T., Weber, D. K. & Veglia, G., May 1 2020, In : Journal of biomolecular NMR. 74, 4-5, p. 267-285 19 p.

Research output: Contribution to journalArticle

Nanosecond-Timescale Dynamics and Conformational Heterogeneity in Human GCK Regulation and Disease

Sternisha, S. M., Whittington, A. C., Martinez Fiesco, J. A., Porter, C., McCray, M. M., Logan, T., Olivieri, C., Veglia, G., Steinbach, P. J. & Miller, B. G., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1109-1118 10 p.

Research output: Contribution to journalArticle

Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons

Gerlits, O., Weiss, K. L., Blakeley, M. P., Veglia, G., Taylor, S. S. & Kovalevsky, A., 2020, Methods in Enzymology. Academic Press Inc., p. 311-331 21 p. (Methods in Enzymology; vol. 634).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
1 Scopus citations
2019

An intramembrane sensory circuit monitors sortase A-mediated processing of streptococcal adhesins

Hall, J. W., Lima, B. P., Herbomel, G. G., Gopinath, T., McDonald, L. A., Shyne, M. T., Lee, J. K., Kreth, J., Ross, K. F., Veglia, G. & Herzberg, M. C., May 7 2019, In : Science signaling. 12, 580, eaas9941.

Research output: Contribution to journalArticle

1 Scopus citations

Cushing’s syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity

Walker, C., Wang, Y., Olivieri, C., Karamafrooz, A., Casby, J., Bathon, K., Calebiro, D., Gao, J., Bernlohr, D. A., Taylor, S. S. & Veglia, G., Aug 28 2019, In : Science advances. 5, 8, eaaw9298.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cysteine-ethylation of tissue-extracted membrane proteins as a tool to detect conformational states by solid-state NMR spectroscopy

Weber, D. K., Bader, T., Larsen, E. K., Wang, S., Gopinath, T., Distefano, M. & Veglia, G., 2019, Methods in Enzymology. Shukla, A. K. (ed.). Academic Press Inc., p. 281-304 24 p. (Methods in Enzymology; vol. 621).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dynamic allostery-based molecular workings of kinase:peptide complexes

Ahuja, L. G., Aoto, P. C., Kornev, A. P., Veglia, G. & Taylor, S. S., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 30, p. 15052-15061 10 p.

Research output: Contribution to journalArticle

Open Access

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase’s enzymatic cycle

Wang, Y., V.S, M., Kim, J., Li, G., Ahuja, L. G., Aoto, P., Taylor, S. S. & Veglia, G., Dec 1 2019, In : Nature communications. 10, 1, 799.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
4 Scopus citations

Improving the quality of oriented membrane protein spectra using heat-compensated separated local field experiments

Wang, S., Gopinath, T. & Veglia, G., Nov 1 2019, In : Journal of biomolecular NMR. 73, 10-11, p. 617-624 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Structure and Function of Tryptophan-Tyrosine Dyads in Biomimetic β Hairpins

McCaslin, T. G., Pagba, C. V., Chi, S. H., Hwang, H. J., Gumbart, J. C., Perry, J. W., Olivieri, C., Porcelli, F., Veglia, G., Guo, Z., McDaniel, M. & Barry, B. A., Apr 4 2019, In : Journal of Physical Chemistry B. 123, 13, p. 2780-2791 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Synthesis and NMR Characterization of the Prenylated Peptide, a-Factor

Bader, T. K., Rappe, T. M., Veglia, G. & Distefano, M. D., Jan 1 2019, Methods in Enzymology. Wand, A. J. (ed.). Academic Press Inc., p. 207-238 32 p. (Methods in Enzymology; vol. 614).

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access
2 Scopus citations

Triply compensated RF pulses in high-resolution NMR spectroscopy

Subrahmanian, M. V., Olivieri, C. & Veglia, G., Jan 1 2019, In : eMagRes. 8, 4, p. 353-362 10 p.

Research output: Contribution to journalArticle

Use of paramagnetic systems to speed-up NMR data acquisition and for structural and dynamic studies

Kocman, V., Di Mauro, G. M., Veglia, G. & Ramamoorthy, A., Oct 2019, In : Solid State Nuclear Magnetic Resonance. 102, p. 36-46 11 p.

Research output: Contribution to journalReview article

4 Scopus citations

Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex

Gerlits, O., Weiss, K. L., Blakeley, M. P., Veglia, G., Taylor, S. S. & Kovalevsky, A., Jan 1 2019, In : Science advances. 5, 3, eaav0482.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2018

ALARM NMR for HTS triage and chemical probe validation

Dahlin, J. L., Cuellar, M., Singh, G., Nelson, K. M., Strasser, J., Rappe, T., Xia, Y., Veglia, G. & Walters, M. A., Mar 1 2018, In : Current protocols in chemical biology. 10, 1, p. 91-117 27 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
Open Access
10 Scopus citations

Clearance kinetics of the VGF-derived neuropeptide TLQP-21

Guo, Z. K., Sahu, B. S., He, R., Finan, B., Cero, C., Verardi, R., Razzoli, M., Veglia, G., Di Marchi, R. D., Miles, J. M. & Bartolomucci, A., Oct 2018, In : Neuropeptides. 71, p. 97-103 7 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

Tomasini, M. D., Wang, Y., Karamafrooz, A., Li, G., Beuming, T., Gao, J., Taylor, S. S., Veglia, G. & Simon, S. M., Dec 1 2018, In : Scientific reports. 8, 1, 720.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Design and characterization of chionodracine-derived antimicrobial peptides with enhanced activity against drug-resistant human pathogens

Olivieri, C., Bugli, F., Menchinelli, G., Veglia, G., Buonocore, F., Scapigliati, G., Stocchi, V., Ceccacci, F., Papi, M., Sanguinetti, M. & Porcelli, F., Jan 1 2018, In : RSC Advances. 8, 72, p. 41331-41346 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers

Nelson, S. E. D., Ha, K. N., Gopinath, T., Exline, M. H., Mascioni, A., Thomas, D. D. & Veglia, G., Jun 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 6, p. 1335-1341 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Experimental aspects of polarization optimized experiments (POE) for magic angle spinning solid-state NMR of microcrystalline and membrane-bound proteins

Gopinath, T. & Veglia, G., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 37-53 17 p. (Methods in Molecular Biology; vol. 1688).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Optimal design of offset-specific radio frequency pulses for solution and solid-state NMR using a genetic algorithm

Subrahmanian, M. V., Dregni, A. J. & Veglia, G., Jun 13 2018, Modern Magnetic Resonance. Springer International Publishing, p. 605-615 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies

Chipot, C., Dehez, F., Schnell, J. R., Zitzmann, N., Pebay-Peyroula, E., Catoire, L. J., Miroux, B., Kunji, E. R. S., Veglia, G., Cross, T. A. & Schanda, P., Apr 11 2018, In : Chemical Reviews. 118, 7, p. 3559-3607 49 p.

Research output: Contribution to journalReview article

Open Access
46 Scopus citations
7 Scopus citations

Probing protein-protein interactions using asymmetric labeling and carbonyl-carbon selective heteronuclear NMR spectroscopy

Larsen, E. K., Olivieri, C., Walker, C., Manu, V. S., Gao, J., Bernlohr, D. A., Tonelli, M., Markley, J. L. & Veglia, G., Jan 1 2018, In : Molecules. 23, 8, 1937.

Research output: Contribution to journalReview article

Open Access
3 Scopus citations

Simultaneous detection of intra-and inter-molecular paramagnetic relaxation enhancements in protein complexes

Olivieri, C., Subrahmanian, M. V., Xia, Y., Kim, J., Porcelli, F. & Veglia, G., Jan 1 2018, In : Journal of biomolecular NMR. 70, 3, p. 133-140 8 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2017
Open Access
7 Scopus citations

A dynamic hydrophobic core orchestrates allostery in protein kinases

Kim, J., Ahuja, L. G., Chao, F. A., Xia, Y., McClendon, C. L., Kornev, A. P., Taylor, S. S. & Veglia, G., Apr 2017, In : Science Advances. 3, 4, e1600663.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein

Fusco, G., Pape, T., Stephens, A. D., Mahou, P., Costa, A. R., Kaminski, C. F., Schierle, G. S. K., Vendruscolo, M., Veglia, G., Dobson, C. M. & De Simone, A., May 11 2017, In : Nature communications. 8, 1 p.

Research output: Contribution to journalArticle

Open Access

Enhancing the sensitivity of multidimensional NMR experiments by using triply-compensated π pulses

Xia, Y., Rossi, P., Subrahmanian, M. V., Huang, C., Saleh, T., Olivieri, C., Kalodimos, C. G. & Veglia, G., Dec 1 2017, In : Journal of biomolecular NMR. 69, 4, p. 237-243 7 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

Ahuja, L. G., Kornev, A. P., Mcclendon, C. L., Veglia, G. & Taylor, S. S., Feb 7 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 6, p. E931-E940

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Optimization of 1H decoupling eliminates sideband artifacts in 3D TROSY-based triple resonance experiments

Xia, Y., Rossi, P., Tonelli, M., Huang, C., Kalodimos, C. G. & Veglia, G., Sep 1 2017, In : Journal of biomolecular NMR. 69, 1, p. 45-52 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
11 Scopus citations

Solution and Solid-State Nuclear Magnetic Resonance Structural Investigations of the Antimicrobial Designer Peptide GL13K in Membranes

Harmouche, N., Aisenbrey, C., Porcelli, F., Xia, Y., Nelson, S. E., Chen, X., Raya, J., Vermeer, L., Aparicio, C., Veglia, G., Gorr, S-U. & Bechinger, B., Aug 15 2017, In : Biochemistry. 56, 32, p. 4269-4278 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

15N and 13C- SOFAST-HMQC editing enhances 3D-NOESY sensitivity in highly deuterated, selectively [1H,13C]-labeled proteins

Rossi, P., Xia, Y., Khanra, N., Veglia, G. & Kalodimos, C. G., Dec 1 2016, In : Journal of biomolecular NMR. 66, 4, p. 259-271 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Accurate Determination of Conformational Transitions in Oligomeric Membrane Proteins

Sanz-Hernández, M., Vostrikov, V. V., Veglia, G. & De Simone, A., Mar 15 2016, In : Scientific reports. 6, 23063.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Allosteric Regulation of the M2 Protein from Influenza A by Cholesterol

Veglia, G., Nelson, S. E. D. & Gopinath, T., Mar 29 2016, In : Biophysical journal. 110, 6, p. 1207-1208 2 p.

Research output: Contribution to journalShort survey

Open Access
1 Scopus citations

A Semiautomated Assignment Protocol for Methyl Group Side Chains in Large Proteins

Kim, J., Wang, Y., Li, G. & Veglia, G., Jan 1 2016, Methods in Enzymology. Academic Press Inc., p. 35-57 23 p. (Methods in Enzymology; vol. 566).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Ca2+ ATPase Conformational Transitions in Lipid Bilayers Mapped by Site-directed Ethylation and Solid-State NMR

Vostrikov, V. V., Gustavsson, M., Tata, G., Mullen, D., Dicke, A. A., Truong, V. & Veglia, G., Feb 19 2016, In : ACS Chemical Biology. 11, 2, p. 329-334 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
14 Scopus citations

NMR structure and conformational dynamics of AtPDFL2.1, a defensin-like peptide from Arabidopsis thaliana

Omidvar, R., Xia, Y., Porcelli, F., Bohlmann, H. & Veglia, G., Dec 1 2016, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1864, 12, p. 1739-1747 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
6 Scopus citations

Orphan Spin Polarization: A Catalyst for High-Throughput Solid-State NMR Spectroscopy of Proteins

Gopinath, T. & Veglia, G., Jan 1 2016, Annual Reports on NMR Spectroscopy, 2016. Webb, G. A. (ed.). Academic Press Inc., p. 103-121 19 p. (Annual Reports on NMR Spectroscopy; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations