Research Output per year
Personal profile
Research interests
My research interest is focused on the discovery, the elucidation of the mode of action of natural and natural-based products as well as their promotion as high added-value bioactive compounds, mainly as therapeutic and anticancer agents.
I obtained my BSc and MSc at the University of Strasbourg (Strasbourg, France) and completed my PhD at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (Luxembourg, Grand Duchy of Luxembourg) in the framework of the European RedCat Project. As Marie Curie Fellow, my research project focused on the discovery and the elucidation of the mode of action of several natural and natural-based products as anticancer drugs. After acquisition of new skills in natural products isolation and structure elucidation at the Fundacíon MEDINA (Granada, Spain),
I joined the Schmidt-Dannert lab in October 2016 as Postdoctoral Research Associate. My research project aims to screen and isolate new antifungal compounds from Basidiomycota.
Education/Academic qualification
PhD, Universite de Lorraine
Sep 1 2009 → Dec 20 2013
Masters, Universite de Strasbourg
Sep 1 2007 → Jun 30 2009
Bachelors, Universite Louis Pasteur
Sep 1 2004 → Jun 30 2007
External positions
Chemist in Natural Products Chemistry, Fundación MEDINA
Nov 3 2014 → Jan 29 2015PhD Student, Recherches Scientifiques Luxembourg asbl
Sep 1 2009 → Dec 20 2013Research interests
- Natural Products
- Drug Discovery
Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.
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Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2010 2015
Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer
Gaascht, F., Dicato, M. & Diederich, M., Nov 1 2015, In : Genes and Nutrition. p. 1-17 17 p.Research output: Contribution to journal › Review article
Pharmacopoeias
Coffee
Neoplasms
Beverages
Insurance Benefits
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines
Seidel, C., Schnekenburger, M., Zwergel, C., Gaascht, F., Mai, A., Dicato, M., Kirsch, G., Valente, S. & Diederich, M., Aug 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3797-3801 5 p.Research output: Contribution to journal › Article
Histone Deacetylases
Bioactivity
Cells
Derivatives
Coumarins
Plumbagin modulates leukemia cell redox status
Gaascht, F., Teiten, M. H., Cerella, C., Dicato, M., Bagrel, D. & Diederich, M., 2014, In : Molecules. 19, 7, p. 10011-10032 22 p.Research output: Contribution to journal › Article
Reactive Oxygen Species
Cell death
Antioxidants
Cytotoxicity
Sulfhydryl Compounds
Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions
Teiten, M. H., Gaascht, F., Dicato, M. & Diederich, M., 2013, In : Biochemical Pharmacology. p. 1239-1247 9 p.Research output: Contribution to journal › Review article
Medicinal Plants
Bioactivity
Medicine
Microorganisms
Animals
Découverte, identification et caractérisation de molécules d'origine naturelle capables de cibler les voies de transduction, de prolifération, d'inflammation et de mort cellulaire dans des cellules cancéreuses
Research output: Other contribution
Open Access
File
Cell Death
Curcumin
Inflammation
Prostatic Neoplasms
Neoplasms
Press/Media
Mushrooms: The Pharmaceuticals of the Future
4/3/17
1 item of media coverage
Press/Media: Expert Comment
Prizes
European Doctorate
Francois Gaascht (Recipient), Dec 20 2013
Prize: Prize (including medals and awards)