Personal profile

Research interests

My research interest is focused on the discovery, the elucidation of the mode of action of natural and natural-based products as well as their promotion as high added-value bioactive compounds, mainly as therapeutic and anticancer agents.

I obtained my BSc and MSc at the University of Strasbourg (Strasbourg, France) and completed my PhD at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (Luxembourg, Grand Duchy of Luxembourg) in the framework of the European RedCat Project. As Marie Curie Fellow, my research project focused on the discovery and the elucidation of the mode of action of several natural and natural-based products as anticancer drugs. After acquisition of new skills in natural products isolation and structure elucidation at the Fundacíon MEDINA (Granada, Spain),

I joined the Schmidt-Dannert lab in October 2016 as Postdoctoral Research Associate. My research project aims to screen and isolate new antifungal compounds from Basidiomycota.

Education / Academic qualification

PhD, Universite de Lorraine

Sep 1 2009Dec 20 2013

Masters, Universite de Strasbourg

Sep 1 2007Jun 30 2009

Bachelors, Universite Louis Pasteur

Sep 1 2004Jun 30 2007

External positions

Chemist in Natural Products Chemistry, Fundación MEDINA

Nov 3 2014Jan 29 2015

PhD Student, Recherches Scientifiques Luxembourg asbl

Sep 1 2009Dec 20 2013

Keywords

  • Natural Products
  • Drug Discovery

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Research Output 2010 2015

  • 6 Review article
  • 5 Article
  • 1 Other contribution
6 Citations

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Gaascht, F., Dicato, M. & Diederich, M. Nov 1 2015 In : Genes and Nutrition. p. 1-17 17 p.

Research output: Contribution to journalReview article

Pharmacopoeias
Coffee
Neoplasms
Beverages
Insurance Benefits
11 Citations

Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines

Seidel, C., Schnekenburger, M., Zwergel, C., Gaascht, F., Mai, A., Dicato, M., Kirsch, G., Valente, S. & Diederich, M. Aug 15 2014 In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3797-3801 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Neoplasms
Cross Circulation
Cerebellar Ataxia
Castration
11 Citations

Plumbagin modulates leukemia cell redox status

Gaascht, F., Teiten, M. H., Cerella, C., Dicato, M., Bagrel, D. & Diederich, M. 2014 In : Molecules. 19, 7, p. 10011-10032 22 p.

Research output: Contribution to journalArticle

Bartonellaceae
Ethical Review
Anthralin
Castration
Oxidation-Reduction
22 Citations

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

Teiten, M. H., Gaascht, F., Dicato, M. & Diederich, M. 2013 In : Biochemical Pharmacology. p. 1239-1247 9 p.

Research output: Contribution to journalReview article

Supravalvular Aortic Stenosis
Aortic Valve Stenosis
Medicinal Plants
Antipain
Porphobilinogen Synthase

Prizes

European Doctorate

Francois Gaascht (Recipient), Dec 20 2013

Prize: Prize (including medals and awards)