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Personal profile

Research interests

My research interest is focused on the discovery, the elucidation of the mode of action of natural and natural-based products as well as their promotion as high added-value bioactive compounds, mainly as therapeutic and anticancer agents.

I obtained my BSc and MSc at the University of Strasbourg (Strasbourg, France) and completed my PhD at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (Luxembourg, Grand Duchy of Luxembourg) in the framework of the European RedCat Project. As Marie Curie Fellow, my research project focused on the discovery and the elucidation of the mode of action of several natural and natural-based products as anticancer drugs. After acquisition of new skills in natural products isolation and structure elucidation at the Fundacíon MEDINA (Granada, Spain),

I joined the Schmidt-Dannert lab in October 2016 as Postdoctoral Research Associate. My research project aims to screen and isolate new antifungal compounds from Basidiomycota.

Education/Academic qualification

PhD, Universite de Lorraine

Sep 1 2009Dec 20 2013

Masters, Universite de Strasbourg

Sep 1 2007Jun 30 2009

Bachelors, Universite Louis Pasteur

Sep 1 2004Jun 30 2007

External positions

Chemist in Natural Products Chemistry, Fundación MEDINA

Nov 3 2014Jan 29 2015

PhD Student, Recherches Scientifiques Luxembourg asbl

Sep 1 2009Dec 20 2013

Research interests

  • Natural Products
  • Drug Discovery

Fingerprint The Fingerprint is created by mining the titles and abstracts of the person's research outputs and projects/funding awards to create an index of weighted terms from discipline-specific thesauri.

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Curcumin Medicine & Life Sciences
Prostatic Neoplasms Medicine & Life Sciences
Bioactivity Chemical Compounds
Cell Death Medicine & Life Sciences
Cell death Chemical Compounds
Neoplasms Medicine & Life Sciences
Wnt Signaling Pathway Medicine & Life Sciences
NF-kappa B Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2010 2015

  • 5 Article
  • 5 Review article
  • 1 Editorial
  • 1 Other contribution
23 Citations (Scopus)

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Gaascht, F., Dicato, M. & Diederich, M., Nov 1 2015, In : Genes and Nutrition. p. 1-17 17 p.

Research output: Contribution to journalReview article

Pharmacopoeias
Coffee
Neoplasms
Beverages
Insurance Benefits
22 Citations (Scopus)

Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines

Seidel, C., Schnekenburger, M., Zwergel, C., Gaascht, F., Mai, A., Dicato, M., Kirsch, G., Valente, S. & Diederich, M., Aug 15 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 16, p. 3797-3801 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Bioactivity
Cells
Derivatives
Coumarins
19 Citations (Scopus)

Plumbagin modulates leukemia cell redox status

Gaascht, F., Teiten, M. H., Cerella, C., Dicato, M., Bagrel, D. & Diederich, M., 2014, In : Molecules. 19, 7, p. 10011-10032 22 p.

Research output: Contribution to journalArticle

Reactive Oxygen Species
Cell death
Antioxidants
Cytotoxicity
Sulfhydryl Compounds
39 Citations (Scopus)

Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

Teiten, M. H., Gaascht, F., Dicato, M. & Diederich, M., 2013, In : Biochemical Pharmacology. p. 1239-1247 9 p.

Research output: Contribution to journalReview article

Medicinal Plants
Bioactivity
Medicine
Microorganisms
Animals

Découverte, identification et caractérisation de molécules d'origine naturelle capables de cibler les voies de transduction, de prolifération, d'inflammation et de mort cellulaire dans des cellules cancéreuses

Translated title of the contribution: Discovery, identification and characterization of natural origins molecules capable of targeting transduction, proliferation inflammation pathways and cell death in cancer cellsGaascht, F., Dec 20 2013

Research output: Other contribution

Open Access
File
Cell Death
Curcumin
Inflammation
Prostatic Neoplasms
Neoplasms

Press/Media

Mushrooms: The Pharmaceuticals of the Future

Francois Gaascht

4/3/17

1 item of Media coverage

Press/Media: Expert Comment

Fellowships, Honors, and Prizes

European Doctorate

Francois Gaascht (Recipient), Dec 20 2013

Prize: Prize (including medals and awards)