FNU Alinakhi



Research activity per year

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Personal profile

Research interests

Currently, my research focuses on the development of TGR5 agonists and gut restricted bile acid analogues inhibitory to Clostridium difficile spore germination. I am also interested in developing new reaction strategies for novel heterocycles of potential therapeutic properties. Most of my research efforts have been focused on developing modulators for Sirtuin enzyme for the post-translational modification studies. 

Personal profile

Post-Doctoral Research Associate

Carnegie Mellon University - Department of Chemistry- Center for DNA Science and Technology (CNAST), Pittsburgh, PA, USA

“Development of Janus-based γ-peptide nucleic acids (J-γPNAs) for targeting unstable CUG-RNA repeats towards the treatment of muscular dystrophy”.


Organic & Medicinal Chemistry – Dr. Reddy’s Institute of Life Sciences, University of Hyderabad, India. 


Selected Publications:

  • 7-Methylation of Chenodeoxycholic Acid Derivatives Yields a Significant Increase in TGR5 Receptor Potency. Ali Nakhi, Connor M. McDermott, Kristen L. Stoltz, Kristen John, Jon Hawkinson, Elizabeth A. Ambrose, Alexander Khoruts, Michael J. Sadowsky, Peter I. Dosa J. Med. Chem, 2019, 62, 14, 6824-6830.
  • Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest. Org. Biomol. Chem. 2013, 11, 4930. Most Read Article. Ali Nakhi, Md. S. Rahman, G. P. K. Seerapu, B. Rakesh Kumar, K. L. Kumar, Pushkar Kulkarni, D. Haldar, Manojit Pal. 
  • AlCl3  mediated hydroarylation–heteroarylation in a single pot: a direct access to densely functionalized olefins of pharmacological interest. Chem. Commun. 2013, 49, 6268. Ali Nakhi, S. Archana, G. P. K. Seerapu, Ch. Keerthana Sarma, K. Lalith Kumar, Pushkar Kulkarni, Devyani Haldar, Manojit Pal

  • A new route to indoles via Sila-Sonogashira strategy: Identification of novel small molecules as potential antituberculosis agents. Med. Chem. Commun. 2011, 2, 1006. Ali Nakhi, Bagineni Prasad, Raja Mohan Rao, Uppender Reddy, Sandhya Sandra, Ravada Kishore, Javed Iqbal, Manojit Pal. 

  • Thieno[3,2-c]pyran-4-one based novel small molecules: their synthesis, crystal structure analysis and in vitro evaluation as potential anticancer agents.  Bioorg.Med. Chem. Lett. 2012, 22, 4418.  Ali Nakhi, Raju Adepu, D. Rambabu, Ravada Kishore, G. R. Vanaja, Arunasree M. Kalle, Manojit Pal


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