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Research Output 1984 2019

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2019

Both the classical and alternative non-homologous end joining pathways contribute to the fusion of drastically shortened telomeres induced by TRF2 overexpression

Nera, B., Huang, H. S., Hendrickson, E. A. & Xu, L., Apr 18 2019, In : Cell Cycle. 18, 8, p. 880-888 9 p.

Research output: Contribution to journalArticle

Telomere Shortening
Ligases
DNA Ligases
Telomere-Binding Proteins
Chromosomes
3 Citations (Scopus)

Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin

Cleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A. & Baird, D. M., May 2019, In : Genome research. 29, 5, p. 737-749 13 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Genome
Genomic Instability
Sequence Analysis
Chromothripsis
1 Citation (Scopus)

CtIP is essential for telomere replication

Stroik, S., Kurtz, K. & Hendrickson, E. A., Sep 26 2019, In : Nucleic acids research. 47, 17, p. 8927-8940 14 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Telomere Shortening
Genomic Instability
Telomere Homeostasis
Double-Stranded DNA Breaks
3 Citations (Scopus)

DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Liddiard, K., Ruis, B. L., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. & Baird, D. M., Jan 1 2019, In : Nucleic acids research. 47, 5, p. 2402-2424 23 p.

Research output: Contribution to journalArticle

Open Access
DNA Ligases
Chromatids
Telomere
Cell Cycle
Ligases

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

Lu, H., Saha, J., Beckmann, P. J., Hendrickson, E. A. & Davis, A. J., Oct 10 2019, In : Nucleic acids research. 47, 18, p. 9467-9479 13 p.

Research output: Contribution to journalArticle

Open Access
DNA-Activated Protein Kinase
DNA Damage
Chromatin
Catalytic Domain
Ataxia Telangiectasia
2018
3 Citations (Scopus)

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length

Gu, P., Jia, S., Takasugi, T., Smith, E., Nandakumar, J., Hendrickson, E. A. & Chang, S., Aug 1 2018, In : Aging cell. 17, 4, e12783.

Research output: Contribution to journalArticle

Telomerase
Telomere
Mutation
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction

Li, G., Martínez-Bonet, M., Wu, D., Yang, Y., Cui, J., Nguyen, H. N., Cunin, P., Levescot, A., Bai, M., Westra, H. J., Okada, Y., Brenner, M. B., Raychaudhuri, S., Hendrickson, E. A., Maas, R. L. & Nigrovic, P. A., Aug 1 2018, In : Nature Genetics. 50, 8, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Enzymes
Genome-Wide Association Study
Juvenile Arthritis
Carrier Proteins
2 Citations (Scopus)

PARP1 is required for preserving telomeric integrity but is dispensable for A-NHEJ

Harvey, A., Mielke, N., Grimstead, J. W., Jones, R. E., Nguyen, T., Mueller, M., Baird, D. M. & Hendrickson, E. A., Oct 1 2018, In : Oncotarget. 9, 78, p. 34821-34837 17 p.

Research output: Contribution to journalArticle

Telomere
Breast Neoplasms
Genetic Markers
Ovarian Neoplasms
DNA Damage

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation

Ngo, G., Hyatt, S., Grimstead, J., Jones, R., Hendrickson, E. A., Pepper, C. & Baird, D., Dec 1 2018, In : Oncotarget. 9, 101, p. 37549-37563 15 p.

Research output: Contribution to journalArticle

Telomere
Plasma Cell Leukemia
Cell Line
Genomic Instability
Telomerase
2 Citations (Scopus)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

Kawale, A. S., Akopiants, K., Valerie, K., Ruis, B. L., Hendrickson, E. A., Huang, S. Y. N., Pommier, Y. & Povirk, L. F., Jan 1 2018, In : Nucleic acids research. 46, 17, p. 8926-8939 14 p.

Research output: Contribution to journalArticle

Open Access
Zinostatin
Double-Stranded DNA Breaks
DNA-Activated Protein Kinase
Null Lymphocytes
Chromosomes
2017
7 Citations (Scopus)

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Thompson, E. L., Yeo, J. E., Lee, E. A., Kan, Y., Raghunandan, M., Wiek, C., Hanenberg, H., Schärer, O. D., Hendrickson, E. A. & Sobeck, A., Jan 1 2017, In : Nucleic acids research. 45, 20, p. 11837-11857 21 p.

Research output: Contribution to journalArticle

Open Access
Fanconi Anemia
Fanconi Anemia Complementation Group D2 Protein
Chromatin
Fanconi Anemia Complementation Group Proteins
Null Lymphocytes
5 Citations (Scopus)

Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair

Kan, Y., Batada, N. N. & Hendrickson, E. A., Jul 1 2017, In : DNA Repair. 55, p. 64-75 12 p.

Research output: Contribution to journalArticle

Open Access
Virus Integration
Repair
Radiation
Genes
Annealing
20 Citations (Scopus)

Mechanisms of precise genome editing using oligonucleotide donors

Kan, Y., Ruis, B. L., Takasugi, T. & Hendrickson, E. A., Jul 2017, In : Genome research. 27, 7, p. 1099-1111 13 p.

Research output: Contribution to journalArticle

Open Access
Oligonucleotides
Oligodeoxyribonucleotides
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Conversion
Deoxyribonuclease I
2016
22 Citations (Scopus)

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

Alotaibi, M., Sharma, K., Saleh, T., Povirk, L. F., Hendrickson, E. A. & Gewirtz, D. A., Mar 1 2016, In : Radiation research. 185, 3, p. 229-245 17 p.

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Autophagy
tumors
deoxyribonucleic acid
recovery
7 Citations (Scopus)

Restoration of ATM expression in DNA-PKcs-deficient cells inhibits signal end joining

Neal, J. A., Xu, Y., Abe, M., Hendrickson, E. A. & Meek, K., Apr 1 2016, In : Journal of Immunology. 196, 7, p. 3032-3042 11 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Catalytic Domain
V(D)J Recombination
Cell Line
Cultured Cells
12 Citations (Scopus)

Sister chromatid telomere fusions, but not NHEJmediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4

Liddiard, K., Ruis, B., Takasugi, T., Harvey, A., Ashelford, K. E., Hendrickson, E. A. & Baird, D. M., May 2016, In : Genome research. 26, 5, p. 588-600 13 p.

Research output: Contribution to journalArticle

DNA Ligases
Chromatids
Telomere
Genome
Telomere Shortening
2015
1 Citation (Scopus)

Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Hendrickson, E. A. & Baird, D. M., Jan 2 2015, In : Molecular and Cellular Oncology. 2, 1, e975623.

Research output: Contribution to journalArticle

Clonal Evolution
Telomere
Genomic Instability
Neoplasms
56 Citations (Scopus)

ATRX represses alternative lengthening of telomeres

Napier, C. E., Huschtscha, L. I., Harvey, A., Bower, K., Noble, J. R., Hendrickson, E. A. & Reddel, R. R., Jan 1 2015, In : Oncotarget. 6, 18, p. 16543-16558 16 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomerase
Telomere Shortening
Chromatin Assembly and Disassembly
Homologous Recombination
27 Citations (Scopus)

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Li, Y., Park, A. I., Mou, H., Colpan, C., Bizhanova, A., Akama-Garren, E., Joshi, N., Hendrickson, E. A., Feldser, D., Yin, H., Anderson, D. G., Jacks, T., Weng, Z. & Xue, W., May 28 2015, In : Genome biology. 16, 1, 111.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
DNA Breaks
Gene Rearrangement
Nucleotides
Liver
22 Citations (Scopus)

Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation

Batenburg, N. L., Thompson, E. L., Hendrickson, E. A. & Zhu, X. D., May 12 2015, In : EMBO Journal. 34, 10, p. 1399-1416 18 p.

Research output: Contribution to journalArticle

Cockayne Syndrome
Double-Stranded DNA Breaks
Chromatin
Repair
Chemical activation
125 Citations (Scopus)

DNA2 drives processing and restart of reversed replication forks in human cells

Thangavel, S., Berti, M., Levikova, M., Pinto, C., Gomathinayagam, S., Vujanovic, M., Zellweger, R., Moore, H., Lee, E. H., Hendrickson, E. A., Cejka, P., Stewart, S., Lopes, M. & Vindigni, A., Jan 1 2015, In : Journal of Cell Biology. 208, 5, p. 545-562 18 p.

Research output: Contribution to journalArticle

DNA Replication
Homologous Recombination
DNA Damage
Adenosine Triphosphatases
Genome
34 Citations (Scopus)

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

Castella, M., Jacquemont, C., Thompson, E. L., Yeo, J. E., Cheung, R. S., Huang, J. W., Sobeck, A., Hendrickson, E. A. & Taniguchi, T., Jan 1 2015, In : PLoS genetics. 11, 10, e1005563.

Research output: Contribution to journalArticle

Fanconi Anemia
anemia
DNA damage
DNA Damage
DNA
28 Citations (Scopus)

XRCC4/XLF Interaction is variably required for DNA repair and is not required for ligase IV stimulation

Roy, S., de Melo, A. J., Xu, Y., Tadi, S. K., Négrel, A., Hendrickson, E., Modesti, M. & Meek, K., Jan 1 2015, In : Molecular and cellular biology. 35, 17, p. 3017-3028 12 p.

Research output: Contribution to journalArticle

Ligases
DNA Repair
Ligation
DNA
In Vitro Techniques
2014
16 Citations (Scopus)

A role for XLF in DNA repair and recombination in human somatic cells

Fattah, F. J., Kweon, J., Wang, Y., Lee, E. H., Kan, Y., Lichter, N., Weisensel, N. & Hendrickson, E. A., Mar 1 2014, In : DNA Repair. 15, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Null Lymphocytes
Joining
DNA Repair
Genetic Recombination
Repair
151 Citations (Scopus)

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J. B., Sallmyr, A., Ruis, B. L., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., Jasin, M. & Brunet, E., Sep 18 2014, In : Molecular Cell. 55, 6, p. 829-842 14 p.

Research output: Contribution to journalArticle

Genetic Translocation
Clustered Regularly Interspaced Short Palindromic Repeats
Neoplasms
Carcinogenesis
Chromosomes
45 Citations (Scopus)

CtIP mediates replication fork recovery in a FANCD2-regulated manner

Yeo, J. E., Lee, E. H., Hendrickson, E. A. & Sobeck, A., Jul 2014, In : Human molecular genetics. 23, 14, p. 3695-3705 11 p., ddu078.

Research output: Contribution to journalArticle

Fanconi Anemia
Proteins
Recombinational DNA Repair
Fanconi Anemia Complementation Group D2 Protein
DNA Repair-Deficiency Disorders
38 Citations (Scopus)

DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

Oh, S., Harvey, A., Zimbric, J., Wang, Y., Nguyen, T., Jackson, P. J. & Hendrickson, E. A., Jan 1 2014, In : DNA Repair. 21, p. 97-110 14 p.

Research output: Contribution to journalArticle

DNA Ligases
Joining
Repair
Gene Targeting
Genes
37 Citations (Scopus)

Escape from telomere-driven crisis is DNA ligase III dependent

Jones, R. E., Oh, S., Grimstead, J. W., Zimbric, J., Roger, L., Heppel, N. H., Ashelford, K. E., Liddiard, K., Hendrickson, E. A. & Baird, D. M., Aug 21 2014, In : Cell reports. 8, 4, p. 1063-1076 14 p.

Research output: Contribution to journalArticle

DNA Ligases
Telomere
Fusion reactions
Joining
Clonal Evolution
13 Citations (Scopus)

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity

Smith, S., Fox, J., Mejia, M., Ruangpradit, W., Saberi, A., Kim, S., Choi, Y., Oh, S., Wang, Y., Choi, K., Li, L., Hendrickson, E. A., Takeda, S., Muller, M. & Myung, K., Jan 23 2014, In : PloS one. 9, 1, e87203.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylase Inhibitors
DNA repair
DNA Repair
Repair
38 Citations (Scopus)

Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells

Karanja, K., Lee, E. H., Hendrickson, E. A. & Campbell, J. L., May 15 2014, In : Cell Cycle. 13, 10, p. 1540-1550 11 p.

Research output: Contribution to journalArticle

Fanconi Anemia
Formaldehyde
Cisplatin
DNA
Ficusin
33 Citations (Scopus)

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

Waters, C. A., Strande, N. T., Pryor, J. M., Strom, C. N., Mieczkowski, P., Burkhalter, M. D., Oh, S., Qaqish, B. F., Moore, D. T., Hendrickson, E. A. & Ramsden, D. A., Jul 3 2014, In : Nature communications. 5, 4286.

Research output: Contribution to journalArticle

Joining
Ligation
bypasses
Chromosome Breakage
Processing
27 Citations (Scopus)

The Mechanism of Gene Targeting in Human Somatic Cells

Kan, Y., Ruis, B. L., Lin, S. & Hendrickson, E. A., Apr 2014, In : PLoS genetics. 10, 4, e1004251.

Research output: Contribution to journalArticle

Gene Targeting
gene targeting
somatic cells
targeting
homologous recombination
2013
17 Citations (Scopus)

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

Yang, Y., Durando, M., Smith-Roe, S. L., Sproul, C., Greenwalt, A. M., Kaufmann, W., Oh, S., Hendrickson, E. A. & Vaziri, C., Feb 1 2013, In : Nucleic acids research. 41, 4, p. 2296-2312 17 p.

Research output: Contribution to journalArticle

S Phase
DNA Damage
Cell Cycle
DNA
Ubiquitin-Protein Ligases
37 Citations (Scopus)
Telomere
Ligases
Genetic Recombination
Chromosomes
Cell Line
2012
34 Citations (Scopus)

Specificity of the dRP/AP lyase of ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends

Strande, N., Roberts, S. A., Oh, S., Hendrickson, E. A. & Ramsden, D. A., Apr 20 2012, In : Journal of Biological Chemistry. 287, 17, p. 13686-13693 8 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
Joining
Ligation
Chromosome Breakage
DNA
46 Citations (Scopus)

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

Schumacher, A. J., Mohni, K. N., Kan, Y., Hendrickson, E. A., Stark, J. M. & Weller, S. K., Aug 1 2012, In : PLoS pathogens. 8, 8, e1002862.

Research output: Contribution to journalArticle

Exonucleases
Human Herpesvirus 1
Genetic Recombination
DNA Replication
Bacteriophage T4
2010
158 Citations (Scopus)

Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells

Fattaha, F., Lee, E. H., Weisenselb, N., Wang, Y., Lichter, N. & Hendrickson, E. A., Feb 1 2010, In : PLoS genetics. 6, 2, e1000855.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
somatic cells
repair
DNA
Null Lymphocytes
31 Citations (Scopus)

Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin

Gonzalvez, F., Pariselli, F., Jalmar, O., Dupaigne, P., Sureau, F., Dellinger, M., Hendrickson, E. A., Bernard, S. & Petit, P. X., Feb 22 2010, In : PloS one. 5, 2, e9342.

Research output: Contribution to journalArticle

Mitochondria
Cardiolipins
cardiolipins
mitochondria
cytochrome c
2009
101 Citations (Scopus)

Ku86 represses lethal telomere deletion events in human somatic cells

Wang, Y., Ghosh, G. & Hendrickson, E. A., Jul 28 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 30, p. 12430-12435 6 p.

Research output: Contribution to journalArticle

Telomere
Double-Stranded DNA Breaks
Genetic Recombination
Maintenance
Bacteria
2008
49 Citations (Scopus)

Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells

Fattah, F. J., Lichter, N. F., Fattah, K. R., Oh, S. & Hendrickson, E. A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8703-8708 6 p.

Research output: Contribution to journalArticle

Dependovirus
Gene Targeting
Essential Genes
Gene Frequency
Gene Knockout Techniques
28 Citations (Scopus)

Mutations to Ku reveal differences in human somatic cell lines

Fattah, K. R., Ruis, B. L. & Hendrickson, E. A., May 3 2008, In : DNA Repair. 7, 5, p. 762-774 13 p.

Research output: Contribution to journalArticle

Genes
Cells
Cell Line
Mutation
Joining
70 Citations (Scopus)
DNA-Activated Protein Kinase
Catalytic DNA
Genomic Instability
Telomere
Catalytic Domain
2007
9 Citations (Scopus)

The lethality of Ku86 (XRCC5) loss-of-function mutations in human cells is independent of p53 (TP53)

Ghosh, G., Li, G., Myung, K. & Hendrickson, E. A., Jan 1 2007, In : Radiation research. 167, 1, p. 66-79 14 p.

Research output: Contribution to journalArticle

lethality
mutations
deoxyribonucleic acid
Mutation
genes
2004
72 Citations (Scopus)

Regulation of telomere length and suppression of genomic instability in human somatic cells by Ku86

Myung, K., Ghosh, G., Fattah, F. J., Li, G., Kim, H., Dutia, A., Pak, E., Smith, S. & Hendrickson, E. A., Jun 1 2004, In : Molecular and cellular biology. 24, 11, p. 5050-5059 10 p.

Research output: Contribution to journalArticle

Genomic Instability
Telomere
Telomere Shortening
Genetic Translocation
Saccharomycetales
2003
18 Citations (Scopus)

Constitutive DNase I hypersensitivity of p53-regulated promoters

Braastad, C. D., Han, Z. & Hendrickson, E. A., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8261-8268 8 p.

Research output: Contribution to journalArticle

Deoxyribonuclease I
Genetic Promoter Regions
Chromatin
Hypersensitivity
Response Elements
24 Citations (Scopus)

Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity

Hu, X., Han, Z., Wyche, J. H. & Hendrickson, E. A., Jun 1 2003, In : Apoptosis. 8, 3, p. 277-289 13 p.

Research output: Contribution to journalArticle

Cytochromes c
Proteolysis
Mitochondria
Cell death
Cell Death
2002
12 Citations (Scopus)

Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element

Braastad, C. D., Leguia, M. & Hendrickson, E. A., Apr 15 2002, In : Nucleic acids research. 30, 8, p. 1713-1724 12 p.

Research output: Contribution to journalArticle

CpG Islands
Autoantigens
Response Elements
Proteins
Deoxyribonuclease I
134 Citations (Scopus)

Ku86 is essential in human somatic cells

Li, G., Nelsen, C. & Hendrickson, E. A., Jan 22 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 2, p. 832-837 6 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Polyploidy
Masks
Ionizing Radiation
Cell Division
205 Citations (Scopus)

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

Han, Z., Wei, W., Dunaway, S., Darnowski, J. W., Calabresi, P., Sedivy, J., Hendrickson, E. A., Balan, K. V., Pantazis, P. & Wyche, J. H., May 10 2002, In : Journal of Biological Chemistry. 277, 19, p. 17154-17160 7 p.

Research output: Contribution to journalArticle

HCT116 Cells
Camptothecin
Colonic Neoplasms
Cells
Apoptosis
2001
40 Citations (Scopus)

A Fas-associated Death Domain Protein-dependent Mechanism Mediates the Apoptotic Action of Non-steroidal Anti-inflammatory Drugs in the Human Leukemic Jurkat Cell Line

Han, Z., Pantazis, P., Wyche, J. H., Kouttab, N., Kidd, V. J. & Hendrickson, E. A., Oct 19 2001, In : Journal of Biological Chemistry. 276, 42, p. 38748-38754 7 p.

Research output: Contribution to journalArticle

Fas-Associated Death Domain Protein
Jurkat Cells
Colonic Neoplasms
Anti-Inflammatory Agents
Cells