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Research Output 1984 2020

Article

Absence of XRCC4 and its paralogs in human cells reveal differences in outcomes for DNA repair and V(D)J recombination

Ruis, B., Molan, A., Takasugi, T. & Hendrickson, E. A., Jan 2020, In : DNA Repair. 85, 102738.

Research output: Contribution to journalArticle

Joining
DNA Repair
Genetic Recombination
Repair
Cells
26 Citations (Scopus)

A cytosolic factor is required for mitochondrial cytochrome c efflux during apoptosis

Han, Z., Li, G., Bremner, T. A., Lange, T. S., Zhang, G., Jemmerson, R., Wyche, J. H. & Hendrickson, E. A., Jun 1998, In : Cell Death and Differentiation. 5, 6, p. 469-479 11 p.

Research output: Contribution to journalArticle

Cytochromes c
Apoptosis
Caspase 3
Staurosporine
HL-60 Cells
40 Citations (Scopus)

A Fas-associated Death Domain Protein-dependent Mechanism Mediates the Apoptotic Action of Non-steroidal Anti-inflammatory Drugs in the Human Leukemic Jurkat Cell Line

Han, Z., Pantazis, P., Wyche, J. H., Kouttab, N., Kidd, V. J. & Hendrickson, E. A., Oct 19 2001, In : Journal of Biological Chemistry. 276, 42, p. 38748-38754 7 p.

Research output: Contribution to journalArticle

Fas-Associated Death Domain Protein
Jurkat Cells
Colonic Neoplasms
Anti-Inflammatory Agents
Cells
274 Citations (Scopus)

A link between double-strand break-related repair and V(D)J recombination: The scid mutation

Hendrickson, E. A., Qin, X. Q., Bump, E. A., Schatz, D. G., Oettinger, M. & Weaver, D. T., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 10, p. 4061-4065 5 p.

Research output: Contribution to journalArticle

Severe Combined Immunodeficiency
Genetic Recombination
Mutation
DNA Repair
Hypersensitivity
1 Citation (Scopus)

Alternative end joining, clonal evolution, and escape from a telomere-driven crisis

Hendrickson, E. A. & Baird, D. M., Jan 2 2015, In : Molecular and Cellular Oncology. 2, 1, e975623.

Research output: Contribution to journalArticle

Clonal Evolution
Telomere
Genomic Instability
Neoplasms
14 Citations (Scopus)

A new X-ray sensitive CHO cell mutant of ionizing radiation group 7, XR- C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination

Errami, A., Overkamp, W. J. I., He, D. M., Friedl, A. A., Gell, D. A., Eckardt-Schupp, F., Jackson, S. P., Hendrickson, E. A., Lohman, P. H. M. & Zdzienicka, M. Z., Sep 15 2000, In : Mutation Research - DNA Repair. 461, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Ionizing radiation
Cricetulus
Ionizing Radiation
DNA-Activated Protein Kinase
16 Citations (Scopus)

A role for XLF in DNA repair and recombination in human somatic cells

Fattah, F. J., Kweon, J., Wang, Y., Lee, E. H., Kan, Y., Lichter, N., Weisensel, N. & Hendrickson, E. A., Mar 1 2014, In : DNA Repair. 15, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Null Lymphocytes
Joining
DNA Repair
Genetic Recombination
Repair
203 Citations (Scopus)

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro

Han, Z., Hendrickson, E. A., Bremner, T. A. & Wyche, J. H., May 16 1997, In : Journal of Biological Chemistry. 272, 20, p. 13432-13436 5 p.

Research output: Contribution to journalArticle

Caspase 3
Peptide Hydrolases
Amino Acids
Aldehydes
Peptides
58 Citations (Scopus)

ATRX represses alternative lengthening of telomeres

Napier, C. E., Huschtscha, L. I., Harvey, A., Bower, K., Noble, J. R., Hendrickson, E. A. & Reddel, R. R., Jan 1 2015, In : Oncotarget. 6, 18, p. 16543-16558 16 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Telomerase
Telomere Shortening
Chromatin Assembly and Disassembly
Homologous Recombination
30 Citations (Scopus)

A versatile reporter system for CRISPR-mediated chromosomal rearrangements

Li, Y., Park, A. I., Mou, H., Colpan, C., Bizhanova, A., Akama-Garren, E., Joshi, N., Hendrickson, E. A., Feldser, D., Yin, H., Anderson, D. G., Jacks, T., Weng, Z. & Xue, W., May 28 2015, In : Genome biology. 16, 1, 111.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
DNA Breaks
Gene Rearrangement
Nucleotides
Liver

Both the classical and alternative non-homologous end joining pathways contribute to the fusion of drastically shortened telomeres induced by TRF2 overexpression

Nera, B., Huang, H. S., Hendrickson, E. A. & Xu, L., Apr 18 2019, In : Cell Cycle. 18, 8, p. 880-888 9 p.

Research output: Contribution to journalArticle

Telomere Shortening
Ligases
DNA Ligases
Telomere-Binding Proteins
Chromosomes
70 Citations (Scopus)

Cell-cycle regulation of mammalian DNA double-strand-break repair

Hendrickson, E. A., Oct 1997, In : American Journal of Human Genetics. 61, 4, p. 795-800 6 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Cell Cycle
17 Citations (Scopus)

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

Yang, Y., Durando, M., Smith-Roe, S. L., Sproul, C., Greenwalt, A. M., Kaufmann, W., Oh, S., Hendrickson, E. A. & Vaziri, C., Feb 1 2013, In : Nucleic acids research. 41, 4, p. 2296-2312 17 p.

Research output: Contribution to journalArticle

S Phase
DNA Damage
Cell Cycle
DNA
Ubiquitin-Protein Ligases
48 Citations (Scopus)

Characterization of a Ku86 variant protein that results in altered DNA binding and diminished DNA-dependent protein kinase activity

Han, Z., Johnston, C., Reeves, W. H., Carter, T., Wyche, J. H. & Hendrickson, E. A., Jun 25 1996, In : Journal of Biological Chemistry. 271, 24, p. 14098-14104 7 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
HL-60 Cells
Electrophoretic Mobility Shift Assay
Double-Stranded DNA Breaks
DNA
6 Citations (Scopus)
V(D)J Recombination
Double-Stranded DNA Breaks
Cricetulus
X-Rays
Cell Line
159 Citations (Scopus)

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

Ghezraoui, H., Piganeau, M., Renouf, B., Renaud, J. B., Sallmyr, A., Ruis, B. L., Oh, S., Tomkinson, A. E., Hendrickson, E. A., Giovannangeli, C., Jasin, M. & Brunet, E., Sep 18 2014, In : Molecular Cell. 55, 6, p. 829-842 14 p.

Research output: Contribution to journalArticle

Genetic Translocation
Clustered Regularly Interspaced Short Palindromic Repeats
Neoplasms
Carcinogenesis
Chromosomes
3 Citations (Scopus)

Chromothripsis during telomere crisis is independent of NHEJ, and consistent with a replicative origin

Cleal, K., Jones, R. E., Grimstead, J. W., Hendrickson, E. A. & Baird, D. M., May 2019, In : Genome research. 29, 5, p. 737-749 13 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Genome
Genomic Instability
Sequence Analysis
Chromothripsis
61 Citations (Scopus)

Cif (cytochrome c efflux-inducing factor) activity is regulated by Bcl- 2 and caspases and correlates with the activation of bid

Han, Z., Bhalla, K., Pantazis, P., Hendrickson, E. A. & Wyche, J. H., Feb 1999, In : Molecular and cellular biology. 19, 2, p. 1381-1389 9 p.

Research output: Contribution to journalArticle

Caspase 2
Cytochromes c
HL-60 Cells
Caspases
Caspase 8
23 Citations (Scopus)

Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation

Batenburg, N. L., Thompson, E. L., Hendrickson, E. A. & Zhu, X. D., May 12 2015, In : EMBO Journal. 34, 10, p. 1399-1416 18 p.

Research output: Contribution to journalArticle

Cockayne Syndrome
Double-Stranded DNA Breaks
Chromatin
Repair
Chemical activation
133 Citations (Scopus)

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen

Boubnov, N. V., Hall, K. T., Wills, Z., Lee, S. E., He, D. M., Benjamin, D. M., Pulaski, C. R., Band, H., Reeves, W., Hendrickson, E. A. & Weaver, D. T., Jan 31 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 3, p. 890-894 5 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Ionizing Radiation
Genetic Recombination
DNA
Genes
19 Citations (Scopus)

Constitutive DNase I hypersensitivity of p53-regulated promoters

Braastad, C. D., Han, Z. & Hendrickson, E. A., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8261-8268 8 p.

Research output: Contribution to journalArticle

Deoxyribonuclease I
Genetic Promoter Regions
Chromatin
Hypersensitivity
Response Elements
4 Citations (Scopus)

CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length

Gu, P., Jia, S., Takasugi, T., Smith, E., Nandakumar, J., Hendrickson, E. A. & Chang, S., Aug 2018, In : Aging cell. 17, 4, e12783.

Research output: Contribution to journalArticle

Telomerase
Telomere
Mutation
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

CtIP is essential for telomere replication

Stroik, S., Kurtz, K. & Hendrickson, E. A., Sep 26 2019, In : Nucleic acids research. 47, 17, p. 8927-8940 14 p.

Research output: Contribution to journalArticle

Open Access
Telomere
Telomere Shortening
Genomic Instability
Telomere Homeostasis
Double-Stranded DNA Breaks
46 Citations (Scopus)

CtIP mediates replication fork recovery in a FANCD2-regulated manner

Yeo, J. E., Lee, E. H., Hendrickson, E. A. & Sobeck, A., Jul 2014, In : Human molecular genetics. 23, 14, p. 3695-3705 11 p., ddu078.

Research output: Contribution to journalArticle

Fanconi Anemia
Proteins
Recombinational DNA Repair
Fanconi Anemia Complementation Group D2 Protein
DNA Repair-Deficiency Disorders
128 Citations (Scopus)

DNA2 drives processing and restart of reversed replication forks in human cells

Thangavel, S., Berti, M., Levikova, M., Pinto, C., Gomathinayagam, S., Vujanovic, M., Zellweger, R., Moore, H., Lee, E. H., Hendrickson, E. A., Cejka, P., Stewart, S., Lopes, M. & Vindigni, A., Jan 1 2015, In : Journal of Cell Biology. 208, 5, p. 545-562 18 p.

Research output: Contribution to journalArticle

DNA Replication
Homologous Recombination
DNA Damage
Adenosine Triphosphatases
Genome
121 Citations (Scopus)

DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease

Han, Z., Malik, N., Carter, T., Reeves, W. H., Wyche, J. H. & Hendrickson, E. A., Oct 15 1996, In : Journal of Biological Chemistry. 271, 40, p. 25035-25040 6 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Peptide Hydrolases
Proteolysis
DNA
Staurosporine
3 Citations (Scopus)

DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Liddiard, K., Ruis, B., Kan, Y., Cleal, K., Ashelford, K. E., Hendrickson, E. A. & Baird, D. M., Jan 1 2019, In : Nucleic acids research. 47, 5, p. 2402-2424 23 p.

Research output: Contribution to journalArticle

Open Access
DNA Ligases
Chromatids
Telomere
Cell Cycle
Ligases
38 Citations (Scopus)

DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells

Oh, S., Harvey, A., Zimbric, J., Wang, Y., Nguyen, T., Jackson, P. J. & Hendrickson, E. A., Sep 2014, In : DNA Repair. 21, p. 97-110 14 p.

Research output: Contribution to journalArticle

DNA Ligases
Joining
Repair
Gene Targeting
Genes

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

Lu, H., Saha, J., Beckmann, P. J., Hendrickson, E. A. & Davis, A. J., Oct 10 2019, In : Nucleic acids research. 47, 18, p. 9467-9479 13 p.

Research output: Contribution to journalArticle

Open Access
DNA-Activated Protein Kinase
DNA Damage
Chromatin
Catalytic Domain
Ataxia Telangiectasia
41 Citations (Scopus)

DNA primase-DNA polymerase α from simian cells: Sequence specificity of initiation sites on simian virus 40 DNA

Yamaguchi, M., Hendrickson, E. A. & DePamphilis, M. L., Dec 1 1985, In : Molecular and cellular biology. 5, 5, p. 1170-1183 14 p.

Research output: Contribution to journalArticle

DNA Primase
Simian virus 40
DNA-Directed DNA Polymerase
DNA
Ribonucleosides
40 Citations (Scopus)

DNA primase-DNA polymerase α from simian cells. Modulation of RNA primer synthesis by ribonucleoside triphosphates

Yamaguchi, M., Hendrickson, E. A. & DePamphilis, M. L., Jan 1 1985, In : Journal of Biological Chemistry. 260, 10, p. 6254-6263 10 p.

Research output: Contribution to journalArticle

DNA Primase
Ribonucleosides
DNA-Directed DNA Polymerase
Modulation
DNA
37 Citations (Scopus)

Escape from telomere-driven crisis is DNA ligase III dependent

Jones, R. E., Oh, S., Grimstead, J. W., Zimbric, J., Roger, L., Heppel, N. H., Ashelford, K. E., Liddiard, K., Hendrickson, E. A. & Baird, D. M., Aug 21 2014, In : Cell reports. 8, 4, p. 1063-1076 14 p.

Research output: Contribution to journalArticle

DNA Ligases
Telomere
Fusion reactions
Joining
Clonal Evolution
103 Citations (Scopus)

Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation

Han, Z., Chatterjee, D., He, D. M., Early, J., Pantazis, P., Wyche, J. H. & Hendrickson, E. A., Nov 1995, In : Molecular and Cellular Biology. 15, 11, p. 5849-5857 9 p.

Research output: Contribution to journalArticle

Apoptosis
Cell Line
HL-60 Cells
DNA Damage
p53 Genes
202 Citations (Scopus)

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

Lee, S. E., Mitchell, R. A., Cheng, A. & Hendrickson, E. A., Mar 1997, In : Molecular and Cellular Biology. 17, 3, p. 1425-1433 9 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Double-Stranded DNA Breaks
Cell Cycle
Severe Combined Immunodeficiency
G2 Phase
7 Citations (Scopus)

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Thompson, E. L., Yeo, J. E., Lee, E. A., Kan, Y., Raghunandan, M., Wiek, C., Hanenberg, H., Schärer, O. D., Hendrickson, E. A. & Sobeck, A., Jan 1 2017, In : Nucleic acids research. 45, 20, p. 11837-11857 21 p.

Research output: Contribution to journalArticle

Open Access
Fanconi Anemia
Fanconi Anemia Complementation Group D2 Protein
Chromatin
Fanconi Anemia Complementation Group Proteins
Null Lymphocytes
35 Citations (Scopus)

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2

Castella, M., Jacquemont, C., Thompson, E. L., Yeo, J. E., Cheung, R. S., Huang, J. W., Sobeck, A., Hendrickson, E. A. & Taniguchi, T., Jan 1 2015, In : PLoS genetics. 11, 10, e1005563.

Research output: Contribution to journalArticle

Fanconi Anemia
anemia
DNA damage
DNA Damage
DNA
28 Citations (Scopus)

Gene mutation and V(D)J recombination in the radiosensitive irs lines

Thacker, J., Ganesh, A. N., Stretch, A., Benjamin, D. M., Zahalsky, A. J. & Hendrickson, E. A., Mar 1994, In : Mutagenesis. 9, 2, p. 163-168 6 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Repair
Genes
Mutation
X-Rays
24 Citations (Scopus)

Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity

Hu, X., Han, Z., Wyche, J. H. & Hendrickson, E. A., Jun 1 2003, In : Apoptosis. 8, 3, p. 277-289 13 p.

Research output: Contribution to journalArticle

Cytochromes c
Proteolysis
Mitochondria
Cell death
Cell Death
1 Citation (Scopus)

High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction

Li, G., Martínez-Bonet, M., Wu, D., Yang, Y., Cui, J., Nguyen, H. N., Cunin, P., Levescot, A., Bai, M., Westra, H. J., Okada, Y., Brenner, M. B., Raychaudhuri, S., Hendrickson, E. A., Maas, R. L. & Nigrovic, P. A., Aug 1 2018, In : Nature Genetics. 50, 8, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

Open Access
Single Nucleotide Polymorphism
Enzymes
Genome-Wide Association Study
Juvenile Arthritis
Carrier Proteins
13 Citations (Scopus)

Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity

Smith, S., Fox, J., Mejia, M., Ruangpradit, W., Saberi, A., Kim, S., Choi, Y., Oh, S., Wang, Y., Choi, K., Li, L., Hendrickson, E. A., Takeda, S., Muller, M. & Myung, K., Jan 23 2014, In : PloS one. 9, 1, e87203.

Research output: Contribution to journalArticle

histone deacetylase
Histone Deacetylase Inhibitors
DNA repair
DNA Repair
Repair
37 Citations (Scopus)
Telomere
Ligases
Genetic Recombination
Chromosomes
Cell Line
5 Citations (Scopus)

Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair

Kan, Y., Batada, N. N. & Hendrickson, E. A., Jul 2017, In : DNA Repair. 55, p. 64-75 12 p.

Research output: Contribution to journalArticle

Open Access
Virus Integration
Repair
Radiation
Genes
Annealing
66 Citations (Scopus)

Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding

Wang, J., Dong, X., Myung, K., Hendrickson, E. A. & Reeves, W. H., Jan 9 1998, In : Journal of Biological Chemistry. 273, 2, p. 842-848 7 p.

Research output: Contribution to journalArticle

Protein Multimerization
Dimerization
DNA
Proteins
DNA-Activated Protein Kinase
77 Citations (Scopus)

Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-XL 1

Han, Z., Chatterjee, D., Early, J., Pantazis, P., Hendrickson, E. A. & Wyche, J. H., Apr 1 1996, In : Cancer Research. 56, 7, p. 1621-1628 8 p.

Research output: Contribution to journalArticle

HL-60 Cells
Leukemia
Apoptosis
Suppressor Genes
bcl-2-Associated X Protein
56 Citations (Scopus)

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination

Lee, S. E., Pulaski, C. R., He, D. M., Benjamin, D. M., Voss, M., Um, J. & Hendrickson, E. A., May 1995, In : Mutation Research-DNA Repair. 336, 3, p. 279-291 13 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Double-Stranded DNA Breaks
Cell Separation
Repair
Cells
41 Citations (Scopus)

KARP-1: A novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity

Myung, K., He, D. M., Lee, S. E. & Hendrickson, E. A., Jun 2 1997, In : EMBO Journal. 16, 11, p. 3172-3184 13 p.

Research output: Contribution to journalArticle

DNA-Activated Protein Kinase
Leucine Zippers
Autoantigens
Proteins
Double-Stranded DNA Breaks
37 Citations (Scopus)

KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

Myung, K., Braastad, C., He, D. M. & Hendrickson, E. A., Jun 23 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 13, p. 7664-7669 6 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Autoantigens
DNA Damage
Proteins
DNA-Activated Protein Kinase
50 Citations (Scopus)

Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells

Fattah, F. J., Lichter, N. F., Fattah, K. R., Oh, S. & Hendrickson, E. A., Jun 24 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 25, p. 8703-8708 6 p.

Research output: Contribution to journalArticle

Dependovirus
Gene Targeting
Essential Genes
Gene Frequency
Gene Knockout Techniques
12 Citations (Scopus)

Ku86 autoantigen related protein-1 transcription initiates from a CpG island and is induced by p53 through a nearby p53 response element

Braastad, C. D., Leguia, M. & Hendrickson, E. A., Apr 15 2002, In : Nucleic acids research. 30, 8, p. 1713-1724 12 p.

Research output: Contribution to journalArticle

CpG Islands
Autoantigens
Response Elements
Proteins
Deoxyribonuclease I
150 Citations (Scopus)

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

Errami, A., Smider, V., Rathmell, W. K., He, D. M., Hendrickson, E. A., Zdzienicka, M. Z. & Chu, G., Apr 1996, In : Molecular and cellular biology. 16, 4, p. 1519-1526 8 p.

Research output: Contribution to journalArticle

V(D)J Recombination
Cricetinae
X-Rays
DNA
Double-Stranded DNA Breaks