Emilyn U Alejandro

Accepting PhD Students

20042023
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Research Output 2004 2019

2019
Carboxypeptidase H
Carboxypeptidases
Proinsulin
Insulin
Medical problems

Males require estrogen signaling too: Sexual dimorphism in the regulation of glucose homeostasis by nuclear era

Alejandro, E. U., Mar 1 2019, In : Diabetes. 68, 3, p. 471-473 3 p.

Research output: Contribution to journalComment/debate

Open Access
Sex Characteristics
Estrogens
Homeostasis
Glucose
1 Citation (Scopus)

Nutrient sensor signaling pathways and cellular stress in fetal growth restriction

Hart, B., Morgan, E. & Alejandro, E. U., Feb 1 2019, In : Journal of molecular endocrinology. 62, 2, p. R155-R165

Research output: Contribution to journalReview article

Open Access
Fetal Development
Placentation
Food
Sirolimus
Placental Insufficiency
2018
4 Citations (Scopus)
Open Access
Placental Insufficiency
Malnutrition
Obesity
Pancreatic Diseases
Fetal Development
1 Citation (Scopus)

Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring

Gregg, B. E., Botezatu, N., Brill, J. D., Hafner, H., Vadrevu, S., Satin, L. S., Alejandro, E. U. & Bernal-Mizrachi, E., Dec 1 2018, In : Scientific reports. 8, 1, 5745.

Research output: Contribution to journalArticle

Open Access
Metformin
Insulin
Glucose
Food
Pregnancy

Reduced uterine perfusion pressure causes loss of pancreatic β-cell area but normal function in fetal rat offspring

Akhaphong, B., Lockridge, A., Jo, S., Mohan, R., Wilcox, J. A., Wing, C. R., Regal, J. F. & Alejandro, E. U., Dec 1 2018, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 315, 6, p. R1220-R1231

Research output: Contribution to journalArticle

Open Access
Perfusion
Pressure
TOR Serine-Threonine Kinases
Pancreas
Insulin
2017
16 Citations (Scopus)

Overexpression of kinase-dead mTOR impairs glucose homeostasis by regulating insulin secretion and not β-cell mass

Alejandro, E. U., Bozadjieva, N., Blandino-Rosano, M., Wasan, M. A., Elghazi, L., Vadrevu, S., Satin, L. & Bernal-Mizrachi, E., Aug 1 2017, In : Diabetes. 66, 8, p. 2150-2162 13 p.

Research output: Contribution to journalArticle

Open Access
Sirolimus
Homeostasis
Phosphotransferases
Insulin
Glucose
12 Citations (Scopus)

Role of nutrients and mTOR signaling in the regulation of pancreatic progenitors development

Elghazi, L., Blandino-Rosano, M., Alejandro, E. U., Cras-Méneur, C. & Bernal-Mizrachi, E., Jun 1 2017, In : Molecular Metabolism. 6, 6, p. 560-573 14 p.

Research output: Contribution to journalArticle

Open Access
Raptors
Intercellular Signaling Peptides and Proteins
Glucose
Pancreas
Food
2016
6 Citations (Scopus)

Serine racemase is expressed in islets and contributes to the regulation of glucose homeostasis

Lockridge, A. D., Baumann, D. C., Akhaphong, B., Abrenica, A., Miller, R. F. & Alejandro, E. U., Nov 1 2016, In : Islets. 8, 6, p. 195-206 12 p.

Research output: Contribution to journalArticle

Homeostasis
Glucose
N-Methyl-D-Aspartate Receptors
Serine
Insulin
2015
12 Citations (Scopus)

Disruption of O-linked N-Acetylglucosamine Signaling Induces ER Stress and β Cell Failure

Alejandro, E. U., Bozadjieva, N., Kumusoglu, D., Abdulhamid, S., Levine, H., Haataja, L., Vadrevu, S., Satin, L. S., Arvan, P. & Bernal-Mizrachi, E., Dec 22 2015, In : Cell Reports. 13, 11, p. 2527-2538 12 p.

Research output: Contribution to journalArticle

Acetylglucosamine
Medical problems
Nutrients
Genes
Cells
68 Citations (Scopus)

Natural history of β-cell adaptation and failure in type 2 diabetes

Alejandro, E. U., Gregg, B., Blandino-Rosano, M., Cras-Méneur, C. & Bernal-Mizrachi, E., Apr 1 2015, In : Molecular Aspects of Medicine. 42, p. 19-41 23 p.

Research output: Contribution to journalReview article

Medical problems
Natural History
Type 2 Diabetes Mellitus
Insulin
Modulators
2014
12 Citations (Scopus)

Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females

Parlee, S. D., Simon, B. R., Scheller, E. L., Alejandro, E. U., Learman, B. S., Krishnan, V., Bernal-Mizrachi, E. & MacDougald, O. A., Apr 1 2014, In : Endocrinology. 155, 4, p. 1313-1326 14 p.

Research output: Contribution to journalArticle

Saccharin
Body Composition
Body Weight
Adipocytes
Weights and Measures
11 Citations (Scopus)

Effects of insulin on human pancreatic cancer progression modeled in vitro

Chan, M. T., Lim, G. E., Skovs�, S., Yang, Y. H. C., Albrecht, T., Alejandro, E. U., Hoesli, C. A., Piret, J. M., Warnock, G. L. & Johnson, J. D., Nov 6 2014, In : BMC Cancer. 14, 1, 814.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Insulin
Cell Survival
Hyperinsulinism
In Vitro Techniques
10 Citations (Scopus)

Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors

Gregg, B., Elghazi, L., Alejandro, E. U., Smith, M. R., Blandino-Rosano, M., El-Gabri, D., Cras-Méneur, C. & Bernal-Mizrachi, E., Sep 24 2014, In : Diabetologia. 57, 12, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

Metformin
Pancreas
AMP-Activated Protein Kinases
Parturition
Pregnancy
39 Citations (Scopus)

Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring

Alejandro, E. U., Gregg, B., Wallen, T., Kumusoglu, D., Meister, D., Chen, A., Merrins, M. J., Satin, L. S., Liu, M., Arvan, P. & Bernal-Mizrachi, E., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4395-4410 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Mothers
Diet
Insulin
Protein-Restricted Diet
2012
13 Citations (Scopus)

Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip

Blandino-Rosano, M., Alejandro, E. U., Sathyamurthy, A., Scheys, J. O., Gregg, B., Chen, A. Y., Rachdi, L., Weiss, A., Barker, D. J., Gould, A. P., Elghazi, L. & Bernal-Mizrachi, E., May 1 2012, In : Diabetologia. 55, 5, p. 1380-1389 10 p.

Research output: Contribution to journalArticle

Alleles
Cell Proliferation
Cyclin D2
Cyclin-Dependent Kinase Inhibitor p21
Insulin
34 Citations (Scopus)

MTORC1 signaling and regulation of pancreatic β-cell mass

Blandino-Rosano, M., Chen, A. Y., Scheys, J. O., Alejandro, E. U., Gould, A. P., Taranukha, T., Elghazi, L., Cras-Méneur, C. & Bernal-Mizrachi, E., May 15 2012, In : Cell Cycle. 11, 10, p. 1892-1902 11 p.

Research output: Contribution to journalReview article

Intercellular Signaling Peptides and Proteins
Glucose
Food
Tuberous Sclerosis
Hyperinsulinism
2011
26 Citations (Scopus)

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

Alejandro, E. U., Lim, G. E., Mehran, A. E., Hu, X., Taghizadeh, F., Pelipeychenko, D., Baccarini, M. & Johnson, J. D., Nov 1 2011, In : FASEB Journal. 25, 11, p. 3884-3895 12 p.

Research output: Contribution to journalArticle

Transcription
Insulin
Glucose
Proto-Oncogene Proteins c-raf
Messenger RNA
2010
30 Citations (Scopus)

Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways

Alejandro, E. U., Kalynyak, T. B., Taghizadeh, F., Gwiazda, K. S., Rawstron, E. K., Jacob, K. J. & Johnson, J. D., Jan 29 2010, In : Endocrinology. 151, 2, p. 502-512 11 p.

Research output: Contribution to journalArticle

Insulin-Secreting Cells
Insulin
Cell Death
Phosphorylation
Serine
2008
100 Citations (Scopus)

Carboxypeptidase E mediates palmitate-induced β-cell ER stress and apoptosis

Jeffrey, K. D., Alejandro, E. U., Luciani, D. S., Kalynyak, T. B., Hu, X., Li, H., Lin, Y., Townsend, R. R., Polonsky, K. S. & Johnson, J. D., Jun 17 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 24, p. 8452-8457 6 p.

Research output: Contribution to journalArticle

Carboxypeptidase H
Endoplasmic Reticulum Stress
Palmitates
Apoptosis
Cell Death
27 Citations (Scopus)

Control of pancreatic β-cell fate by insulin signaling: The sweet spot hypothesis

Johnson, J. D. & Alejandro, E. U., May 15 2008, In : Cell Cycle. 7, 10, p. 1343-1347 5 p.

Research output: Contribution to journalReview article

Insulin
Type 2 Diabetes Mellitus
Autocrine Communication
Proto-Oncogene Proteins c-raf
Paracrine Communication
44 Citations (Scopus)

Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic β-cell apoptosis

Alejandro, E. U. & Johnson, J. D., Jan 25 2008, In : Journal of Biological Chemistry. 283, 4, p. 2407-2417 11 p.

Research output: Contribution to journalArticle

Cell death
Proto-Oncogene Proteins c-raf
Apoptosis
Phosphorylation
Cells
70 Citations (Scopus)

Insulin stimulates primary β-cell proliferation via Raf-1 kinase

Beith, J. L., Alejandro, E. U. & Johnson, J. D., May 1 2008, In : Endocrinology. 149, 5, p. 2251-2260 10 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-raf
Cell Proliferation
Insulin
Type 2 Diabetes Mellitus
Phosphatidylinositol 3-Kinase
24 Citations (Scopus)

The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells

Simpkins, F. A., Devoogdt, N. M., Rasool, N., Tchabo, N. E., Alejandro, E. U., Kamrava, M. M. R. N. & Kohn, E. C., Mar 1 2008, In : Carcinogenesis. 29, 3, p. 466-472 7 p.

Research output: Contribution to journalArticle

Secretory Leukocyte Peptidase Inhibitor
Ovarian Neoplasms
Peptide Hydrolases
Pancreatic Elastase
Apoptosis
2006
141 Citations (Scopus)

Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome

Johnson, J. D., Bernal-Mizrachi, E., Alejandro, E. U., Han, Z., Kalynyak, T. B., Li, H., Beith, J. L., Gross, J., Warnock, G. L., Townsend, R. R., Permutt, M. A. & Polonsky, K. S., Dec 19 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 51, p. 19575-19580 6 p.

Research output: Contribution to journalArticle

Proteome
Insulin
Apoptosis
Proteomics
Energy Metabolism
2005
54 Citations (Scopus)

Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer

Kamrava, M., Simpkins, F., Alejandro, E. U., Michener, C., Meltzer, E. & Kohn, E. C., Oct 27 2005, In : Oncogene. 24, 47, p. 7084-7093 10 p.

Research output: Contribution to journalArticle

Endothelins
Ovarian Neoplasms
Cell Line
granulin precursor protein
lysophosphatidic acid
2004
9 Citations (Scopus)

Epitope-restricted 65-kilodalton glutamic acid decarboxylase autoantibodies among new-onset sardinian type 2 diabetes patients define phenotypes of autoimmune diabetes

Maioli, M., Alejandro, E., Tonolo, G., Gilliam, L. K., Bekris, L., Hampe, C. S., Obinu, D. A., Manconi, A., Puddu, L., Lynch, K. & Lernmark, Å., Nov 1 2004, In : Journal of Clinical Endocrinology and Metabolism. 89, 11, p. 5675-5682 8 p.

Research output: Contribution to journalArticle

Glutamate Decarboxylase
Medical problems
Type 1 Diabetes Mellitus
Autoantibodies
Type 2 Diabetes Mellitus
82 Citations (Scopus)

Granulin-Epithelin Precursor Is a Novel Prognostic Marker in Epithelial Ovarian Carcinoma

Davidson, B., Alejandro, E., Flørenes, V. A., Goderstad, J. M., Risberg, B., Kristensen, G. B., Trope, C. G. & Kohn, E. C., May 15 2004, In : Cancer. 100, 10, p. 2139-2147 9 p.

Research output: Contribution to journalArticle

Carcinoma
Neoplasms
Stromal Cells
granulin precursor protein
Survival