Personal profile
Research interests
I am a physician-scientist with a strong interest and a translational approach to investigation of solid tumor malignancies at the cellular and molecular level. As a fellowship-trained and practicing medical oncologist and neuro-oncologist, I have a strong interest in a ‘bedside-to-bench-and-back’ approach to translational oncology and laboratory research. At the national level, I served on the American Society of Clinical Oncology (ASCO) Scientific Committee for GI Cancers (2012-15). Identifying pertinent clinical problems in oncology that can be investigated in the laboratory setting is a high priority for our research program and collaborative efforts. I am board-certified in medical oncology, neuro-oncology, and internal medicine.
Research Interest Keywords
- intercellular communication
- cancer
- tumor microenvironment
- cancer cell biology
- tunneling nanotubes
- tumor genomics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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A Phase 3, Open-Label, Randomized Study of Perioperative Dostarlimab Monotherapy versus Standard ofCare in Participants with Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer
Prakash, A. (PI) & Lou, E. (Prior Principal Investigator)
11/13/24 → 1/31/34
Project: Research project
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Elucidating the role of ovarian tumor cell networking in spatial architecture and tumor heterogeneity and implications for chemoresistance
Abrahante Llorens, J. E. (PI), Lou, E. (PI) & Carlton, B. (Prior Principal Investigator)
7/1/22 → 6/30/26
Project: Research project
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Molecular Analysis for Therapy Choice (MATCH)
Lou, E. (PI) & Peterson, B. A. (Prior Principal Investigator)
BRIGHAM AND WOMEN'S HOSPITAL, NIH NATIONAL CANCER INSTITUTE
4/1/16 → 12/31/27
Project: Research project
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Targeting channels of ovarian tumor cell communication
Lou, E. (PI)
MINNESOTA OVARIAN CANCER ALLIANCE
7/1/22 → 6/30/23
Project: Research project
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Age- and sex-based differences in the genomic profiles of patients with gastrointestinal and pancreatic neuroendocrine neoplasms
Li, S., Liu, L., Gandhi, N., Farrell, A., Lou, E., Soares, H., Nazha, B., Swensen, J., Oberley, M., Evans, M. G., Kunz, P. & Vijayvergia, N., Mar 1 2026, In: Oncologist. 31, 3, oyaf440.Research output: Contribution to journal › Article › peer-review
Open Access -
CISH, a key intracellular checkpoint, in comparison and combination to existing and emerging cancer immune checkpoints
Cano, F., Bravo-Blas, A., Colombe, M., Cerrato, C., Venigalla, R. K. C., Preham, O., Burns, E., Mortimer, P., Choudhry, A., Slipek, N., Johnson, M. J., Webber, B. R., Moriarity, B. S., Lou, E., Choudhry, M., Klebanoff, C. A. & Henley, T., Dec 2026, In: Communications biology. 9, 1, 319.Research output: Contribution to journal › Article › peer-review
Open Access -
Clinical and molecular characteristics of Class II and III BRAF mutations in colorectal cancer
Sahin, I. H., Xiu, J., Baca, Y., Khushman, M., Grothey, A., Palumbo, E., Rahman, S., Weinberg, B. A., Goel, S., Akce, M., Gorantla, V., Lou, E., Kasi, A., Shields, A. F., Oberley, M., Sledge, G., Shen, J. P., Saeed, A. & Tejani, M., Dec 2026, In: npj Precision Oncology. 10, 1, 146.Research output: Contribution to journal › Article › peer-review
Open Access -
CXCR4 mRNA overexpression: an indicator of poor survival and predictor of response to immune checkpoint inhibitors in patients with metastatic colorectal cancer
Gholami, S., Saeed, A., Baca, Y., Hinton, A., Demyan, L., Abidalhassan, M., Xiu, J., Manji, G. A., Seeber, A., Weinberg, B. A., Khushman, M., Shields, A. F., Lenz, H. J., Marshall, J. & Lou, E., Mar 31 2026, In: BMJ Oncology. 5, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of immuno-oncologic biomarkers and β-catenin expression in response of hepatocellular carcinomas to immunotherapy
Sharma, G., Baca, Y., Goel, S., Shields, A. F., Prakash, A., Weinberg, B. A., Saeed, A., Nabhan, C., Oberley, M., Xiu, J., Hwang, J., Antonarakis, E. S., Chiu, V. K. & Lou, E., Dec 2026, In: npj Precision Oncology. 10, 1, 86.Research output: Contribution to journal › Article › peer-review
Open Access
Datasets
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Perceptions of COVID-19 and Health Survey in the United States, Cross-sectional study April 2020
Vogel, R. I., Lou, E., Mburu, W., Thomaier, L., Hui, J., Nelson, H. H., Teoh, D. G., Brown, K., Blaes, A. H., Holtan, S. G., Jewett, P. I. & Parsons, H. M., Data Repository for the University of Minnesota, 2020
DOI: 10.13020/fxwc-np62, http://hdl.handle.net/11299/216556
Dataset
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COVID-19 Concerns among Physicians who treat cancer survey in the United States, Cross-sectional study March/April 2020
Vogel, R. I., Thomaier, L., Lou, E., Teoh, D. G., Jewett, P. I., Beckwith, H. C., Parsons, H. M., Yuan, J., Blaes, A. H. & Hui, J., Data Repository for the University of Minnesota, 2020
DOI: 10.13020/bmsy-hb61, http://hdl.handle.net/11299/216451
Dataset
Press/Media
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6 Colon Cancer Symptoms That Are Easily Overlooked
5/8/20
1 item of Media coverage
Press/Media: Expert Comment or Interview