Elizabeth W Bradley

Assistant Professor, Stem Cell Institute

Accepting PhD Students

20032019

Research output per year

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Research Output

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Article
2019

Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E. W., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

Research output: Contribution to journalArticle

Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

Zhang, C., Smith, M. P., Zhou, G. K., Lai, A., Hoy, R. C., Mroz, V., Torre, O. M., Laudier, D. M., Bradley, E. W., Westendorf, J. J., Iatridis, J. C. & Illien-Jünger, S., Oct 1 2019, In : Cell Death and Disease. 10, 10, 754.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

Castillejo Becerra, C. M., Mattson, A. M., Molstad, D. H. H., Lorang, I. M., Westendorf, J. J. & Bradley, E. W., Sep 2018, In : Journal of Cellular Biochemistry. 119, 9, p. 7470-7478 9 p.

Research output: Contribution to journalArticle

Open Access

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

McGee-Lawrence, M. E., Pierce, J. L., Yu, K., Culpepper, N. R., Bradley, E. W. & Westendorf, J. J., Apr 2018, In : Journal of Cellular Physiology. 233, 4, p. 2671-2680 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano-Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H. J., Karperien, M., Krych, A. J., Westendorf, J. J., Noelle Larson, A. & Van Wijnen, A. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 49, p. 19001-19011 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis

Hwang, S. M., Feigenson, M., Begun, D. L., Shull, L. C., Culley, K. L., Otero, M., Goldring, M. B., Ta, L. E., Kakar, S., Bradley, E. W. & Westendorf, J. J., May 2018, In : Journal of Orthopaedic Research. 36, 5, p. 1487-1497 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Histone Deacetylase 3 Deletion in Mesenchymal Progenitor Cells Hinders Long Bone Development

Feigenson, M., Shull, L. C., Taylor, E. L., Camilleri, E. T., Riester, S. M., van Wijnen, A. J., Bradley, E. W. & Westendorf, J. J., Dec 2017, In : Journal of Bone and Mineral Research. 32, 12, p. 2453-2465 13 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Histone deacetylase 3 suppresses Erk phosphorylation and matrix metalloproteinase (Mmp)-13 activity in chondrocytes

Carpio, L. R., Bradley, E. W. & Westendorf, J. J., Jan 2 2017, In : Connective Tissue Research. 58, 1, p. 27-36 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., Lowe, V., Tchkonia, T., Westendorf, J. J. & Kirkland, J. L., Jun 1 2017, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 72, 6, p. 780-785 6 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations
2016

Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling

Carpio, L. R., Bradley, E. W., McGee-Lawrence, M. E., Weivoda, M. M., Poston, D. D., Dudakovic, A., Xu, M., Tchkonia, T., Kirkland, J. L., Van Wijnen, A. J., Oursler, M. J. & Westendorf, J. J., Aug 9 2016, In : Science signaling. 9, 440, ra79.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Identification of differentially methylated regions in new genes associated with knee osteoarthritis

Bonin, C. A., Lewallen, E. A., Baheti, S., Bradley, E. W., Stuart, M. J., Berry, D. J., van Wijnen, A. J. & Westendorf, J. J., Jan 15 2016, In : Gene. 576, 1, p. 312-318 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

Bradley, E. W., Carpio, L. R., McGee-Lawrence, M. E., Castillejo Becerra, C., Amanatullah, D. F., Ta, L. E., Otero, M., Goldring, M. B., Kakar, S. & Westendorf, J. J., Jun 1 2016, In : Osteoarthritis and Cartilage. 24, 6, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

Fang, D., Gan, H., Lee, J. H., Han, J., Wang, Z., Riester, S. M., Jin, L., Chen, J., Zhou, H., Wang, J., Zhang, H., Yang, N., Bradley, E. W., Ho, T. H., Rubin, B. P., Bridge, J. A., Thibodeau, S. N., Ordog, T., Chen, Y., Van Wijnen, A. J. & 4 others, Oliveira, A. M., Xu, R. M., Westendorf, J. J. & Zhang, Z., Jun 10 2016, In : Science. 352, 6291, p. 1344-1348 5 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations
2015

Deletion of the PH-domain and leucine-rich repeat protein phosphatase 1 (Phlpp1) increases fibroblast growth factor (Fgf) 18 expression and promotes chondrocyte proliferation

Bradley, E. W., Carpio, L. R., Newton, A. C. & Westendorf, J. J., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 16272-16280 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Epigenetic control of skeletal development by the histone methyltransferase Ezh2

Dudakovic, A., Camilleri, E. T., Xu, F., Riester, S. M., McGee-Lawrence, M. E., Bradley, E. W., Paradise, C. R., Lewallen, E. A., Thaler, R., Deyle, D. R., Larson, A. N., Lewallen, D. G., Dietz, A. B., Stein, G. S., Montecino, M. A., Westendorf, J. J. & Van Wijnen, A. J., Nov 13 2015, In : Journal of Biological Chemistry. 290, 46, p. 27604-27617 14 p.

Research output: Contribution to journalArticle

63 Scopus citations

Histone deacetylase 7 (Hdac7) suppresses chondrocyte proliferation and β-catenin activity during endochondral ossification

Bradley, E. W., Carpio, L. R., Olson, E. N. & Westendorf, J. J., Jan 2 2015, In : Journal of Biological Chemistry. 290, 1, p. 118-126 9 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Histone deacetylases in bone development and skeletal disorders

Bradley, E. W., Carpio, L. R., Van Wijnen, A. J., McGee-Lawrence, M. E. & Westendorf, J. J., Sep 9 2015, In : Physiological Reviews. 95, 4, p. 1359-1381 23 p.

Research output: Contribution to journalArticle

50 Scopus citations
2014

Runx2 is required for early stages of endochondral bone formation but delays final stages of bone repair in Axin2-deficient mice

McGee-Lawrence, M. E., Carpio, L. R., Bradley, E. W., Dudakovic, A., Lian, J. B., van Wijnen, A. J., Kakar, S., Hsu, W. & Westendorf, J. J., Sep 2014, In : Bone. 66, p. 277-286 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Histone deacetylase 3 is required for maintenance of bone mass during aging

McGee-Lawrence, M. E., Bradley, E. W., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Jan 1 2013, In : Bone. 52, 1, p. 296-307 12 p.

Research output: Contribution to journalArticle

48 Scopus citations
Open Access
46 Scopus citations
2011

Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway

Bradley, E. W. & Drissi, M. H., Jun 1 2011, In : Journal of Cellular Physiology. 226, 6, p. 1683-1693 11 p.

Research output: Contribution to journalArticle

42 Scopus citations
2010

Transforming growth factor-β coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis

Ruan, M., Pederson, L., Bradley, E. W., Bamberger, A. M. & Oursler, M. J., Apr 1 2010, In : Endocrinology. 151, 4, p. 1713-1722 10 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-κB pathways

Bradley, E. W. & Drissi, M. H., Aug 1 2010, In : Molecular Endocrinology. 24, 8, p. 1581-1593 13 p.

Research output: Contribution to journalArticle

Open Access
79 Scopus citations
2008
Open Access
34 Scopus citations

PAK1 is a novel MEK-independent Raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival

Bradley, E. W., Ruan, M. M. & Oursler, M. J., Dec 1 2008, In : Journal of Cellular Physiology. 217, 3, p. 752-758 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pathway crosstalk between Ras/RAF and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival

Bradley, E. W., Ruan, M. M., Vrable, A. & Oursler, M. J., Jul 1 2008, In : Journal of Cellular Biochemistry. 104, 4, p. 1439-1451 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

Gingery, A., Bradley, E. W., Pederson, L., Ruan, M., Horwood, N. J. & Oursler, M. J., Sep 10 2008, In : Experimental Cell Research. 314, 15, p. 2725-2738 14 p.

Research output: Contribution to journalArticle

126 Scopus citations
2005

Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis

Oursler, M. J., Bradley, E. W., Elfering, S. L. & Giulivi, C., Jan 1 2005, In : American Journal of Physiology - Cell Physiology. 288, 1 57-1, p. C156-C168

Research output: Contribution to journalArticle

30 Scopus citations
2003

Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFκB pathways to maintain osteoclast survival

Gingery, A., Bradley, E., Shaw, A. K. & Oursler, M. J., May 1 2003, In : Journal of Cellular Biochemistry. 89, 1, p. 165-179 15 p.

Research output: Contribution to journalArticle

138 Scopus citations