Projects per year
Personal profile
Research interests
My graduate training focused on osteoclast cell biology, specifically on signaling that represses osteoclast apoptosis. I then continued with a cell signaling emphasis during my post-doctoral training, but shifted to study chondrocyte cell biology, cartilage development and osteoarthritis pathophysiology. This work examined functions of Hdac3 and Phlpp1, two chromatin modifiers, in cartilage development. It also refined my molecular and epigenetic techniques. During this time I was awarded two training grants, an F32 post-doctoral fellowship and a K01 Career Development Award. In my K01 mentored work, we were the first to demonstrate that the protein phosphatase Phlpp1 controls bone mass accrual and maintenance. In these studies, we found that Phlpp1 contributes to cartilage development and OA and have also contributed to our understanding of how transcription of the Phlpp1 gene is epigenetically controlled. Simultaneously, we were amongst the first to demonstrate the importance of histone deacetylases in cartilage development.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Mayo Clinic
Award Date: Jun 3 2008
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Collaborations and top research areas from the last five years
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Cellular Mechanisms of Age-Associated Cortical Bone Remodeling
Bradley, E. W. (PI)
NIH NIAMS NATL INST OF ARTHRIT
9/20/24 → 8/31/26
Project: Research project
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Characterization of Mandibular Osteoclast Progenitors during Physiological and Bone Healing
Mansky, K. (PI) & Bradley, E. W. (CoI)
1/1/23 → 12/31/24
Project: Research project
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Functions of the PH-Domain Leucine Rich Protein Phosphatase (Phlpp) 1 in Osteoclasts
Bradley, E. W. (PI)
NIH NIAMS NATL INST OF ARTHRIT
9/21/17 → 7/31/23
Project: Research project
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Postnatal deletion of Phlpp1 in chondrocytes delays post-traumatic osteoarthritis in male mice
Weaver, S. R., Arnold, K. M., Peralta-Herrera, E., Oviedo, M., Zars, E. L., Bradley, E. W. & Westendorf, J. J., Mar 2025, In: Osteoarthritis and Cartilage Open. 7, 1, 100525.Research output: Contribution to journal › Article › peer-review
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Girk3 deletion increases osteoblast maturation and bone mass accrual in adult male mice
Weaver, S. R., Torres, H. M., Arnold, K. M., Zars, E. L., Peralta-Herrera, E., Taylor, E. L., Yu, K., de Velasco, E. M. F., Wickman, K., McGee-Lawrence, M. E., Bradley, E. W. & Westendorf, J. J., Oct 1 2024, In: JBMR Plus. 8, 10, ziae108.Research output: Contribution to journal › Article › peer-review
Open Access -
Hdac3 deficiency limits periosteal reaction associated with Western diet feeding in female mice
Vu, E. K., Karkache, I. Y., Pham, A., Koroth, J. & Bradley, E. W., Sep 2024, In: Journal of Cellular and Molecular Medicine. 28, 17, e70081.Research output: Contribution to journal › Article › peer-review
Open Access -
Mouse mandibular-derived osteoclast progenitors have differences in intrinsic properties compared with femoral-derived progenitors
Clark, R., Park, S. Y., Bradley, E. W., Mansky, K. & Tasca, A., May 2024, In: JBMR Plus. 8, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Phlpp1 alters the murine chondrocyte phospho-proteome during endochondral bone formation
Weaver, S. R., Peralta-Herrera, E., Torres, H. M., Jessen, E., Bradley, E. W. & Westendorf, J. J., Dec 2024, In: Bone. 189, 117265.Research output: Contribution to journal › Article › peer-review