Elizabeth W Bradley

Assistant Professor, Stem Cell Institute

Accepting PhD Students


Research activity per year

Personal profile

Research interests

My graduate training focused on osteoclast cell biology, specifically on signaling that represses osteoclast apoptosis.  I then continued with a cell signaling emphasis during my post-doctoral training, but shifted to study chondrocyte cell biology, cartilage development and osteoarthritis pathophysiology. This work examined functions of Hdac3 and Phlpp1, two chromatin modifiers, in cartilage development.  It also refined my molecular and epigenetic techniques.  During this time I was awarded two training grants, an F32 post-doctoral fellowship and a K01 Career Development Award.  In my K01 mentored work, we were the first to demonstrate that the protein phosphatase Phlpp1 controls bone mass accrual and maintenance.  In these studies, we found that Phlpp1 contributes to cartilage development and OA and have also contributed to our understanding of how transcription of the Phlpp1 gene is epigenetically controlled. Simultaneously, we were amongst the first to demonstrate the importance of histone deacetylases in cartilage development. 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

PhD, Mayo Clinic

Award Date: Jun 3 2008


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