Elizabeth W Bradley

Assistant Professor, Stem Cell Institute

Accepting PhD Students


Research output per year

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Personal profile

Research interests

My graduate training focused on osteoclast cell biology, specifically on signaling that represses osteoclast apoptosis.  I then continued with a cell signaling emphasis during my post-doctoral training, but shifted to study chondrocyte cell biology, cartilage development and osteoarthritis pathophysiology. This work examined functions of Hdac3 and Phlpp1, two chromatin modifiers, in cartilage development.  It also refined my molecular and epigenetic techniques.  During this time I was awarded two training grants, an F32 post-doctoral fellowship and a K01 Career Development Award.  In my K01 mentored work, we were the first to demonstrate that the protein phosphatase Phlpp1 controls bone mass accrual and maintenance.  In these studies, we found that Phlpp1 contributes to cartilage development and OA and have also contributed to our understanding of how transcription of the Phlpp1 gene is epigenetically controlled. Simultaneously, we were amongst the first to demonstrate the importance of histone deacetylases in cartilage development. 

Education/Academic qualification

PhD, Mayo Clinic

Award Date: Jun 3 2008

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  • Research Output

    Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice

    Mattson, A. M., Begun, D. L., Molstad, D. H. H., Meyer, M. A., Oursler, M. J., Westendorf, J. J. & Bradley, E. W., Jan 1 2019, In : Journal of Biological Chemistry. 294, 31, p. 11772-11784 13 p.

    Research output: Contribution to journalArticle

  • Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice

    Zhang, C., Smith, M. P., Zhou, G. K., Lai, A., Hoy, R. C., Mroz, V., Torre, O. M., Laudier, D. M., Bradley, E. W., Westendorf, J. J., Iatridis, J. C. & Illien-Jünger, S., Oct 1 2019, In : Cell Death and Disease. 10, 10, 754.

    Research output: Contribution to journalArticle

    Open Access
  • 1 Scopus citations

    DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes

    Castillejo Becerra, C. M., Mattson, A. M., Molstad, D. H. H., Lorang, I. M., Westendorf, J. J. & Bradley, E. W., Sep 2018, In : Journal of Cellular Biochemistry. 119, 9, p. 7470-7478 9 p.

    Research output: Contribution to journalArticle

    Open Access
  • Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

    McGee-Lawrence, M. E., Pierce, J. L., Yu, K., Culpepper, N. R., Bradley, E. W. & Westendorf, J. J., Apr 2018, In : Journal of Cellular Physiology. 233, 4, p. 2671-2680 10 p.

    Research output: Contribution to journalArticle

    Open Access
  • 2 Scopus citations

    Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development

    Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano-Garces, C., Paradise, C. R., Bradley, E. W., McGee-Lawrence, M. E., Im, H. J., Karperien, M., Krych, A. J., Westendorf, J. J., Noelle Larson, A. & Van Wijnen, A. J., Jan 1 2018, In : Journal of Biological Chemistry. 293, 49, p. 19001-19011 11 p.

    Research output: Contribution to journalArticle

    Open Access
  • 4 Scopus citations